المؤلفون: Konagaya Y; Department of Cell and Developmental Biology, Weill Cornell Medicine, New York, NY, USA. yumi.konagaya@riken.jp.; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA. yumi.konagaya@riken.jp.; Laboratory for Quantitative Biology of Cell Fate Decision, RIKEN Center for Biosystems Dynamics Research, Kobe, Hyogo, Japan. yumi.konagaya@riken.jp., Rosenthal D; Department of Cell and Developmental Biology, Weill Cornell Medicine, New York, NY, USA., Ratnayeke N; Department of Cell and Developmental Biology, Weill Cornell Medicine, New York, NY, USA.; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA., Fan Y; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Meyer T; Department of Cell and Developmental Biology, Weill Cornell Medicine, New York, NY, USA. tom4003@med.cornell.edu.; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA. tom4003@med.cornell.edu.

المصدر: Nature [Nature] 2024 Jul; Vol. 631 (8020), pp. 424-431. Date of Electronic Publication: 2024 Jun 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Cell Proliferation* , E2F Transcription Factors*/metabolism , Retinoblastoma Protein*/chemistry , Retinoblastoma Protein*/metabolism, Humans ; Cell Line ; Chromatin/metabolism ; Cyclin-Dependent Kinase 2/metabolism ; Cyclin-Dependent Kinase 4/metabolism ; Cyclin-Dependent Kinase 4/antagonists & inhibitors ; Cyclin-Dependent Kinase 6/metabolism ; Feedback, Physiological ; G1 Phase ; Phosphorylation ; Single-Cell Analysis ; Phosphoproteins/chemistry ; Phosphoproteins/metabolism

المصدر: International journal of cancer [Int J Cancer] 2024 Sep 15; Vol. 155 (6), pp. E9. Date of Electronic Publication: 2024 May 31.

نوع المنشور: Letter; Expression of Concern

بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0215 (Electronic) Linking ISSN: 00207136 NLM ISO Abbreviation: Int J Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Colonic Neoplasms*/metabolism , Colonic Neoplasms*/pathology , Colonic Neoplasms*/genetics , Adenoma*/metabolism , Adenoma*/pathology , DNA-Binding Proteins*/metabolism , Transcription Factors*/metabolism , Retinoblastoma Protein*/metabolism, Humans ; Cell Line, Tumor

المؤلفون: Sanidas I; Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA., Lawrence MS; Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA., Dyson NJ; Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA. Electronic address: ndyson@mgh.harvard.edu.

المصدر: Trends in cell biology [Trends Cell Biol] 2024 Apr; Vol. 34 (4), pp. 288-298. Date of Electronic Publication: 2023 Aug 28.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier Science Publishers Country of Publication: England NLM ID: 9200566 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3088 (Electronic) Linking ISSN: 09628924 NLM ISO Abbreviation: Trends Cell Biol Subsets: MEDLINE

مواضيع طبية MeSH: Chromatin* , Retinoblastoma Protein*/genetics , Retinoblastoma Protein*/metabolism, Animals ; E2F Transcription Factors/metabolism ; Cell Cycle/genetics ; Cell Division

المؤلفون: Barrett AK; Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA, USA., Shingare MR; Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA, USA., Rechtsteiner A; Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, CA, USA., Rodriguez KM; Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA, USA., Le QN; Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA, USA., Wijeratne TU; Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA, USA., Mitchell CE; Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA, USA., Membreno MW; Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA, USA., Rubin SM; Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA, USA. srubin@ucsc.edu., Müller GA; Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA, USA. gemuelle@ucsc.edu.

المصدر: Nature communications [Nat Commun] 2024 May 24; Vol. 15 (1), pp. 4450. Date of Electronic Publication: 2024 May 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Histone Deacetylases*/metabolism , Histone Deacetylases*/genetics , Repressor Proteins*/metabolism , Repressor Proteins*/genetics , E2F Transcription Factors*/metabolism , E2F Transcription Factors*/genetics , Retinoblastoma Protein*/metabolism , Retinoblastoma Protein*/genetics, Humans ; HCT116 Cells ; Mice ; Animals ; Sin3 Histone Deacetylase and Corepressor Complex/metabolism ; Sin3 Histone Deacetylase and Corepressor Complex/genetics ; Kv Channel-Interacting Proteins/metabolism ; Kv Channel-Interacting Proteins/genetics ; Cell Cycle/genetics ; Promoter Regions, Genetic/genetics ; Gene Expression Regulation ; Genes, cdc

المؤلفون: Ren D; Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.; Uro-Oncology Institute of Central South University, Changsha, Hunan, 410011, China., Li W; Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.; Uro-Oncology Institute of Central South University, Changsha, Hunan, 410011, China., Zeng R; Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.; Uro-Oncology Institute of Central South University, Changsha, Hunan, 410011, China., Liu X; Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.; Uro-Oncology Institute of Central South University, Changsha, Hunan, 410011, China., Liang H; Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.; Uro-Oncology Institute of Central South University, Changsha, Hunan, 410011, China., Xiong W; Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.; Uro-Oncology Institute of Central South University, Changsha, Hunan, 410011, China., Yang C; Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. cgyang-hust@hotmail.com., Jin X; Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China. jinxinxy2@csu.edu.cn.; Uro-Oncology Institute of Central South University, Changsha, Hunan, 410011, China. jinxinxy2@csu.edu.cn.

المصدر: Cell death and differentiation [Cell Death Differ] 2024 May; Vol. 31 (5), pp. 592-604. Date of Electronic Publication: 2024 Mar 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9437445 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5403 (Electronic) Linking ISSN: 13509047 NLM ISO Abbreviation: Cell Death Differ Subsets: MEDLINE

مواضيع طبية MeSH: Retinoblastoma Protein*/metabolism , Signal Transduction* , TOR Serine-Threonine Kinases*/metabolism, Animals ; Humans ; Male ; Mice ; Carrier Proteins/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Mice, Nude ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms, Castration-Resistant/metabolism ; Prostatic Neoplasms, Castration-Resistant/pathology ; Prostatic Neoplasms, Castration-Resistant/genetics ; Dual Specificity Phosphatase 2/metabolism

المؤلفون: Suleman M; Laboratory of Animal Research Center (LARC) Qatar University, Doha, Qatar; Center for Biotechnology and Microbiology, University of Swat, Swat, Pakistan. Electronic address: suleman@uswat.edu.pk., Khattak A; Department of Bioinformatics, Shaheed Benazir butto women university Peshawar, Pakistan., Akbar F; Center for Biotechnology and Microbiology, University of Swat, Swat, Pakistan. Electronic address: fazalakbar@uswat.edu.pk., Rizwan M; Center for Biotechnology and Microbiology, University of Swat, Swat, Pakistan. Electronic address: rizwan@uswat.edu.pk., Tayyab M; Institute of Biotechnology and Genetic Engineering, the University of Agriculture Peshawar. Electronic address: muhammadtayyab@aup.edu.pk., Yousaf M; Centre for Animal Sciences and Fisheries, University of Swat, Swat, Pakistan. Electronic address: dyousaf@uswat.edu.pk., Khan A; Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China. Electronic address: abbaskhan@sjtu.edu.cn., Albekairi NA; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Post Box 2455, Riyadh 11451, Saudi Arabia. Electronic address: nalbekairi@ksu.edu.sa., Agouni A; Department of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar University, P.O. Box 2713, Doha, Qatar. Electronic address: aagouni@qu.edu.qa., Crovella S; Laboratory of Animal Research Center (LARC) Qatar University, Doha, Qatar. Electronic address: sgrovella@qu.edu.qa.

المصدر: International journal of biological macromolecules [Int J Biol Macromol] 2024 Mar; Vol. 260 (Pt 1), pp. 129559. Date of Electronic Publication: 2024 Jan 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

مواضيع طبية MeSH: Retinoblastoma Protein*/genetics , Retinoblastoma Protein*/metabolism , Neoplasms*/genetics, Humans ; Polymorphism, Single Nucleotide/genetics ; Molecular Docking Simulation ; Cell Cycle ; E2F1 Transcription Factor/genetics ; E2F1 Transcription Factor/metabolism

المؤلفون: Tateishi K; Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa, Yokohama, 2360004, Japan. ktate12@yokohama-cu.ac.jp.; Laboratory of Biopharmaceutical and Regenerative Science, Graduate School of Medical Science, Yokohama City University, Yokohama, Japan. ktate12@yokohama-cu.ac.jp.; Neurosurgical-Oncology Laboratory, Yokohama City University, Yokohama, Japan. ktate12@yokohama-cu.ac.jp., Miyake Y; Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa, Yokohama, 2360004, Japan.; Neurosurgical-Oncology Laboratory, Yokohama City University, Yokohama, Japan., Nakamura T; Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa, Yokohama, 2360004, Japan.; Neurosurgical-Oncology Laboratory, Yokohama City University, Yokohama, Japan., Iwashita H; Department of Pathology, Yokohama City University Hospital, Yokohama, Japan.; Department of Diagnostic Pathology, Yokohama City University Hospital, Yokohama, Japan., Hayashi T; Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa, Yokohama, 2360004, Japan.; Neurosurgical-Oncology Laboratory, Yokohama City University, Yokohama, Japan., Oshima A; Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa, Yokohama, 2360004, Japan.; Neurosurgical-Oncology Laboratory, Yokohama City University, Yokohama, Japan., Honma H; Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa, Yokohama, 2360004, Japan.; Neurosurgical-Oncology Laboratory, Yokohama City University, Yokohama, Japan., Hayashi H; Neurosurgical-Oncology Laboratory, Yokohama City University, Yokohama, Japan.; Department of Pediatrics, Graduate School of Medicine, Yokohama City University, Yokohama, Japan., Sugino K; Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa, Yokohama, 2360004, Japan.; Laboratory of Biopharmaceutical and Regenerative Science, Graduate School of Medical Science, Yokohama City University, Yokohama, Japan.; Neurosurgical-Oncology Laboratory, Yokohama City University, Yokohama, Japan., Kato M; Laboratory of Biopharmaceutical and Regenerative Science, Graduate School of Medical Science, Yokohama City University, Yokohama, Japan.; Neurosurgical-Oncology Laboratory, Yokohama City University, Yokohama, Japan., Satomi K; Department of Pathology, Kyorin University School of Medicine, Tokyo, Japan., Fujii S; Department of Diagnostic Pathology, Yokohama City University Hospital, Yokohama, Japan.; Department of Molecular Pathology, Graduate School of Medicine, Yokohama City University, Yokohama, Japan., Komori T; Department of Laboratory Medicine and Pathology (Neuropathology), Tokyo Metropolitan Neurological Hospital, Tokyo, Japan., Yamamoto T; Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa, Yokohama, 2360004, Japan., Cahill DP; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA.; Translational-Neurooncology Laboratory, Brain Tumor Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA., Wakimoto H; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA.; Translational-Neurooncology Laboratory, Brain Tumor Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.

المصدر: Acta neuropathologica communications [Acta Neuropathol Commun] 2023 Nov 27; Vol. 11 (1), pp. 186. Date of Electronic Publication: 2023 Nov 27.

نوع المنشور: Case Reports; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE

مواضيع طبية MeSH: Astrocytoma*/genetics , Astrocytoma*/pathology , Brain Neoplasms*/genetics , Brain Neoplasms*/pathology , Receptor, Platelet-Derived Growth Factor alpha*/genetics , Retinoblastoma Protein*/genetics, Animals ; Humans ; Mice ; Homozygote ; Isocitrate Dehydrogenase/genetics ; Mutation ; Sequence Deletion ; Signal Transduction

المؤلفون: Zhao S; The Innovation Centre of Ministry of Education for Development and Diseases, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China., Wang C; The Innovation Centre of Ministry of Education for Development and Diseases, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China., Luo H; The Innovation Centre of Ministry of Education for Development and Diseases, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China., Li F; The Innovation Centre of Ministry of Education for Development and Diseases, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China., Wang Q; The Innovation Centre of Ministry of Education for Development and Diseases, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China., Xu J; The Innovation Centre of Ministry of Education for Development and Diseases, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China., Huang Z; The Innovation Centre of Ministry of Education for Development and Diseases, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China., Liu W; The Innovation Centre of Ministry of Education for Development and Diseases, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China. Electronic address: liuwei7@scut.edu.cn., Zhang W; The Innovation Centre of Ministry of Education for Development and Diseases, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China; Greater Bay Biomedical Innocenter, Shenzhen Bay Laboratory, Shenzhen, Guangdong 518055, China. Electronic address: mczhangwq@scut.edu.cn.

المصدر: Journal of genetics and genomics = Yi chuan xue bao [J Genet Genomics] 2024 Sep; Vol. 51 (9), pp. 900-910. Date of Electronic Publication: 2024 Apr 01.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Science press Country of Publication: China NLM ID: 101304616 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1673-8527 (Print) Linking ISSN: 16738527 NLM ISO Abbreviation: J Genet Genomics Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation, Developmental*/genetics , Homeodomain Proteins*/genetics , Homeodomain Proteins*/metabolism , Morphogenesis*/genetics , Rhombencephalon*/metabolism , Rhombencephalon*/growth & development , Rhombencephalon*/embryology , Zebrafish*/genetics , Zebrafish*/metabolism, Animals ; Mice ; Cell Proliferation/genetics ; Neurons/metabolism ; Neurons/cytology ; Retinoblastoma Protein/genetics ; Retinoblastoma Protein/metabolism ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism

المؤلفون: Lara-Sáez I; Charles Institute of Dermatology, School of Medicine, University College Dublin, Belfield, Dublin D04 V1W8, Ireland., Mencía Á; Biomedical Innovation Unit, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, Madrid 28040, Spain.; CB06/07/0019 Unit, Centro de Investigación Biomédica en Red en Enfermedades Raras, Madrid 28029, Spain.; Regenerative Medicine and Tissue Bioengineering Group, Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz, Madrid 28040, Spain., Recuero E; Biomedical Innovation Unit, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, Madrid 28040, Spain.; Cellular and Molecular Genitourinary Oncology Group, Institute of Biomedical Research Hospital '12 de Octubre', Madrid 28041, Spain., Li Y; Charles Institute of Dermatology, School of Medicine, University College Dublin, Belfield, Dublin D04 V1W8, Ireland., García M; CB06/07/0019 Unit, Centro de Investigación Biomédica en Red en Enfermedades Raras, Madrid 28029, Spain.; Regenerative Medicine and Tissue Bioengineering Group, Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz, Madrid 28040, Spain.; Department of Biomedical Engineering, Polytechnic School, Carlos III University, Leganés, Madrid 28911, Spain., Oteo M; Biomedical Applications and Pharmacokinetics Unit, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, Madrid 28040, Spain., Gallego MI; Unidad de Histología, Unidades Centrales Científico Tecnológicas, Instituto de Salud Carlos III, Madrid 28220, Spain., Enguita AB; Pathology Department, University Hospital '12 de Octubre', Madrid 28041, Spain., de Prado-Verdún D; Biomedical Innovation Unit, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, Madrid 28040, Spain.; CB06/07/0019 Unit, Centro de Investigación Biomédica en Red en Enfermedades Raras, Madrid 28029, Spain.; Regenerative Medicine and Tissue Bioengineering Group, Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz, Madrid 28040, Spain., A S; Research and Clinical Translation Center of Gene Medicine and Tissue Engineering, School of Public Health, Anhui University of Science and Technology, Huainan 232001, China., Wang W; Charles Institute of Dermatology, School of Medicine, University College Dublin, Belfield, Dublin D04 V1W8, Ireland., García-Escudero R; Biomedical Innovation Unit, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, Madrid 28040, Spain.; Cellular and Molecular Genitourinary Oncology Group, Institute of Biomedical Research Hospital '12 de Octubre', Madrid 28041, Spain.; Tumor Progression Mechanisms Program, Centro de Investigación Biomédica en Red de Cáncer, Madrid 28029, Spain., Murillas R; Biomedical Innovation Unit, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, Madrid 28040, Spain.; CB06/07/0019 Unit, Centro de Investigación Biomédica en Red en Enfermedades Raras, Madrid 28029, Spain.; Regenerative Medicine and Tissue Bioengineering Group, Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz, Madrid 28040, Spain., Santos M; Biomedical Innovation Unit, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, Madrid 28040, Spain.; Cellular and Molecular Genitourinary Oncology Group, Institute of Biomedical Research Hospital '12 de Octubre', Madrid 28041, Spain.; Tumor Progression Mechanisms Program, Centro de Investigación Biomédica en Red de Cáncer, Madrid 28029, Spain.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Jul 09; Vol. 121 (28), pp. e2322917121. Date of Electronic Publication: 2024 Jul 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Lung Neoplasms*/genetics , Lung Neoplasms*/pathology , CRISPR-Cas Systems* , PTEN Phosphohydrolase*/genetics , Tumor Suppressor Protein p53*/genetics , Small Cell Lung Carcinoma*/genetics , Small Cell Lung Carcinoma*/pathology , Mutagenesis*, Animals ; Mice ; Humans ; Disease Models, Animal ; Retinoblastoma-Like Protein p107/genetics ; Retinoblastoma-Like Protein p107/metabolism ; Retinoblastoma Protein/genetics ; Retinoblastoma Protein/metabolism ; Gene Editing/methods

المؤلفون: Hu YM; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Basic Science Research Center Base (Pharmaceutical Science), Yantai University, Yantai 264005, China., Liu XC; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Basic Science Research Center Base (Pharmaceutical Science), Yantai University, Yantai 264005, China., Hu L; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Basic Science Research Center Base (Pharmaceutical Science), Yantai University, Yantai 264005, China., Dong ZW; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Basic Science Research Center Base (Pharmaceutical Science), Yantai University, Yantai 264005, China; Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, China., Yao HY; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Basic Science Research Center Base (Pharmaceutical Science), Yantai University, Yantai 264005, China., Wang YJ; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Basic Science Research Center Base (Pharmaceutical Science), Yantai University, Yantai 264005, China., Zhao WJ; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Basic Science Research Center Base (Pharmaceutical Science), Yantai University, Yantai 264005, China., Xiang YK; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China., Liu Y; School of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, China., Wang HB; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Basic Science Research Center Base (Pharmaceutical Science), Yantai University, Yantai 264005, China. Electronic address: hongbowang@ytu.edu.cn., Yin QK; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Basic Science Research Center Base (Pharmaceutical Science), Yantai University, Yantai 264005, China. Electronic address: qkyin@ytu.edu.cn.

المصدر: Biochemical pharmacology [Biochem Pharmacol] 2024 Jul; Vol. 225, pp. 116310. Date of Electronic Publication: 2024 May 22.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Ataxia Telangiectasia Mutated Proteins*/metabolism , Ataxia Telangiectasia Mutated Proteins*/antagonists & inhibitors , Ataxia Telangiectasia Mutated Proteins*/genetics , Triple Negative Breast Neoplasms*/metabolism , Triple Negative Breast Neoplasms*/genetics , Triple Negative Breast Neoplasms*/drug therapy , DNA, Cruciform*/metabolism , DNA, Cruciform*/genetics, Humans ; Cell Line, Tumor ; Retinoblastoma Protein/metabolism ; Retinoblastoma Protein/genetics ; Female ; S Phase/drug effects ; S Phase/physiology ; Animals ; Antineoplastic Agents/pharmacology ; DNA Damage/physiology ; DNA Damage/drug effects