المؤلفون: Shane D. Falcinelli, Jackson J. Peterson, Anne-Marie W. Turner, David Irlbeck, Jenna Read, Samuel L.M. Raines, Katherine S. James, Cameron Sutton, Anthony Sanchez, Ann Emery, Gavin Sampey, Robert Ferris, Brigitte Allard, Simon Ghofrani, Jennifer L. Kirchherr, Caroline Baker, JoAnn D. Kuruc, Cynthia L. Gay, Lindsey I. James, Guoxin Wu, Paul Zuck, Inmaculada Rioja, Rebecca C. Furze, Rab K. Prinjha, Bonnie J. Howell, Ronald Swanstrom, Edward P. Browne, Brian D. Strahl, Richard M. Dunham, Nancie M. Archin, David M. Margolis

المصدر: The Journal of Clinical Investigation, Vol 132, Iss 8 (2022)

مصطلحات موضوعية: AIDS/HIV, Infectious disease, Medicine

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1558-8238

URL الوصول: https://doaj.org/article/4373bee6f4264a5fa37799577488e1df

المؤلفون: Ahmed M. I. Elfiky, Ishtu L. Hageman, Marte A. J. Becker, Jan Verhoeff, Andrew Y. F. Li Yim, Vincent W. Joustra, Lieven Mulders, Ivan Fung, Inmaculada Rioja, Rab K. Prinjha, Nicholas N. Smithers, Rebecca C. Furze, Palwinder K. Mander, Matthew J. Bell, Christianne J. Buskens, Geert R. D’Haens, Manon E. Wildenberg, Wouter J. de Jonge

المصدر: Cells, Vol 11, Iss 18, p 2846 (2022)

مصطلحات موضوعية: BET inhibitor, CES1, IBD, Cytology, QH573-671

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2073-4409/11/18/2846; https://doaj.org/toc/2073-4409

URL الوصول: https://doaj.org/article/006cf9b280ac4952bda401939457b659

المؤلفون: Rosario Luque-Martin, Jan Van den Bossche, Rebecca C. Furze, Annette E. Neele, Saskia van der Velden, Marion J.J. Gijbels, Cindy P.P.A. van Roomen, Sharon G. Bernard, Wouter J. de Jonge, Inmaculada Rioja, Rab K. Prinjha, Huw D. Lewis, Palwinder K. Mander, Menno P.J. de Winther

المصدر: Frontiers in Pharmacology, Vol 10 (2019)

مصطلحات موضوعية: histone deacetylase, atherosclerosis, therapeutic targeting, monocyte, macrophage maturation, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphar.2019.01242/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/0bd1c20ec87342d695539812e636ba12

المؤلفون: Rebecca C. Furze, Judit Molnar, Nigel J. Parr, Faiz Ahmad, Yvette Henry, David Howe, Rajendra Singh, Martin Toal, Anna K. Bassil, Sharon G. Bernard, Robert P. Davis, Adele Gibson, N. Claire Maller, Catriona Sharp, David F. Tough, Rab K. Prinjha, Huw D. Lewis

المصدر: British Journal of Clinical Pharmacology. 88:5238-5256

مصطلحات موضوعية: Histone Deacetylase Inhibitors, Pharmacology, Mice, Macrophage Colony-Stimulating Factor, Esterases, Humans, Animals, Cytokines, Pharmacology (medical)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b986a405b103538adcd6ab638dd0581c
https://doi.org/10.1111/bcp.15428

المؤلفون: Patricia van Hamersveld, Laura Tomlinson, Ishtu Hageman, Ahmed M. I. Elfiky, Sigrid E.M. Heinsbroek, Juan J. Garcia-Vallejo, Jan Verhoeff, Wouter J. de Jonge, Andrew Y. F. Li Yim, Matthew J Bell, Huw D. Lewis, Manon E. Wildenberg, Iris Admiraal, Rab K. Prinjha, Rebecca C. Furze, Richard Gregory, Mohammed Ghiboub, Palwinder K. Mander, Inmaculada Rioja, Manon de Krijger, Olaf Welting, Shafaque Rahman

المساهمون: Molecular cell biology and Immunology, Graduate School, Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology Endocrinology Metabolism, AII - Inflammatory diseases, Human Genetics, ACS - Atherosclerosis & ischemic syndromes, Amsterdam Reproduction & Development (AR&D), Gastroenterology and Hepatology

المصدر: Elfiky, A M I, Ghiboub, M, Li Yim, A Y F, Hageman, I L, Verhoeff, J, de Krijger, M, van Hamersveld, P H P, Welting, O, Admiraal, I, Rahman, S, Garcia-Vallejo, J J, Wildenberg, M E, Tomlinson, L, Gregory, R, Rioja, I, Prinjha, R K, Furze, R C, Lewis, H D, Mander, P K, Heinsbroek, S E M, Bell, M J & de Jonge, W J 2022, ' Carboxylesterase-1 Assisted Targeting of HDAC Inhibitors to Mononuclear Myeloid Cells in Inflammatory Bowel Disease ', Journal of Crohn's and Colitis, vol. 16, no. 4, pp. 668-681 . https://doi.org/10.1093/ecco-jcc/jjab176
Journal of Crohn's and Colitis, 16(4), 668-681. Elsevier
Journal of Crohn's & colitis, 16(4), 668-681. Elsevier

مصطلحات موضوعية: Lipopolysaccharides, T cell, CD14, IBD, CD16, Inflammatory bowel disease, Monocytes, Mice, HDAC inhibitor, Crohn Disease, medicine, Macrophage, CES1, Animals, Humans, Myeloid Cells, Colitis, Intestinal Mucosa, CD68, business.industry, Gastroenterology, General Medicine, medicine.disease, Inflammatory Bowel Diseases, Histone Deacetylase Inhibitors, medicine.anatomical_structure, Monocyte differentiation, Cancer research, business, Carboxylic Ester Hydrolases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::082c0316620861e7964614f67286a50a
https://doi.org/10.1093/ecco-jcc/jjab176

المؤلفون: Trees Jansen, Rab K. Prinjha, Anaísa V Ferreira, Rebecca C. Furze, Nicholas Smithers, Mihai G. Netea, Jorge Domínguez-Andrés

المصدر: European Journal of Immunology, 49, 2044-2050
European Journal of Immunology, 49, 11, pp. 2044-2050
European Journal of Immunology

مصطلحات موضوعية: 0301 basic medicine, Neutrophils, Short Communication, Interleukin-1beta, Primary Cell Culture, Immunology, Immunity to infection, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], chemical and pharmacologic phenomena, Inflammation, Biology, Heterocyclic Compounds, 4 or More Rings, Monocytes, Proinflammatory cytokine, BET inhibitor, Interferon-gamma, 03 medical and health sciences, 0302 clinical medicine, Immune system, All institutes and research themes of the Radboud University Medical Center, Immunity, Candida albicans, medicine, Humans, Immunologic Factors, Immunology and Allergy, Basic, Innate immune system, Interleukin-6, Tumor Necrosis Factor-alpha, Aspergillus fumigatus, Interleukins, Interleukin-17, I‐BET151, biology.organism_classification, Endocytosis, Interleukin-10, Bromodomain, Short Communication|Basic, 030104 developmental biology, Gene Expression Regulation, Host-Pathogen Interactions, medicine.symptom, Signal Transduction, 030215 immunology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4375b4e76740131d3d10ff08c1165f10
https://doi.org/10.1002/eji.201848081

المؤلفون: Andrew D. Roberts, Peter Francis, Paola Grandi, Emma J. Jones, David P. Dixon, Robert J. Watson, Christina Rau, Peter Pogány, Angela Bridges, Chun-wa Chung, Darren Jason Mitchell, Rab K. Prinjha, Peter D. Craggs, Kelly Locke, Emmanuel Hubert Demont, Anne-Marie Michon, Bhumika Karamshi, Rebecca C. Furze, Paul Bamborough, Robert J. Sheppard, Simon C. C. Lucas, Ana Maria Roa

المصدر: Journal of medicinal chemistry. 62(16)

مصطلحات موضوعية: Models, Molecular, 0303 health sciences, Molecular Structure, Chemistry, High-throughput screening, Computational biology, 01 natural sciences, Biophysical Phenomena, 0104 chemical sciences, Bromodomain, High-Throughput Screening Assays, DNA-Binding Proteins, Small Molecule Libraries, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Protein Domains, Catalytic Domain, Drug Design, Drug Discovery, Hit rate, Molecular Medicine, ATPases Associated with Diverse Cellular Activities, Humans, 030304 developmental biology, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f80874ffd274bf81cab3a201c3f2f1c
https://pubmed.ncbi.nlm.nih.gov/31398032

المؤلفون: Patricia van Hamersveld, Jan Verhoeff, Ishtu Hageman, Rebecca C. Furze, Pal Mander, Sigrid E.M. Heinsbroek, Juan J. Garcia-Vallejo, Wouter J. de Jonge, Ahmed M. I. Elfiky, Manon E. Wildenberg, Nicholas Smithers, Inmaculada Rioja, Matthew J Bell, Huw D. Lewis, Olaf Welting, M Becker

المصدر: Gastroenterology. 160:S-325

مصطلحات موضوعية: Hepatology, Chemistry, T cell, Carboxylesterase 1, Gastroenterology, Colon inflammation, medicine.disease, medicine.anatomical_structure, Murine model, Myeloid cells, medicine, HDAC inhibitor, Cancer research, Colitis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::655ff223879d3aa25c957fd687afa49d
https://doi.org/10.1016/s0016-5085(21)01502-x

المؤلفون: Clement Douault, Tony Kouzarides, Robert J. Sheppard, Hawa Diallo, Paola Grandi, Samuel Robson, Chun-wa Chung, Ka Hing Che, Rab K. Prinjha, Richard J. Upton, Darren Jason Mitchell, Rebecca C. Furze, Emmanuel Hubert Demont, Andrew J. Bannister, Anne-Marie Michon, Robert J. Watson, Christina Rau, Paul Bamborough

المساهمون: Bannister, Andrew [0000-0002-6312-4436], Kouzarides, Tony [0000-0002-8918-4162], Apollo - University of Cambridge Repository

المصدر: Angew Chem Int Ed Engl

مصطلحات موضوعية: 0301 basic medicine, 010405 organic chemistry, Chemistry, Stereochemistry, Druggability, Chemical probe, General Medicine, General Chemistry, 01 natural sciences, Article, Catalysis, 0104 chemical sciences, Bromodomain, Sulfone, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, 030104 developmental biology, 030220 oncology & carcinogenesis, Piperidine, Bioisostere, Selectivity

وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4422b24c26e10a43ba070267a1d8114d
https://doi.org/10.1002/anie.201603928

المؤلفون: Anaísa V Ferreira, Trees Jansen, Nicholas Smithers, Jorge Domínguez-Andrés, Rab K. Prinjha, Rebecca C. Furze, Mihai G. Netea

مصطلحات موضوعية: Immune system, Biology, Bromodomain, Cell biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9332fc7fdf0453d173b14ba0ff032f41
https://doi.org/10.1002/eji.201848081/v2/response1