المؤلفون: Tim Esbenshade, Martin D. Brand, Ramzi F. Sweis, Simon Melov, Vojtech Mezera, Bryan McKibben, Pratiksha A. Dighe, Marina A. Pliushchev, Akos A. Gerencser, Zhi Wang, Stephan Riedmaier, Hoi Shan Wong

المصدر: Free Radical Biology and Medicine. 164:223-232

مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, medicine.medical_specialty, Reactive oxygen species, biology, Superoxide, Succinate dehydrogenase, SOD2, Mitochondrion, medicine.disease, Biochemistry, Superoxide dismutase, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Endocrinology, chemistry, In vivo, Physiology (medical), Internal medicine, medicine, biology.protein, Steatosis, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c095b845147d44d9a789b4ecdc70dc50
https://doi.org/10.1016/j.freeradbiomed.2020.12.447

المؤلفون: William N Pappano, Jun Guo, Yupeng He, Debra Ferguson, Sujatha Jagadeeswaran, Donald J Osterling, Wenqing Gao, Julie K Spence, Marina Pliushchev, Ramzi F Sweis, Fritz G Buchanan, Michael R Michaelides, Alexander R Shoemaker, Chris Tse, Gary G Chiang

المصدر: PLoS ONE, Vol 10, Iss 7, p e0131716 (2015)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC4492996?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/22fb11e246334a9a820a7722967d47ee

المؤلفون: Weiguo Liu, Ramzi F. Sweis, Feroze Ujjainwalla, Remond Moningka, F. Anthony Romero, Yi Zang, Paul E. Finke, Zahid Hussain, Karen H. Dingley, Michael A. Plotkin, Andrew D. Howard, Jin Shang, Beth Ann Murphy, Jianming Bao, Gino Salituro, Harold B. Wood, Joseph L. Duffy

المصدر: ACS Medicinal Chemistry Letters. 9:1088-1093

مصطلحات موضوعية: 0301 basic medicine, Somatostatin receptor, Chemistry, Organic Chemistry, 030209 endocrinology & metabolism, Metabolism, Pharmacology, Biochemistry, In vitro, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Somatostatin, Pharmacokinetics, In vivo, Pharmacodynamics, Drug Discovery, Lead compound

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3022cb6ad0fbfbeb2a2945fb1685174d
https://doi.org/10.1021/acsmedchemlett.8b00306

المؤلفون: Hoi-Shan, Wong, Vojtech, Mezera, Pratiksha, Dighe, Simon, Melov, Akos A, Gerencser, Ramzi F, Sweis, Marina, Pliushchev, Zhi, Wang, Tim, Esbenshade, Bryan, McKibben, Stephan, Riedmaier, Martin D, Brand

المصدر: Free radical biologymedicine. 164

مصطلحات موضوعية: Mice, Knockout, Succinate Dehydrogenase, Mice, Superoxide Dismutase, Superoxides, Animals, Hydrogen Peroxide, Mitochondria

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::7f36ffc5a6222cba52805e9f8a4f309b
https://pubmed.ncbi.nlm.nih.gov/33421588

المؤلفون: Kathy Sarris, Ying Wang, Gary G. Chiang, Yupeng He, Mikkel Algire, Ramzi F. Sweis, Huan-Qiu Li, Marina A. Pliushchev, Zhiqin Ji, Paul L. Richardson, Maricel Torrent, Bailin Shaw, Richard F. Clark, Michael L. Curtin, Justin D. Dietrich, Clarissa G. Jakob, Chaohong Sun, Sujatha Selvaraju, Haizhong Zhu, Hongyu Zhao, Michael R. Michaelides

المصدر: Bioorganic & Medicinal Chemistry Letters. 27:1576-1583

مصطلحات موضوعية: 0301 basic medicine, Pyrrolidines, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Stereoisomerism, macromolecular substances, Plasma protein binding, Ligands, Biochemistry, Mice, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Mouse xenograft, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, PRC2 complex, Molecular Biology, Indole test, Sulfonamides, biology, Novel protein, Chemistry, Organic Chemistry, Polycomb Repressive Complex 2, Xenograft Model Antitumor Assays, 030104 developmental biology, 030220 oncology & carcinogenesis, Microsomes, Liver, biology.protein, Molecular Medicine, PRC2, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd9b193e84408c501ad0a0b9d7c9b5bc
https://doi.org/10.1016/j.bmcl.2017.02.030

المؤلفون: Gary G. Chiang, Masoud Vedadi, Alberto Martin, Dalia Barsyte-Lovejoy, William N. Pappano, Cheryl H. Arrowsmith, Alexander Nuber, Vijayaratnam Santhakumar, Kenneth M. Comess, Judd C. Rice, Maricel Torrent, Gunnar Schotta, Peter Brown, Conglei Li, Anup K. Upadhyay, Fengling Li, Alex R Shoemaker, Ramzi F. Sweis, Mikkel Algire, Yujia Dai, Loren M. Lasko, Taylor R H Mitchell, Creighton T. Tuzon, Kenneth D. Bromberg, Mohammad S. Eram, Michael R. Michaelides, Niru B. Soni, Clarissa G. Jakob, Chaohong Sun, Manisha A Jhala, Vlasios Manaves

المصدر: Nature Chemical Biology. 13:317-324

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Methyltransferase, DNA Repair, DNA repair, Crystallography, X-Ray, Heterocyclic Compounds, 4 or More Rings, Methylation, Genomic Instability, Epigenesis, Genetic, 03 medical and health sciences, Transcription (biology), Cell Line, Tumor, Histone H2A, Humans, Epigenetics, Enzyme Inhibitors, Molecular Biology, Molecular Structure, biology, Histone-Lysine N-Methyltransferase, Cell Biology, Cell biology, 030104 developmental biology, Histone, Histone methyltransferase, biology.protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa83d9f95eebf4a7288c158fbe1c7aaf
https://doi.org/10.1038/nchembio.2282

المؤلفون: Nirupama B. Soni, Anil Vasudevan, Jun Guo, Marina A. Pliushchev, Julie L. Wilsbacher, H. Robin Heyman, Michael R. Michaelides, Kathy Sarris, Bryan K. Sorensen, Richard F. Clark, Noah Tu, Min Cheng, George Doherty, Alla Korepanova, Anurupa Shrestha, Michael L. Curtin, Mikkel Algire, Badagnani Ilaria, Kenton L. Longenecker, Chris Tse, Diana Raich, Woller Kevin R, Robin R. Frey, Violeta L. Marin, Gary G. Chiang, T. Matthew Hansen, Ana L. Aguirre, F. Greg Buchanan, Peter Kovar, David Maag, Dong Cheng, Paul L. Richardson, Ramzi F. Sweis

المصدر: Bioorganicmedicinal chemistry letters. 27(15)

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Clinical Biochemistry, Nicotinamide phosphoribosyltransferase, Pharmaceutical Science, Antineoplastic Agents, Isoindoles, Crystallography, X-Ray, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Cell Line, Tumor, Neoplasms, Drug Discovery, Structure–activity relationship, Animals, Humans, Urea, Enzyme Inhibitors, Nicotinamide Phosphoribosyltransferase, Molecular Biology, Cell Proliferation, Antitumor activity, Drug discovery, Cell growth, Organic Chemistry, Substrate (chemistry), Isoindoline, 030104 developmental biology, chemistry, Molecular Medicine, Cytokines

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e1bc793c61a6d664d259131a9672269
https://pubmed.ncbi.nlm.nih.gov/28610984

المؤلفون: John S. Debenham, Dann L. Parker, Birgit T. Priest, Ravi P. Nargund, Feroze Ujjainwalla, Randal M. Bugianesi, Michele Pachanski, Liangqin Guo, William K. Hagmann, George J. Eiermann, Yi Zang, Ramzi F. Sweis, Andrew D. Howard, Jenna L. Terebetski, Melissa Kirkland, Yue Feng, Gino Salituro, Derun Li, Christopher Joseph Sinz, Stan Mitelman, Maria E. Trujillo, Scott D. Edmondson, Karen H. Dingley, Jin Shang, Nicole Buist, Xiaofang Li, Weiguo Liu, Mary Ann Powles, Terri M. Kelly, Edward C. Sherer

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Organic Chemistry, Triazole, Type 2 Diabetes Mellitus, Glucose excursion, Type 2 diabetes, Metabolic stability, medicine.disease, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, Endocrinology, chemistry, Internal medicine, Drug Discovery, medicine, Deficient mouse, Potency, Lead compound

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05666abdc0e69d7961b4edf099a12f0b
https://europepmc.org/articles/PMC5150677/

المؤلفون: Kenneth M. Comess, Steven Kennedy, Donald J. Osterling, Michael L. Curtin, Masoud Vedadi, Ramzi F. Sweis, Guillermo Senisterra, Mikkel Algire, Evelyne Lima-Fernandes, Dalia Barsyte-Lovejoy, Justin D. Dietrich, William N. Pappano, Bailin Shaw, David Maag, Dong Cheng, Cheryl H. Arrowsmith, Fengling Li, Marina A. Pliushchev, Kelly L Klinge, Jun Guo, Chaohong Sun, Andrew M. Petros, Gary G. Chiang, Magdalena M. Szewczyk, Huan-Qiu Li, Maricel Torrent, Scott Galasinski, Sujatha Selvaraju, Yupeng He, David Lindley, Clarissa G. Jakob, Sanjay C. Panchal, Wenqing Gao, Lance J Bigelow, Haizhong Zhu, Fritz G. Buchanan, Qin Wu

المصدر: Nature chemical biology. 13(4)

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Cell Survival, Protein subunit, Allosteric regulation, Antineoplastic Agents, macromolecular substances, Protein–protein interaction, 03 medical and health sciences, Histone H3, Structure-Activity Relationship, 0302 clinical medicine, Cell Line, Tumor, Tumor Cells, Cultured, Gene silencing, Humans, Epigenetics, Molecular Biology, Cell Proliferation, chemistry.chemical_classification, Sulfonamides, biology, Dose-Response Relationship, Drug, Molecular Structure, Polycomb Repressive Complex 2, Cell Biology, 030104 developmental biology, Enzyme, Biochemistry, chemistry, 030220 oncology & carcinogenesis, Indans, biology.protein, Drug Screening Assays, Antitumor, PRC2, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df1801f71a6c72b86efbe30951bf648
https://pubmed.ncbi.nlm.nih.gov/28853738

المؤلفون: Carl P. Sparrow, Milton L. Hammond, Denise P. Milot, Peter J. Sinclair, Suzanne S. Eveland, Ramzi F. Sweis, Ying Chen, Samuel D. Wright, Florida Kallashi, Julianne A. Hunt, Qiu Guo, Melanie Latham, Sheryl A. Hyland, Anne-Marie Cumiskey, Ray Rosa, Matt S. Anderson, Larry Peterson

المصدر: Bioorganic & Medicinal Chemistry Letters. 21:1890-1895

مصطلحات موضوعية: Scaffold, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Mice, Transgenic, Carboxamide, Biochemistry, Chemical synthesis, Mice, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Drug Discovery, Cholesterylester transfer protein, medicine, Animals, Potency, Molecular Biology, Benzoxazoles, biology, Cholesterol, HDL, Organic Chemistry, Biological activity, Benzoxazole, Cholesterol Ester Transfer Proteins, chemistry, Drug Design, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd6a4e5b4fb86bec5c2667ebcf40fd52
https://doi.org/10.1016/j.bmcl.2010.11.090