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1
المؤلفون: Tim Esbenshade, Martin D. Brand, Ramzi F. Sweis, Simon Melov, Vojtech Mezera, Bryan McKibben, Pratiksha A. Dighe, Marina A. Pliushchev, Akos A. Gerencser, Zhi Wang, Stephan Riedmaier, Hoi Shan Wong
المصدر: Free Radical Biology and Medicine. 164:223-232
مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, medicine.medical_specialty, Reactive oxygen species, biology, Superoxide, Succinate dehydrogenase, SOD2, Mitochondrion, medicine.disease, Biochemistry, Superoxide dismutase, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Endocrinology, chemistry, In vivo, Physiology (medical), Internal medicine, medicine, biology.protein, Steatosis, 030217 neurology & neurosurgery
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2دورية أكاديمية
المؤلفون: William N Pappano, Jun Guo, Yupeng He, Debra Ferguson, Sujatha Jagadeeswaran, Donald J Osterling, Wenqing Gao, Julie K Spence, Marina Pliushchev, Ramzi F Sweis, Fritz G Buchanan, Michael R Michaelides, Alexander R Shoemaker, Chris Tse, Gary G Chiang
المصدر: PLoS ONE, Vol 10, Iss 7, p e0131716 (2015)
وصف الملف: electronic resource
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3
المؤلفون: Weiguo Liu, Ramzi F. Sweis, Feroze Ujjainwalla, Remond Moningka, F. Anthony Romero, Yi Zang, Paul E. Finke, Zahid Hussain, Karen H. Dingley, Michael A. Plotkin, Andrew D. Howard, Jin Shang, Beth Ann Murphy, Jianming Bao, Gino Salituro, Harold B. Wood, Joseph L. Duffy
المصدر: ACS Medicinal Chemistry Letters. 9:1088-1093
مصطلحات موضوعية: 0301 basic medicine, Somatostatin receptor, Chemistry, Organic Chemistry, 030209 endocrinology & metabolism, Metabolism, Pharmacology, Biochemistry, In vitro, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Somatostatin, Pharmacokinetics, In vivo, Pharmacodynamics, Drug Discovery, Lead compound
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4
المؤلفون: Hoi-Shan, Wong, Vojtech, Mezera, Pratiksha, Dighe, Simon, Melov, Akos A, Gerencser, Ramzi F, Sweis, Marina, Pliushchev, Zhi, Wang, Tim, Esbenshade, Bryan, McKibben, Stephan, Riedmaier, Martin D, Brand
المصدر: Free radical biologymedicine. 164
مصطلحات موضوعية: Mice, Knockout, Succinate Dehydrogenase, Mice, Superoxide Dismutase, Superoxides, Animals, Hydrogen Peroxide, Mitochondria
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5
المؤلفون: Kathy Sarris, Ying Wang, Gary G. Chiang, Yupeng He, Mikkel Algire, Ramzi F. Sweis, Huan-Qiu Li, Marina A. Pliushchev, Zhiqin Ji, Paul L. Richardson, Maricel Torrent, Bailin Shaw, Richard F. Clark, Michael L. Curtin, Justin D. Dietrich, Clarissa G. Jakob, Chaohong Sun, Sujatha Selvaraju, Haizhong Zhu, Hongyu Zhao, Michael R. Michaelides
المصدر: Bioorganic & Medicinal Chemistry Letters. 27:1576-1583
مصطلحات موضوعية: 0301 basic medicine, Pyrrolidines, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Stereoisomerism, macromolecular substances, Plasma protein binding, Ligands, Biochemistry, Mice, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Mouse xenograft, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, PRC2 complex, Molecular Biology, Indole test, Sulfonamides, biology, Novel protein, Chemistry, Organic Chemistry, Polycomb Repressive Complex 2, Xenograft Model Antitumor Assays, 030104 developmental biology, 030220 oncology & carcinogenesis, Microsomes, Liver, biology.protein, Molecular Medicine, PRC2, Protein Binding
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6
المؤلفون: Gary G. Chiang, Masoud Vedadi, Alberto Martin, Dalia Barsyte-Lovejoy, William N. Pappano, Cheryl H. Arrowsmith, Alexander Nuber, Vijayaratnam Santhakumar, Kenneth M. Comess, Judd C. Rice, Maricel Torrent, Gunnar Schotta, Peter Brown, Conglei Li, Anup K. Upadhyay, Fengling Li, Alex R Shoemaker, Ramzi F. Sweis, Mikkel Algire, Yujia Dai, Loren M. Lasko, Taylor R H Mitchell, Creighton T. Tuzon, Kenneth D. Bromberg, Mohammad S. Eram, Michael R. Michaelides, Niru B. Soni, Clarissa G. Jakob, Chaohong Sun, Manisha A Jhala, Vlasios Manaves
المصدر: Nature Chemical Biology. 13:317-324
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Methyltransferase, DNA Repair, DNA repair, Crystallography, X-Ray, Heterocyclic Compounds, 4 or More Rings, Methylation, Genomic Instability, Epigenesis, Genetic, 03 medical and health sciences, Transcription (biology), Cell Line, Tumor, Histone H2A, Humans, Epigenetics, Enzyme Inhibitors, Molecular Biology, Molecular Structure, biology, Histone-Lysine N-Methyltransferase, Cell Biology, Cell biology, 030104 developmental biology, Histone, Histone methyltransferase, biology.protein
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7
المؤلفون: Nirupama B. Soni, Anil Vasudevan, Jun Guo, Marina A. Pliushchev, Julie L. Wilsbacher, H. Robin Heyman, Michael R. Michaelides, Kathy Sarris, Bryan K. Sorensen, Richard F. Clark, Noah Tu, Min Cheng, George Doherty, Alla Korepanova, Anurupa Shrestha, Michael L. Curtin, Mikkel Algire, Badagnani Ilaria, Kenton L. Longenecker, Chris Tse, Diana Raich, Woller Kevin R, Robin R. Frey, Violeta L. Marin, Gary G. Chiang, T. Matthew Hansen, Ana L. Aguirre, F. Greg Buchanan, Peter Kovar, David Maag, Dong Cheng, Paul L. Richardson, Ramzi F. Sweis
المصدر: Bioorganicmedicinal chemistry letters. 27(15)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Clinical Biochemistry, Nicotinamide phosphoribosyltransferase, Pharmaceutical Science, Antineoplastic Agents, Isoindoles, Crystallography, X-Ray, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Cell Line, Tumor, Neoplasms, Drug Discovery, Structure–activity relationship, Animals, Humans, Urea, Enzyme Inhibitors, Nicotinamide Phosphoribosyltransferase, Molecular Biology, Cell Proliferation, Antitumor activity, Drug discovery, Cell growth, Organic Chemistry, Substrate (chemistry), Isoindoline, 030104 developmental biology, chemistry, Molecular Medicine, Cytokines
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8
المؤلفون: John S. Debenham, Dann L. Parker, Birgit T. Priest, Ravi P. Nargund, Feroze Ujjainwalla, Randal M. Bugianesi, Michele Pachanski, Liangqin Guo, William K. Hagmann, George J. Eiermann, Yi Zang, Ramzi F. Sweis, Andrew D. Howard, Jenna L. Terebetski, Melissa Kirkland, Yue Feng, Gino Salituro, Derun Li, Christopher Joseph Sinz, Stan Mitelman, Maria E. Trujillo, Scott D. Edmondson, Karen H. Dingley, Jin Shang, Nicole Buist, Xiaofang Li, Weiguo Liu, Mary Ann Powles, Terri M. Kelly, Edward C. Sherer
مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Organic Chemistry, Triazole, Type 2 Diabetes Mellitus, Glucose excursion, Type 2 diabetes, Metabolic stability, medicine.disease, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, Endocrinology, chemistry, Internal medicine, Drug Discovery, medicine, Deficient mouse, Potency, Lead compound
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05666abdc0e69d7961b4edf099a12f0b
https://europepmc.org/articles/PMC5150677/ -
9
المؤلفون: Kenneth M. Comess, Steven Kennedy, Donald J. Osterling, Michael L. Curtin, Masoud Vedadi, Ramzi F. Sweis, Guillermo Senisterra, Mikkel Algire, Evelyne Lima-Fernandes, Dalia Barsyte-Lovejoy, Justin D. Dietrich, William N. Pappano, Bailin Shaw, David Maag, Dong Cheng, Cheryl H. Arrowsmith, Fengling Li, Marina A. Pliushchev, Kelly L Klinge, Jun Guo, Chaohong Sun, Andrew M. Petros, Gary G. Chiang, Magdalena M. Szewczyk, Huan-Qiu Li, Maricel Torrent, Scott Galasinski, Sujatha Selvaraju, Yupeng He, David Lindley, Clarissa G. Jakob, Sanjay C. Panchal, Wenqing Gao, Lance J Bigelow, Haizhong Zhu, Fritz G. Buchanan, Qin Wu
المصدر: Nature chemical biology. 13(4)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Cell Survival, Protein subunit, Allosteric regulation, Antineoplastic Agents, macromolecular substances, Protein–protein interaction, 03 medical and health sciences, Histone H3, Structure-Activity Relationship, 0302 clinical medicine, Cell Line, Tumor, Tumor Cells, Cultured, Gene silencing, Humans, Epigenetics, Molecular Biology, Cell Proliferation, chemistry.chemical_classification, Sulfonamides, biology, Dose-Response Relationship, Drug, Molecular Structure, Polycomb Repressive Complex 2, Cell Biology, 030104 developmental biology, Enzyme, Biochemistry, chemistry, 030220 oncology & carcinogenesis, Indans, biology.protein, Drug Screening Assays, Antitumor, PRC2, Protein Binding
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المؤلفون: Carl P. Sparrow, Milton L. Hammond, Denise P. Milot, Peter J. Sinclair, Suzanne S. Eveland, Ramzi F. Sweis, Ying Chen, Samuel D. Wright, Florida Kallashi, Julianne A. Hunt, Qiu Guo, Melanie Latham, Sheryl A. Hyland, Anne-Marie Cumiskey, Ray Rosa, Matt S. Anderson, Larry Peterson
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:1890-1895
مصطلحات موضوعية: Scaffold, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Mice, Transgenic, Carboxamide, Biochemistry, Chemical synthesis, Mice, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Drug Discovery, Cholesterylester transfer protein, medicine, Animals, Potency, Molecular Biology, Benzoxazoles, biology, Cholesterol, HDL, Organic Chemistry, Biological activity, Benzoxazole, Cholesterol Ester Transfer Proteins, chemistry, Drug Design, biology.protein, Molecular Medicine