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المؤلفون: Symon Gathiaka, Rachel L. Palte, Sung-Sau So, Xiaomei Chai, J. Richard Miller, Reshma Kuvelkar, Xiujuan Wen, Steven Cifelli, Anthony Kreamer, Andy Liaw, David G. McLaren, Christian Fischer
المصدر: Bioorganic & Medicinal Chemistry Letters. 84:129193
مصطلحات موضوعية: Organic Chemistry, Clinical Biochemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Molecular Biology, Biochemistry
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المؤلفون: Kevin P. Bateman, David G. McLaren, R. Graham Cooks, Zhenwei Wei, Reshma Kuvelkar, Vinit Shah, Zhuoer Xie
المصدر: Angewandte Chemie International Edition. 58:17594-17598
مصطلحات موضوعية: Spectrometry, Mass, Electrospray Ionization, Materials science, 010402 general chemistry, Mass spectrometry, 01 natural sciences, Multiplexing, Catalysis, Matrix (chemical analysis), Microtiter plate, Limit of Detection, Bioassay, Throughput (business), Chromatography, High Pressure Liquid, Chromatography, 010405 organic chemistry, Hydrolysis, General Medicine, General Chemistry, High-Throughput Screening Assays, Nanostructures, 0104 chemical sciences, Kinetics, Electrophoresis, Amyloid Precursor Protein Secretases, Peptides, Oligopeptides, Quantitative analysis (chemistry)
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3
المؤلفون: Hongwu Wang, Leonard Favreau, Jairam Palamanda, Xinjie Lin, Diane Rindgen, John P. Caldwell, Zhaoning Zhu, Pramila Kumari, Alexei V. Buevich, Reshma Kuvelkar, Edward C. Sherer, Andrew Stamford, Kathleen Cox, Jared N. Cumming, Diane Grotz, Matthew E. Kennedy, Xiaoxang Liu, Mihir Mandal, Lynn A. Hyde, Kaushik Mitra, Eric M. Parker, Xia Chen, Robert Mazzola
المصدر: Journal of Medicinal Chemistry. 61:10700-10708
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Metabolite, Oxidative phosphorylation, 030226 pharmacology & pharmacy, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Drug Discovery, Cytochrome P-450 CYP3A, Animals, Humans, Moiety, Structure–activity relationship, Tissue Distribution, Cytochrome P-450 CYP3A Inhibitors, CYP3A4, Rats, Kinetics, Pyrimidines, 030104 developmental biology, chemistry, Reactive metabolite, Molecular Medicine
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المؤلفون: Mark S. Forman, Peter Orth, Ulrich Iserloh, Yusheng Wu, Hongwu Wang, William J. Greenlee, Reshma Kuvelkar, Xia Chen, Jack D. Scott, John Meredith, Lana M. Rossiter, Lynn A. Hyde, Robert A. Hodgson, Andrew Stamford, Julie A. Stone, Irina Kazakevich, Ganfeng Wang, Eric M. Parker, Eric J. Gilbert, Kathleen Cox, Corey O. Strickland, Sarah W. Li, Meagan Slater, Qin Jiang, Johannes H. Voigt, Hong Mei, Andrew Brunskill, Matthew E. Kennedy, Misiaszek Jeffrey A, Jared N. Cumming
المصدر: Journal of Medicinal Chemistry. 59:10435-10450
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, High selectivity, Cathepsin D, Rats, Sprague-Dawley, Amyloid beta-Protein Precursor, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Dogs, Aspartate protease, Alzheimer Disease, Drug Discovery, Amyloid precursor protein, Animals, Humans, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, Thiadiazines, biology, Cyclic S-Oxides, Rats, Macaca fascicularis, 030104 developmental biology, Enzyme, Biochemistry, chemistry, biology.protein, Molecular Medicine, Verubecestat, Clinical evaluation, Derivative (chemistry)
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5
المؤلفون: Presscott T. Leach, Jared N. Cumming, Peter Orth, Yusheng Wu, Zhaoning Zhu, Xiaoxiang Liu, Guoqing Li, Kaushik Mitra, Leonard Favreau, Misiaszek Jeffrey A, Corey Strickland, Hongwu Wang, Brad E. Smith, Robert Mazzola, Diane Grotz, Xia Chen, William J. Greenlee, Mihirbaran Mandal, Michael Grzelak, Matthew E. Kennedy, Eric M. Parker, Johannes H. Voigt, John P. Caldwell, Andrew Stamford, Irina Kazakevich, Kathleen Cox, Reshma Kuvelkar, Lili Zhang, Giuseppe Terracina, Qi Zhang, Maria S. Michener, Lynn A. Hyde, Alexei V. Buevich, Mckittrick Brian A
المصدر: Journal of Medicinal Chemistry. 59:3231-3248
مصطلحات موضوعية: 0301 basic medicine, Pyrimidine, Stereochemistry, Substituent, Pyrrolidine, Amyloid beta-Protein Precursor, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Heterocyclic Compounds, In vivo, mental disorders, Drug Discovery, Amyloid precursor protein, Animals, Structure–activity relationship, Enzyme Inhibitors, Cerebral Cortex, chemistry.chemical_classification, Amyloid beta-Peptides, Molecular Structure, CYP3A4, biology, Rats, Macaca fascicularis, 030104 developmental biology, Enzyme, chemistry, Biochemistry, Drug Design, biology.protein, Molecular Medicine, Imines, Amyloid Precursor Protein Secretases, 030217 neurology & neurosurgery
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المؤلفون: Lili Zhang, Qi Zhang, Andrew Stamford, Liyang Wang, Peter Orth, Reshma Kuvelkar, Corey Strickland, James Durkin, Mckittrick Brian A, Zhaoning Zhu, Johannes H. Voigt, Julie Lee, Robert Mazzola, Nansie A. McHugh, Leonard Favreau, Xia Chen, Matthew E. Kennedy, Joseph Chen, John P. Caldwell
المصدر: Bioorganic & Medicinal Chemistry Letters. 24:5455-5459
مصطلحات موضوعية: Models, Molecular, Molecular Structure, Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Affinities, Rats, Structure-Activity Relationship, Aspartate protease, Alzheimer Disease, Oral administration, Drug Design, Drug Discovery, β secretase, Animals, Aspartic Acid Endopeptidases, Molecular Medicine, Potency, Amyloid Precursor Protein Secretases, Binding site, Molecular Biology
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المؤلفون: Joel M. Harris, Xiaoping Zhou, John A. Morrow, Sue-Ing Lin, Marco A. S. Baptista, John M. Sanders, Xiaoping Zhang, Hong Mei, Mark W. Embrey, Sylvie M. Sur, Duane E. DeMong, Ravi P. Nargund, Alan Hruza, Heather E. Tiscia, Matthew J. Fell, Zhizhang Yin, Gautam Agnihotri, Honglu Zhang, Thomas J. Greshock, Jack D. Scott, Yinghui Lin, Zhi-Cai Shi, John A. Mccauley, Sarah W. Li, Ronald K. Chang, Mark T. Bilodeau, Michael W. Miller, Reshma Kuvelkar, Andrew Stamford, Marc Poirier, Hong Liu, Megan K. Macala, Kallol Basu, Li Xiao, Lynn A. Hyde, Jonathan T. Kern, Xing Dai, Christian Mirescu, Paul L. Walsh, Matthew E. Kennedy, John J. Renger, Zhiyong Hu, John Columbus, Robert E. Drolet, Eric M. Parker
المصدر: Journal of medicinal chemistry. 60(7)
مصطلحات موضوعية: 0301 basic medicine, Male, Indazoles, Leucine-rich repeat, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, Animals, Humans, c-Raf, Kinase activity, Enzyme Inhibitors, Rats, Wistar, biology, Cyclin-dependent kinase 4, Kinase, Chemistry, Cyclin-dependent kinase 2, Brain, Parkinson Disease, LRRK2, nervous system diseases, Rats, Molecular Docking Simulation, 030104 developmental biology, Protein kinase domain, Biochemistry, biology.protein, Molecular Medicine, 030217 neurology & neurosurgery
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المؤلفون: Zheng Tan, Mihir Mandal, Michelle Batchlett, Reshma Kuvelkar, Paul Mann, Todd Mayhood, Sookhee Ha, Paul Zuck, Yan Hou, Xiujuan Wen, Christine Yang, Christopher M. Tan, Carl J. Balibar, Hao Wang, Terry Roemer, Charles Gill, Jenny Liu, Amy M. Flattery, Payal R. Sheth, Jing Xiao, Kristine Devito, Jianying Xiao, Jing Su, Marc A. Labroli, Charles G. Garlisi, Shu-Wei Yang, Nicholas Murgolo, Sang Ho Lee, Lianzhu Liang, Paul Tawa, Sandra Koseoglu, Xinwei Sher
المصدر: Science Translational Medicine. 8
مصطلحات موضوعية: Methicillin-Resistant Staphylococcus aureus, Models, Molecular, 0301 basic medicine, medicine.drug_class, Phenotypic screening, Antibiotics, Treatment outcome, Growth inhibitory, Microbial Sensitivity Tests, beta-Lactams, Bioinformatics, medicine.disease_cause, Microbiology, 03 medical and health sciences, chemistry.chemical_compound, Bacterial Proteins, Cell Wall, medicine, Wall teichoic acid biosynthesis, Animals, Dicloxacillin, Mice, Inbred BALB C, business.industry, Treatment options, General Medicine, Staphylococcal Infections, biochemical phenomena, metabolism, and nutrition, Biosynthetic Pathways, Teichoic Acids, Phenotype, Treatment Outcome, 030104 developmental biology, chemistry, Staphylococcus aureus, Lactam, Female, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b972016b6c6deb96f0183383f68f38a2
https://doi.org/10.1126/scitranslmed.aad7364 -
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المؤلفون: Huub Jan Kleijn, Jared N. Cumming, Xia Chen, John Palcza, Britta A. Mattson, Michael Tanen, Julie A. Stone, Wei Li, Eric M. Parker, Hong Mei, Reshma Kuvelkar, Stanford Jhee, Robert A. Hodgson, Jack Tseng, Lynn A. Hyde, Andrew Stamford, Matthew E. Kennedy, Kathleen Cox, Michael F. Egan, Larry Ereshefsky, Mark S. Forman, Marissa F. Dockendorf, Jack D. Scott, Matthew D. Troyer
المصدر: Science translational medicine. 8(363)
مصطلحات موضوعية: 0301 basic medicine, Central Nervous System, Magnetic Resonance Spectroscopy, Administration, Oral, Disease, Pharmacology, Crystallography, X-Ray, Toxicology studies, 03 medical and health sciences, Mice, 0302 clinical medicine, Cerebrospinal fluid, β amyloid, Alzheimer Disease, Catalytic Domain, mental disorders, Medicine, Animals, Aspartic Acid Endopeptidases, Myelin Sheath, Amyloid beta-Peptides, Human studies, Thiadiazines, business.industry, Brain, General Medicine, Small molecule, Cyclic S-Oxides, Rats, Macaca fascicularis, 030104 developmental biology, Glucose, Drug Design, Knockout mouse, Verubecestat, Female, Rabbits, Amyloid Precursor Protein Secretases, business, Peptides, 030217 neurology & neurosurgery
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea76cf4560a861dae44bfdba275020bd
https://pubmed.ncbi.nlm.nih.gov/27807285 -
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المؤلفون: Ji Zhang, Yvette Crawley, Reshma Kuvelkar, Hong Bian, M. Motasim Billah, Peng Wang, Ping Wu, Robert W. Egan, Ted T. Kung
المصدر: Biochemical Journal. 380:425-433
مصطلحات موضوعية: CD4-Positive T-Lymphocytes, Transcriptional Activation, Gene isoform, Cell type, Insecta, CD3 Complex, T-Lymphocytes, Receptors, Antigen, T-Cell, Neuraminidase, Mice, Inbred Strains, Biology, Lymphocyte Activation, Sialidase, Biochemistry, Jurkat cells, Gene Expression Regulation, Enzymologic, Cell Line, Jurkat Cells, Leukocyte Count, Mice, CD28 Antigens, T-Lymphocyte Subsets, Cell Line, Tumor, Eosinophilia, Animals, Humans, RNA, Messenger, Receptor, Lung, Molecular Biology, Cells, Cultured, Cell Membrane, Interleukin, Cell Biology, Molecular biology, Isoenzymes, Mice, Inbred DBA, Organ Specificity, Cell culture, Enzyme Induction, Cytokines, Lysosomes, Cell activation, Research Article
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15129696ffaf64e44c5e7e967fd925c3
https://doi.org/10.1042/bj20031896
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