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المؤلفون: Michael Adam, Jong Yu, Ramona Plant, Chris Shelton, Hank Schmidt, Jingsong Yang
المصدر: Blood. 140:11829-11829
مصطلحات موضوعية: Immunology, Cell Biology, Hematology, Biochemistry
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ea180f7673bac2a4dbbc91b823c7b80d
https://doi.org/10.1182/blood-2022-167652 -
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المؤلفون: Michael L. Moore, Liping Wang, Mary Ann Hardwicke, Kristin K. Brown, Rachel D. Totoritis, William Burkhart, Ramona Plant, Shawn P. Williams, Guofeng Zhang, Alan R. Rendina, Cynthia A. Parrish, Julie A. Krueger, Jacques Briand
المصدر: Nature Chemical Biology. 10:774-779
مصطلحات موضوعية: Models, Molecular, Pyrrolidines, Protein Conformation, Biology, Reductase, chemistry.chemical_compound, Protein structure, X-Ray Diffraction, Catalytic Domain, Cell Line, Tumor, Humans, Enzyme Inhibitors, Molecular Biology, Fatty acid synthesis, chemistry.chemical_classification, Cell growth, Cell Biology, Triazoles, Molecular biology, De novo synthesis, Fatty acid synthase, Enzyme, chemistry, Biochemistry, Cell culture, biology.protein, 3-Oxoacyl-(Acyl-Carrier-Protein) Reductase, Fatty Acid Synthases
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المؤلفون: Michael D. Spengler, Ramona Plant, Kaushik Raha, Hong Lin, Hongyi Yu, Cynthia M. Rominger, Ralph A. Rivero, Michael L. Moore, Mary Ann Hardwicke, Michael D. Schaber, Jeanelle McSurdy-Freed, Karl F. Erhard, Juan I. Luengo, Junya Qu
المصدر: ACS Medicinal Chemistry Letters. 4:230-234
مصطلحات موضوعية: Kinase, Stereochemistry, High protein, Organic Chemistry, Biology, Biochemistry, Pyrazolopyrimidine, chemistry.chemical_compound, chemistry, Drug Discovery, Structure–activity relationship, Potency, Phosphatidylinositol
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المؤلفون: Octerloney B. McDonald, Carla A. Donatelli, William F. Huffman, Toshihiro Hamajima, Christine Thompson, Kelly E. Fisher, Martha A. Sarpong, Jamin C Wang, David Sutton, Dashyant Dhanak, Peter J. Tummino, Jun Tang, Ken A. Newlander, Zhihong V Lai, Hong Xiang, Kosuke Sasaki, Domingos J. Silva, Mary Ann Hardwicke, Jerry L. Adams, Cynthia A. Parrish, Schmidt Stanley J, Denis R. Patrick, Hiroko Nakamura, Jingsong Yang, Catherine A. Oleykowski, Robert A. Copeland, Amita M. Chaudhari, Ramona Plant, David H. Drewry, Kristin K Koretke-Brown, Nicholas D. Adams, Joelle Lorraine Burgess
المصدر: Journal of Medicinal Chemistry. 53:3973-4001
مصطلحات موضوعية: Indoles, Transplantation, Heterologous, Aurora inhibitor, Aurora B kinase, Protein Serine-Threonine Kinases, Histones, Mice, Structure-Activity Relationship, Histone H3, Aurora kinase, Aurora Kinases, Cell Line, Tumor, Drug Discovery, Animals, Aurora Kinase B, Humans, Phosphorylation, Aurora Kinase A, Aza Compounds, Kinase, Chemistry, Stereoisomerism, Transplantation, Biochemistry, Cancer research, Molecular Medicine, Drug Screening Assays, Antitumor, Neoplasm Transplantation
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المؤلفون: Ken A. Newlander, Denis R. Patrick, Dashyant Dhanak, Jingsong Yang, Mary Ann Hardwicke, Catherine A. Oleykowski, Jerry L. Adams, Zhihong Lai, David Sutton, Jamin Wang, Ramona Plant, Qiaoyin Liao, Katherine G. Moss
المصدر: Molecular Cancer Therapeutics. 8:1808-1817
مصطلحات موضوعية: Umbilical Veins, Cancer Research, Indoles, Blotting, Western, Aurora inhibitor, Aurora B kinase, Fluorescent Antibody Technique, Mice, Nude, Antineoplastic Agents, Enzyme-Linked Immunosorbent Assay, Mice, SCID, Protein Serine-Threonine Kinases, Biology, Immunoenzyme Techniques, Mice, Aurora Kinases, Mice, Inbred NOD, Animals, Aurora Kinase B, Humans, Phosphorylation, Protein Kinase Inhibitors, Cells, Cultured, Aurora Kinase A, Cell Proliferation, Aza Compounds, Cell growth, Kinase, Cell Cycle, Neoplasms, Experimental, Cell cycle, Xenograft Model Antitumor Assays, Molecular biology, Oncology, Cell culture, Female, Endothelium, Vascular
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cedbacc1a81457f1d1b91b5a6ac65011
https://doi.org/10.1158/1535-7163.mct-09-0041 -
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المؤلفون: Marcel, Margulies, Michael, Egholm, William E, Altman, Said, Attiya, Joel S, Bader, Lisa A, Bemben, Jan, Berka, Michael S, Braverman, Yi-Ju, Chen, Zhoutao, Chen, Scott B, Dewell, Lei, Du, Joseph M, Fierro, Xavier V, Gomes, Brian C, Godwin, Wen, He, Scott, Helgesen, Chun Heen, Ho, Chun He, Ho, Gerard P, Irzyk, Szilveszter C, Jando, Maria L I, Alenquer, Thomas P, Jarvie, Kshama B, Jirage, Jong-Bum, Kim, James R, Knight, Janna R, Lanza, John H, Leamon, Steven M, Lefkowitz, Ming, Lei, Jing, Li, Kenton L, Lohman, Hong, Lu, Vinod B, Makhijani, Keith E, McDade, Michael P, McKenna, Eugene W, Myers, Elizabeth, Nickerson, John R, Nobile, Ramona, Plant, Bernard P, Puc, Michael T, Ronan, George T, Roth, Gary J, Sarkis, Jan Fredrik, Simons, John W, Simpson, Maithreyan, Srinivasan, Karrie R, Tartaro, Alexander, Tomasz, Kari A, Vogt, Greg A, Volkmer, Shally H, Wang, Yong, Wang, Michael P, Weiner, Pengguang, Yu, Richard F, Begley, Jonathan M, Rothberg
المصدر: Nature. 437:376-380
مصطلحات موضوعية: Time Factors, 2 base encoding, Sequence assembly, Mycoplasma genitalium, Hybrid genome assembly, Computational biology, Biology, Polymerase Chain Reaction, Sensitivity and Specificity, Article, symbols.namesake, Fiber Optic Technology, Paired-end tag, Genetics, Sanger sequencing, Multidisciplinary, Massive parallel sequencing, Shotgun sequencing, Microchemistry, Electrophoresis, Capillary, Reproducibility of Results, DNA sequencing theory, Genomics, Sequence Analysis, DNA, symbols, Emulsions, Genome, Bacterial
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المؤلفون: Victoria Ortiz, Melissa C. Musso, Olena Barbash, Christopher L. Carpenter, Lijoy K. Mathew, Xi-Ping Zhang, Charles F. McHugh, Anastasia Wyce, Peter J. Tummino, Susan Korenchuk, Daniel J. Felitsky, Melissa Stern, Ramona Plant, Jeanne J. Matteo, Yan Degenhardt, Sakina Khaku, Kathryn Keenan
المصدر: Cancer Research. 76:4709-4709
مصطلحات موضوعية: Cancer Research, MEK inhibitor, Biology, medicine.disease_cause, Bromodomain, chemistry.chemical_compound, Oncology, chemistry, Apoptosis, Cell culture, Cancer research, medicine, Epigenetics, Growth inhibition, Signal transduction, Carcinogenesis
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::453cac0112661846f672903ab86a9392
https://doi.org/10.1158/1538-7445.am2016-4709 -
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المؤلفون: Hong Lin, Charles B. Davis, Kaushik Raha, Ralph A. Rivero, Michael D. Schaber, Jeanelle McSurdy-Freed, Mary Ann Hardwicke, Karl F. Erhard, James F. Mack, Ren Xie, Michael D. Spengler, Ramona Plant, Cynthia M. Rominger, Junya Qu, Rosanna Tedesco, Jennifer L. Ariazi, Juan I. Luengo, Mark J. Schulz, Michael D. Squire, Christian S. Sherk, Jin Zeng
مصطلحات موضوعية: business.industry, Organic Chemistry, Rational design, medicine.disease, Bioinformatics, Biochemistry, Prostate cancer, chemistry.chemical_compound, chemistry, Breast cancer cell line, Drug Discovery, Cancer research, Medicine, Structure–activity relationship, Homology modeling, Growth inhibition, business, Beta (finance), PI3K/AKT/mTOR pathway
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ace88350b0677b6d5e549d1aab456577
https://europepmc.org/articles/PMC4025772/ -
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المؤلفون: Sanchez Robert, Jeanelle McSurdy-Freed, Hongyi Yu, Michael L. Moore, Rosanna Tedesco, Mary Ann Hardwicke, Karl F. Erhard, Ralph A. Rivero, Kaushik Raha, Michael D. Spengler, Juan I. Luengo, Ramona Plant, Hong Lin, Michael D. Schaber, Cynthia M. Rominger
المصدر: Bioorganicmedicinal chemistry letters. 22(9)
مصطلحات موضوعية: Gene isoform, education, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Biochemistry, Substrate Specificity, chemistry.chemical_compound, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, PTEN, Structure–activity relationship, Humans, Protein Isoforms, Phosphatidylinositol, Molecular Biology, Protein kinase B, Protein Kinase Inhibitors, Cell Proliferation, Phosphoinositide-3 Kinase Inhibitors, biology, Kinase, Organic Chemistry, PTEN Phosphohydrolase, humanities, Pyrimidines, chemistry, biology.protein, Molecular Medicine, Phosphorylation, Growth inhibition
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المؤلفون: Michael D. Spengler, Rosanna Tedesco, Sanchez Robert, Michael D. Schaber, Ramona Plant, Hong Lin, Mary Ann Hardwicke, Karl F. Erhard, James F. Mack, Kaushik Raha, Ralph A. Rivero, Cynthia M. Rominger, Juan I. Luengo, Mark J. Schulz, Jeanelle McSurdy-Freed, Ren Xie, Jin J. Zeng
المصدر: Bioorganicmedicinal chemistry letters. 22(6)
مصطلحات موضوعية: Gene isoform, Models, Molecular, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Breast Neoplasms, Pyrimidinones, Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, Structure–activity relationship, Humans, Homology modeling, Phosphatidylinositol, Molecular Biology, Protein Kinase Inhibitors, Phosphoinositide-3 Kinase Inhibitors, Binding Sites, Kinase, Organic Chemistry, Imidazoles, PTEN Phosphohydrolase, Isoenzymes, Kinetics, chemistry, Docking (molecular), Molecular Medicine, Female, Growth inhibition, Enantiomer, Drug Screening Assays, Antitumor, Phosphatidylinositol 3-Kinase, Gene Deletion, Protein Binding