المؤلفون: Estefanía Méndez-Álvarez, Antón Cruces-Sande, Ramón Soto-Otero

المصدر: Journal of Neurochemistry. 141:738-749

مصطلحات موضوعية: Male, 0301 basic medicine, Time Factors, Ascorbic Acid, medicine.disease_cause, Protein oxidation, Biochemistry, Antioxidants, Statistics, Nonparametric, Rats, Sprague-Dawley, Lipid peroxidation, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Adrenergic Agents, Oxygen Consumption, 0302 clinical medicine, medicine, Animals, Neurotoxin, Oxidopamine, Hydroxydopamine, Chemistry, Dopaminergic, Neurotoxicity, Brain, Drug Synergism, Hydrogen Peroxide, Glutathione, medicine.disease, Mitochondria, Rats, Oxidative Stress, 030104 developmental biology, nervous system, Biophysics, Lipid Peroxidation, Oxidation-Reduction, Copper, 030217 neurology & neurosurgery, Oxidative stress

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a05c865cceced1e74011d381df6e126
https://doi.org/10.1111/jnc.14019

المؤلفون: Roberta Farina, Cosimo Altomare, Rosa Maria Iacobazzi, Orazio Nicolotti, Leonardo Pisani, Saverio Cellamare, Angelo Carotti, Giuseppe Felice Mangiatordi, Marco Catto, Nunzio Denora, Ramón Soto-Otero, Lydia Siragusa

المصدر: Journal of medicinal chemistry 59 (2016): 6791–6806. doi:10.1021/acs.jmedchem.6b00562
info:cnr-pdr/source/autori:Pisani, Leonardo; Farina, Roberta; Catto, Marco; Iacobazzi, Rosa Maria; Nicolotti, Orazio; Cellamare, Saverio; Mangiatordi, Giuseppe Felice; Denora, Nunzio; Soto-Otero, Ramon; Siragusa, Lydia; Altomare, Cosimo Damian; Carotti, Angelo/titolo:Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents/doi:10.1021%2Facs.jmedchem.6b00562/rivista:Journal of medicinal chemistry/anno:2016/pagina_da:6791/pagina_a:6806/intervallo_pagine:6791–6806/volume:59

مصطلحات موضوعية: 0301 basic medicine, Monoamine Oxidase Inhibitors, Cell Survival, Monoamine oxidase, 01 natural sciences, Neuroprotection, Madin Darby Canine Kidney Cells, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Dogs, Coumarins, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, Cytotoxicity, Monoamine Oxidase, IC50, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Water, Rotenone, Acetylcholinesterase, 0104 chemical sciences, Oxidative Stress, Neuroprotective Agents, 030104 developmental biology, Solubility, chemistry, Biochemistry, Molecular Medicine, Cholinesterase Inhibitors, Monoamine oxidase B, Medicinal Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fd602b86f863e6fb085cd996912bed9
https://doi.org/10.1021/acs.jmedchem.6b00562

المؤلفون: Javier Iglesias-Gonzalez, Sofía Sánchez-Iglesias, Andrés Beiras-Iglesias, Estefanía Méndez-Álvarez, Ramón Soto-Otero

المصدر: Molecular Neurobiology. 54:563-570

مصطلحات موضوعية: Male, 0301 basic medicine, Parkinson's disease, Antioxidant, Bioenergetics, medicine.medical_treatment, Neuroscience (miscellaneous), Oxidative phosphorylation, Biology, Pharmacology, Mitochondrion, medicine.disease_cause, Membrane Potentials, Rats, Sprague-Dawley, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, medicine, Animals, Body Weight, Dopaminergic, Neurodegeneration, medicine.disease, Mitochondria, Rats, Oxidative Stress, 030104 developmental biology, Neurology, Biochemistry, Energy Metabolism, 030217 neurology & neurosurgery, Oxidative stress, Aluminum

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::337039c1bf454c0cddde9ada65702252
https://doi.org/10.1007/s12035-015-9650-z

المؤلفون: Jose L. Labandeira-Garcia, Ana I. Rodriguez-Perez, Ramón Soto-Otero, Paloma Herbello-Hermelo, Estefanía Méndez-Álvarez, Pilar Bermejo-Barrera, Antón Cruces-Sande

المصدر: Molecular neurobiology. 56(4)

مصطلحات موضوعية: 0301 basic medicine, Male, medicine.medical_specialty, Parkinson's disease, Neuroscience (miscellaneous), Striatum, medicine.disease_cause, Thiobarbituric Acid Reactive Substances, Rats, Sprague-Dawley, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, medicine, Animals, Oxidopamine, chemistry.chemical_classification, Hydroxydopamine, Glutathione Peroxidase, Glutathione peroxidase, Dopaminergic Neurons, Neurodegeneration, Dopaminergic, Brain, Parkinson Disease, Glutathione, medicine.disease, Catalase, Disease Models, Animal, Oxidative Stress, 030104 developmental biology, Endocrinology, Neurology, chemistry, Nerve Degeneration, Lipid Peroxidation, Oxidation-Reduction, 030217 neurology & neurosurgery, Oxidative stress, Biomarkers, Copper

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b13095dafaa1e0e576233fbfeb498bc
https://pubmed.ncbi.nlm.nih.gov/30066305

المؤلفون: Leonardo Pisani, Ramón Soto-Otero, Roberta Farina, Marco Catto, Angelo Carotti, Estefanía Méndez-Álvarez, Orazio Nicolotti, Domenico Gadaleta, Mario Di Braccio

المصدر: European Journal of Medicinal Chemistry. 89:98-105

مصطلحات موضوعية: Male, Models, Molecular, Steric effects, Monoamine Oxidase Inhibitors, Stereochemistry, In silico, Quantitative Structure-Activity Relationship, Crystallography, X-Ray, Rats, Sprague-Dawley, Drug Discovery, Animals, Potency, Computer Simulation, Homology modeling, Monoamine Oxidase, Pharmacology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, General Medicine, Rats, Chromones, Docking (molecular), Drug Design, Chromen-2-one, Monoamine oxidase B, Selectivity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e9e1a976a485c2676a71ddf228e596
https://doi.org/10.1016/j.ejmech.2014.10.029

المؤلفون: Javier Iglesias-Gonzalez, Ramón Soto-Otero, Andrés Beiras-Iglesias, Estefanía Méndez-Álvarez, Sofía Sánchez-Iglesias

المصدر: Journal of Neuroscience Methods. 213:39-42

مصطلحات موضوعية: Male, Sucrose, Citrate (si)-Synthase, Mitochondrion, Biology, Cell Fractionation, medicine.disease_cause, Electron Transport Complex IV, Rats, Sprague-Dawley, chemistry.chemical_compound, Oxygen Consumption, Respiration, medicine, Animals, Distribution (pharmacology), Chelation, Egtazic Acid, Edetic Acid, Chelating Agents, Brain Chemistry, Differential centrifugation, L-Lactate Dehydrogenase, General Neuroscience, Brain, Mitochondria, Rats, Microscopy, Electron, EGTA, chemistry, Biochemistry, Biomarkers, Oxidative stress

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29679ff436e9eb80929498a47cf874e8
https://doi.org/10.1016/j.jneumeth.2012.12.005

المؤلفون: José L. Domínguez, Fernando Fernández-Nieto, Marco Catto, Silvia Porto, M. Carmen Villaverde, M. Rita Paleo, Ramón Soto-Otero, Fredy Sussman, Marián Castro, F. Javier Sardina, Estefanía Méndez-Álvarez, Angelo Carotti, Leonardo Pisani, José Brea

المساهمون: Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares, Universidade de Santiago de Compostela. Departamento de Química Orgánica

المصدر: Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname

مصطلحات موضوعية: 0301 basic medicine, Computational chemistry, Aché, Stereochemistry, Chemistry, General Chemistry, Alzheimer's disease, Coumarin, First generation, language.human_language, Drug design, Multitarget leads, 03 medical and health sciences, Inhibitory potency, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, 8-aminomethyl-7-hydroxy-4-methylcoumarins, Docking (molecular), 030220 oncology & carcinogenesis, language, Cholinesterases inhibition, Potency, Pharmacophore

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb512f5bfb77d465ec6aeba578abba0
https://hdl.handle.net/10347/16984

المؤلفون: Ramón Soto-Otero, Estefanía Méndez-Álvarez, Roberta Farina, Leonardo Pisani, Nunzio Denora, Giuseppe Felice Mangiatordi, Marco Catto, Cosimo Altomare, Angelo Carotti, Orazio Nicolotti

المساهمون: Universidade de Santiago de Compostela. Departamento de Bioquímica e Bioloxía Molecular

المصدر: Molecules
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname
Molecules (Basel, Online) 21 (2016). doi:10.3390/molecules21030362
info:cnr-pdr/source/autori:Pisani, Leonardo; Farina, Roberta; Soto-Otero, Ramon; Denora, Nunzio; Mangiatordi, Giuseppe Felice; Nicolotti, Orazio; Mendez-Alvarez, Estefania; Altomare, Cosimo Damiano; Catto, Marco; Carotti, Angelo/titolo:Searching for multi-targeting neurotherapeutics against Alzheimer's: Discovery of potent AChE-MAO B inhibitors through the decoration of the 2H-Chromen-2-one structural motif/doi:10.3390%2Fmolecules21030362/rivista:Molecules (Basel, Online)/anno:2016/pagina_da:/pagina_a:/intervallo_pagine:/volume:21
Molecules, Vol 21, Iss 3, p 362 (2016)
Molecules; Volume 21; Issue 3; Pages: 362

مصطلحات موضوعية: 0301 basic medicine, cholinesterase inhibitors, Monoamine Oxidase Inhibitors, Multi-target-directed ligands, Pharmaceutical Science, Alzheimer’s disease, coumarins, MAO inhibitors, multi-target-directed ligands, Pharmacology, 01 natural sciences, Neuroprotection, Article, Analytical Chemistry, Cell Line, lcsh:QD241-441, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, lcsh:Organic chemistry, Coumarins, Alzheimer Disease, Drug Discovery, Structure–activity relationship, Animals, Humans, Physical and Theoretical Chemistry, Cytotoxicity, IC50, Molecular Structure, 010405 organic chemistry, Drug discovery, Chemistry, Organic Chemistry, Cholinesterase inhibitors, Alzheimer's disease, Acetylcholinesterase, 0104 chemical sciences, Enzyme Activation, 030104 developmental biology, Biochemistry, Chemistry (miscellaneous), Molecular Medicine, Efflux, Monoamine oxidase B

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::111b44ae89ec4a116763ea115b9b380d
http://europepmc.org/articles/PMC6273473

المؤلفون: Atsuko Hikima, Sarah Rose, Ramón Soto-Otero, Sofía Sánchez-Iglesias, Estefanía Méndez-Álvarez, Peter Jenner, Javier Iglesias-Gonzalez

المصدر: Neurochemical Research. 37:2150-2160

مصطلحات موضوعية: Male, Programmed cell death, animal structures, SH-SY5Y, Oxidative phosphorylation, Mitochondrion, Pharmacology, Biology, medicine.disease_cause, Biochemistry, Rats, Sprague-Dawley, Superoxide dismutase, Neuroblastoma, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Cell Line, Tumor, medicine, Animals, Humans, Oxidopamine, Superoxide Dismutase, Superoxide, Neurodegeneration, Brain, General Medicine, Catalase, medicine.disease, Molecular biology, Mitochondria, Rats, nervous system, chemistry, biology.protein, Oxidative stress

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e87cf91bda8a28440e1b12d70f0bd6
https://doi.org/10.1007/s11064-012-0838-6

المؤلفون: Ramón Soto-Otero, Alexey V. Varlamov, Filomena Fiorella, Fedor I. Zubkov, Leonid G. Voskressensky, Sofía Sánchez-Iglesias, Jose L. Labandeira-Garcia, Vladimir P. Zaytsev, Jannette Rodriguez-Pallares, Modesto de Candia, Estefanía Méndez-Álvarez, Cosimo Altomare

المصدر: Archiv der Pharmazie. 345:598-609

مصطلحات موضوعية: Primary Cell Culture, Pharmaceutical Science, Nigrostriatal pathway, Cell Count, Neuroprotection, Benzazepine, Cyclic N-Oxides, Protein Carbonylation, Lipid peroxidation, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, TBARS, Animals, Parkinson Disease, Secondary, Oxidopamine, Cells, Cultured, Hydroxydopamine, Molecular Structure, Chemistry, Dopaminergic Neurons, Neurodegeneration, Dopaminergic, Brain, Benzazepines, medicine.disease, Mitochondria, Disease Models, Animal, Oxidative Stress, Neuroprotective Agents, medicine.anatomical_structure, Biochemistry, Nitrogen Oxides, Cholinesterase Inhibitors, Lipid Peroxidation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3e182a6d41f1764394a88ef54aa3bca
https://doi.org/10.1002/ardp.201200007