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1دورية أكاديمية
المؤلفون: Alison E. John, Rebecca H. Graves, K. Tao Pun, Giovanni Vitulli, Ellen J. Forty, Paul F. Mercer, Josie L. Morrell, John W. Barrett, Rebecca F. Rogers, Maryam Hafeji, Lloyd I. Bibby, Elaine Gower, Valerie S. Morrison, Yim Man, James A. Roper, Jeni C. Luckett, Lee A. Borthwick, Ben S. Barksby, Rachel A. Burgoyne, Rory Barnes, Joelle Le, David J. Flint, Susan Pyne, Anthony Habgood, Louise A. Organ, Chitra Joseph, Rochelle C. Edwards-Pritchard, Toby M. Maher, Andrew J. Fisher, Natasja Stæhr Gudmann, Diana J. Leeming, Rachel C. Chambers, Pauline T. Lukey, Richard P. Marshall, Simon J. F. Macdonald, R. Gisli Jenkins, Robert J. Slack
المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
مصطلحات موضوعية: Science
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2041-1723
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المؤلفون: Natasja Stæhr Gudmann, Richard P. Marshall, Jeni Luckett, Rebecca F. Rogers, Robert J. Slack, Simon J. F. Macdonald, Diana Julie Leeming, Rachel C. Chambers, Joelle Le, Pauline T. Lukey, Anthony Habgood, Paul F. Mercer, Rachel A. Burgoyne, Ben S. Barksby, Lloyd I. Bibby, Yim Man, Maryam Hafeji, Andrew J. Fisher, David J. Flint, Toby M. Maher, Louise Organ, Susan Pyne, Lee A. Borthwick, James A. Roper, Valerie S. Morrison, Alison E. John, Giovanni Vitulli, Rebecca H. Graves, Rochelle C. Edwards-Pritchard, R. Gisli Jenkins, John Barrett, Josie Morrell, K. Tao Pun, Elaine Gower, Rory Barnes, Ellen J. Forty, Chitra Joseph
المساهمون: National Institute for Health Research
المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communicationsمصطلحات موضوعية: Male, 0301 basic medicine, Integrins, Pyrrolidines, General Physics and Astronomy, Pharmacology, INTEGRIN-ALPHA-V-BETA-6, NINTEDANIB, Translational Research, Biomedical, Idiopathic pulmonary fibrosis, 0302 clinical medicine, Transforming Growth Factor beta, Fibrosis, Medicine, lcsh:Science, Internalization, media_common, Multidisciplinary, PIRFENIDONE, respiratory system, Small molecule, Multidisciplinary Sciences, Molecular Docking Simulation, Butyrates, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Science & Technology - Other Topics, Collagen, TYROSINE KINASE INHIBITOR, media_common.quotation_subject, Science, MODELS, Article, General Biochemistry, Genetics and Molecular Biology, RS, Small Molecule Libraries, Bleomycin, 03 medical and health sciences, Mediator, Antigen, Antigens, Neoplasm, Administration, Inhalation, Animals, Humans, Naphthyridines, Tomography, Emission-Computed, Single-Photon, Respiratory tract diseases, Science & Technology, Lung, business.industry, Epithelial Cells, General Chemistry, EFFICACY, medicine.disease, Idiopathic Pulmonary Fibrosis, respiratory tract diseases, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Pharmacodynamics, Pyrazoles, lcsh:Q, business, Transforming growth factor
وصف الملف: application/pdf
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المؤلفون: Chris D. Edwards, Edward Taylor, Rebecca H Graves, Olivia J. Robb, Brett O'Brien, Andrew W Harrell, Edith M. Hessel, Augustin Amour, Aarti Patel, Neil A Miller
المصدر: Clinical pharmacokinetics. 61(2)
مصطلحات موضوعية: Drug, Physiologically based pharmacokinetic modelling, Indazoles, Indoles, media_common.quotation_subject, Administration, Oral, Pharmacology, Models, Biological, Piperazines, Pulmonary Absorption, Route of administration, Pharmacokinetics, Administration, Inhalation, medicine, Distribution (pharmacology), Animals, Humans, Pharmacology (medical), Computer Simulation, Oxazoles, media_common, medicine.diagnostic_test, Inhalation, business.industry, Absorption, Physiological, Rats, Bronchoalveolar lavage, business
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المؤلفون: Rebecca H. Graves, Panayiotis A. Procopiou, Simon Teanby Hodgson, Afjal Hussain Miah, Jonathan M. Percy, Aurelie C. Champigny
المصدر: Bioorganicmedicinal chemistry. 25(20)
مصطلحات موضوعية: 0301 basic medicine, Male, Receptors, CCR4, Stereochemistry, Clinical Biochemistry, Substituent, Pharmaceutical Science, Biochemistry, Pyrazolopyrimidine, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, 0302 clinical medicine, Dogs, Drug Discovery, Structure–activity relationship, Potency, Animals, Humans, Solubility, Rats, Wistar, Molecular Biology, chemistry.chemical_classification, Indazole, Sulfonamides, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Sulfonamide, Rats, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Lipophilicity, Molecular Medicine
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المؤلفون: Rebecca H. Graves, Elaine Gower, Richard P. Marshall, Pan Procopiou, Andrew J. Fisher, Giovanni Vitulli, Ellen J. Forty, Tao Pun, Steve Ludbrook, Simon J. F. Macdonald, Anderson Niall Andrew, Jane Denyer, Alison E. John, David C. Budd, Susan Pyne, Gisli Jenkins, John Pritchard, Pauline T. Lukey, David J. Flint, John Marshall, Rachel C. Chambers, Valerie S. Morrison, Carmel B. Nanthakumar, Paul F. Mercer, Robert J. Slack
المصدر: QJM: An International Journal of Medicine.
مصطلحات موضوعية: 0301 basic medicine, Pathology, medicine.medical_specialty, αvβ6 integrin, business.industry, Scar tissue, Inflammation, General Medicine, medicine.disease, Small molecule, 03 medical and health sciences, Idiopathic pulmonary fibrosis, 030104 developmental biology, Fibrosis, medicine, medicine.symptom, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7464da6e9014e4cc1e1841f8366720bf
https://doi.org/10.1093/qjmed/hcw120.013 -
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المؤلفون: John Barrett, Catherine Nye, Don O. Somers, Roberto Solari, John D. Harling, Sebastien Andre Campos, Rachel Grimley, Rebecca H. Graves, Christina M. Bessant, Angela M. Deakin, Laura Hanns, William J. Kerr, Oxana Polyakova, Nick Barton, Laiq Chaudry
المصدر: Journal of Biological Chemistry. 288:28195-28206
مصطلحات موضوعية: Male, Drug Evaluation, Preclinical, Biology, Crystallography, X-Ray, Ligands, Biochemistry, Jurkat cells, Gene Expression Regulation, Enzymologic, Jurkat Cells, chemistry.chemical_compound, Adenosine Triphosphate, immune system diseases, In vivo, Animals, Humans, Cysteine, Enzyme Inhibitors, Particle Size, Rats, Wistar, Mode of action, Molecular Biology, Kinase, Drug discovery, Cell Biology, Protein-Tyrosine Kinases, Asthma, respiratory tract diseases, Rats, chemistry, Drug Design, Leukocytes, Mononuclear, Enzymology, Cytokines, Signal transduction, Adenosine triphosphate, Tyrosine kinase, Protein Binding, Signal Transduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae4f29a0279ef07ef494bc4aa68fb8c
https://doi.org/10.1074/jbc.m113.474114 -
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المؤلفون: Rebecca H. Graves, Alan P. Hill, David E. Clapham, Steven L. Sollis, Karen M. L. Morriss, Robert J. Slack, Nick Barton, Ashley Paul Hancock, Heather Hobbs, Afjal Hussain Miah, Coline Jumeaux, Alison J. Ford, Claire E. Smith, Deborah Needham, Emma B. Sheriff, Panayiotis A. Procopiou, Simon Teanby Hodgson, John Barrett, Malcolm Begg, David A. Hall, Yannick M. L. Lacroix, Royston C. B. Copley, Hugo Staton
المصدر: Journal of Medicinal Chemistry. 56:1946-1960
مصطلحات موضوعية: Male, chemistry.chemical_classification, Sulfonamides, Indazole, Indazoles, Receptors, CCR4, Stereochemistry, Aryl, Allosteric regulation, Rats, Sulfonamide, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, chemistry, In vivo, Intramolecular force, Drug Discovery, Animals, Humans, Molecular Medicine, Structure–activity relationship, Receptor
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المؤلفون: Jonathan M. Percy, Simon Teanby Hodgson, Sean M. Lynn, Brian Evans, Panayiotis A. Procopiou, Rebecca H. Graves, Laura Ajram, Stephen A. Richards, Afjal Hussain Miah, Malcolm Begg, Robert J. Slack, Lena Shukla
مصطلحات موضوعية: 0301 basic medicine, Receptors, CCR4, Stereochemistry, Allosteric regulation, Endocytosis, 03 medical and health sciences, Chemokine receptor, Structure-Activity Relationship, Cell surface receptor, Drug Discovery, Structure–activity relationship, Humans, Spiro Compounds, QD, Receptor, Pharmacology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Ligand binding assay, Organic Chemistry, General Medicine, Molecular biology, Small molecule, 030104 developmental biology, Pyrimidines
وصف الملف: application/pdf
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المؤلفون: David A. Hall, Yannick M. L. Lacroix, Alison J. Ford, Deborah Needham, Rebecca H. Graves, Robert J. Slack, Panayiotis A. Procopiou, Simon Teanby Hodgson
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:2730-2733
مصطلحات موضوعية: Indazoles, Stereochemistry, Clinical Biochemistry, Substituent, CCR4, Pharmaceutical Science, Biochemistry, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Chemokine receptor, Clinical investigation, Drug Discovery, Humans, Structure–activity relationship, Molecular Biology, chemistry.chemical_classification, Sulfonamides, Indazole, Molecular Structure, Organic Chemistry, Antagonist, Sulfonamide, chemistry, Molecular Medicine, Receptors, Chemokine, Protein Binding
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المؤلفون: Anthony Cahn, Simon Teanby Hodgson, Rebecca H. Graves, Steve Hughes, Joanna Watson, Misba Beerahee, Robert Wilson, Sjoerd van Marle, Roberto Solari, Jonathan Robertson, Graeme Young, David A. Hall
المصدر: BMC Pharmacology & Toxicology
مصطلحات موضوعية: Adult, Diarrhea, Male, Indazoles, Receptors, CCR4, Metabolic Clearance Rate, Cmax, Administration, Oral, Biological Availability, Pharmacology, Drug Administration Schedule, GSK2239633, Young Adult, Pharmacokinetics, Double-Blind Method, Oral administration, Distribution (pharmacology), Medicine, Humans, Microdose, Pharmacology (medical), Adverse effect, Infusions, Intravenous, Aged, Rhinitis, Sulfonamides, Healthy, Dose-Response Relationship, Drug, business.industry, Antagonist, Headache, Middle Aged, Bioavailability, Abdominal Pain, Tolerability, Area Under Curve, CCR4, business, Research Article