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المؤلفون: Antonia Serrano, Samir Badran, Dolores Bautista, Ana Luisa Gavito, Juan Suárez, Elena Baixeras, Juan Decara, Patricia Rivera, Fernando Rodríguez-de-Fonseca, Antonio Luis Cuesta, Francisco Javier Pavón, Rocío Arco
المساهمون: [Gavito,AL, Suarez,J, Arco,J, Pavón,FJ, Serrano,A, Rivera,P, Decara,J, Rodríguez-de-Fonseca,F, Baixera,E] Laboratorio de Investigación, IBIMA, Hospital Regional Universitario de Málaga, Málaga, Spain. Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, Málaga Spain. [Bautista,D] Unidad de Gestión Clínica de Anatomía Patológica, Hospital Regional Universitario de Málaga, Málaga, Spain. [Pavón,FJ] University College South Denmark, Esbjerg, Denmark. [Cuestya,AL] Danish Diabetes Academy, Department of Biomedical Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark., The present study was financially supported through funding from the Instituto de Salud Carlos III, Red de Trastornos Adictivos UE-FEDER 2012 (RD12/0028/0001), Ministerio de Economía y Competitividad(PI13/02261), Ministerio de Sanidad, Servicios Sociales e Igualdad, Plan Nacional sobre Drogas 049/2009 and 049/2013, Consejería de Economía, Innovación y Ciencia, Junta de Andalucía (CTS-433), Consejería de Salud y Bienestar Social, Junta Andalucía (PI0552, PI0228-2013 and PI0823-2012).
المصدر: PLoS ONE, Vol 11, Iss 6, p e0157956 (2016)
Gavito, A L, Bautista, D, Suarez, J, Badran, S, Arco, R, Pavón, F J, Serrano, A, Rivera, P, Decara, J, Cuesta-Muñoz, A L, Rodríguez-de-Fonseca, F & Baixeras, E 2016, ' Chronic IL-6 Administration Desensitizes IL-6 Response in Liver, Causes Hyperleptinemia and Aggravates Steatosis in Diet-Induced-Obese Mice ', P L o S One, vol. 11, no. 6, e0157956 . https://doi.org/10.1371/journal.pone.0157956
PLoS ONEمصطلحات موضوعية: Leptin, Male, Steatosis, Peptide Hormones, Obesidad, Signal transduction, Pathology and Laboratory Medicine, Biochemistry, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], 0302 clinical medicine, Metabolismo lipídico, Phenomena and Processes::Metabolic Phenomena::Metabolism::Lipid Metabolism [Medical Subject Headings], Cytokine Receptor gp130, Organisms::Eukaryota::Animals [Medical Subject Headings], lcsh:Science, Liver Diseases, Fatty Acids, Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body Weight::Overweight::Obesity [Medical Subject Headings], Up-Regulation, Humanos, STAT signaling, Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Adipokines::Leptin [Medical Subject Headings], 030220 oncology & carcinogenesis, Lípidos, medicine.medical_specialty, Phenomena and Processes::Metabolic Phenomena::Metabolism::Lipid Metabolism::Lipogenesis [Medical Subject Headings], Down-Regulation, Gastroenterology and Hepatology, Chemicals and Drugs::Lipids [Medical Subject Headings], Diet, High-Fat, Receptores de interleucina-6, Interleucina-6, 03 medical and health sciences, Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet::Diet, High-Fat [Medical Subject Headings], Leptina, Genetics, PPAR alpha, Ratones obesos, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice [Medical Subject Headings], Carnitine O-Palmitoyltransferase, Tumor Necrosis Factor-alpha, lcsh:R, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Intercellular Signaling Peptides and Proteins::Cytokines [Medical Subject Headings], Biology and Life Sciences, Proteins, medicine.disease, Hormones, Factor de necrosis tumoral alfa, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats [Medical Subject Headings], Anatomical Pathology, Suppressor of Cytokine Signaling 3 Protein, Animales, Glucosa, lcsh:Q, Ratas Zucker, Blood Glucose, 0301 basic medicine, Cell signaling, Physiology, Ratones, Chemicals and Drugs::Carbohydrates::Monosaccharides::Hexoses::Glucose [Medical Subject Headings], Gene Expression, Mice, Obese, lcsh:Medicine, Cytopathology, Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Tumor Necrosis Factors::Tumor Necrosis Factor-alpha [Medical Subject Headings], Medicine and Health Sciences, SOCS3, Post-Translational Modification, Phosphorylation, Multidisciplinary, Fatty liver, Recombinant Proteins, Physiological Parameters, Liver, Lipogenesis, Receptors, Leptin, Signal Transduction, Research Article, STAT3 Transcription Factor, Cell biology, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats::Rats, Mutant Strains::Rats, Zucker [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice::Mice, Mutant Strains::Mice, Obese [Medical Subject Headings], Diseases::Digestive System Diseases::Liver Diseases::Fatty Liver [Medical Subject Headings], Context (language use), Biology, Models, Biological, Alimentación rica en grasa, Ratas, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Immunologic::Receptors, Cytokine::Receptors, Interleukin::Receptors, Interleukin-6 [Medical Subject Headings], Internal medicine, medicine, Animals, Lipogénesis, Obesity, Carnitine O-palmitoyltransferase, Nutrition, Interleukin-6, Body Weight, Hígado graso, Ratones consanguíneos C57BL, Diet, Rats, Zucker, Fatty Liver, Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Laboratory::Animals, Inbred Strains::Mice, Inbred Strains::Mice, Inbred C57BL [Medical Subject Headings], Diet-induced obese
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