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1
المؤلفون: Dana Huskens, Marilyn C. Darkes, Gary Bridger, Jennifer H. Cox, Simon P. Fricker, Zefferino Santucci, Renee Mosi, Jean Labrecque, Kim L. Nelson, Renato Skerlj, Stefan R. Idzan, Virginia Anastassova, Dominique Schols, Ketan Patel, Rebecca S.Y. Wong, Gloria Lau
المصدر: Biochemical Pharmacology. 83:472-479
مصطلحات موضوعية: CCR1, Receptors, CXCR4, Anti-HIV Agents, Allosteric regulation, Administration, Oral, Biological Availability, C-C chemokine receptor type 7, Pharmacology, Biology, Butylamines, Virus Replication, CXCR3, Biochemistry, Cell Line, Heterocyclic Compounds, 1-Ring, Dogs, Calcium flux, medicine, Animals, Humans, Receptor, Molecular Structure, Ligand binding assay, Virus Internalization, Chemokine CXCL12, Entry inhibitor, Gene Expression Regulation, Aminoquinolines, HIV-1, Benzimidazoles, Protein Binding, Signal Transduction, medicine.drug
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2
المؤلفون: Renato Skerlj, Tuya Ba, Ernest J. McEachern, Elyse Bourque, Ian Baird, Dominique Schols, Wilson Trevor R, Renee Mosi, Jonathan Langille, Yuanxi Zhou, Bryon Carpenter, Michael Bey, Simon P. Fricker, Dana Huskens, Duane Veale, Rebecca S.Y. Wong, Gary Bridger, Curtis Harwig, Veronique Bodart, Ron MacFarland, Markus Metz, Sanjay Danthi
المصدر: ACS Medicinal Chemistry Letters. 3:216-221
مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, biology, business.industry, Purkinje fibers, Organic Chemistry, hERG, Human immunodeficiency virus (HIV), Pharmacology, medicine.disease_cause, Biochemistry, Bioavailability, Chemokine receptor, medicine.anatomical_structure, Drug Discovery, Lipophilicity, biology.protein, Medicine, Action potential duration, cardiovascular diseases, business, Ion channel
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3
المؤلفون: Renato Skerlj, Gary Bridger, Yuanxi Zhou, Elyse Bourque, Ernest McEachern, Jonathan Langille, Curtis Harwig, Duane Veale, Wen Yang, Tongshong Li, Yongbao Zhu, Michael Bey, Ian Baird, Michael Sartori, Markus Metz, Renee Mosi, Kim Nelson, Veronique Bodart, Rebecca Wong, Simon Fricker, Ron Mac Farland, Dana Huskens, Dominique Schols
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:6950-6954
مصطلحات موضوعية: Tertiary amine, Anti-HIV Agents, Pyridines, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, CCR5 receptor antagonist, Pharmacology, Virus Replication, Biochemistry, Peripheral blood mononuclear cell, Chemical synthesis, Inhibitory Concentration 50, Dogs, Piperidines, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Molecular Biology, Molecular Structure, Chemistry, Organic Chemistry, virus diseases, Amides, In vitro, Rats, Viral replication, Drug Design, CCR5 Receptor Antagonists, HIV-1, Leukocytes, Mononuclear, Molecular Medicine
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4
المؤلفون: Ling Qin, Renato Skerlj, Yongbao Zhu, Zefferino Santucci, Renee Mosi, Jennifer H. Cox, Simon P. Fricker, Virginia Anastassov, Beth R. Cameron, Markus Metz
المصدر: Journal of Inorganic Biochemistry. 105:754-762
مصطلحات موضوعية: Male, Cathepsin, Chemistry, Stereochemistry, Cathepsin K, Antineoplastic Agents, Biological activity, Mice, SCID, Cysteine Proteinase Inhibitors, Biochemistry, Cysteine protease, Cathepsin B, Inorganic Chemistry, Mice, Cathepsin O, Cysteine Proteases, Cell Line, Tumor, Animals, Humans, Gold, Cysteine
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5
المؤلفون: Patricia S. Doyle, Zefferino Santucci, Gloria Lau, Ling Qin, Elizabeth Hansell, Jonathan Langille, Youngbao Zhu, Simon P. Fricker, Virginia Anastassov, Renato Skerlj, Beth R. Cameron, Micki Olsen, Jennifer H. Cox, Ian Baird, James H. McKerrow, Rebecca S.Y. Wong, Renee Mosi
المصدر: Journal of Inorganic Biochemistry. 102:1839-1845
مصطلحات موضوعية: Trypanosoma, Proteases, Stereochemistry, chemistry.chemical_element, Cysteine Proteinase Inhibitors, Biochemistry, Cathepsin B, Rhodium, Inorganic Chemistry, Metal, Animals, Humans, Chagas Disease, Osmium, Leishmaniasis, Leishmania, Chemistry, Trypanocidal Agents, Cysteine protease, Cysteine Endopeptidases, Inorganic Chemicals, Metals, visual_art, visual_art.visual_art_medium, Cysteine, Palladium
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6
المؤلفون: David J. Vocadlo, David L. Shen, Subramaniapillai Kolappan, Ernest J. McEachern, Renee Mosi, Jianyu Sun, Lisa Craig
مصطلحات موضوعية: Protein Conformation, NADH binding, Lactate dehydrogenase A, Biology, Crystallography, X-Ray, chemistry.chemical_compound, Structural Biology, Oxidoreductase, Neoplasms, Lactate dehydrogenase, Humans, Glycolysis, Enzyme Inhibitors, education, chemistry.chemical_classification, education.field_of_study, Binding Sites, L-Lactate Dehydrogenase, Oxalic Acid, General Medicine, NAD, Warburg effect, Isoenzymes, Molecular Docking Simulation, Enzyme, chemistry, Biochemistry, NAD+ kinase, Lactate Dehydrogenase 5
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f33be9666e2fcba9f28dea840485577
http://summit.sfu.ca/item/20481 -
7
المؤلفون: Ling Qin, Rebecca Wong, Virginia Anastassov, Simon P. Fricker, Jennifer H. Cox, Renee Mosi, Stefan R. Idzan, Jean Labrecque, Kim L. Nelson, Ognjen Grujic, Gloria Lau, Marilyn C. Darkes, Zeffy Santucci
المصدر: Biochemical Pharmacology. 72:588-596
مصطلحات موضوعية: CCR1, Benzylamines, Receptors, CXCR4, Chemokine receptor CCR5, C-C chemokine receptor type 7, C-C chemokine receptor type 6, Cyclams, Biochemistry, Cell Line, Chemokine receptor, Heterocyclic Compounds, Humans, CCL17, CXCL14, Pharmacology, biology, Chemotaxis, Chemokine CXCL12, Cell biology, biology.protein, Cancer research, XCL2, Calcium, Chemokines, CXC, Protein Binding, Signal Transduction
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8
المؤلفون: Simon P. Fricker, Virginia Anastassov, Beth R. Cameron, Ian R. Baird, Renee Mosi, Jennifer H. Cox, Renato T. Skerlj
المصدر: Journal of Medicinal Chemistry. 49:5262-5272
مصطلحات موضوعية: Time Factors, Stereochemistry, Cathepsin K, chemistry.chemical_element, Cysteine Proteinase Inhibitors, Ligands, Chemical synthesis, Cathepsin B, Structure-Activity Relationship, chemistry.chemical_compound, Bromide, Drug Discovery, Organometallic Compounds, Humans, Cathepsin, Binding Sites, Molecular Structure, Ligand, Leaving group, Stereoisomerism, Rhenium, Cathepsins, chemistry, Molecular Medicine, Selectivity
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9
المؤلفون: Simon P. Fricker, Beth R. Cameron, Micki Olsen, Renee Mosi, Ian R. Baird, Renato T. Skerlj
المصدر: Inorganica Chimica Acta. 359:2736-2750
مصطلحات موضوعية: chemistry.chemical_classification, Proteases, Chemistry, Stereochemistry, Aryl, Cathepsin B, In vitro, Inorganic Chemistry, chemistry.chemical_compound, Enzyme, Materials Chemistry, Cathepsin K, Physical and Theoretical Chemistry, Alkyl, Cysteine
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10
المؤلفون: Curtis Harwig, Dominique Schols, Gang Chen, Wen Yang, Duane Veale, Susan Nan, Simon P. Fricker, Alan Kaller, Danielle Guay, Jason M. Crawford, Michael Satori, Markus Metz, Yongbao Zhu, Helen Yee, Maria Krumpak, Elyse Bourque, Wilson Trevor R, David Bogucki, Bryon Carpenter, Michael Bey, David C. Leitch, Ron MacFarland, David Gauthier, Ian Baird, Rebecca Wong, Renato T. Skerlj, Jonathan Langille, Yuanxi Zhou, Gary Bridger, Renee Mosi, Ernest J. McEachern, Tuya Ba, Tong-Shuang Li, Krystyna Vocadlo, Veronique Bodart
المصدر: Journal of medicinal chemistry. 56(20)
مصطلحات موضوعية: Receptors, CCR5, Anti-HIV Agents, Cell Survival, hERG, Human immunodeficiency virus (HIV), CHO Cells, Pharmacology, medicine.disease_cause, Imidazolidines, Virus Replication, Benzoates, Chemokine receptor, Structure-Activity Relationship, Cricetulus, Piperidines, In vivo, Cricetinae, Drug Discovery, medicine, Animals, Humans, Cells, Cultured, Cardiotoxicity, biology, Molecular Structure, Chemistry, Imidazoles, In vitro, Receptor selectivity, HEK293 Cells, Biochemistry, Models, Chemical, Drug Design, Lipophilicity, CCR5 Receptor Antagonists, Host-Pathogen Interactions, biology.protein, HIV-1, Leukocytes, Mononuclear, Molecular Medicine