المؤلفون: Lin C; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., McCarthy CP; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Mohebi R; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Liu Y; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Blankstein R; Cardiovascular Division, Department of Medicine and Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA., Murphy SP; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Miksenas H; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Rogers C; HeartFlow Inc, Mountain View, California, USA., Amponsah DK; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Rambarat PK; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Raghavan A; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Levin A; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Ghoshhajra B; Division of Cardiovascular Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA., Wasfy JH; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Hedgire S; Division of Cardiovascular Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA., Januzzi JL Jr; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Heart Failure and Biomarker Clinical Trials, Baim Institute for Clinical Research, Boston, Massachusetts, USA.

المصدر: JACC. Advances [JACC Adv] 2023 Dec 22; Vol. 3 (2), pp. 100795. Date of Electronic Publication: 2023 Dec 22 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 9918419284106676 Publication Model: eCollection Cited Medium: Internet ISSN: 2772-963X (Electronic) Linking ISSN: 2772963X NLM ISO Abbreviation: JACC Adv Subsets: PubMed not MEDLINE

المؤلفون: Ma JI; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston (J.I.M., E.P., M.H.P.)., Zern EK; Providence Heart Institute, Center for Cardiovascular Analytics, Research, and Data Science (CARDS), Providence St. Joseph Health, Portland, OR (E.K.Z.)., Parekh JK; Cardiovascular Institute and Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (J.K.P., N.O., N.J., D.W., J.E.H.)., Owunna N; Cardiovascular Institute and Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (J.K.P., N.O., N.J., D.W., J.E.H.)., Jiang N; Cardiovascular Institute and Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (J.K.P., N.O., N.J., D.W., J.E.H.)., Wang D; Cardiovascular Institute and Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (J.K.P., N.O., N.J., D.W., J.E.H.).; Department of Biostatistics, Boston University School of Public Health, MA (D.W.)., Rambarat PK; Division of Cardiology, Duke University Medical Center, Durham, NC (P.K.R.)., Pomerantsev E; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston (J.I.M., E.P., M.H.P.)., Picard MH; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston (J.I.M., E.P., M.H.P.)., Ho JE; Cardiovascular Institute and Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (J.K.P., N.O., N.J., D.W., J.E.H.).

المصدر: Circulation. Heart failure [Circ Heart Fail] 2023 Nov; Vol. 16 (11), pp. e010524. Date of Electronic Publication: 2023 Oct 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 101479941 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1941-3297 (Electronic) Linking ISSN: 19413289 NLM ISO Abbreviation: Circ Heart Fail Subsets: MEDLINE

مواضيع طبية MeSH: Ventricular Dysfunction, Right* , Heart Failure* , Stroke*, Humans ; Female ; Middle Aged ; Male ; Retrospective Studies ; Pulmonary Artery ; Obesity/complications ; Ventricular Function, Right

المؤلفون: McCarthy CP; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA. Electronic address: https://twitter.com/CianPMcCarthy., Murphy SP; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Amponsah DK; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Rambarat PK; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Lin C; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Liu Y; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Mohebi R; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Levin A; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Raghavan A; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Miksenas H; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Rogers C; HeartFlow Inc, Mountain View, California, USA., Wasfy JH; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Blankstein R; Department of Medicine (Cardiovascular Division) and Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA., Ghoshhajra B; Division of Cardiovascular Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA., Hedgire S; Division of Cardiovascular Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA., Januzzi JL Jr; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA; Baim Institute for Clinical Research, Boston, Massachusetts, USA. Electronic address: jjanuzzi@mgh.harvard.edu.

المصدر: Journal of the American College of Cardiology [J Am Coll Cardiol] 2023 Oct 24; Vol. 82 (17), pp. 1676-1687. Date of Electronic Publication: 2023 Sep 29.

نوع المنشور: Clinical Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Biomedical Country of Publication: United States NLM ID: 8301365 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-3597 (Electronic) Linking ISSN: 07351097 NLM ISO Abbreviation: J Am Coll Cardiol Subsets: MEDLINE

مواضيع طبية MeSH: Anterior Wall Myocardial Infarction* , Coronary Artery Disease*/diagnostic imaging , Coronary Artery Disease*/epidemiology , Coronary Stenosis* , Fractional Flow Reserve, Myocardial*/physiology , Myocardial Infarction*/diagnostic imaging , Myocardial Infarction*/epidemiology , Plaque, Atherosclerotic*/complications , Plaque, Atherosclerotic*/diagnostic imaging , Plaque, Atherosclerotic*/epidemiology, Aged ; Female ; Humans ; Male ; Middle Aged ; Computed Tomography Angiography ; Constriction, Pathologic ; Coronary Angiography/methods ; Predictive Value of Tests ; Prospective Studies ; Tomography, X-Ray Computed

المؤلفون: Lee C; Division of Cardiology, Columbia University Irving Medical Center, NewYork-Presbyterian Hospital, New York, New York, USA., Drobni ZD; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Heart and Vascular Center, Semmelweis University, Budapest, Hungary., Zafar A; Division of Cardiovascular Diseases and Hypertension, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA., Gongora CA; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Zlotoff DA; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Alvi RM; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Taron J; Department of Radiology, University Hospital Freiburg, Freiburg, Germany., Rambarat PK; Department of Internal Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Schoenfeld S; Division of Rheumatology, Massachusetts General Hospital, Boston, Massachusetts, USA., Mosarla RC; Division of Cardiology, New York University, New York, New York, USA., Raghu VK; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Hartmann SE; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Gilman HK; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Murphy SP; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Sullivan RJ; Division of Oncology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Faje A; Division of Endocrinology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Hoffmann U; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Zhang L; Department of Cardiology, Department of Medicine, Montefiore Medical Center, Bronx, New York, USA., Mayrhofer T; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Reynolds KL; Division of Oncology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Neilan TG; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Cardio-Oncology Program, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.

المصدر: JACC. CardioOncology [JACC CardioOncol] 2022 Dec 20; Vol. 4 (5), pp. 660-669. Date of Electronic Publication: 2022 Dec 20 (Print Publication: 2022).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101761697 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-0873 (Electronic) Linking ISSN: 26660873 NLM ISO Abbreviation: JACC CardioOncol Subsets: PubMed not MEDLINE

المؤلفون: Pani B; Department of Medicine (B.P., S.A., S.V., A.W.K., A.L., B.N.V., D.P.S., R.J.L.), Department of Biochemistry (R.J.L.), and Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, North Carolina, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA (P.K.R.); and Viale America 111, Rome, Italy (T.C.)., Ahn S; Department of Medicine (B.P., S.A., S.V., A.W.K., A.L., B.N.V., D.P.S., R.J.L.), Department of Biochemistry (R.J.L.), and Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, North Carolina, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA (P.K.R.); and Viale America 111, Rome, Italy (T.C.)., Rambarat PK; Department of Medicine (B.P., S.A., S.V., A.W.K., A.L., B.N.V., D.P.S., R.J.L.), Department of Biochemistry (R.J.L.), and Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, North Carolina, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA (P.K.R.); and Viale America 111, Rome, Italy (T.C.)., Vege S; Department of Medicine (B.P., S.A., S.V., A.W.K., A.L., B.N.V., D.P.S., R.J.L.), Department of Biochemistry (R.J.L.), and Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, North Carolina, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA (P.K.R.); and Viale America 111, Rome, Italy (T.C.)., Kahsai AW; Department of Medicine (B.P., S.A., S.V., A.W.K., A.L., B.N.V., D.P.S., R.J.L.), Department of Biochemistry (R.J.L.), and Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, North Carolina, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA (P.K.R.); and Viale America 111, Rome, Italy (T.C.)., Liu A; Department of Medicine (B.P., S.A., S.V., A.W.K., A.L., B.N.V., D.P.S., R.J.L.), Department of Biochemistry (R.J.L.), and Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, North Carolina, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA (P.K.R.); and Viale America 111, Rome, Italy (T.C.)., Valan BN; Department of Medicine (B.P., S.A., S.V., A.W.K., A.L., B.N.V., D.P.S., R.J.L.), Department of Biochemistry (R.J.L.), and Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, North Carolina, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA (P.K.R.); and Viale America 111, Rome, Italy (T.C.)., Staus DP; Department of Medicine (B.P., S.A., S.V., A.W.K., A.L., B.N.V., D.P.S., R.J.L.), Department of Biochemistry (R.J.L.), and Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, North Carolina, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA (P.K.R.); and Viale America 111, Rome, Italy (T.C.)., Costa T; Department of Medicine (B.P., S.A., S.V., A.W.K., A.L., B.N.V., D.P.S., R.J.L.), Department of Biochemistry (R.J.L.), and Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, North Carolina, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA (P.K.R.); and Viale America 111, Rome, Italy (T.C.)., Lefkowitz RJ; Department of Medicine (B.P., S.A., S.V., A.W.K., A.L., B.N.V., D.P.S., R.J.L.), Department of Biochemistry (R.J.L.), and Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, North Carolina, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA (P.K.R.); and Viale America 111, Rome, Italy (T.C.) lefko001@receptor-biol.duke.edu.

المصدر: Molecular pharmacology [Mol Pharmacol] 2021 Nov; Vol. 100 (5), pp. 513-525. Date of Electronic Publication: 2021 Sep 27.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0035623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0111 (Electronic) Linking ISSN: 0026895X NLM ISO Abbreviation: Mol Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Receptors, Adrenergic, beta-2*/metabolism, Adrenergic beta-Antagonists/*pharmacology , Carvedilol/*pharmacology , beta-Arrestins/*pharmacology, Adrenergic beta-Antagonists/chemistry ; Adrenergic beta-Antagonists/metabolism ; Allosteric Regulation/drug effects ; Allosteric Regulation/physiology ; Animals ; Carvedilol/chemistry ; Carvedilol/metabolism ; Dose-Response Relationship, Drug ; HEK293 Cells ; Humans ; Sf9 Cells ; beta-Arrestins/chemistry ; beta-Arrestins/metabolism

المؤلفون: Drobni ZD; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary.; Cardio-Oncology Program, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Murphy SP; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Alvi RM; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Lee C; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Gong J; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Mosarla RC; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Rambarat PK; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Hartmann SB; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Gilman HK; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Zubiri L; Division of Oncology and Hematology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Raghu VK; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Sullivan RJ; Division of Oncology and Hematology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Zafar A; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Zlotoff DA; Cardio-Oncology Program, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Sise ME; Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Guidon AC; Division of Neuromuscular Medicine, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Reynolds KL; Division of Oncology and Hematology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Dougan M; Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Neilan TG; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Cardio-Oncology Program, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

المصدر: Immunotherapy advances [Immunother Adv] 2021 Jun 16; Vol. 1 (1), pp. ltab014. Date of Electronic Publication: 2021 Jun 16 (Print Publication: 2021).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 101776979 Publication Model: eCollection Cited Medium: Internet ISSN: 2732-4303 (Electronic) Linking ISSN: 27324303 NLM ISO Abbreviation: Immunother Adv Subsets: PubMed not MEDLINE

المؤلفون: Drobni ZD; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology (Z.D.D., R.M.A., J.T., A.Z., V.K.R., S.E.H., H.K.G., J.G., T.M., U.H., T.G.N.), Massachusetts General Hospital, Harvard Medical School, Boston.; Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary (Z.D.D.)., Alvi RM; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology (Z.D.D., R.M.A., J.T., A.Z., V.K.R., S.E.H., H.K.G., J.G., T.M., U.H., T.G.N.), Massachusetts General Hospital, Harvard Medical School, Boston., Taron J; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology (Z.D.D., R.M.A., J.T., A.Z., V.K.R., S.E.H., H.K.G., J.G., T.M., U.H., T.G.N.), Massachusetts General Hospital, Harvard Medical School, Boston.; Department of Radiology, University Hospital Freiburg, Freiburg, Germany (J.T.)., Zafar A; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology (Z.D.D., R.M.A., J.T., A.Z., V.K.R., S.E.H., H.K.G., J.G., T.M., U.H., T.G.N.), Massachusetts General Hospital, Harvard Medical School, Boston., Murphy SP; Division of Internal Medicine (S.P.M., P.K.R., R.C.M., C.L.), Massachusetts General Hospital, Harvard Medical School, Boston., Rambarat PK; Division of Internal Medicine (S.P.M., P.K.R., R.C.M., C.L.), Massachusetts General Hospital, Harvard Medical School, Boston., Mosarla RC; Division of Internal Medicine (S.P.M., P.K.R., R.C.M., C.L.), Massachusetts General Hospital, Harvard Medical School, Boston., Lee C; Division of Internal Medicine (S.P.M., P.K.R., R.C.M., C.L.), Massachusetts General Hospital, Harvard Medical School, Boston., Zlotoff DA; Division of Cardiology (D.A.Z., T.G.N.), Massachusetts General Hospital, Harvard Medical School, Boston., Raghu VK; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology (Z.D.D., R.M.A., J.T., A.Z., V.K.R., S.E.H., H.K.G., J.G., T.M., U.H., T.G.N.), Massachusetts General Hospital, Harvard Medical School, Boston., Hartmann SE; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology (Z.D.D., R.M.A., J.T., A.Z., V.K.R., S.E.H., H.K.G., J.G., T.M., U.H., T.G.N.), Massachusetts General Hospital, Harvard Medical School, Boston., Gilman HK; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology (Z.D.D., R.M.A., J.T., A.Z., V.K.R., S.E.H., H.K.G., J.G., T.M., U.H., T.G.N.), Massachusetts General Hospital, Harvard Medical School, Boston., Gong J; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology (Z.D.D., R.M.A., J.T., A.Z., V.K.R., S.E.H., H.K.G., J.G., T.M., U.H., T.G.N.), Massachusetts General Hospital, Harvard Medical School, Boston., Zubiri L; Division of Oncology and Hematology, Department of Medicine (L. Zubiri, R.J.S., K.L.R.), Massachusetts General Hospital, Harvard Medical School, Boston., Sullivan RJ; Division of Oncology and Hematology, Department of Medicine (L. Zubiri, R.J.S., K.L.R.), Massachusetts General Hospital, Harvard Medical School, Boston., Reynolds KL; Division of Oncology and Hematology, Department of Medicine (L. Zubiri, R.J.S., K.L.R.), Massachusetts General Hospital, Harvard Medical School, Boston., Mayrhofer T; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology (Z.D.D., R.M.A., J.T., A.Z., V.K.R., S.E.H., H.K.G., J.G., T.M., U.H., T.G.N.), Massachusetts General Hospital, Harvard Medical School, Boston.; School of Business Studies, Stralsund University of Applied Sciences, Stralsund, Germany (T.M.)., Zhang L; Cardio-Oncology Program, Division of Cardiology, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY (L. Zhang)., Hoffmann U; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology (Z.D.D., R.M.A., J.T., A.Z., V.K.R., S.E.H., H.K.G., J.G., T.M., U.H., T.G.N.), Massachusetts General Hospital, Harvard Medical School, Boston., Neilan TG; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology (Z.D.D., R.M.A., J.T., A.Z., V.K.R., S.E.H., H.K.G., J.G., T.M., U.H., T.G.N.), Massachusetts General Hospital, Harvard Medical School, Boston.; Division of Cardiology (D.A.Z., T.G.N.), Massachusetts General Hospital, Harvard Medical School, Boston.

المصدر: Circulation [Circulation] 2020 Dec 15; Vol. 142 (24), pp. 2299-2311. Date of Electronic Publication: 2020 Oct 02.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0147763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4539 (Electronic) Linking ISSN: 00097322 NLM ISO Abbreviation: Circulation Subsets: MEDLINE

مواضيع طبية MeSH: Plaque, Atherosclerotic*, Atherosclerosis/*epidemiology , Immune Checkpoint Inhibitors/*adverse effects , Ischemic Stroke/*epidemiology , Myocardial Infarction/*epidemiology , Neoplasms/*drug therapy, Academic Medical Centers ; Adrenal Cortex Hormones/therapeutic use ; Aged ; Atherosclerosis/diagnostic imaging ; Atherosclerosis/drug therapy ; Boston/epidemiology ; Disease Progression ; Female ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Ischemic Stroke/diagnostic imaging ; Ischemic Stroke/therapy ; Male ; Middle Aged ; Myocardial Infarction/diagnostic imaging ; Myocardial Infarction/therapy ; Myocardial Revascularization ; Neoplasms/diagnosis ; Neoplasms/epidemiology ; Prognosis ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Time Factors

المؤلفون: Liu X; Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Medicine, Tsinghua University, Beijing 100084, China., Masoudi A; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA., Kahsai AW; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA., Huang LY; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA., Pani B; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA., Staus DP; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA., Shim PJ; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA., Hirata K; Advanced Photon Technology Division, Research Infrastructure Group, SR Life Science Instrumentation Unit, RIKEN/SPring-8 Center, 1-1-1 Kouto Sayo-cho Sayo-gun, Hyogo 679-5148, Japan.; Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan., Simhal RK; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA., Schwalb AM; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA., Rambarat PK; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA., Ahn S; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA., Lefkowitz RJ; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. lefko001@receptor-biol.duke.edu kobilka@stanford.edu.; Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA., Kobilka B; Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Medicine, Tsinghua University, Beijing 100084, China. lefko001@receptor-biol.duke.edu kobilka@stanford.edu.; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA.

المصدر: Science (New York, N.Y.) [Science] 2019 Jun 28; Vol. 364 (6447), pp. 1283-1287. Date of Electronic Publication: 2019 Jun 27.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: Adrenergic beta-2 Receptor Agonists/*chemistry , Phthalic Anhydrides/*chemistry , Receptors, Adrenergic, beta-2/*chemistry, Adrenergic beta-2 Receptor Agonists/pharmacology ; Allosteric Regulation ; Crystallography, X-Ray ; Gain of Function Mutation ; Humans ; Phthalic Anhydrides/pharmacology ; Receptors, Adrenergic, beta-2/genetics

المؤلفون: Ahn S; Departments of Medicine (S.A., B.P., A.W.K., L.M.W., P.K.R., R.K.S., T.T.X., L.D.S., D.P.S., L.-Y.H., R.J.L.) and Biochemistry (R.J.L.) and Howard Hughes Medical Institute (L.M.W., D.P.S., R.J.L.), Duke University Medical Center, Durham, North Carolina; Nuevolution A/S, Copenhagen, Denmark (E.K.O., G.H., M.V., T.F.); Department of Medicinal Chemistry, School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou, Jiangsu, China (L.J., S.Z., X.C.); and Department of Biology, Duke University, Durham, North Carolina (P.J.S.)., Pani B; Departments of Medicine (S.A., B.P., A.W.K., L.M.W., P.K.R., R.K.S., T.T.X., L.D.S., D.P.S., L.-Y.H., R.J.L.) and Biochemistry (R.J.L.) and Howard Hughes Medical Institute (L.M.W., D.P.S., R.J.L.), Duke University Medical Center, Durham, North Carolina; Nuevolution A/S, Copenhagen, Denmark (E.K.O., G.H., M.V., T.F.); Department of Medicinal Chemistry, School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou, Jiangsu, China (L.J., S.Z., X.C.); and Department of Biology, Duke University, Durham, North Carolina (P.J.S.)., Kahsai AW; Departments of Medicine (S.A., B.P., A.W.K., L.M.W., P.K.R., R.K.S., T.T.X., L.D.S., D.P.S., L.-Y.H., R.J.L.) and Biochemistry (R.J.L.) and Howard Hughes Medical Institute (L.M.W., D.P.S., R.J.L.), Duke University Medical Center, Durham, North Carolina; Nuevolution A/S, Copenhagen, Denmark (E.K.O., G.H., M.V., T.F.); Department of Medicinal Chemistry, School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou, Jiangsu, China (L.J., S.Z., X.C.); and Department of Biology, Duke University, Durham, North Carolina (P.J.S.)., Olsen EK; Departments of Medicine (S.A., B.P., A.W.K., L.M.W., P.K.R., R.K.S., T.T.X., L.D.S., D.P.S., L.-Y.H., R.J.L.) and Biochemistry (R.J.L.) and Howard Hughes Medical Institute (L.M.W., D.P.S., R.J.L.), Duke University Medical Center, Durham, North Carolina; Nuevolution A/S, Copenhagen, Denmark (E.K.O., G.H., M.V., T.F.); Department of Medicinal Chemistry, School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou, Jiangsu, China (L.J., S.Z., X.C.); and Department of Biology, Duke University, Durham, North Carolina (P.J.S.)., Husemoen G; Departments of Medicine (S.A., B.P., A.W.K., L.M.W., P.K.R., R.K.S., T.T.X., L.D.S., D.P.S., L.-Y.H., R.J.L.) and Biochemistry (R.J.L.) and Howard Hughes Medical Institute (L.M.W., D.P.S., R.J.L.), Duke University Medical Center, Durham, North Carolina; Nuevolution A/S, Copenhagen, Denmark (E.K.O., G.H., M.V., T.F.); Department of Medicinal Chemistry, School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou, Jiangsu, China (L.J., S.Z., X.C.); and Department of Biology, Duke University, Durham, North Carolina (P.J.S.)., Vestergaard M; Departments of Medicine (S.A., B.P., A.W.K., L.M.W., P.K.R., R.K.S., T.T.X., L.D.S., D.P.S., L.-Y.H., R.J.L.) and Biochemistry (R.J.L.) and Howard Hughes Medical Institute (L.M.W., D.P.S., R.J.L.), Duke University Medical Center, Durham, North Carolina; Nuevolution A/S, Copenhagen, Denmark (E.K.O., G.H., M.V., T.F.); Department of Medicinal Chemistry, School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou, Jiangsu, China (L.J., S.Z., X.C.); and Department of Biology, Duke University, Durham, North Carolina (P.J.S.)., Jin L; Departments of Medicine (S.A., B.P., A.W.K., L.M.W., P.K.R., R.K.S., T.T.X., L.D.S., D.P.S., L.-Y.H., R.J.L.) and Biochemistry (R.J.L.) and Howard Hughes Medical Institute (L.M.W., D.P.S., R.J.L.), Duke University Medical Center, Durham, North Carolina; Nuevolution A/S, Copenhagen, Denmark (E.K.O., G.H., M.V., T.F.); Department of Medicinal Chemistry, School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou, Jiangsu, China (L.J., S.Z., X.C.); and Department of Biology, Duke University, Durham, North Carolina (P.J.S.)., Zhao S; Departments of Medicine (S.A., B.P., A.W.K., L.M.W., P.K.R., R.K.S., T.T.X., L.D.S., D.P.S., L.-Y.H., R.J.L.) and Biochemistry (R.J.L.) and Howard Hughes Medical Institute (L.M.W., D.P.S., R.J.L.), Duke University Medical Center, Durham, North Carolina; Nuevolution A/S, Copenhagen, Denmark (E.K.O., G.H., M.V., T.F.); Department of Medicinal Chemistry, School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou, Jiangsu, China (L.J., S.Z., X.C.); and Department of Biology, Duke University, Durham, North Carolina (P.J.S.)., Wingler LM; Departments of Medicine (S.A., B.P., A.W.K., L.M.W., P.K.R., R.K.S., T.T.X., L.D.S., D.P.S., L.-Y.H., R.J.L.) and Biochemistry (R.J.L.) and Howard Hughes Medical Institute (L.M.W., D.P.S., R.J.L.), Duke University Medical Center, Durham, North Carolina; Nuevolution A/S, Copenhagen, Denmark (E.K.O., G.H., M.V., T.F.); Department of Medicinal Chemistry, School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou, Jiangsu, China (L.J., S.Z., X.C.); and Department of Biology, Duke University, Durham, North Carolina (P.J.S.)., Rambarat PK; Departments of Medicine (S.A., B.P., A.W.K., L.M.W., P.K.R., R.K.S., T.T.X., L.D.S., D.P.S., L.-Y.H., R.J.L.) and Biochemistry (R.J.L.) and Howard Hughes Medical Institute (L.M.W., D.P.S., R.J.L.), Duke University Medical Center, Durham, North Carolina; Nuevolution A/S, Copenhagen, Denmark (E.K.O., G.H., M.V., T.F.); Department of Medicinal Chemistry, School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou, Jiangsu, China (L.J., S.Z., X.C.); and Department of Biology, Duke University, Durham, North Carolina (P.J.S.)., Simhal RK; Departments of Medicine (S.A., B.P., A.W.K., L.M.W., P.K.R., R.K.S., T.T.X., L.D.S., D.P.S., L.-Y.H., R.J.L.) and Biochemistry (R.J.L.) and Howard Hughes Medical Institute (L.M.W., D.P.S., R.J.L.), Duke University Medical Center, Durham, North Carolina; Nuevolution A/S, Copenhagen, Denmark (E.K.O., G.H., M.V., T.F.); Department of Medicinal Chemistry, School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou, Jiangsu, China (L.J., S.Z., X.C.); and Department of Biology, Duke University, Durham, North Carolina (P.J.S.)., Xu TT; Departments of Medicine (S.A., B.P., A.W.K., L.M.W., P.K.R., R.K.S., T.T.X., L.D.S., D.P.S., L.-Y.H., R.J.L.) and Biochemistry (R.J.L.) and Howard Hughes Medical Institute (L.M.W., D.P.S., R.J.L.), Duke University Medical Center, Durham, North Carolina; Nuevolution A/S, Copenhagen, Denmark (E.K.O., G.H., M.V., T.F.); Department of Medicinal Chemistry, School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou, Jiangsu, China (L.J., S.Z., X.C.); and Department of Biology, Duke University, Durham, North Carolina (P.J.S.)., Sun LD; Departments of Medicine (S.A., B.P., A.W.K., L.M.W., P.K.R., R.K.S., T.T.X., L.D.S., D.P.S., L.-Y.H., R.J.L.) and Biochemistry (R.J.L.) and Howard Hughes Medical Institute (L.M.W., D.P.S., R.J.L.), Duke University Medical Center, Durham, North Carolina; Nuevolution A/S, Copenhagen, Denmark (E.K.O., G.H., M.V., T.F.); Department of Medicinal Chemistry, School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou, Jiangsu, China (L.J., S.Z., X.C.); and Department of Biology, Duke University, Durham, North Carolina (P.J.S.)., Shim PJ; Departments of Medicine (S.A., B.P., A.W.K., L.M.W., P.K.R., R.K.S., T.T.X., L.D.S., D.P.S., L.-Y.H., R.J.L.) and Biochemistry (R.J.L.) and Howard Hughes Medical Institute (L.M.W., D.P.S., R.J.L.), Duke University Medical Center, Durham, North Carolina; Nuevolution A/S, Copenhagen, Denmark (E.K.O., G.H., M.V., T.F.); Department of Medicinal Chemistry, School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou, Jiangsu, China (L.J., S.Z., X.C.); and Department of Biology, Duke University, Durham, North Carolina (P.J.S.)., Staus DP; Departments of Medicine (S.A., B.P., A.W.K., L.M.W., P.K.R., R.K.S., T.T.X., L.D.S., D.P.S., L.-Y.H., R.J.L.) and Biochemistry (R.J.L.) and Howard Hughes Medical Institute (L.M.W., D.P.S., R.J.L.), Duke University Medical Center, Durham, North Carolina; Nuevolution A/S, Copenhagen, Denmark (E.K.O., G.H., M.V., T.F.); Department of Medicinal Chemistry, School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou, Jiangsu, China (L.J., S.Z., X.C.); and Department of Biology, Duke University, Durham, North Carolina (P.J.S.)., Huang LY; Departments of Medicine (S.A., B.P., A.W.K., L.M.W., P.K.R., R.K.S., T.T.X., L.D.S., D.P.S., L.-Y.H., R.J.L.) and Biochemistry (R.J.L.) and Howard Hughes Medical Institute (L.M.W., D.P.S., R.J.L.), Duke University Medical Center, Durham, North Carolina; Nuevolution A/S, Copenhagen, Denmark (E.K.O., G.H., M.V., T.F.); Department of Medicinal Chemistry, School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou, Jiangsu, China (L.J., S.Z., X.C.); and Department of Biology, Duke University, Durham, North Carolina (P.J.S.)., Franch T; Departments of Medicine (S.A., B.P., A.W.K., L.M.W., P.K.R., R.K.S., T.T.X., L.D.S., D.P.S., L.-Y.H., R.J.L.) and Biochemistry (R.J.L.) and Howard Hughes Medical Institute (L.M.W., D.P.S., R.J.L.), Duke University Medical Center, Durham, North Carolina; Nuevolution A/S, Copenhagen, Denmark (E.K.O., G.H., M.V., T.F.); Department of Medicinal Chemistry, School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou, Jiangsu, China (L.J., S.Z., X.C.); and Department of Biology, Duke University, Durham, North Carolina (P.J.S.)., Chen X; Departments of Medicine (S.A., B.P., A.W.K., L.M.W., P.K.R., R.K.S., T.T.X., L.D.S., D.P.S., L.-Y.H., R.J.L.) and Biochemistry (R.J.L.) and Howard Hughes Medical Institute (L.M.W., D.P.S., R.J.L.), Duke University Medical Center, Durham, North Carolina; Nuevolution A/S, Copenhagen, Denmark (E.K.O., G.H., M.V., T.F.); Department of Medicinal Chemistry, School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou, Jiangsu, China (L.J., S.Z., X.C.); and Department of Biology, Duke University, Durham, North Carolina (P.J.S.)., Lefkowitz RJ; Departments of Medicine (S.A., B.P., A.W.K., L.M.W., P.K.R., R.K.S., T.T.X., L.D.S., D.P.S., L.-Y.H., R.J.L.) and Biochemistry (R.J.L.) and Howard Hughes Medical Institute (L.M.W., D.P.S., R.J.L.), Duke University Medical Center, Durham, North Carolina; Nuevolution A/S, Copenhagen, Denmark (E.K.O., G.H., M.V., T.F.); Department of Medicinal Chemistry, School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou, Jiangsu, China (L.J., S.Z., X.C.); and Department of Biology, Duke University, Durham, North Carolina (P.J.S.) lefko001@receptor-biol.duke.edu.

المصدر: Molecular pharmacology [Mol Pharmacol] 2018 Aug; Vol. 94 (2), pp. 850-861. Date of Electronic Publication: 2018 May 16.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0035623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0111 (Electronic) Linking ISSN: 0026895X NLM ISO Abbreviation: Mol Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Adrenergic beta-2 Receptor Agonists/*metabolism , Receptors, Adrenergic, beta-2/*chemistry , Receptors, Adrenergic, beta-2/*metabolism , Small Molecule Libraries/*pharmacology, Allosteric Regulation/drug effects ; Allosteric Site/drug effects ; Drug Synergism ; GTP-Binding Proteins/metabolism ; Gene Library ; Molecular Structure ; Small Molecule Libraries/chemistry ; Structure-Activity Relationship ; Substrate Specificity ; beta-Arrestin 1/metabolism