-
1
المؤلفون: Michael J. Sofia, Ralph T. Mosley, Thomas E. Edwards, Eisuke Murakami, Michael J. Otto, Phillip A. Furman, Christopher Lugo, Angela M. Lam, Shalini Bansal, Haiying Bao
المصدر: Antimicrobial Agents and Chemotherapy. 58:6861-6869
مصطلحات موضوعية: Viral protein, viruses, Guanosine Monophosphate, RNA-dependent RNA polymerase, Hepacivirus, Viral Nonstructural Proteins, Crystallography, X-Ray, Virus Replication, medicine.disease_cause, Antiviral Agents, chemistry.chemical_compound, Drug Resistance, Viral, medicine, Humans, Pharmacology (medical), Replicon, NS5B, Polymerase, Pharmacology, biology, RNA-Binding Proteins, RNA, Nucleosides, Resistance mutation, Cyclic P-Oxides, Protein Structure, Tertiary, Infectious Diseases, chemistry, Biochemistry, Viral replication, biology.protein, RNA, Viral
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::564c24caade73b95b2365c7c335225a6
https://doi.org/10.1128/aac.03847-14 -
2
المؤلفون: Meg Keilman, Angela M. Lam, Michael J. Otto, Shalini Bansal, Ralph T. Mosley, Wonsuk Chang, Phillip A. Furman, Michael J. Sofia
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:2938-2942
مصطلحات موضوعية: Models, Molecular, Isostere, Stereochemistry, Peptidomimetic, viruses, Clinical Biochemistry, Pharmaceutical Science, Peptide, Hepacivirus, Alkenes, Viral Nonstructural Proteins, Biochemistry, Turn (biochemistry), Drug Discovery, Humans, Moiety, Replicon, NS5A, Cytotoxicity, Molecular Biology, chemistry.chemical_classification, Chemistry, Organic Chemistry, virus diseases, Hydrogen Bonding, Fluorine, biochemical phenomena, metabolism, and nutrition, digestive system diseases, Molecular Medicine, Peptidomimetics
-
3
المؤلفون: Michael J. Sofia, Michael J. Otto, Peiyuan Wang, Phillip A. Furman, Congrong Niu, Ralph T. Mosley, Devan Naduthambi
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:4642-4647
مصطلحات موضوعية: Hepatitis B virus, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Carboxamide, Crystallography, X-Ray, medicine.disease_cause, Antiviral Agents, Biochemistry, Chemical synthesis, Cell Line, Structure-Activity Relationship, Isomerism, Orthohepadnavirus, Drug Discovery, medicine, Humans, Molecular Biology, biology, Chemistry, Organic Chemistry, biology.organism_classification, Amides, E-Z notation, Mechanism of action, Hepadnaviridae, Molecular Medicine, medicine.symptom, Cis–trans isomerism
-
4
المؤلفون: Michael J. Sofia, Phillip A. Furman, Jinfa Du, Ralph T. Mosley, Haiying Bao, Eisuke Murakami
المصدر: Journal of Medicinal Chemistry. 54:5902-5914
مصطلحات موضوعية: Purine, Molecular Sequence Data, Purine nucleoside phosphorylase, Nucleoside Deaminases, Substrate Specificity, chemistry.chemical_compound, Adenosine deaminase, Aminohydrolases, Sequence Analysis, Protein, Cell Line, Tumor, Drug Discovery, medicine, Humans, Nucleotide, Amino Acid Sequence, Cloning, Molecular, Phosphorylation, 2-Aminopurine, Aminohydrolase, chemistry.chemical_classification, Molecular Structure, Sequence Homology, Amino Acid, biology, Hydrolysis, Nucleotidyltransferase, Adenosine, Adenosine Monophosphate, Recombinant Proteins, Isoenzymes, Molecular Weight, Kinetics, Zinc, Biochemistry, chemistry, Purines, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Biocatalysis, biology.protein, Molecular Medicine, Electrophoresis, Polyacrylamide Gel, Nucleoside, medicine.drug
-
5
المؤلفون: Aleksandr Petrov, Lihu Yang, Ralph T. Mosley, Carina P. Tan, George J. Eiermann, Joel P. Berger, Sanjeev Kumar, Peter T. Meinke, Eric Chang, Sander G. Mills, Nancy A. Thornberry, Cheng Tang, Monica Einstein, Eric Cline, Yun-Ping Zhou, Min Ge, Songnian Lin, Andrew D. Howard, Yue Feng, Changyou Zhou, Taro E. Akiyama, Gino Salituro
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:1298-1301
مصطلحات موضوعية: Agonist, endocrine system, medicine.medical_specialty, medicine.drug_class, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Receptors, G-Protein-Coupled, Mice, Structure-Activity Relationship, Pharmacokinetics, Oral administration, Internal medicine, Free fatty acid receptor 1, Diabetes mellitus, Drug Discovery, medicine, Animals, Molecular Biology, Pancreatic hormone, Mice, Knockout, Glucose tolerance test, medicine.diagnostic_test, Chemistry, Insulin, Organic Chemistry, medicine.disease, Endocrinology, Molecular Medicine, Thiazolidinediones, Protein Binding
-
6
المؤلفون: Ralph T. Mosley, Jason E. Imbriglio, Steven L. Colletti, Nancy N. Tsou, Subharekha Raghavan, Daniel A. DiRocco, James R. Tata, Richard G. Ball
المصدر: Tetrahedron Letters. 49:4897-4900
مصطلحات موضوعية: chemistry.chemical_classification, chemistry, Scope (project management), Stereochemistry, Organic Chemistry, Drug Discovery, Molecule, Biochemistry, Combinatorial chemistry, Amino acid
-
7
المؤلفون: Lihu Yang, Ralph T. Mosley, Peter T. Meinke, Yue Feng, Nancy A. Thornberry, Monica Einstein, Carina P. Tan, George J. Eiermann, Changyou Zhou, Sander G. Mills, Sanjeev Kumar, Songnian Lin, Andrew D. Howard, Joel P. Berger, Aleksandr Petrov, Yun Ping Zhou, Gino Salituro, Taro E. Akiyama
المصدر: Diabetes
مصطلحات موضوعية: Blood Glucose, Male, Agonist, endocrine system, medicine.medical_specialty, medicine.drug_class, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, CHO Cells, Inositol 1,4,5-Trisphosphate, Type 2 diabetes, Fatty Acids, Nonesterified, In Vitro Techniques, Biology, Cell Line, Diabetes Mellitus, Experimental, Receptors, G-Protein-Coupled, Islets of Langerhans, Mice, Cricetulus, Pregnancy, Cricetinae, Internal medicine, Free fatty acid receptor 1, Diabetes mellitus, Insulin Secretion, Internal Medicine, medicine, Animals, Humans, Insulin, Obesity, Rats, Wistar, Receptor, Pancreatic hormone, Mice, Knockout, geography, geography.geographical_feature_category, Fatty Acids, Islet, medicine.disease, Dietary Fats, Pharmacology and Therapeutics, Rats, Mice, Inbred C57BL, Endocrinology, Animals, Newborn, Female
-
8
المؤلفون: Susan P. Rohrer, Sheng Jian Cai, James Schaeffer, Elizabeth T. Birzin, J. Don Chen, Osvaldo A. Flores, Paul Zuck, Ralph T. Mosley, Michael J. Chisamore, Hilary A. Wilkinson, Gregory O'Donnell
المصدر: Drug Development Research. 69:203-218
مصطلحات موضوعية: Estrogen-related receptor, Estrogen-related receptor alpha, Nuclear receptor, Biochemistry, Docking (molecular), Drug Discovery, Coactivator, Estrogen receptor, Homology modeling, Biology, Receptor
-
9
المؤلفون: Harold B. Wood, Monica Einstein, Taro E. Akiyama, Joseph W. Becker, Peter T. Meinke, Joel P. Berger, Chuanlin F. Wang, Brian M. McKeever, Gino Castriota, Ralph T. Mosley, David E. Moller
المصدر: Molecular Pharmacology. 73:62-74
مصطلحات موضوعية: Pharmacology, chemistry.chemical_classification, medicine.drug_class, Cell, Peroxisome proliferator-activated receptor, Peroxisome, Biology, Ligands, Partial agonist, Cell biology, PPAR gamma, medicine.anatomical_structure, Biochemistry, chemistry, Adipogenesis, medicine, Humans, Tyrosine, Molecular Medicine, Thiazolidinedione, Rosiglitazone, Receptor, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c89a57730ac5b84482512bdee574b0b8
https://doi.org/10.1124/mol.107.041202 -
10
المؤلفون: Sandro Belvedere, Liqiang Chen, J. Paul Secrist, Thomas A. Miller, Ralph T. Mosley, David J. Witter
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:4562-4567
مصطلحات موضوعية: Models, Molecular, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Thiophenes, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Thiophene, Combinatorial Chemistry Techniques, Computer Simulation, Molecular Biology, Vorinostat, Hydroxamic acid, Molecular Structure, Chemistry, Organic Chemistry, Histone deacetylase inhibitor, Small molecule, HDAC1, Histone Deacetylase Inhibitors, Molecular Medicine, Histone deacetylase, medicine.drug