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1
المؤلفون: Stephen M. Soisson, Tom Y.-H. Wu, Michel Gallant, Austin Chen, Dwight Macdonald, Daniel Dube, Robert Houle, Jean-Pierre Falgueyret, Renee Aspiotis, Dan McKay, Jean-François Lévesque, Patrick Roy, Helene Juteau, Sébastien Gagné, M. David Percival, Erich L. Grimm, Sebastien Laliberte, Patrick Lacombe, Elizabeth Cauchon
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:2430-2436
مصطلحات موضوعية: Stereochemistry, Carboxylic acid, Clinical Biochemistry, hERG, Drug Evaluation, Preclinical, Administration, Oral, Pharmaceutical Science, Biochemistry, Chemical synthesis, Rats, Sprague-Dawley, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Piperidines, Catalytic Domain, Renin, Drug Discovery, Animals, Humans, Structure–activity relationship, Computer Simulation, Protease Inhibitors, Molecular Biology, chemistry.chemical_classification, biology, Organic Chemistry, Prodrug, Rats, Enzyme, chemistry, Enzyme inhibitor, Zwitterion, biology.protein, Molecular Medicine
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2
المؤلفون: Christopher I. Bayly, Dan McKay, Tom Y.-H. Wu, Patrick Roy, Suzanna Liu, Michel Gallant, Austin Chen, Helene Juteau, Rejean Fortin, Daniel Dube, Renee Aspiotis, Patrick Lacombe
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:5822-5826
مصطلحات موضوعية: Molecular model, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, Structure-Activity Relationship, Bibenzyls, Renin, Drug Discovery, Renin–angiotensin system, medicine, Animals, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, biology, fungi, Organic Chemistry, Amides, In vitro, Rats, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Amine gas treating
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3
المؤلفون: Renee Aspiotis, Denis Deschênes, Daniel Dubé, Yves Girard, Zheng Huang, France Laliberté, Susana Liu, Robert Papp, Donald W. Nicholson, Robert N. Young
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:5502-5505
مصطلحات موضوعية: Male, Phosphodiesterase Inhibitors, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, Inhibitory Concentration 50, Structure-Activity Relationship, In vivo, Drug Discovery, Animals, Humans, Structure–activity relationship, Rats, Wistar, Molecular Biology, biology, Chemistry, Organic Chemistry, Phosphodiesterase, 3',5'-cyclic-AMP phosphodiesterase, Asthma, In vitro, Cyclic Nucleotide Phosphodiesterases, Type 4, Rats, Enzyme inhibitor, Quinolines, biology.protein, Molecular Medicine, Selectivity
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4
المؤلفون: Andre Giroux, Dita M. Rasper, Steven Xanthoudakis, Johanne Renaud, Rejean Fortin, Christophe Mellon, Erich L. Grimm, John P. Vaillancourt, John Tam, Renee Aspiotis, Yongxin Han, Sophie Roy, W. Cameron Black, John Colucci, Paul Tawa, Robert Zamboni, Elise Isabel, Donald W. Nicholson
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:1671-1674
مصطلحات موضوعية: Programmed cell death, Stereochemistry, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, Caspase 3, Biochemistry, Chemical synthesis, Catalysis, Mass Spectrometry, Cell Line, Structure-Activity Relationship, Drug Discovery, medicine, Humans, Protease Inhibitors, Molecular Biology, Chromatography, High Pressure Liquid, Amination, Caspase, chemistry.chemical_classification, Protease, biology, Chemistry, Organic Chemistry, Biological activity, Caspase Inhibitors, Recombinant Proteins, Enzyme, Pyrazines, biology.protein, Molecular Medicine, Indicators and Reagents, Palladium
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5
المؤلفون: Joel Rubin, Erich L. Grimm, Joseph A. Mancini, Richard Friesen, Diane Ethier, Denis Riendeau, Nathalie Méthot, Renee Aspiotis, Jocelyne Guay, Helene Juteau, Sébastien Guiral, Yves Gareau
المصدر: Bioorganic & Medicinal Chemistry Letters. 15:3352-3355
مصطلحات موضوعية: musculoskeletal diseases, Indoles, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Structure-Activity Relationship, Cell Line, Tumor, Microsomes, Drug Discovery, medicine, Humans, Structure–activity relationship, Cyclooxygenase Inhibitors, Prostaglandin E2, Molecular Biology, Cell Proliferation, Prostaglandin-E Synthases, chemistry.chemical_classification, Indole test, biology, ATP synthase, Chemistry, Organic Chemistry, Enzyme assay, Intramolecular Oxidoreductases, Enzyme, Enzyme inhibitor, biology.protein, Molecular Medicine, lipids (amino acids, peptides, and proteins), Thromboxane-A synthase, medicine.drug
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6
المؤلفون: Dan McKay, Michel Gallant, Marga Garcia-Calvo, Jennifer Rotonda, Johanne Renaud, Stephen M. Soisson, Christopher I. Bayly, Renee Aspiotis, Sébastien Francoeur, Andre Giroux, Robert Zamboni, Yongxin Han, Erin P. Peterson, Erich L. Grimm, Sophie Roy, Joseph W. Becker, Donald W. Nicholson, Nancy A. Thornberry
المصدر: Journal of Medicinal Chemistry. 47:2466-2474
مصطلحات موضوعية: Models, Molecular, Protein Conformation, Stereochemistry, Peptidomimetic, Caspase 3, Crystallography, X-Ray, Ligands, Niacin, Structure-Activity Relationship, Protein structure, Drug Discovery, Structure–activity relationship, Enzyme Inhibitors, Binding site, Caspase, Molecular Structure, biology, Tetrapeptide, Chemistry, Molecular Mimicry, Caspase Inhibitors, Biochemistry, Enzyme inhibitor, Caspases, Pyrazines, biology.protein, Molecular Medicine, Peptides, Heterocyclic Compounds, 3-Ring, Oligopeptides
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7
المؤلفون: Robert Zamboni, John Tam, Bruno Roy, John P. Vaillancourt, Steven Xanthoudakis, Renee Aspiotis, Johanne Renaud, Donald W. Nicholson, Christopher I. Bayly, Erich L. Grimm, Dita M. Rasper, Paul Tawa, Sophie Roy
المصدر: Bioorganic & Medicinal Chemistry. 12:845-851
مصطلحات موضوعية: Cell Survival, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Caspase 3, Peptide, Cleavage (embryo), Biochemistry, Chemical synthesis, Cell Line, Inhibitory Concentration 50, chemistry.chemical_compound, Solid-phase synthesis, Drug Discovery, Peptide synthesis, Combinatorial Chemistry Techniques, Humans, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, biology, Tetrapeptide, Chemistry, Organic Chemistry, food and beverages, Caspase Inhibitors, Combinatorial chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Oligopeptides
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8
المؤلفون: John P. Vaillancourt, Daniel J. McKay, Robert Zamboni, Steve Xanthoudakis, Margarita Garcia-Calvo, Nancy A. Thornberry, Yongxin Han, Donald W. Nicholson, Christopher I. Bayly, Jennifer Rotonda, Andre Giroux, Sophie Roy, Joseph W. Becker, Erich L. Grimm, Paul Tawa, Renee Aspiotis, Erin P. Paterson, John Tam, Sébastien Francoeur, Dita M. Rasper
المصدر: Bioorganic & Medicinal Chemistry Letters. 14:805-808
مصطلحات موضوعية: Models, Molecular, Ketone, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, Substrate Specificity, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Peptide synthesis, Combinatorial Chemistry Techniques, Humans, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, Cells, Cultured, chemistry.chemical_classification, Aspartic Acid, Binding Sites, Dipeptide, biology, Caspase 3, Organic Chemistry, Dipeptides, Ketones, Caspase Inhibitors, chemistry, Structural biology, Enzyme inhibitor, biology.protein, Molecular Medicine
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9
المؤلفون: Mélissa Arbour, Gavin Chit Tsui, Jean-Pierre Falgueyret, Pierre-André Fournier, Yongxin Han, Michel Gallant, Patrick Lacombe, Daniel Dube, Daniel Simard, Elizabeth Cauchon, Austin Chen, Renee Aspiotis, Suzanna Liu, René St-Jacques, Christophe Mellon, Erich L. Grimm, Yeeman K. Ramtohul, Helene Juteau
المصدر: Bioorganicmedicinal chemistry letters. 22(5)
مصطلحات موضوعية: Transgene, Clinical Biochemistry, hERG, Pharmaceutical Science, Biological Availability, Pharmacology, Biochemistry, Plasma renin activity, Rats, Sprague-Dawley, Structure-Activity Relationship, Dogs, Piperidines, Drug Discovery, Renin–angiotensin system, Renin, Structure–activity relationship, Animals, Cytochrome P-450 CYP3A, Humans, Animal species, Molecular Biology, Antihypertensive Agents, Cytochrome P-450 CYP3A Inhibitors, biology, Chemistry, Organic Chemistry, Ether-A-Go-Go Potassium Channels, Bioavailability, Rats, Hypertension, biology.protein, Molecular Medicine, Rats, Transgenic
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10
المؤلفون: Renee Aspiotis, Amadine Chefson, Jean-François Lévesque, Yongxin Han, Louis-Charles Campeau, Dan McKay, Guillaume Larouche, Jean-Pierre Falgueyret, Robert Houle, Elizabeth Cauchon, David Percival, Austin Chen, Sébastien Gagné, Yves Ducharme, Sebastien Laliberte
المصدر: Bioorganicmedicinal chemistry letters. 21(24)
مصطلحات موضوعية: medicine.drug_class, Stereochemistry, Clinical Biochemistry, hERG, Pharmaceutical Science, Biochemistry, Renin inhibitor, Structure-Activity Relationship, Dogs, Piperidines, Catalytic Domain, Drug Discovery, Renin–angiotensin system, Renin, medicine, Animals, Cytochrome P-450 CYP3A, Humans, Computer Simulation, Protease Inhibitors, Spiro Compounds, Molecular Biology, Antihypertensive Agents, Binding Sites, biology, CYP3A4, Chemistry, Organic Chemistry, Macaca mulatta, Rats, Drug Design, Hypertension, biology.protein, Molecular Medicine, Cytochrome P-450 CYP3A Inhibitors