المؤلفون: Walker JT; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA., Saunders DC; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Rai V; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Chen HH; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Orchard P; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Dai C; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Pettway YD; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA., Hopkirk AL; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Reihsmann CV; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Tao Y; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Fan S; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Shrestha S; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Varshney A; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Petty LE; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Wright JJ; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Ventresca C; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA., Agarwala S; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Aramandla R; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Poffenberger G; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Jenkins R; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Mei S; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Hart NJ; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Phillips S; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Kang H; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Greiner DL; Department of Molecular Medicine, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, MA, USA., Shultz LD; The Jackson Laboratory, Bar Harbor, ME, USA., Bottino R; Imagine Pharma, Devon, PA, USA.; Institute of Cellular Therapeutics, Allegheny-Singer Research Institute, Allegheny Health Network, Pittsburgh, PA, USA., Liu J; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Below JE; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Parker SCJ; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA. scjp@umich.edu.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA. scjp@umich.edu.; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA. scjp@umich.edu., Powers AC; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA. al.powers@vumc.org.; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. al.powers@vumc.org.; VA Tennessee Valley Healthcare System, Nashville, TN, USA. al.powers@vumc.org., Brissova M; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. marcela.brissova@vanderbilt.edu.

مؤلفون مشاركون: HPAP Consortium

المصدر: Nature [Nature] 2023 Dec; Vol. 624 (7992), pp. 621-629. Date of Electronic Publication: 2023 Dec 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Diabetes Mellitus, Type 2*/genetics , Diabetes Mellitus, Type 2*/metabolism , Diabetes Mellitus, Type 2*/pathology , Diabetes Mellitus, Type 2*/physiopathology , Gene Expression Profiling* , Gene Regulatory Networks*/genetics , Genetic Predisposition to Disease* , Islets of Langerhans*/metabolism , Islets of Langerhans*/pathology, Humans ; Case-Control Studies ; Cell Separation ; Chromatin/metabolism ; Genome-Wide Association Study ; Insulin Secretion ; Reproducibility of Results

المؤلفون: Haliyur R; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Walker JT; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Sanyoura M; Department of Medicine and Pediatrics-Section of Endocrinology, Diabetes, and Metabolism, University of Chicago, Chicago, IL, USA., Reihsmann CV; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Shrestha S; HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA., Aramandla R; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Poffenberger G; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Ramirez AH; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Redick SD; Program in Molecular Medicine, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, MA, USA., Babon JAB; Department of Medicine, Division of Diabetes, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, MA, USA., Prasad N; HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA., Hegele RA; Department of Medicine and Robarts Research Institute, Schulich School of Medicine, Western University, London, Ontario, Canada., Kent SC; Department of Medicine, Division of Diabetes, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, MA, USA., Harlan DM; Department of Medicine, Division of Diabetes, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, MA, USA., Bottino R; Institute of Cellular Therapeutics, Allegheny-Singer Research Institute, Allegheny Health Network, Pittsburgh, PA, USA., Philipson LH; Department of Medicine and Pediatrics-Section of Endocrinology, Diabetes, and Metabolism, University of Chicago, Chicago, IL, USA., Brissova M; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Powers AC; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA.

المصدر: Journal of the Endocrine Society [J Endocr Soc] 2021 Oct 29; Vol. 5 (12), pp. bvab162. Date of Electronic Publication: 2021 Oct 29 (Print Publication: 2021).

نوع المنشور: Case Reports

بيانات الدورية: Publisher: Endocrine Society Country of Publication: United States NLM ID: 101697997 Publication Model: eCollection Cited Medium: Internet ISSN: 2472-1972 (Electronic) Linking ISSN: 24721972 NLM ISO Abbreviation: J Endocr Soc Subsets: PubMed not MEDLINE