المؤلفون: Isci D; Laboratory of Nervous System Diseases and Therapy, GIGA Neuroscience, GIGA Institute, University of Liège, Liège, Belgium., Kuppens A; Laboratory of Nervous System Diseases and Therapy, GIGA Neuroscience, GIGA Institute, University of Liège, Liège, Belgium., Scalisi J; Laboratory of Nervous System Diseases and Therapy, GIGA Neuroscience, GIGA Institute, University of Liège, Liège, Belgium., Cokaiko J; Laboratory of Nervous System Diseases and Therapy, GIGA Neuroscience, GIGA Institute, University of Liège, Liège, Belgium., D'Uonnolo G; Immuno-Pharmacology and Interactomics, Department of Infection and Immunity, Luxembourg Institute of Health, Strassen, Luxembourg.; Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg., Wantz M; Immuno-Pharmacology and Interactomics, Department of Infection and Immunity, Luxembourg Institute of Health, Strassen, Luxembourg., Szpakowska M; Immuno-Pharmacology and Interactomics, Department of Infection and Immunity, Luxembourg Institute of Health, Strassen, Luxembourg., Chevigné A; Immuno-Pharmacology and Interactomics, Department of Infection and Immunity, Luxembourg Institute of Health, Strassen, Luxembourg., Rogister B; Laboratory of Nervous System Diseases and Therapy, GIGA Neuroscience, GIGA Institute, University of Liège, Liège, Belgium.; Neurology Department, University Hospital, University of Liège, Liège, Belgium., Neirinckx V; Laboratory of Nervous System Diseases and Therapy, GIGA Neuroscience, GIGA Institute, University of Liège, Liège, Belgium. virginie.neirinckx@uliege.be.

المصدر: Scientific reports [Sci Rep] 2024 Sep 20; Vol. 14 (1), pp. 21925. Date of Electronic Publication: 2024 Sep 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Glioblastoma*/pathology , Glioblastoma*/genetics , Glioblastoma*/metabolism , Receptors, CXCR*/metabolism , Receptors, CXCR*/genetics , Brain Neoplasms*/pathology , Brain Neoplasms*/genetics , Brain Neoplasms*/metabolism, Humans ; Gene Expression Regulation, Neoplastic ; Cell Proliferation ; Cell Line, Tumor ; Cell Movement/genetics ; Chemokine CXCL12/metabolism ; Chemokine CXCL12/genetics ; Receptors, CXCR4/metabolism ; Receptors, CXCR4/genetics ; Tumor Microenvironment/genetics

المؤلفون: Piñeiro-Sabarís R; Intercellular Signaling in Cardiovascular Development and Disease Laboratory, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Melchor Fernández Almagro 3, 28029 Madrid, Spain.; Ciber de Enfermedades Cardiovasculares, Instituto de Salud Carlos III, Melchor Fernández Almagro 3, 28029 Madrid, Spain., MacGrogan D; Intercellular Signaling in Cardiovascular Development and Disease Laboratory, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Melchor Fernández Almagro 3, 28029 Madrid, Spain.; Ciber de Enfermedades Cardiovasculares, Instituto de Salud Carlos III, Melchor Fernández Almagro 3, 28029 Madrid, Spain., de la Pompa JL; Intercellular Signaling in Cardiovascular Development and Disease Laboratory, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Melchor Fernández Almagro 3, 28029 Madrid, Spain.; Ciber de Enfermedades Cardiovasculares, Instituto de Salud Carlos III, Melchor Fernández Almagro 3, 28029 Madrid, Spain.

المصدر: Disease models & mechanisms [Dis Model Mech] 2024 Sep 01; Vol. 17 (9). Date of Electronic Publication: 2024 Sep 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Company of Biologists Ltd Country of Publication: England NLM ID: 101483332 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1754-8411 (Electronic) Linking ISSN: 17548403 NLM ISO Abbreviation: Dis Model Mech Subsets: MEDLINE

مواضيع طبية MeSH: GATA6 Transcription Factor*/metabolism , GATA6 Transcription Factor*/genetics , Signal Transduction* , Bicuspid Aortic Valve Disease*/pathology , Receptors, CXCR*/metabolism , Receptors, CXCR*/genetics , Cell Proliferation*, Animals ; Neural Crest/metabolism ; Neural Crest/pathology ; Mice ; Cell Movement ; Aortic Valve/abnormalities ; Aortic Valve/pathology ; Aortic Valve/metabolism ; Heart Valve Diseases/pathology ; Heart Valve Diseases/metabolism ; Heart Valve Diseases/genetics ; Phenotype ; Mice, Inbred C57BL

المؤلفون: Bayrak A; Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany., Szpakowska M; Department of Infection and Immunity, Immuno-Pharmacology and Interactomics, Luxembourg Institute of Health (LIH), L-4354 Esch-sur-Alzette, Luxembourg., Dicenta-Baunach V; Department of Internal Medicine III, Cardiology and Angiology, University Hospital Tübingen, Otfried-Müller-Strasse 10, 72076 Tübingen, Germany., Counson M; Department of Infection and Immunity, Immuno-Pharmacology and Interactomics, Luxembourg Institute of Health (LIH), L-4354 Esch-sur-Alzette, Luxembourg., Rasch A; Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany., Rohlfing AK; Department of Internal Medicine III, Cardiology and Angiology, University Hospital Tübingen, Otfried-Müller-Strasse 10, 72076 Tübingen, Germany., Chevigné A; Department of Infection and Immunity, Immuno-Pharmacology and Interactomics, Luxembourg Institute of Health (LIH), L-4354 Esch-sur-Alzette, Luxembourg., Gawaz M; Department of Internal Medicine III, Cardiology and Angiology, University Hospital Tübingen, Otfried-Müller-Strasse 10, 72076 Tübingen, Germany., Laufer SA; Department of Infection and Immunity, Immuno-Pharmacology and Interactomics, Luxembourg Institute of Health (LIH), L-4354 Esch-sur-Alzette, Luxembourg.; Tübingen Center for Academic Drug Discovery (TüCAD2), Auf der Morgenstelle 8, 72076 Tübingen, Germany.; iFIT Cluster of Excellence (EXC 2180) 'Image-guided and Functionally Instructed Tumor Therapies', Eberhard Karls University Tübingen, 72076 Tübingen, Germany., Pillaiyar T; Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany.; Tübingen Center for Academic Drug Discovery (TüCAD2), Auf der Morgenstelle 8, 72076 Tübingen, Germany.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Aug 22; Vol. 67 (16), pp. 14553-14573. Date of Electronic Publication: 2024 Aug 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Platelet Aggregation Inhibitors*/pharmacology , Platelet Aggregation Inhibitors*/chemical synthesis , Platelet Aggregation Inhibitors*/chemistry , Drug Design* , Platelet Aggregation*/drug effects , Receptors, CXCR*/agonists , Receptors, CXCR*/metabolism, Humans ; Structure-Activity Relationship ; Animals ; Small Molecule Libraries/pharmacology ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/chemical synthesis ; P-Selectin/metabolism ; Blood Platelets/drug effects ; Blood Platelets/metabolism

المؤلفون: Eberle SA; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark., Gustavsson M; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark. Electronic address: martin@sund.ku.dk.

المصدر: Structure (London, England : 1993) [Structure] 2024 Aug 08; Vol. 32 (8), pp. 1174-1183.e5. Date of Electronic Publication: 2024 May 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101087697 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4186 (Electronic) Linking ISSN: 09692126 NLM ISO Abbreviation: Structure Subsets: MEDLINE

مواضيع طبية MeSH: Lipid Bilayers*/metabolism , Lipid Bilayers*/chemistry , Protein Binding* , Receptors, CXCR*/metabolism , Receptors, CXCR*/chemistry , Receptors, CXCR*/genetics , Chemokine CXCL12*/metabolism , Chemokine CXCL12*/chemistry, Humans ; Chemokine CXCL11/metabolism ; Chemokine CXCL11/chemistry ; Binding Sites ; Ligands ; Kinetics ; Models, Molecular

المؤلفون: Otun O; Institut de Génomique Fonctionnelle, University of Montpellier, CNRS, INSERM, Montpellier Cedex 5 34094, France., Aljamous C; Institut de Génomique Fonctionnelle, University of Montpellier, CNRS, INSERM, Montpellier Cedex 5 34094, France., Del Nero E; Institut de Génomique Fonctionnelle, University of Montpellier, CNRS, INSERM, Montpellier Cedex 5 34094, France., Arimont-Segura M; Department of Medicinal Chemistry, Amsterdam Institute for Molecular Life Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam 1081 HV, The Netherlands., Bosma R; Department of Medicinal Chemistry, Amsterdam Institute for Molecular Life Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam 1081 HV, The Netherlands., Zarzycka B; Department of Medicinal Chemistry, Amsterdam Institute for Molecular Life Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam 1081 HV, The Netherlands., Girbau T; Institut de Génomique Fonctionnelle, University of Montpellier, CNRS, INSERM, Montpellier Cedex 5 34094, France., Leyrat C; Institut de Génomique Fonctionnelle, University of Montpellier, CNRS, INSERM, Montpellier Cedex 5 34094, France., de Graaf C; Department of Medicinal Chemistry, Amsterdam Institute for Molecular Life Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam 1081 HV, The Netherlands., Leurs R; Department of Medicinal Chemistry, Amsterdam Institute for Molecular Life Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam 1081 HV, The Netherlands., Durroux T; Institut de Génomique Fonctionnelle, University of Montpellier, CNRS, INSERM, Montpellier Cedex 5 34094, France., Granier S; Institut de Génomique Fonctionnelle, University of Montpellier, CNRS, INSERM, Montpellier Cedex 5 34094, France., Cong X; Institut de Génomique Fonctionnelle, University of Montpellier, CNRS, INSERM, Montpellier Cedex 5 34094, France., Bechara C; Institut de Génomique Fonctionnelle, University of Montpellier, CNRS, INSERM, Montpellier Cedex 5 34094, France.; Institut Universitaire de France, Paris 75005, France.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Jul 23; Vol. 121 (30), pp. e2404000121. Date of Electronic Publication: 2024 Jul 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Molecular Dynamics Simulation* , Receptors, CXCR*/metabolism , Receptors, CXCR*/genetics , Protein Binding*, Humans ; Binding Sites ; Protein Conformation ; beta-Arrestin 1/metabolism ; beta-Arrestin 1/genetics ; Ligands ; HEK293 Cells ; Mutagenesis, Site-Directed ; Allosteric Regulation ; Structure-Activity Relationship

المؤلفون: Liu CC; National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan., Yang WB; Research Center for Neuroscience, Taipei Medical University, Taipei, Taiwan.; Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan., Chien CH; National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan.; School of Medicine, I-Shou University, Kaohsiung, Taiwan., Wu CL; Department of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng-Kung University, Tainan, Taiwan., Chuang JY; Research Center for Neuroscience, Taipei Medical University, Taipei, Taiwan.; International Master Program in Medical Neuroscience, Taipei Medical University, Taipei, Taiwan.; Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan., Chen PY; School of Medicine, Chang Gung University, Taoyuan, Taiwan.; Department of Neurosurgery, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan., Chu JM; National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan., Cheng SM; National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan., Qiu LY; National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan., Chang YC; National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan.; TMU Research Center of Cancer Translational Medicine; Taipei Cancer Center; Taipei Medical University Hospital, College of Medicine, Taipei Medical University, Taipei, Taiwan., Hwang DY; National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan., Huang CY; Division of Neurosurgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan., Lee JS; Division of Neurosurgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan., Chang KY; National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan. kwang2@nhri.edu.tw.; Department of Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. kwang2@nhri.edu.tw.; Center of Cell Therapy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. kwang2@nhri.edu.tw.

المصدر: Cell death & disease [Cell Death Dis] 2024 Jun 19; Vol. 15 (6), pp. 434. Date of Electronic Publication: 2024 Jun 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE

مواضيع طبية MeSH: Glioblastoma*/pathology , Glioblastoma*/immunology , Glioblastoma*/genetics , Glioblastoma*/metabolism , Receptors, CXCR*/metabolism , Receptors, CXCR*/genetics , Chemokine CXCL12*/metabolism , B7-H1 Antigen*/metabolism, Humans ; Animals ; Mice ; Cell Line, Tumor ; Tumor Microenvironment ; Brain Neoplasms/pathology ; Brain Neoplasms/immunology ; Brain Neoplasms/genetics ; Brain Neoplasms/metabolism ; Signal Transduction/drug effects

المؤلفون: Schlimgen RR; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Peterson FC; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Heukers R; Amsterdam Institute of Molecular and Life Sciences, Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit, 1081 HZ, Amsterdam, The Netherlands., Smit MJ; Amsterdam Institute of Molecular and Life Sciences, Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit, 1081 HZ, Amsterdam, The Netherlands., McCorvy JD; Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Volkman BF; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, 53226, USA. bvolkman@mcw.edu.

المصدر: Nature communications [Nat Commun] 2024 May 30; Vol. 15 (1), pp. 4611. Date of Electronic Publication: 2024 May 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Single-Domain Antibodies*/chemistry , Single-Domain Antibodies*/metabolism , Receptors, CXCR*/metabolism , Receptors, CXCR*/genetics , Receptors, CXCR*/antagonists & inhibitors , Receptors, CXCR*/chemistry, Humans ; HEK293 Cells ; Protein Binding ; Receptors, G-Protein-Coupled/metabolism ; Receptors, G-Protein-Coupled/chemistry ; Receptors, G-Protein-Coupled/antagonists & inhibitors ; Animals

المؤلفون: Adamska JM; Amsterdam Institute of Molecular and Life Sciences, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands., Leftheriotis S; Amsterdam Institute of Molecular and Life Sciences, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands., Bosma R; Amsterdam Institute of Molecular and Life Sciences, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands., Vischer HF; Amsterdam Institute of Molecular and Life Sciences, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands., Leurs R; Amsterdam Institute of Molecular and Life Sciences, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 May 04; Vol. 25 (9). Date of Electronic Publication: 2024 May 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Receptors, CXCR4*/metabolism , Receptors, CXCR*/metabolism , Receptors, CXCR*/genetics , Chemokine CXCL12*/metabolism , Protein Binding* , Receptors, CXCR3*/metabolism, Humans ; Bioluminescence Resonance Energy Transfer Techniques/methods ; Ligands ; Fluorescent Dyes/chemistry

المؤلفون: Meng P; Department of Central Laboratory, Huadu District People's Hospital of Guangzhou, Guangzhou, China., Liu C; Department of Central Laboratory, Huadu District People's Hospital of Guangzhou, Guangzhou, China., Li J; Department of Central Laboratory, Huadu District People's Hospital of Guangzhou, Guangzhou, China., Fang P; Department of Laboratory Medicine, Huadu District People's Hospital of Guangzhou, Guangzhou, China., Yang B; Department of Clinical Nutrition, Huadu District People's Hospital of Guangzhou, Guangzhou, China., Sun W; Department of Central Laboratory, Huadu District People's Hospital of Guangzhou, Guangzhou, China., Zhang Y; Department of Nephrology, Huadu District People's Hospital of Guangzhou, Guangzhou, China.

المصدر: Renal failure [Ren Fail] 2024 Dec; Vol. 46 (1), pp. 2300727. Date of Electronic Publication: 2024 Jan 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8701128 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6049 (Electronic) Linking ISSN: 0886022X NLM ISO Abbreviation: Ren Fail Subsets: MEDLINE

مواضيع طبية MeSH: Kidney Diseases*/etiology , Receptors, CXCR*/genetics, Animals ; Mice ; beta Catenin ; Disease Models, Animal ; Epithelial Cells ; Epithelial-Mesenchymal Transition ; Fibrosis

المؤلفون: Fukuoka A; Chemokine Research Group, School of Infection and Immunity , College of Medical, Veterinary and Life Sciences, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK., Wilson GJ; Chemokine Research Group, School of Infection and Immunity , College of Medical, Veterinary and Life Sciences, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK., Pitmon E; Chemokine Research Group, School of Infection and Immunity , College of Medical, Veterinary and Life Sciences, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK., Koumbas Foley L; Chemokine Research Group, School of Infection and Immunity , College of Medical, Veterinary and Life Sciences, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK., Johnsson H; Chemokine Research Group, School of Infection and Immunity , College of Medical, Veterinary and Life Sciences, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK., Pingen M; Chemokine Research Group, School of Infection and Immunity , College of Medical, Veterinary and Life Sciences, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK., Graham GJ; Chemokine Research Group, School of Infection and Immunity , College of Medical, Veterinary and Life Sciences, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK.

المصدر: Development (Cambridge, England) [Development] 2024 Feb 15; Vol. 151 (4). Date of Electronic Publication: 2024 Feb 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Company Of Biologists Limited Country of Publication: England NLM ID: 8701744 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-9129 (Electronic) Linking ISSN: 09501991 NLM ISO Abbreviation: Development Subsets: MEDLINE

مواضيع طبية MeSH: Placenta*/metabolism , Receptors, CXCR*/genetics , Receptors, CXCR*/metabolism, Animals ; Female ; Mice ; Pregnancy ; Chemokine CXCL12/genetics ; Chemokine CXCL12/metabolism ; Movement ; Mutation ; Signal Transduction/genetics