المؤلفون: Laura I. Prugar, Stanford Schor, Shirit Einav, Steven De Jonghe, Jef Rozenski, Cecilia M. O’Brien, Randy Wouters, Jennifer M. Brannan, Rina Barouch-Bentov, Piet Herdewijn, John M. Dye, Szu-Yuan Pu

المصدر: Journal of Medicinal Chemistry. 61:6178-6192

مصطلحات موضوعية: 0301 basic medicine, Pyridines, viruses, Regulator, Protein Serine-Threonine Kinases, Dengue virus, medicine.disease_cause, Antiviral Agents, Article, Cell Line, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, medicine, Humans, Protein Kinase Inhibitors, Cyclin, Kinase, Chemistry, Intracellular Signaling Peptides and Proteins, RNA, Signal transducing adaptor protein, Virology, In vitro, Thiazoles, 030104 developmental biology, 030220 oncology & carcinogenesis, Molecular Medicine, Intracellular

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aeadce3e83c0bd8e0cc0bb4d3dbe2d9
https://doi.org/10.1021/acs.jmedchem.8b00613

المؤلفون: Steven De Jonghe, Piet Herdewijn, Junjun Tian, Randy Wouters

المصدر: ChemMedChem. 14(2)

مصطلحات موضوعية: isothiazolo[4,3-b]pyridines, Stereochemistry, Pyridines, cyclin G associated kinase, scaffold hopping, Protein Serine-Threonine Kinases, Scaffold hopping, Biochemistry, Antiviral Agents, Structure-Activity Relationship, medicinal chemistry, Drug Discovery, General Pharmacology, Toxicology and Pharmaceutics, Protein Kinase Inhibitors, Cyclin, Pharmacology, Bicyclic molecule, Molecular Structure, Kinase, Chemistry, Organic Chemistry, Thiazoles, Cyclization, Drug Design, Molecular Medicine, Thermodynamics, nitrogen heterocycles, Oxidation-Reduction, Protein Binding

وصف الملف: Print-Electronic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a10aada8ee6a4d349469cbdcded6438
https://pubmed.ncbi.nlm.nih.gov/30548533

المؤلفون: Thelma A. Pertinhez, Roberto Benoni, Andrea Mozzarelli, Randy Wouters, Barbara Campanini, Giannamaria Annunziato, Claudia Beato, Stefano Bettati, Marco Pieroni, Gabriele Costantino

المصدر: Journal of medicinal chemistry 59 (2016): 2567–2578. doi:10.1021/acs.jmedchem.5b01775
info:cnr-pdr/source/autori:Pieroni M, Annunziato G, Beato C, Wouters R, Benoni R, Campanini B, Pertinhez TA, Bettati S, Mozzarelli A, Costantino G/titolo:Rational Design, Synthesis, and Preliminary Structure-Activity Relationships of alpha-Substituted-2-Phenylcyclopropane Carboxylic Acids as Inhibitors of Salmonella typhimurium O-Acetylserine Sulfhydrylase/doi:10.1021%2Facs.jmedchem.5b01775/rivista:Journal of medicinal chemistry/anno:2016/pagina_da:2567/pagina_a:2578/intervallo_pagine:2567–2578/volume:59

مصطلحات موضوعية: 0301 basic medicine, Cyclopropanes, Models, Molecular, Salmonella typhimurium, Magnetic Resonance Spectroscopy, Stereochemistry, Carboxylic Acids, Swarming motility, Microbial Sensitivity Tests, Cysteine synthase, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Biosynthesis, alpha-aminoacrylate intermediate, ligand-receptor complexes, cysteine synthase complex, transfer difference nmr, anion-binding site, serine acetyltransferase, mycobacterium-tuberculosis, escherichia-coli, gene-expression, 3-dimensional structure, Drug Discovery, Drug Resistance, Bacterial, Structure–activity relationship, Pyridoxal phosphate, chemistry.chemical_classification, Cysteine Synthase, biology, Chemistry, Rational design, Anti-Bacterial Agents, Isoenzymes, 030104 developmental biology, Enzyme, Biochemistry, Pyridoxal Phosphate, biology.protein, Molecular Medicine, Cysteine, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9017a5c688bd21239305f71f7627cbeb
https://pubmed.ncbi.nlm.nih.gov/26894308