المؤلفون: Johnston PA; 1 Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh , Pittsburgh, Pennsylvania.; 2 University of Pittsburgh Cancer Institute , Pittsburgh, Pennsylvania.; 3 Pittsburgh Specialized Application Center, University of Pittsburgh Drug Discovery Institute , Pittsburgh, Pennsylvania., Sen M; 4 Department of Otolaryngology, University of Pittsburgh , Pittsburgh, Pennsylvania., Hua Y; 1 Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh , Pittsburgh, Pennsylvania., Camarco DP; 1 Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh , Pittsburgh, Pennsylvania., Shun TY; 3 Pittsburgh Specialized Application Center, University of Pittsburgh Drug Discovery Institute , Pittsburgh, Pennsylvania., Lazo JS; 5 Departments of Pharmacology and Chemistry, University of Virginia , Charlottesville, Virginia., Wilson GM; 6 University of Pittsburgh Chemical Diversity Center , Pittsburgh, Pennsylvania.; 7 Department of Health Services and Health Administration, College of Nursing and Health Professions, University of Southern Indiana , Evansville, Indiana., Resnick LO; 6 University of Pittsburgh Chemical Diversity Center , Pittsburgh, Pennsylvania., LaPorte MG; 6 University of Pittsburgh Chemical Diversity Center , Pittsburgh, Pennsylvania., Wipf P; 1 Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh , Pittsburgh, Pennsylvania.; 2 University of Pittsburgh Cancer Institute , Pittsburgh, Pennsylvania.; 6 University of Pittsburgh Chemical Diversity Center , Pittsburgh, Pennsylvania.; 8 Department of Chemistry, University of Pittsburgh , Pittsburgh, Pennsylvania., Huryn DM; 1 Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh , Pittsburgh, Pennsylvania.; 6 University of Pittsburgh Chemical Diversity Center , Pittsburgh, Pennsylvania., Grandis JR; 9 Clinical and Translational Science Institute, Otolaryngology - Head and Neck Surgery, University of California , San Francisco, California.

المصدر: Assay and drug development technologies [Assay Drug Dev Technol] 2015 Sep; Vol. 13 (7), pp. 356-76.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101151468 Publication Model: Print Cited Medium: Internet ISSN: 1557-8127 (Electronic) Linking ISSN: 1540658X NLM ISO Abbreviation: Assay Drug Dev Technol Subsets: MEDLINE

مواضيع طبية MeSH: High-Throughput Screening Assays*, Carcinoma, Squamous Cell/*drug therapy , Head and Neck Neoplasms/*drug therapy , Interleukin-6/*antagonists & inhibitors , STAT3 Transcription Factor/*antagonists & inhibitors , Signal Transduction/*drug effects, Cell Line, Tumor ; Humans ; Interferon-gamma/pharmacology ; Interleukin-6/physiology ; STAT1 Transcription Factor/physiology ; STAT3 Transcription Factor/physiology ; Squamous Cell Carcinoma of Head and Neck

المؤلفون: LaPorte MG; University of Pittsburgh Chemical Diversity Center, University of Pittsburgh, Pittsburgh, PA 15260, USA. Electronic address: mgl12@pitt.edu., da Paz Lima DJ; University of Pittsburgh Chemical Diversity Center, University of Pittsburgh, Pittsburgh, PA 15260, USA., Zhang F; University of Pittsburgh Chemical Diversity Center, University of Pittsburgh, Pittsburgh, PA 15260, USA., Sen M; Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA 15260, USA., Grandis JR; Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA 15260, USA; University of Pittsburgh Cancer Institute, Pittsburgh, PA 15260, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA., Camarco D; Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA., Hua Y; Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA., Johnston PA; University of Pittsburgh Cancer Institute, Pittsburgh, PA 15260, USA; Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA., Lazo JS; Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA., Resnick LO; University of Pittsburgh Chemical Diversity Center, University of Pittsburgh, Pittsburgh, PA 15260, USA., Wipf P; University of Pittsburgh Chemical Diversity Center, University of Pittsburgh, Pittsburgh, PA 15260, USA; University of Pittsburgh Cancer Institute, Pittsburgh, PA 15260, USA; Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA., Huryn DM; University of Pittsburgh Chemical Diversity Center, University of Pittsburgh, Pittsburgh, PA 15260, USA; Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA. Electronic address: huryn@pitt.edu.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2014 Nov 01; Vol. 24 (21), pp. 5081-5. Date of Electronic Publication: 2014 Sep 15.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Guanidine/*chemistry , Quinazolines/*chemistry , STAT3 Transcription Factor/*antagonists & inhibitors, Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Humans ; Protein Binding ; Quinazolines/metabolism ; Quinazolines/toxicity ; STAT3 Transcription Factor/metabolism ; Structure-Activity Relationship

المؤلفون: Huryn DM; Department of Pharmaceutical Sciences, University of Pittsburgh Chemical Diversity Center (UP-CDC) , 3501 Terrace Street, Pittsburgh, Pennsylvania 15261, United States., Resnick LO, Wipf P

المصدر: Journal of medicinal chemistry [J Med Chem] 2013 Sep 26; Vol. 56 (18), pp. 7161-76. Date of Electronic Publication: 2013 May 31.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Review

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery* , Laboratories*, Biology/*methods , Biomedical Research/*methods , Chemistry/*methods, Animals ; Humans ; Reactive Oxygen Species/metabolism