المؤلفون: Hs, Friedman, Me, Dolan, Scott Kaufmann, Om, Colvin, Ow, Griffith, Rc, Moschel, Sc, Schold, Dd, Bigner, Ali-Osman F

المصدر: Europe PubMed Central

مصطلحات موضوعية: Male, Mice, Inbred BALB C, Alkyl and Aryl Transferases, Transplantation, Heterologous, Drug Resistance, Mice, Nude, Antineoplastic Agents, DNA Polymerase II, DNA Polymerase I, Carmustine, Mice, DNA Topoisomerases, Type II, Transferases, Rhabdomyosarcoma, Animals, Humans, Camptothecin, Female, Drug Screening Assays, Antitumor, Topotecan, Melphalan

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::87a2474dec6942d0b39ca871f0d1ae49
http://europepmc.org/abstract/med/8012971

المؤلفون: Fang Q; Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA., Loktionova NA, Moschel RC, Javanmard S, Pauly GT, Pegg AE

المصدر: Biochemical pharmacology [Biochem Pharmacol] 2008 Feb 01; Vol. 75 (3), pp. 618-26. Date of Electronic Publication: 2007 Oct 02.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0006-2952 (Print) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Enzyme Inhibitors/*pharmacology , O(6)-Methylguanine-DNA Methyltransferase/*antagonists & inhibitors, Clinical Trials as Topic ; Humans ; O(6)-Methylguanine-DNA Methyltransferase/genetics ; Polymorphism, Genetic

المؤلفون: Coulter R; Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA., Blandino M, Tomlinson JM, Pauly GT, Krajewska M, Moschel RC, Peterson LA, Pegg AE, Spratt TE

المصدر: Chemical research in toxicology [Chem Res Toxicol] 2007 Dec; Vol. 20 (12), pp. 1966-71. Date of Electronic Publication: 2007 Nov 01.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 8807448 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0893-228X (Print) Linking ISSN: 0893228X NLM ISO Abbreviation: Chem Res Toxicol Subsets: MEDLINE

مواضيع طبية MeSH: DNA Repair*, Guanine/*analogs & derivatives , Guanine/*chemistry , O(6)-Methylguanine-DNA Methyltransferase/*chemistry, Base Sequence ; Kinetics ; Molecular Sequence Data ; Oligonucleotides/chemistry ; Substrate Specificity

المؤلفون: Javanmard S; Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Post Office Box B, Building 538, Frederick, Maryland 21702, USA., Loktionova NA, Fang Q, Pauly GT, Pegg AE, Moschel RC

المصدر: Journal of medicinal chemistry [J Med Chem] 2007 Oct 18; Vol. 50 (21), pp. 5193-201. Date of Electronic Publication: 2007 Sep 20.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Deoxyguanosine/*analogs & derivatives , Folic Acid/*analogs & derivatives , Folic Acid/*chemical synthesis , Guanine/*analogs & derivatives , O(6)-Methylguanine-DNA Methyltransferase/*antagonists & inhibitors, Antineoplastic Agents, Alkylating/pharmacology ; Carmustine/pharmacology ; Carrier Proteins/metabolism ; Cell Line, Tumor ; Deoxyguanosine/chemical synthesis ; Deoxyguanosine/pharmacology ; Drug Resistance, Neoplasm ; Esters ; Folate Receptors, GPI-Anchored ; Folic Acid/pharmacology ; Guanine/chemical synthesis ; Guanine/pharmacology ; Humans ; Hydrolysis ; O(6)-Methylguanine-DNA Methyltransferase/chemistry ; Receptors, Cell Surface/metabolism ; Solubility ; Structure-Activity Relationship

المؤلفون: Fishel ML; Department of Medicine, University of Chicago, Chicago, IL 60637, USA., Rabik CA, Bleibel WK, Li X, Moschel RC, Dolan ME

المصدر: Biochemical pharmacology [Biochem Pharmacol] 2006 Jan 12; Vol. 71 (3), pp. 239-47. Date of Electronic Publication: 2005 Dec 01.

نوع المنشور: Comparative Study; Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0006-2952 (Print) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Antigens, Differentiation/*genetics , Antineoplastic Agents/*pharmacology , Apoptosis/*drug effects , Cell Cycle Proteins/*genetics , Cisplatin/*pharmacology , Gene Expression Regulation, Neoplastic/*drug effects , Guanine/*analogs & derivatives, Antigens, Differentiation/biosynthesis ; Apoptosis/genetics ; Cell Cycle Proteins/biosynthesis ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Drug Synergism ; Guanine/pharmacology ; Humans ; Oligonucleotide Array Sequence Analysis ; Protein Phosphatase 1 ; Reverse Transcriptase Polymerase Chain Reaction

المؤلفون: Quinn JA; Department of Surgery, Duke University Medical Center, Durham, NC, USA. quinn008@mc.duke.edu, Desjardins A, Weingart J, Brem H, Dolan ME, Delaney SM, Vredenburgh J, Rich J, Friedman AH, Reardon DA, Sampson JH, Pegg AE, Moschel RC, Birch R, McLendon RE, Provenzale JM, Gururangan S, Dancey JE, Maxwell J, Tourt-Uhlig S, Herndon JE 2nd, Bigner DD, Friedman HS

المصدر: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2005 Oct 01; Vol. 23 (28), pp. 7178-87.

نوع المنشور: Clinical Trial; Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.

بيانات الدورية: Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 8309333 Publication Model: Print Cited Medium: Print ISSN: 0732-183X (Print) Linking ISSN: 0732183X NLM ISO Abbreviation: J Clin Oncol Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Combined Chemotherapy Protocols/*therapeutic use , Brain Neoplasms/*drug therapy , Glioma/*drug therapy, Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/pharmacokinetics ; Brain Neoplasms/pathology ; Dacarbazine/administration & dosage ; Dacarbazine/adverse effects ; Dacarbazine/analogs & derivatives ; Dacarbazine/pharmacokinetics ; Disease Progression ; Female ; Glioma/pathology ; Guanine/administration & dosage ; Guanine/adverse effects ; Guanine/analogs & derivatives ; Guanine/pharmacokinetics ; Humans ; Infusions, Intravenous ; Injections, Intravenous ; Male ; Maximum Tolerated Dose ; Middle Aged ; Temozolomide

المؤلفون: Fishel ML; Department of Medicine, Committee on Cancer Biology and Cancer Research Center, University of Chicago, Chicago, IL, 60637, USA., Gamcsik MP; Duke University Medical Center, Durham, NC, 27701, USA., Delaney SM; Department of Medicine, Committee on Cancer Biology and Cancer Research Center, University of Chicago, Chicago, IL, 60637, USA., Zuhowski EG; University of Pittsburgh Cancer Institute, Pittsburgh, PA, 15213, USA., Maher VM; The Carcinogenesis Laboratory, Michigan State University, East Lansing, MI, 48824, USA., Karrison T; Department of Health Studies, University of Chicago, Chicago, IL, 60637, USA., Moschel RC; Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, MD, 21702-1201, USA., Egorin MJ; University of Pittsburgh Cancer Institute, Pittsburgh, PA, 15213, USA., Dolan ME; Department of Medicine, Committee on Cancer Biology and Cancer Research Center, University of Chicago, Chicago, IL, 60637, USA. edolan@medicine.bsd.uchicago.edu.; University of Chicago, 5841 S. Maryland Ave., P.O. Box MC2115, Chicago, IL, 60637, USA. edolan@medicine.bsd.uchicago.edu.

المصدر: Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2005 Apr; Vol. 55 (4), pp. 333-342. Date of Electronic Publication: 2004 Oct 02.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, P.H.S.

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7806519 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0344-5704 (Print) Linking ISSN: 03445704 NLM ISO Abbreviation: Cancer Chemother Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Cisplatin/*pharmacology , DNA Repair/*drug effects , Glutathione/*metabolism , Guanine/*analogs & derivatives , Guanine/*pharmacology, Cell Line ; Cell Survival/drug effects ; DNA Damage ; Drug Synergism ; Humans ; Platinum/metabolism ; Tumor Cells, Cultured

المؤلفون: Kanugula S; Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA., Pauly GT, Moschel RC, Pegg AE

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2005 Mar 08; Vol. 102 (10), pp. 3617-22. Date of Electronic Publication: 2005 Feb 24.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, P.H.S.

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0027-8424 (Print) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: DNA Repair*, Archaeal Proteins/*metabolism , Deoxyribonuclease (Pyrimidine Dimer)/*metabolism , O(6)-Methylguanine-DNA Methyltransferase/*metabolism , Thermoplasmales/*chemistry, Amino Acid Sequence ; Archaeal Proteins/chemistry ; Molecular Sequence Data

المؤلفون: Wei G; Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, PO Box B, Bldg. 538, Frederick, Maryland 21702, USA., Loktionova NA, Pegg AE, Moschel RC

المصدر: Journal of medicinal chemistry [J Med Chem] 2005 Jan 13; Vol. 48 (1), pp. 256-61.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Deoxyguanosine/*analogs & derivatives , Deoxyguanosine/*metabolism , Glucuronidase/*metabolism , Guanine/*analogs & derivatives , Guanine/*metabolism , Prodrugs/*metabolism, Alkyl and Aryl Transferases/antagonists & inhibitors ; Alkyl and Aryl Transferases/drug effects ; Animals ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Biochemistry/methods ; Carmustine/pharmacology ; Cattle ; Cell Death/drug effects ; Deoxyguanosine/chemical synthesis ; Deoxyguanosine/pharmacology ; Drug Stability ; Enzyme Activation/drug effects ; Escherichia coli/enzymology ; Guanine/chemical synthesis ; Guanine/pharmacology ; HT29 Cells/drug effects ; Humans ; Hydrolysis ; Kinetics ; Liver/enzymology ; Prodrugs/pharmacology

المؤلفون: Fishel ML; Department of Medicine, Committe on Cancer Biology and Cancer Research Center, University of Chicago, Chicago, IL 60637, USA., Newell DR, Griffin RJ, Davison R, Wang LZ, Curtin NJ, Zuhowski EG, Kasza K, Egorin MJ, Moschel RC, Dolan ME

المصدر: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2005 Jan; Vol. 312 (1), pp. 206-13. Date of Electronic Publication: 2004 Aug 10.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0022-3565 (Print) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , CDC2-CDC28 Kinases/*antagonists & inhibitors , Cell Cycle/*drug effects , Cisplatin/*pharmacology , Guanine/*analogs & derivatives , Guanine/*pharmacology, Cyclin-Dependent Kinase 2 ; DNA/drug effects ; DNA/metabolism ; Drug Combinations ; Drug Synergism ; Enzyme Inhibitors/pharmacology ; Humans ; Hydroxamic Acids/pharmacology ; O(6)-Methylguanine-DNA Methyltransferase/antagonists & inhibitors ; Tumor Cells, Cultured