يعرض 1 - 10 نتائج من 13 نتيجة بحث عن '"Ratna Karuna"', وقت الاستعلام: 0.94s تنقيح النتائج
  1. 1
    First-in-class monoclonal antibody (mAb) PBP1510 targeting pancreatic adenocarcinoma upregulated factor (PAUF) for pancreatic cancer (PC) treatment: Preclinical perspectives

    المؤلفون: Kedar Diwakar Mandakhalikar, Sang Seok Koh, Seong-Yun Jeong, Deborah Moshinsky, Peggy Feyaerts, Ratna Karuna, Jamie Kim, Litha Jaison, Sumita Pradhan, Yeon Jeong Kim, Jin Park

    المصدر: Journal of Clinical Oncology. 40:e16274-e16274

    مصطلحات موضوعية: Cancer Research, Oncology

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8ef6f135f39dd0d985d96fa6d31eb9d2
    https://doi.org/10.1200/jco.2022.40.16_suppl.e16274

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  2. 2
    NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models

    المؤلفون: Haoying Xu, Wei Lin Sandra Sim, Cheah Chen Seh, Feng Wang, Thierry T. Diagana, Wai Ling Chan, Jae-Geun Song, Kah Fei Wan, Bin Zou, Ghislain M. C. Bonamy, David Beer, David T. Barkan, Min Li, Stephanie A. Moquin, Francesca Blasco, Suresh B. Lakshminarayana, Jin Zhang, Oliver Simon, Vito G. Sasseville, Craig W. Day, Qing-Yin Wang, Chandrassegar Saravanan, Katherine Chan, Fumiaki Yokokawa, Bryan K. S. Yeung, Ratna Karuna, Hui-Quan Yeo, Colin Osborne, Christopher Sarko, Pei Yong Shi, Hongping Dong, Mei Ding, Siew Pheng Lim, Yen Liang Chen, Feng Gu, Cyrille Kounde, Gang Wang, Siyan Lu, Wei Liu

    المصدر: Science Translational Medicine. 13

    مصطلحات موضوعية: 0301 basic medicine, biology, medicine.drug_class, business.industry, 030106 microbiology, Viremia, General Medicine, Dengue virus, Pharmacology, medicine.disease_cause, medicine.disease, biology.organism_classification, Dengue fever, Bioavailability, 03 medical and health sciences, Flavivirus, 030104 developmental biology, Pharmacokinetics, medicine, Potency, Antiviral drug, business

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::88cb7c9fc29a66acc799682b5292b913
    https://doi.org/10.1126/scitranslmed.abb2181

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  3. 3
    A Cyclic Phosphoramidate Prodrug of 2′-Deoxy-2′-Fluoro-2′-C-Methylguanosine for the Treatment of Dengue Virus Infection

    المؤلفون: Martijn Fenaux, Andrea Leonardi, Sreehari Babu, Peck Gee Seah, Wei Liu, Pei Yong Shi, Rao P S Srinivasa, Suresh B. Lakshminarayana, Haoying Xu, Jin Zhang, Fumiaki Yokokawa, Cheah Chen Seh, Francesca Blasco, Nahdiyah Abdul Ghafar, Wai Ling Chan, Gang Wang, Ellie Growcott, Feng Gu, Weidong Zhong, Keshi Wang, Mei Ding, Ratna Karuna, Siew Pheng Lim, Yen Liang Chen

    المصدر: Antimicrob Agents Chemother

    مصطلحات موضوعية: Male, Hepatitis C virus, Hepacivirus, Pharmacology, Dengue virus, medicine.disease_cause, Peripheral blood mononuclear cell, Antiviral Agents, Dengue, 03 medical and health sciences, chemistry.chemical_compound, Dogs, Oral administration, medicine, Animals, Pharmacology (medical), Phosphoric Acids, Prodrugs, 030304 developmental biology, 0303 health sciences, Guanosine, 030306 microbiology, Chemistry, Phosphoramidate, Prodrug, Amides, Infectious Diseases, Nucleoside triphosphate, Leukocytes, Mononuclear, Female, Nucleoside

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18dd646098b1cf2a7e9cd9dd08f0a432
    https://europepmc.org/articles/PMC7674056/

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  4. 4
    A Cyclic Phosphoramidate Prodrug of 2’-deoxy-2’-fluoro-2’-C-methylguanosine for the Treatment of Dengue Infection

    المؤلفون: Wei Liu, Sreehari Babu, Wai Ling Chan, Suresh B. Lakshminarayana, Ellena Growcott, Peck Gee Seah, Martijn Fenaux, Mei Ding, Nahdiyah Abdul Ghafar, Gang Wang, Ratna Karuna, Cheah Chen Seh, Haoying Xu, Feng Gu, Weidong Zhong, Pei Yong Shi, Keshi Wang, Andrea Leonardi, Francesca Blasco, Yen Liang Chen, Srinivasa P. S. Rao, Siew Pheng Lim, Fumiaki Yokokawa, Jin Zhang

    مصطلحات موضوعية: Chemistry, Oral administration, Hepatitis C virus, Toxicity, medicine, Phosphoramidate, Prodrug, Dengue virus, Pharmacology, medicine.disease_cause, Peripheral blood mononuclear cell, Nucleoside

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f8d10b314ef2182303dfcf7c75456ce

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  5. 5
    A head-to-head comparison of the inhibitory activities of 15 peptidomimetic SARS-CoV-2 3CLpro inhibitors

    المؤلفون: Jia Yi Fong, Gang Wang, Xue Guo, Joma Joy, Shu Ting Tan, Yun Xuan Wong, Qian Wen Tan, Subramanyam Vankadara, Yi Yang See, Boping Liu, C. S. Brian Chia, Li Hong Tan, Ratna Karuna

    المصدر: Bioorganic & Medicinal Chemistry Letters

    مصطلحات موضوعية: 2019-20 coronavirus outbreak, Research groups, Coronavirus disease 2019 (COVID-19), Peptidomimetic, Head to head, medicine.medical_treatment, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Clinical Biochemistry, Drug target, Pharmaceutical Science, Pharmacology, Cysteine Proteinase Inhibitors, Cysteine protease inhibitors, Biochemistry, Antiviral Agents, Article, Inhibitory Concentration 50, Drug Discovery, medicine, Fluorescence Resonance Energy Transfer, Molecular Biology, Coronavirus 3C Proteases, ComputingMethodologies_COMPUTERGRAPHICS, Enzyme Assays, Protease, Chemistry, SARS-CoV-2, Organic Chemistry, 3CLpro, Molecular Medicine, Peptidomimetics, Peptidomimetic inhibitors, Mpro, Protein Binding

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef98aee81980e9ae4d7f27b5d23b5038
    http://europepmc.org/articles/PMC8277557

    View record from ScienceDirect
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  6. 6
    Discovery of 2-oxopiperazine dengue inhibitors by scaffold morphing of a phenotypic high-throughput screening hit

    المؤلفون: Hongping Dong, Bryan K. S. Yeung, Ratna Karuna, Bin Zou, Trixie Wagner, Hui-Quan Yeo, Cyrille Kounde, Oliver Simon, Kah Fei Wan, Qing-Yin Wang, Ghislain M. C. Bonamy, Fumiaki Yokokawa, Ina Dix

    المصدر: Bioorganic & Medicinal Chemistry Letters. 27:1385-1389

    مصطلحات موضوعية: 0301 basic medicine, Scaffold, High-throughput screening, Clinical Biochemistry, Pharmaceutical Science, Dengue virus, medicine.disease_cause, Antiviral Agents, 01 natural sciences, Biochemistry, Piperazines, Virus, Cell Line, Pyrrolopiperazinone, Dengue fever, Structure-Activity Relationship, 03 medical and health sciences, Drug Discovery, medicine, Humans, Molecular Biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Dengue Virus, medicine.disease, Phenotype, Virology, High-Throughput Screening Assays, 0104 chemical sciences, 030104 developmental biology, Molecular Medicine

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ada04bec55172ef37cc6806daf8ac826
    https://doi.org/10.1016/j.bmcl.2017.02.005

    View record from ScienceDirect
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  7. 7
    Discovery of Dengue Virus NS4B Inhibitors

    المؤلفون: Julien Lescar, Feng Gu, Kah Fei Wan, Francesca Blasco, CongBao Kang, Wai Ling Chan, Wei Liu, Paul W. Smith, Agatha Susila, Bin Zou, Qing Yin Wang, K.L. Yeo, Mei Ding, Chao Shan, Andy M. Yip, Haoying Xu, Hongping Dong, Jing Zou, Suresh B. Lakshminarayana, Ratna Karuna, Pei Yong Shi, Peck Gee Seah

    المساهمون: Diamond, M. S., School of Biological Sciences

    المصدر: Journal of Virology. 89:8233-8244

    مصطلحات موضوعية: viruses, Immunology, Viremia, Viral Nonstructural Proteins, Dengue virus, Biology, medicine.disease_cause, Antiviral Agents, Microbiology, Cell Line, In vivo, Cricetinae, Virology, Vaccines and Antiviral Agents, Drug Discovery, medicine, Animals, Humans, Spiro Compounds, Replicon, chemistry.chemical_classification, Drug discovery, virus diseases, Dengue Virus, biochemical phenomena, metabolism, and nutrition, medicine.disease, In vitro, Amino acid, chemistry, Insect Science, Viral replication complex

    وصف الملف: application/pdf

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9c6a3590eab912cf760905f732513b3
    https://doi.org/10.1128/jvi.00855-15

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  8. 8
    Lead Optimization of Spiropyrazolopyridones: A New and Potent Class of Dengue Virus Inhibitors

    المؤلفون: Hao Ying Xu, Wei Liu, Feng Gu, Bin Zou, Wai Ling Chan, Paul W. Smith, Kah Fei Wan, Ratna Karuna, Agatha Susila, Peck Gee Seah, Andy Yip, Pei Yong Shi, Trixie Wagner, Thierry T. Diagana, Qing Yin Wang, Alex Chao, Mei Ding, Hongping Dong, Seh Yong Leong, Francesca Blasco, Katherine Chan, Shahul Nilar, Ina Dix

    المصدر: ACS Medicinal Chemistry Letters. 6:344-348

    مصطلحات موضوعية: Organic Chemistry, virus diseases, Viremia, Biology, Dengue virus, medicine.disease, medicine.disease_cause, Biochemistry, Virology, Dengue fever, Pharmacokinetics, In vivo, Drug Discovery, medicine, Structure–activity relationship, Potency, Enantiomer

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9867f21db7401bc0dd808defa261115
    https://doi.org/10.1021/ml500521r

    Find this issue from the American Chemical Society
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  9. 9
    Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design

    المؤلفون: Christian G. Noble, Fumiaki Yokokawa, Gang Wang, Jürg Hunziker, Stefani Tania, Ujjini H. Manjunatha, Gladys Lee, Pei Yong Shi, Siew Pheng Lim, Shahul Nilar, Ratna Karuna, Paul W. Smith, Ranga Rao

    المصدر: Journal of medicinal chemistry. 59(8)

    مصطلحات موضوعية: 0301 basic medicine, viruses, Calorimetry, Antiviral Agents, Dengue fever, Cell Line, 03 medical and health sciences, chemistry.chemical_compound, RNA polymerase, Drug Discovery, medicine, Potency, Humans, Enzyme Inhibitors, Gene, Polymerase, Genetics, biology, Molecular Structure, Dengue Virus, Surface Plasmon Resonance, medicine.disease, RNA-Dependent RNA Polymerase, Virology, In vitro, 030104 developmental biology, chemistry, Cell culture, Drug Design, biology.protein, Molecular Medicine, Nucleoside

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ffdb2bc4eb402cfc0939d880e6551e
    https://pubmed.ncbi.nlm.nih.gov/26984786

    Find this issue from the American Chemical Society
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  10. 10
    Lipoprotein distribution and serum concentrations of 7α-hydroxy-4-cholesten-3-one and bile acids

    المؤلفون: Anne Tybjærg-Hansen, Ratna Karuna, Katharina Rentsch, Jan Albert Kuivenhoven, Adriaan G. Holleboom, Lucia Rohrer, Ruth Frikke-Schmidt, M. Mahdi Motazacker, Arnold von Eckardstein, Carine Steiner

    المساهمون: Vascular Medicine, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, ACS - Amsterdam Cardiovascular Sciences, Human Genetics, Experimental Vascular Medicine, University of Zurich, von Eckardstein, Arnold, Cardiovascular Centre (CVC), Lifestyle Medicine (LM), Vascular Ageing Programme (VAP), Center for Liver, Digestive and Metabolic Diseases (CLDM)

    المصدر: Clinical science (London, England, 122(7-8), 385-396. Portland Press Ltd.
    Clinical Science, 122(8), 385-400. PORTLAND PRESS LTD
    Clinical science (London England : 1979)

    مصطلحات موضوعية: Very low-density lipoprotein, Scavenger Receptors, Denmark, 2700 General Medicine, 030204 cardiovascular system & hematology, Phosphatidylcholine-Sterol O-Acyltransferase, chemistry.chemical_compound, 0302 clinical medicine, High-density lipoprotein, 540 Chemistry, 10038 Institute of Clinical Chemistry, 0303 health sciences, biology, Inborn Errors, Reverse cholesterol transport, General Medicine, Scavenger Receptors, Class B, lipids (amino acids, peptides, and proteins), Lipoproteins, HDL, ATP Binding Cassette Transporter 1, medicine.medical_specialty, HDL, Lipoproteins, education, 610 Medicine & health, Bile Acids and Salts, 03 medical and health sciences, 7α-Hydroxy-4-cholesten-3-one, Internal medicine, Cholesterylester transfer protein, medicine, Humans, Cholestenones, 030304 developmental biology, Apolipoprotein A-I, nutritional and metabolic diseases, Lipase, SCARB1, Cholesterol Ester Transfer Proteins, Endocrinology, Metabolism, chemistry, Case-Control Studies, Mutation, biology.protein, ATP-Binding Cassette Transporters, Hepatic lipase, Class B, Metabolism, Inborn Errors, Lipoprotein

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e506ca7c903f4310eb12a340f2ed06
    https://doi.org/10.1042/CS20110482

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