المؤلفون: Montaño-Rodriguez AR; Department of Pharmacology, Faculty of Medicine, Helsinki Institute of Life Science, University of Helsinki, 00290 Helsinki, Finland., Schorling T; Department of Pharmacology, Faculty of Medicine, Helsinki Institute of Life Science, University of Helsinki, 00290 Helsinki, Finland., Andressoo JO; Department of Pharmacology, Faculty of Medicine, Helsinki Institute of Life Science, University of Helsinki, 00290 Helsinki, Finland.; Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, 17177 Stockholm, Sweden.

المصدر: Cells [Cells] 2024 Jun 19; Vol. 13 (12). Date of Electronic Publication: 2024 Jun 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE

مواضيع طبية MeSH: Glial Cell Line-Derived Neurotrophic Factor*/metabolism , Axons*/metabolism , Corpus Striatum*/metabolism , Corpus Striatum*/cytology , Proto-Oncogene Proteins c-ret*/metabolism , Proto-Oncogene Proteins c-ret*/genetics , Dopaminergic Neurons*/metabolism, Animals ; Mice ; Dopamine/metabolism ; Tyrosine 3-Monooxygenase/metabolism ; Mice, Inbred C57BL ; Neurons/metabolism ; Medium Spiny Neurons

المؤلفون: Sayyah E; Computational Biology and Molecular Simulations Lab, Department of Biophysics, School of Medicine, Bahçeşehir University, Istanbul, Turkey.; Computational Drug Design Center (HITMER), Bahçeşehir University, Istanbul, Turkey., Oktay L; Computational Biology and Molecular Simulations Lab, Department of Biophysics, School of Medicine, Bahçeşehir University, Istanbul, Turkey.; Computational Drug Design Center (HITMER), Bahçeşehir University, Istanbul, Turkey., Tunc H; Department of Biostatistics and Medical Informatics, School of Medicine, Bahçeşehir University, Istanbul, Turkey., Durdagi S; Computational Biology and Molecular Simulations Lab, Department of Biophysics, School of Medicine, Bahçeşehir University, Istanbul, Turkey.; Computational Drug Design Center (HITMER), Bahçeşehir University, Istanbul, Turkey.; Molecular Therapy Lab, Department of Pharmaceutical Chemistry, School of Pharmacy, Bahçeşehir University, Istanbul, Turkey.

المصدر: ChemMedChem [ChemMedChem] 2024 Jun 17; Vol. 19 (12), pp. e202300644. Date of Electronic Publication: 2024 May 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

مواضيع طبية MeSH: Proto-Oncogene Proteins c-ret*/antagonists & inhibitors , Proto-Oncogene Proteins c-ret*/metabolism , Protein Kinase Inhibitors*/chemistry , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemical synthesis , Quantitative Structure-Activity Relationship* , Proto-Oncogene Mas* , Molecular Dynamics Simulation*, Humans ; Molecular Structure ; Drug Discovery ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/pharmacology ; Small Molecule Libraries/chemical synthesis ; Tyrosine Kinase Inhibitors ; Pharmacophore

عنوان ترانسليتريتد: 30 Jahre prophylaktische Thyreoidektomie beim hereditären medullären Schilddrüsenkarzinom : Ein Meilenstein translationaler Medizin.

المؤلفون: Dralle H; Klinik für Allgemein‑, Viszeral-und Transplantationschirurgie, Sektion Endokrine Chirurgie, Universitätsmedizin Essen, Hufelandstr. 55, 45147, Essen, Deutschland., Weber F; Klinik für Allgemein‑, Viszeral-und Transplantationschirurgie, Sektion Endokrine Chirurgie, Universitätsmedizin Essen, Hufelandstr. 55, 45147, Essen, Deutschland. frank.weber@uk-essen.de., Lorenz K; Klinik für Viszeral‑, Gefäss- und Endokrine Chirurgie, Universitätsmedizin Halle, Ernst Grube Str. 40, 06097, Halle (Saale), Deutschland., Machens A; Klinik für Viszeral‑, Gefäss- und Endokrine Chirurgie, Universitätsmedizin Halle, Ernst Grube Str. 40, 06097, Halle (Saale), Deutschland.

المصدر: Chirurgie (Heidelberg, Germany) [Chirurgie (Heidelb)] 2024 Aug; Vol. 95 (8), pp. 638-650. Date of Electronic Publication: 2024 May 28.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Springer Medizin Country of Publication: Germany NLM ID: 9918383081906676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2731-698X (Electronic) Linking ISSN: 27316971 NLM ISO Abbreviation: Chirurgie (Heidelb) Subsets: MEDLINE

مواضيع طبية MeSH: Thyroid Neoplasms*/genetics , Thyroid Neoplasms*/surgery , Thyroid Neoplasms*/pathology , Thyroid Neoplasms*/prevention & control , Thyroidectomy* , Translational Research, Biomedical* , Proto-Oncogene Proteins c-ret*/genetics , Multiple Endocrine Neoplasia Type 2a*/genetics , Multiple Endocrine Neoplasia Type 2a*/surgery , Multiple Endocrine Neoplasia Type 2a*/pathology, Humans ; Carcinoma, Medullary/genetics ; Carcinoma, Medullary/surgery ; Carcinoma, Medullary/congenital ; Carcinoma, Medullary/pathology ; Prophylactic Surgical Procedures ; Carcinoma, Neuroendocrine/genetics

SCR Disease Name: Thyroid cancer, medullary

المؤلفون: Karkala F; Departments of Clinical Genetics and Pediatric Surgery, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands., Wang M; Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Alves MM; Departments of Clinical Genetics and Pediatric Surgery, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands., Parikh K; Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

المصدر: Gastroenterology [Gastroenterology] 2024 Aug; Vol. 167 (3), pp. 629-630. Date of Electronic Publication: 2024 Apr 07.

نوع المنشور: Letter

بيانات الدورية: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 0374630 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0012 (Electronic) Linking ISSN: 00165085 NLM ISO Abbreviation: Gastroenterology Subsets: MEDLINE

مواضيع طبية MeSH: Proto-Oncogene Proteins c-ret*/genetics , Proto-Oncogene Proteins c-ret*/metabolism , Signal Transduction* , Gastrointestinal Motility*/physiology , Intestinal Mucosa*/metabolism, Humans ; Animals ; Mice

المؤلفون: Shiba-Ishii A; Department of Diagnostic Pathology, Institute of Medicine, University of Tsukuba, Ibaraki, Japan., Isagawa T; Center for Data Science, Jichi Medical University, Tochigi, Japan., Shiozawa T; Department of Respiratory Medicine, Institute of Medicine, University of Tsukuba, Ibaraki, Japan., Mato N; Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Ibaraki, Japan., Nakagawa T; Department of Pathology, University of Tsukuba Hospital, Ibaraki, Japan., Takada Y; Department of Diagnostic Pathology, Institute of Medicine, University of Tsukuba, Ibaraki, Japan., Hirai K; Department of Diagnostic Pathology, Institute of Medicine, University of Tsukuba, Ibaraki, Japan., Hong J; Department of Medicine, Boston University School of Medicine, Boston, MA, USA., Saitoh A; Division of Molecular Pathology, Institute of Medical Science, University of Tokyo, Tokyo, Japan., Takeda N; Division of Cardiology and Metabolism, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan., Niki T; Department of Pathology, Jichi Medical University, Tochigi, Japan., Murakami Y; Division of Molecular Pathology, Institute of Medical Science, University of Tokyo, Tokyo, Japan., Matsubara D; Department of Diagnostic Pathology, Institute of Medicine, University of Tsukuba, Ibaraki, Japan. Electronic address: matsubarad@md.tsukuba.ac.jp.

المصدر: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2024 Aug; Vol. 1870 (6), pp. 167249. Date of Electronic Publication: 2024 May 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-260X (Electronic) Linking ISSN: 09254439 NLM ISO Abbreviation: Biochim Biophys Acta Mol Basis Dis Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Non-Small-Cell Lung*/drug therapy , Carcinoma, Non-Small-Cell Lung*/pathology , Carcinoma, Non-Small-Cell Lung*/genetics , Carcinoma, Non-Small-Cell Lung*/metabolism , Proto-Oncogene Proteins c-ret*/antagonists & inhibitors , Proto-Oncogene Proteins c-ret*/genetics , Proto-Oncogene Proteins c-ret*/metabolism , Drug Resistance, Neoplasm*/drug effects , Drug Resistance, Neoplasm*/genetics , Lung Neoplasms*/drug therapy , Lung Neoplasms*/pathology , Lung Neoplasms*/genetics , Lung Neoplasms*/metabolism , Mitochondria*/metabolism , Mitochondria*/drug effects , Piperidines*/pharmacology , Piperidines*/therapeutic use , Protein Kinase Inhibitors*/therapeutic use , Protein Kinase Inhibitors*/pharmacology, Humans ; Cell Line, Tumor ; Quinazolines/pharmacology ; Quinazolines/therapeutic use ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transcription Factors/antagonists & inhibitors ; Signal Transduction/drug effects ; Oncogene Proteins, Fusion/genetics ; Oncogene Proteins, Fusion/metabolism ; Oncogene Proteins, Fusion/antagonists & inhibitors ; DNA Helicases/genetics ; DNA Helicases/metabolism ; DNA Helicases/antagonists & inhibitors ; Cytoskeletal Proteins

المؤلفون: Barsouk A; Department of Medical Oncology, Abramson Cancer Center, Hospital of the University of Pennsylvania., Elghawy O; Department of Medical Oncology, Abramson Cancer Center, Hospital of the University of Pennsylvania., Stone S; Department of Pathology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA., Singh A; Department of Medical Oncology, Abramson Cancer Center, Hospital of the University of Pennsylvania.

المصدر: Anti-cancer drugs [Anticancer Drugs] 2024 Aug 01; Vol. 35 (7), pp. 653-657. Date of Electronic Publication: 2024 Apr 29.

نوع المنشور: Case Reports; Journal Article

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 9100823 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5741 (Electronic) Linking ISSN: 09594973 NLM ISO Abbreviation: Anticancer Drugs Subsets: MEDLINE

مواضيع طبية MeSH: Proto-Oncogene Proteins c-ret*/genetics , Proto-Oncogene Proteins c-ret*/antagonists & inhibitors , Mediastinal Neoplasms*/drug therapy , Mediastinal Neoplasms*/genetics , Neoplasms, Unknown Primary*/drug therapy , Neoplasms, Unknown Primary*/genetics , Neoplasms, Unknown Primary*/pathology, Humans ; Female ; Aged ; Pyrazoles/therapeutic use ; Pyridines/therapeutic use ; Pyridines/pharmacology ; Oncogene Proteins, Fusion/genetics

المؤلفون: Valente FOF; Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil., Camacho CP; Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil., Lindsey SC; Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil., Yang JH; Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil., Kunii IS; Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil., Santos RB; Division of Endocrinology, Pontifícia Universidade Católica de Campinas, Campinas, São Paulo, Brazil., Kizys MML; Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil., Cerutti JM; Genetic Basis of Thyroid Tumor Laboratory, Division of Genetics, Department of Morphology and Genetics, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil., Dias-da-Silva MR; Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil., Maciel RMB; Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil.

المصدر: American journal of medical genetics. Part A [Am J Med Genet A] 2024 Jul; Vol. 194 (7), pp. e63576. Date of Electronic Publication: 2024 Feb 26.

نوع المنشور: Case Reports; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 101235741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4833 (Electronic) Linking ISSN: 15524825 NLM ISO Abbreviation: Am J Med Genet A Subsets: MEDLINE

مواضيع طبية MeSH: Multiple Endocrine Neoplasia Type 2a*/genetics , Multiple Endocrine Neoplasia Type 2a*/pathology , Proto-Oncogene Proteins c-ret*/genetics , Mosaicism* , Germ-Line Mutation*/genetics , Pedigree*, Humans ; Female ; Male ; Adult ; Amino Acid Substitution ; Thyroid Neoplasms/genetics ; Thyroid Neoplasms/pathology ; Genotype ; Exome Sequencing

المؤلفون: Ju H; Department of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China; Shanghai Kidney Development & Pediatric Kidney Disease Research Center, Shanghai, China., Yu M; Department of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China; Shanghai Kidney Development & Pediatric Kidney Disease Research Center, Shanghai, China., Du X; Department of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China; Shanghai Kidney Development & Pediatric Kidney Disease Research Center, Shanghai, China., Xue S; Department of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China; Shanghai Kidney Development & Pediatric Kidney Disease Research Center, Shanghai, China., Ye N; Department of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China; Shanghai Kidney Development & Pediatric Kidney Disease Research Center, Shanghai, China., Sun L; State Key Laboratory of Genetic Engineering and National Center for International Research of Development and Disease, Institute of Developmental Biology and Molecular Medicine, Fudan University, Shanghai, China., Wu X; Shanghai Kidney Development & Pediatric Kidney Disease Research Center, Shanghai, China; State Key Laboratory of Genetic Engineering and National Center for International Research of Development and Disease, Institute of Developmental Biology and Molecular Medicine, Fudan University, Shanghai, China., Xu H; Department of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China; Shanghai Kidney Development & Pediatric Kidney Disease Research Center, Shanghai, China; National Key Laboratory of Kidney Diseases, China. Electronic address: hxu@shmu.edu.cn., Shen Q; Department of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China; Shanghai Kidney Development & Pediatric Kidney Disease Research Center, Shanghai, China; National Key Laboratory of Kidney Diseases, China. Electronic address: shenqian@shmu.edu.cn.

المصدر: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Jun 25; Vol. 714, pp. 149959. Date of Electronic Publication: 2024 Apr 16.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

مواضيع طبية MeSH: Diabetes, Gestational*/metabolism , MAP Kinase Signaling System* , Proto-Oncogene Proteins c-ret*/metabolism , Proto-Oncogene Proteins c-ret*/genetics , Urogenital Abnormalities*/etiology , Urogenital Abnormalities*/genetics , Urogenital Abnormalities*/pathology , Vesico-Ureteral Reflux*, Animals ; Female ; Mice ; Pregnancy ; Kidney/abnormalities ; Kidney/metabolism ; Kidney/embryology ; Urinary Tract/abnormalities ; Urinary Tract/embryology

SCR Disease Name: Cakut

المؤلفون: Cheong TC; Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA. taekchin.cheong@childrens.harvard.edu., Jang A; Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, 02115, USA., Wang Q; Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA., Leonardi GC; Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.; Department of Biomedical and Biotechnological Sciences, University of Catania, 95123, Catania, Italy., Ricciuti B; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, 02115, USA., Alessi JV; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, 02115, USA., Di Federico A; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, 02115, USA., Awad MM; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, 02115, USA., Lehtinen MK; Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA., Harris MH; Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA., Chiarle R; Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA. roberto.chiarle@childrens.harvard.edu.; Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, 10126, Italy. roberto.chiarle@childrens.harvard.edu.; Division of Hematopathology, IEO European Institute of Oncology IRCCS, 20141, Milan, Italy. roberto.chiarle@childrens.harvard.edu.

المصدر: Nature communications [Nat Commun] 2024 Jun 14; Vol. 15 (1), pp. 5110. Date of Electronic Publication: 2024 Jun 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Neoplasms*/genetics , Neoplasms*/drug therapy , Oncogene Proteins, Fusion*/genetics , Oncogene Proteins, Fusion*/metabolism , Protein-Tyrosine Kinases*/genetics , Protein-Tyrosine Kinases*/metabolism , Proto-Oncogene Proteins c-ret*/genetics , Proto-Oncogene Proteins c-ret*/metabolism , Translocation, Genetic*, Humans ; Anaplastic Lymphoma Kinase/genetics ; Anaplastic Lymphoma Kinase/metabolism ; Receptor, trkA/genetics ; Receptor, trkA/metabolism ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism ; Signal Transduction/genetics ; Cell Line, Tumor

المؤلفون: Qiu T; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China., Kong Y; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China., Wei G; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China., Sun K; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China., Wang R; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China., Wang Y; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China., Chen Y; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China., Wang W; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China., Zhang Y; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; School of Life Sciences, Westlake University, Hangzhou 310024, China., Jiang C; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China., Yang P; School of Life Sciences, Westlake University, Hangzhou 310024, China., Xie T; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China., Chen X; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Jun 04; Vol. 121 (23), pp. e2322359121. Date of Electronic Publication: 2024 May 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: GRB2 Adaptor Protein*/metabolism , GRB2 Adaptor Protein*/genetics , MAP Kinase Signaling System* , Oncogene Proteins, Fusion*/metabolism , Oncogene Proteins, Fusion*/genetics , Proto-Oncogene Proteins c-ret*/metabolism , Proto-Oncogene Proteins c-ret*/genetics , ras Proteins*/metabolism , ras Proteins*/genetics , Src Homology 2 Domain-Containing, Transforming Protein 1*/metabolism , Src Homology 2 Domain-Containing, Transforming Protein 1*/genetics, Humans ; HEK293 Cells ; Phosphorylation ; Signal Transduction