المؤلفون: Perrin J; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany., Werner T; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany., Kurzawa N; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Rutkowska A; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany., Childs DD; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Kalxdorf M; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany., Poeckel D; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany., Stonehouse E; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany., Strohmer K; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany., Heller B; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany., Thomson DW; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany., Krause J; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany., Becher I; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Eberl HC; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany., Vappiani J; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany., Sevin DC; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany., Rau CE; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany., Franken H; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany., Huber W; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Faelth-Savitski M; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany., Savitski MM; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany. mikhail.savitski@embl.de., Bantscheff M; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany. marcus.x.bantscheff@gsk.com., Bergamini G; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany. giovanna.2.bergamini@gsk.com.

المصدر: Nature biotechnology [Nat Biotechnol] 2020 Mar; Vol. 38 (3), pp. 303-308. Date of Electronic Publication: 2020 Jan 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE

مواضيع طبية MeSH: Blood/*metabolism , Proteome/*chemistry , Proteome/*metabolism , Small Molecule Libraries/*administration & dosage, Animals ; Azepines/administration & dosage ; Azepines/pharmacology ; Hep G2 Cells ; Humans ; Kidney/chemistry ; Kidney/metabolism ; Liver/chemistry ; Liver/metabolism ; Lung/chemistry ; Lung/metabolism ; Male ; Mass Spectrometry ; Mice ; Organ Specificity ; Panobinostat/administration & dosage ; Panobinostat/pharmacology ; Protein Stability ; Rats ; Small Molecule Libraries/pharmacology ; Spleen/chemistry ; Spleen/metabolism ; Testis/chemistry ; Testis/metabolism ; Thermodynamics ; Triazoles/administration & dosage ; Triazoles/pharmacology ; Vemurafenib/administration & dosage ; Vemurafenib/pharmacology