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المؤلفون: Flinders B; Centre for Mass Spectrometry Imaging, Biomedical Research Centre, City Campus, Sheffield Hallam University, Sheffield, S1 1WB, UK.; Hair Diagnostix, Dutch Screening Group, Gaetano Martinolaan 63A, Maastricht, 6229 GS, The Netherlands.; Maastricht Multimodal Molecular Imaging Institute (M4I), Maastricht University, Universiteitssingel 50, Maastricht, 6229 ER, The Netherlands., Morrell J; GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Marshall PS; GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Ranshaw LE; GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Heeren RMA; Maastricht Multimodal Molecular Imaging Institute (M4I), Maastricht University, Universiteitssingel 50, Maastricht, 6229 ER, The Netherlands., Clench MR; Centre for Mass Spectrometry Imaging, Biomedical Research Centre, City Campus, Sheffield Hallam University, Sheffield, S1 1WB, UK.

المصدر: Rapid communications in mass spectrometry : RCM [Rapid Commun Mass Spectrom] 2021 Jan 15; Vol. 35 (1), pp. e8957.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: John Wiley And Sons Ltd Country of Publication: England NLM ID: 8802365 Publication Model: Print Cited Medium: Internet ISSN: 1097-0231 (Electronic) Linking ISSN: 09514198 NLM ISO Abbreviation: Rapid Commun Mass Spectrom Subsets: MEDLINE

مواضيع طبية MeSH: Lung*/chemistry , Lung*/diagnostic imaging, Imaging, Three-Dimensional/*methods , Molecular Imaging/*methods , Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/*methods, Animals ; Mice ; Rats

المؤلفون: Flinders B; Biomedical Research Centre, Sheffield Hallam University, City Campus, Sheffield, S1 1WB, UK, bryn.flinders@student.shu.ac.uk., Morrell J, Marshall PS, Ranshaw LE, Clench MR

المصدر: Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2015 Mar; Vol. 407 (8), pp. 2085-94. Date of Electronic Publication: 2014 Nov 01.

نوع المنشور: Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 101134327 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-2650 (Electronic) Linking ISSN: 16182642 NLM ISO Abbreviation: Anal Bioanal Chem Subsets: MEDLINE

مواضيع طبية MeSH: Fluticasone/*analysis , Glucocorticoids/*analysis , Hydrazines/*chemistry , Lung/*chemistry , Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/*methods, Animals ; Rats

المؤلفون: Tralau-Stewart CJ; Drug Discovery Institute, Faculty of Medicine, Imperial College London, London, United Kingdom., Williamson RA, Nials AT, Gascoigne M, Dawson J, Hart GJ, Angell AD, Solanke YE, Lucas FS, Wiseman J, Ward P, Ranshaw LE, Knowles RG

المصدر: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2011 Apr; Vol. 337 (1), pp. 145-54. Date of Electronic Publication: 2011 Jan 04.

نوع المنشور: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE

مواضيع طبية MeSH: Aminoquinolines/*administration & dosage , Cyclic Nucleotide Phosphodiesterases, Type 4/*metabolism , Phosphodiesterase 4 Inhibitors/*administration & dosage , Sulfones/*administration & dosage, Administration, Inhalation ; Aminoquinolines/metabolism ; Aminoquinolines/pharmacokinetics ; Animals ; Cyclic Nucleotide Phosphodiesterases, Type 4/pharmacokinetics ; Dose-Response Relationship, Drug ; Humans ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/enzymology ; Phosphodiesterase 4 Inhibitors/metabolism ; Phosphodiesterase 4 Inhibitors/pharmacokinetics ; Protein Binding/physiology ; Rats ; Rats, Sprague-Dawley ; Sulfones/metabolism ; Sulfones/pharmacokinetics

المؤلفون: Nials AT; UK Discovery Biology, Respiratory Centre of Excellence for Drug Discovery, GlaxoSmithKline Research and Development Ltd, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, United Kingdom SG1 2NY. tony.t.nials@gsk.com, Tralau-Stewart CJ, Gascoigne MH, Ball DI, Ranshaw LE, Knowles RG

المصدر: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2011 Apr; Vol. 337 (1), pp. 137-44. Date of Electronic Publication: 2011 Jan 04.

نوع المنشور: Comparative Study; Journal Article

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE

مواضيع طبية MeSH: Aminoquinolines/*administration & dosage , Cyclic Nucleotide Phosphodiesterases, Type 4/*metabolism , Phosphodiesterase 4 Inhibitors/*administration & dosage , Sulfones/*administration & dosage, Administration, Inhalation ; Aminoquinolines/metabolism ; Animals ; Eosinophilia/drug therapy ; Eosinophilia/enzymology ; Ferrets ; Male ; Phosphodiesterase 4 Inhibitors/metabolism ; Rats ; Rats, Inbred BN ; Rats, Sprague-Dawley ; Sulfones/metabolism

المؤلفون: Woodrow MD; Immuno-Inflammation CEDD Medicinal Chemistry Dept, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, UK. michael.d.woodrow@gsk.com, Ballantine SP, Barker MD, Clarke BJ, Dawson J, Dean TW, Delves CJ, Evans B, Gough SL, Guntrip SB, Holman S, Holmes DS, Kranz M, Lindvaal MK, Lucas FS, Neu M, Ranshaw LE, Solanke YE, Somers DO, Ward P, Wiseman JO

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 Sep 01; Vol. 19 (17), pp. 5261-5. Date of Electronic Publication: 2009 Apr 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Phosphodiesterase 4 Inhibitors*, Anti-Inflammatory Agents/*chemistry , Phosphodiesterase Inhibitors/*chemistry , Quinolines/*chemistry, Administration, Inhalation ; Animals ; Anti-Inflammatory Agents/chemical synthesis ; Anti-Inflammatory Agents/pharmacokinetics ; Binding Sites ; Catalytic Domain ; Crystallography, X-Ray ; Cyclic Nucleotide Phosphodiesterases, Type 4/metabolism ; Humans ; Leukocytes, Mononuclear/metabolism ; Lipopolysaccharides/pharmacology ; Phosphodiesterase Inhibitors/chemical synthesis ; Phosphodiesterase Inhibitors/pharmacokinetics ; Quinolines/chemical synthesis ; Quinolines/pharmacokinetics ; Rats ; Structure-Activity Relationship ; Tumor Necrosis Factor-alpha/metabolism

المؤلفون: Lunniss CJ; GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, England., Cooper AW, Eldred CD, Kranz M, Lindvall M, Lucas FS, Neu M, Preston AG, Ranshaw LE, Redgrave AJ, Ed Robinson J, Shipley TJ, Solanke YE, Somers DO, Wiseman JO

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 Mar 01; Vol. 19 (5), pp. 1380-5. Date of Electronic Publication: 2009 Jan 19.

نوع المنشور: Comparative Study; Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Phosphodiesterase 4 Inhibitors*, Phosphodiesterase Inhibitors/*administration & dosage , Phosphodiesterase Inhibitors/*chemistry , Quinolines/*administration & dosage , Quinolines/*chemistry, Administration, Oral ; Animals ; Cattle ; Cyclic Nucleotide Phosphodiesterases, Type 4/metabolism ; Humans ; Male ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Rats ; Rats, Sprague-Dawley ; Structure-Activity Relationship

المؤلفون: Hamblin JN; GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK. nicole.j.hamblin@gsk.com, Angell TD, Ballantine SP, Cook CM, Cooper AW, Dawson J, Delves CJ, Jones PS, Lindvall M, Lucas FS, Mitchell CJ, Neu MY, Ranshaw LE, Solanke YE, Somers DO, Wiseman JO

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2008 Jul 15; Vol. 18 (14), pp. 4237-41. Date of Electronic Publication: 2008 May 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Phosphodiesterase 4 Inhibitors*, Chemistry, Pharmaceutical/*methods , Cyclic Nucleotide Phosphodiesterases, Type 4/*chemistry , Pyrazoles/*chemical synthesis , Pyrazoles/*pharmacokinetics , Pyridines/*chemical synthesis , Pyridines/*pharmacokinetics, Aminopyridines/pharmacology ; Animals ; Benzamides/pharmacology ; Crystallography, X-Ray/methods ; Cyclopropanes/pharmacology ; Drug Design ; Humans ; Leukocytes, Mononuclear/cytology ; Leukocytes, Mononuclear/metabolism ; Models, Biological ; Models, Chemical ; Pyrrolidinones/chemistry ; Rats ; Rolipram/pharmacology ; Tumor Necrosis Factor-alpha/metabolism

المؤلفون: Bamborough P; GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK. Paul.A.Bamborough@gsk.com, Angell RM, Bhamra I, Brown D, Bull J, Christopher JA, Cooper AW, Fazal LH, Giordano I, Hind L, Patel VK, Ranshaw LE, Sims MJ, Skone PA, Smith KJ, Vickerstaff E, Washington M

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2007 Aug 01; Vol. 17 (15), pp. 4363-8. Date of Electronic Publication: 2007 Apr 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Enzyme Inhibitors/*pharmacology , Indazoles/*pharmacology , Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/*antagonists & inhibitors, Enzyme Inhibitors/pharmacokinetics ; Indazoles/pharmacokinetics ; Models, Molecular