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المؤلفون: Chakravorty SJ; 1 GlaxoSmithKline R&D Pharmaceuticals, Computational Chemistry, Collegeville, PA, USA., Chan J; 2 GlaxoSmithKline R&D Pharmaceuticals, Sample Management Technologies, Collegeville, PA, USA.; 3 Retired, PA, USA., Greenwood MN; 2 GlaxoSmithKline R&D Pharmaceuticals, Sample Management Technologies, Collegeville, PA, USA., Popa-Burke I; 4 GlaxoSmithKline R&D Pharmaceuticals, Sample Management Technologies, Research Triangle Park, NC, USA.; 5 Sandoz, Munich, Germany., Remlinger KS; 6 GlaxoSmithKline R&D Pharmaceuticals, Statistical Sciences, Research Triangle Park, NC, USA., Pickett SD; 7 GlaxoSmithKline R&D Pharmaceuticals, Computational Chemistry, Stevenage, UK., Green DVS; 7 GlaxoSmithKline R&D Pharmaceuticals, Computational Chemistry, Stevenage, UK., Fillmore MC; 8 GlaxoSmithKline R&D Pharmaceuticals, Medicinal Chemistry, Stevenage, UK., Dean TW; 8 GlaxoSmithKline R&D Pharmaceuticals, Medicinal Chemistry, Stevenage, UK., Luengo JI; 9 GlaxoSmithKline R&D Pharmaceuticals, Medicinal Chemistry, Collegeville, PA, USA.; 10 Prelude Therapeutics, Newark, DE, USA., Macarrón R; 2 GlaxoSmithKline R&D Pharmaceuticals, Sample Management Technologies, Collegeville, PA, USA.

المصدر: SLAS discovery : advancing life sciences R & D [SLAS Discov] 2018 Jul; Vol. 23 (6), pp. 532-545. Date of Electronic Publication: 2018 Apr 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101697563 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2472-5560 (Electronic) Linking ISSN: 24725552 NLM ISO Abbreviation: SLAS Discov Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery/*methods , High-Throughput Screening Assays/*methods , Small Molecule Libraries/*chemistry, Biological Assay/methods

المؤلفون: Patel K; Duke Clinical Research Institute, Durham, North Carolina; Liver Cell Biology, Centenary Institute, University of Sydney, Sydney, NSW, Australia. Electronic address: keyur.patel@duke.edu., Remlinger KS; GlaxoSmithKline, Research Triangle Park, North Carolina., Walker TG; OpGen, Gaithersburg, Maryland., Leitner P; BioAgilytix Labs, Research Triangle Park, North Carolina., Lucas JE; Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina., Gardner SD; GlaxoSmithKline, Research Triangle Park, North Carolina., McHutchison JG; Duke Clinical Research Institute, Durham, North Carolina; Gilead Sciences, Foster City, California., Irving W; National Institute for Health Research Biomedical Research Unit in Gastrointestinal and Liver Diseases at Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, United Kingdom., Guha IN; National Institute for Health Research Biomedical Research Unit in Gastrointestinal and Liver Diseases at Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, United Kingdom.

المصدر: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association [Clin Gastroenterol Hepatol] 2014 Dec; Vol. 12 (12), pp. 2113-20.e1-3. Date of Electronic Publication: 2014 May 09.

نوع المنشور: Evaluation Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: W.B. Saunders for the American Gastroenterological Association Country of Publication: United States NLM ID: 101160775 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-7714 (Electronic) Linking ISSN: 15423565 NLM ISO Abbreviation: Clin Gastroenterol Hepatol Subsets: MEDLINE

مواضيع طبية MeSH: Biomarkers/*blood , Cytokines/*blood , Fibrosis/*diagnosis , Fibrosis/*pathology , Hepatitis C, Chronic/*diagnosis , Hepatitis C, Chronic/*pathology , Liver/*pathology, Adult ; Biopsy ; Blood Chemical Analysis ; Cohort Studies ; Cytokines/analysis ; Enzyme-Linked Immunosorbent Assay ; Extracellular Matrix Proteins/analysis ; Female ; Histocytochemistry ; Humans ; Male ; Middle Aged ; Prognosis

المؤلفون: Irlbeck DM, Vernon SD, McCleary KK, Bateman L, Klimas NG, Lapp CW, Peterson DL, Brown JR, Remlinger KS, Wilfret DA, Gerondelis P; Division of Infectious Diseases, GlaxoSmithKline, Research Triangle Park, NC, USA. peter.z.gerondelis@gsk.com.

المصدر: BMC research notes [BMC Res Notes] 2014 Aug 04; Vol. 7, pp. 461. Date of Electronic Publication: 2014 Aug 04.

نوع المنشور: Journal Article; Multicenter Study

بيانات الدورية: Publisher: Biomed Central Country of Publication: England NLM ID: 101462768 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-0500 (Electronic) Linking ISSN: 17560500 NLM ISO Abbreviation: BMC Res Notes Subsets: MEDLINE

مواضيع طبية MeSH: Biological Specimen Banks*, Fatigue Syndrome, Chronic/*virology , Leukemia Virus, Murine/*isolation & purification , Xenotropic murine leukemia virus-related virus/*isolation & purification, Adult ; Animals ; Base Sequence ; Case-Control Studies ; DNA, Viral/genetics ; DNA, Viral/isolation & purification ; Demography ; Female ; Humans ; Male ; Mice ; Middle Aged ; Phylogeny ; Polymerase Chain Reaction ; Prospective Studies ; Reproducibility of Results ; Sensitivity and Specificity ; Viral Proteins/metabolism

المؤلفون: Stimpson SA; Muscle Metabolism Discovery Performance Unit, Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, Research Triangle Park, NC, 27709, USA, stephen.a.stimpson@gsk.com., Leonard MS, Clifton LG, Poole JC, Turner SM, Shearer TW, Remlinger KS, Clark RV, Hellerstein MK, Evans WJ

المصدر: Journal of cachexia, sarcopenia and muscle [J Cachexia Sarcopenia Muscle] 2013 Jun 25, pp. . Date of Electronic Publication: 2013 Jun 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders Country of Publication: Germany NLM ID: 101552883 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2190-5991 (Print) Linking ISSN: 21905991 NLM ISO Abbreviation: J Cachexia Sarcopenia Muscle

المؤلفون: Stimpson SA; Muscle Metabolism Discovery Performance Unit, Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, Research Triangle Park, NC 27709, USA. stephen.a.stimpson@gsk.com, Turner SM, Clifton LG, Poole JC, Mohammed HA, Shearer TW, Waitt GM, Hagerty LL, Remlinger KS, Hellerstein MK, Evans WJ

المصدر: Journal of applied physiology (Bethesda, Md. : 1985) [J Appl Physiol (1985)] 2012 Jun; Vol. 112 (11), pp. 1940-8. Date of Electronic Publication: 2012 Mar 15.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Physiological Society Country of Publication: United States NLM ID: 8502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1601 (Electronic) Linking ISSN: 01617567 NLM ISO Abbreviation: J Appl Physiol (1985) Subsets: MEDLINE

مواضيع طبية MeSH: Creatine/*pharmacokinetics , Muscle, Skeletal/*metabolism , Muscular Atrophy/*metabolism, Animals ; Creatine/blood ; Creatine/urine ; Male ; Metabolic Clearance Rate/drug effects ; Metabolic Clearance Rate/physiology ; Methylation ; Random Allocation ; Rats ; Rats, Sprague-Dawley

المؤلفون: Rong JX; Metabolic Discovery Technology Group, Molecular Discovery Research, GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, USA., Klein JL, Qiu Y, Xie M, Johnson JH, Waters KM, Zhang V, Kashatus JA, Remlinger KS, Bing N, Crosby RM, Jackson TK, Witherspoon SM, Moore JT, Ryan TE, Neill SD, Strum JC

المصدر: PPAR research [PPAR Res] 2011; Vol. 2011, pp. 179454. Date of Electronic Publication: 2011 Oct 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 101269101 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1687-4765 (Electronic) NLM ISO Abbreviation: PPAR Res Subsets: PubMed not MEDLINE

المؤلفون: Alaynick WA; Gene Expression Laboratory and the Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, California 92037, USA. alaynick@salk.edu, Way JM, Wilson SA, Benson WG, Pei L, Downes M, Yu R, Jonker JW, Holt JA, Rajpal DK, Li H, Stuart J, McPherson R, Remlinger KS, Chang CY, McDonnell DP, Evans RM, Billin AN

المصدر: Molecular endocrinology (Baltimore, Md.) [Mol Endocrinol] 2010 Feb; Vol. 24 (2), pp. 299-309. Date of Electronic Publication: 2009 Dec 04.

نوع المنشور: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Endocrine Society Country of Publication: United States NLM ID: 8801431 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-9917 (Electronic) Linking ISSN: 08888809 NLM ISO Abbreviation: Mol Endocrinol Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation*, Gastric Mucosa/*metabolism , Heart/*physiology , Kidney/*metabolism , Myocardium/*metabolism , Potassium/*metabolism , Receptors, Estrogen/*physiology, Adult ; Animals ; Animals, Newborn ; Body Mass Index ; Female ; Genetic Association Studies ; Homeostasis ; Humans ; Hypertension/genetics ; Kidney/pathology ; Long QT Syndrome/genetics ; Male ; Mice ; Middle Aged ; Myocardium/pathology ; Oligonucleotide Array Sequence Analysis ; Organ Specificity ; Polymorphism, Single Nucleotide ; Potassium Channels, Voltage-Gated/genetics ; Potassium Channels, Voltage-Gated/metabolism ; Receptors, Estrogen/deficiency ; Receptors, Estrogen/genetics ; Stomach/pathology

المؤلفون: Alaynick WA, Way JM, Wilson SA, Benson WG, Pei L, Downes M, Yu R, Jonker JW, Holt JA, Rajpal DK, Li H, Stuart J, McPherson R, Remlinger KS, Yi-Chang C, McDonnell DP, Evans RM, Billin AN

المصدر: Endocrine reviews [Endocr Rev] 2009 Dec 01; Vol. 30 (7), pp. 931.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 8006258 Publication Model: Print Cited Medium: Internet ISSN: 1945-7189 (Electronic) Linking ISSN: 0163769X NLM ISO Abbreviation: Endocr Rev Subsets: PubMed not MEDLINE