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1دورية أكاديمية
المؤلفون: Barrett AK; Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA, USA., Shingare MR; Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA, USA., Rechtsteiner A; Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, CA, USA., Rodriguez KM; Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA, USA., Le QN; Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA, USA., Wijeratne TU; Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA, USA., Mitchell CE; Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA, USA., Membreno MW; Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA, USA., Rubin SM; Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA, USA. srubin@ucsc.edu., Müller GA; Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA, USA. gemuelle@ucsc.edu.
المصدر: Nature communications [Nat Commun] 2024 May 24; Vol. 15 (1), pp. 4450. Date of Electronic Publication: 2024 May 24.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
مواضيع طبية MeSH: Histone Deacetylases*/metabolism , Histone Deacetylases*/genetics , Repressor Proteins*/metabolism , Repressor Proteins*/genetics , E2F Transcription Factors*/metabolism , E2F Transcription Factors*/genetics , Retinoblastoma Protein*/metabolism , Retinoblastoma Protein*/genetics, Humans ; HCT116 Cells ; Mice ; Animals ; Sin3 Histone Deacetylase and Corepressor Complex/metabolism ; Sin3 Histone Deacetylase and Corepressor Complex/genetics ; Kv Channel-Interacting Proteins/metabolism ; Kv Channel-Interacting Proteins/genetics ; Cell Cycle/genetics ; Promoter Regions, Genetic/genetics ; Gene Expression Regulation ; Genes, cdc
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2دورية أكاديمية
المؤلفون: Sanidas I; Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA., Lawrence MS; Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA., Dyson NJ; Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA. Electronic address: ndyson@mgh.harvard.edu.
المصدر: Trends in cell biology [Trends Cell Biol] 2024 Apr; Vol. 34 (4), pp. 288-298. Date of Electronic Publication: 2023 Aug 28.
نوع المنشور: Journal Article; Review
بيانات الدورية: Publisher: Elsevier Science Publishers Country of Publication: England NLM ID: 9200566 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3088 (Electronic) Linking ISSN: 09628924 NLM ISO Abbreviation: Trends Cell Biol Subsets: MEDLINE
مواضيع طبية MeSH: Chromatin* , Retinoblastoma Protein*/genetics , Retinoblastoma Protein*/metabolism, Animals ; E2F Transcription Factors/metabolism ; Cell Cycle/genetics ; Cell Division
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3دورية أكاديمية
المؤلفون: Suleman M; Laboratory of Animal Research Center (LARC) Qatar University, Doha, Qatar; Center for Biotechnology and Microbiology, University of Swat, Swat, Pakistan. Electronic address: suleman@uswat.edu.pk., Khattak A; Department of Bioinformatics, Shaheed Benazir butto women university Peshawar, Pakistan., Akbar F; Center for Biotechnology and Microbiology, University of Swat, Swat, Pakistan. Electronic address: fazalakbar@uswat.edu.pk., Rizwan M; Center for Biotechnology and Microbiology, University of Swat, Swat, Pakistan. Electronic address: rizwan@uswat.edu.pk., Tayyab M; Institute of Biotechnology and Genetic Engineering, the University of Agriculture Peshawar. Electronic address: muhammadtayyab@aup.edu.pk., Yousaf M; Centre for Animal Sciences and Fisheries, University of Swat, Swat, Pakistan. Electronic address: dyousaf@uswat.edu.pk., Khan A; Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China. Electronic address: abbaskhan@sjtu.edu.cn., Albekairi NA; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Post Box 2455, Riyadh 11451, Saudi Arabia. Electronic address: nalbekairi@ksu.edu.sa., Agouni A; Department of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar University, P.O. Box 2713, Doha, Qatar. Electronic address: aagouni@qu.edu.qa., Crovella S; Laboratory of Animal Research Center (LARC) Qatar University, Doha, Qatar. Electronic address: sgrovella@qu.edu.qa.
المصدر: International journal of biological macromolecules [Int J Biol Macromol] 2024 Mar; Vol. 260 (Pt 1), pp. 129559. Date of Electronic Publication: 2024 Jan 18.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE
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4دورية أكاديمية
المؤلفون: Tateishi K; Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa, Yokohama, 2360004, Japan. ktate12@yokohama-cu.ac.jp.; Laboratory of Biopharmaceutical and Regenerative Science, Graduate School of Medical Science, Yokohama City University, Yokohama, Japan. ktate12@yokohama-cu.ac.jp.; Neurosurgical-Oncology Laboratory, Yokohama City University, Yokohama, Japan. ktate12@yokohama-cu.ac.jp., Miyake Y; Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa, Yokohama, 2360004, Japan.; Neurosurgical-Oncology Laboratory, Yokohama City University, Yokohama, Japan., Nakamura T; Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa, Yokohama, 2360004, Japan.; Neurosurgical-Oncology Laboratory, Yokohama City University, Yokohama, Japan., Iwashita H; Department of Pathology, Yokohama City University Hospital, Yokohama, Japan.; Department of Diagnostic Pathology, Yokohama City University Hospital, Yokohama, Japan., Hayashi T; Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa, Yokohama, 2360004, Japan.; Neurosurgical-Oncology Laboratory, Yokohama City University, Yokohama, Japan., Oshima A; Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa, Yokohama, 2360004, Japan.; Neurosurgical-Oncology Laboratory, Yokohama City University, Yokohama, Japan., Honma H; Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa, Yokohama, 2360004, Japan.; Neurosurgical-Oncology Laboratory, Yokohama City University, Yokohama, Japan., Hayashi H; Neurosurgical-Oncology Laboratory, Yokohama City University, Yokohama, Japan.; Department of Pediatrics, Graduate School of Medicine, Yokohama City University, Yokohama, Japan., Sugino K; Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa, Yokohama, 2360004, Japan.; Laboratory of Biopharmaceutical and Regenerative Science, Graduate School of Medical Science, Yokohama City University, Yokohama, Japan.; Neurosurgical-Oncology Laboratory, Yokohama City University, Yokohama, Japan., Kato M; Laboratory of Biopharmaceutical and Regenerative Science, Graduate School of Medical Science, Yokohama City University, Yokohama, Japan.; Neurosurgical-Oncology Laboratory, Yokohama City University, Yokohama, Japan., Satomi K; Department of Pathology, Kyorin University School of Medicine, Tokyo, Japan., Fujii S; Department of Diagnostic Pathology, Yokohama City University Hospital, Yokohama, Japan.; Department of Molecular Pathology, Graduate School of Medicine, Yokohama City University, Yokohama, Japan., Komori T; Department of Laboratory Medicine and Pathology (Neuropathology), Tokyo Metropolitan Neurological Hospital, Tokyo, Japan., Yamamoto T; Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa, Yokohama, 2360004, Japan., Cahill DP; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA.; Translational-Neurooncology Laboratory, Brain Tumor Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA., Wakimoto H; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA.; Translational-Neurooncology Laboratory, Brain Tumor Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
المصدر: Acta neuropathologica communications [Acta Neuropathol Commun] 2023 Nov 27; Vol. 11 (1), pp. 186. Date of Electronic Publication: 2023 Nov 27.
نوع المنشور: Case Reports; Journal Article; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE
مواضيع طبية MeSH: Astrocytoma*/genetics , Astrocytoma*/pathology , Brain Neoplasms*/genetics , Brain Neoplasms*/pathology , Receptor, Platelet-Derived Growth Factor alpha*/genetics , Retinoblastoma Protein*/genetics, Animals ; Humans ; Mice ; Homozygote ; Isocitrate Dehydrogenase/genetics ; Mutation ; Sequence Deletion ; Signal Transduction
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5دورية أكاديمية
المؤلفون: Militi S; Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Old Road, Headington, Oxford OX3 7LD, UK., Nibhani R; Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Old Road, Headington, Oxford OX3 7LD, UK., Jalali M; Anne McLaren Laboratory for Regenerative Medicine, Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Pauklin S; Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Old Road, Headington, Oxford OX3 7LD, UK. Electronic address: siim.pauklin@ndorms.ox.ac.uk.
المصدر: Cell reports [Cell Rep] 2023 Sep 26; Vol. 42 (9), pp. 113146. Date of Electronic Publication: 2023 Sep 19.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
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6دورية أكاديمية
المؤلفون: Hu YM; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Basic Science Research Center Base (Pharmaceutical Science), Yantai University, Yantai 264005, China., Liu XC; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Basic Science Research Center Base (Pharmaceutical Science), Yantai University, Yantai 264005, China., Hu L; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Basic Science Research Center Base (Pharmaceutical Science), Yantai University, Yantai 264005, China., Dong ZW; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Basic Science Research Center Base (Pharmaceutical Science), Yantai University, Yantai 264005, China; Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, China., Yao HY; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Basic Science Research Center Base (Pharmaceutical Science), Yantai University, Yantai 264005, China., Wang YJ; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Basic Science Research Center Base (Pharmaceutical Science), Yantai University, Yantai 264005, China., Zhao WJ; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Basic Science Research Center Base (Pharmaceutical Science), Yantai University, Yantai 264005, China., Xiang YK; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China., Liu Y; School of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, China., Wang HB; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Basic Science Research Center Base (Pharmaceutical Science), Yantai University, Yantai 264005, China. Electronic address: hongbowang@ytu.edu.cn., Yin QK; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Basic Science Research Center Base (Pharmaceutical Science), Yantai University, Yantai 264005, China. Electronic address: qkyin@ytu.edu.cn.
المصدر: Biochemical pharmacology [Biochem Pharmacol] 2024 Jul; Vol. 225, pp. 116310. Date of Electronic Publication: 2024 May 22.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE
مواضيع طبية MeSH: Ataxia Telangiectasia Mutated Proteins*/metabolism , Ataxia Telangiectasia Mutated Proteins*/antagonists & inhibitors , Ataxia Telangiectasia Mutated Proteins*/genetics , Triple Negative Breast Neoplasms*/metabolism , Triple Negative Breast Neoplasms*/genetics , Triple Negative Breast Neoplasms*/drug therapy , DNA, Cruciform*/metabolism , DNA, Cruciform*/genetics, Humans ; Cell Line, Tumor ; Retinoblastoma Protein/metabolism ; Retinoblastoma Protein/genetics ; Female ; S Phase/drug effects ; S Phase/physiology ; Animals ; Antineoplastic Agents/pharmacology ; DNA Damage/physiology ; DNA Damage/drug effects
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7دورية أكاديمية
المؤلفون: Vincent A; Radheshyam Kanoi Stem Cell Laboratory, Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology, Vision Research Foundation, 41, College Road, Chennai, Tamilnadu, India.; School of Chemical and Biotechnology, SASTRA Deemed-to-Be University, Thanjavur, India., Krishnakumar S; Radheshyam Kanoi Stem Cell Laboratory, Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology, Vision Research Foundation, 41, College Road, Chennai, Tamilnadu, India., Parameswaran S; Radheshyam Kanoi Stem Cell Laboratory, Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology, Vision Research Foundation, 41, College Road, Chennai, Tamilnadu, India. drpsowmya@snmail.org.
المصدر: Molecular biology reports [Mol Biol Rep] 2024 May 05; Vol. 51 (1), pp. 606. Date of Electronic Publication: 2024 May 05.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE
مواضيع طبية MeSH: Adenosine Triphosphate*/metabolism , Cell Differentiation*/genetics , Induced Pluripotent Stem Cells*/metabolism , Induced Pluripotent Stem Cells*/cytology , Organoids*/metabolism , Retina*/metabolism , Retina*/cytology , Retinoblastoma*/genetics , Retinoblastoma*/metabolism , Retinoblastoma Binding Proteins*/genetics , Retinoblastoma Binding Proteins*/metabolism , Ubiquitin-Protein Ligases*/genetics , Ubiquitin-Protein Ligases*/metabolism, Humans ; Glycolysis/genetics ; Heterozygote ; Mutation/genetics ; Retinoblastoma Protein/genetics ; Retinoblastoma Protein/metabolism
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8دورية أكاديمية
المؤلفون: Gu P; Department of Medical Oncology, Affiliated Hospital of Nanjing University of Chinese Medicine, 210004 Nanjing, Jiangsu, China., Huang W; Department of Medical Oncology, Affiliated Hospital of Nanjing University of Chinese Medicine, 210004 Nanjing, Jiangsu, China., Lu W; Department of Medical Oncology, Affiliated Hospital of Nanjing University of Chinese Medicine, 210004 Nanjing, Jiangsu, China., Shu P; Department of Medical Oncology, Affiliated Hospital of Nanjing University of Chinese Medicine, 210004 Nanjing, Jiangsu, China.
المصدر: Discovery medicine [Discov Med] 2024 May; Vol. 36 (184), pp. 923-935.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Discovery medicine Country of Publication: United States NLM ID: 101250006 Publication Model: Print Cited Medium: Internet ISSN: 1944-7930 (Electronic) Linking ISSN: 15396509 NLM ISO Abbreviation: Discov Med Subsets: MEDLINE
مواضيع طبية MeSH: Stomach Neoplasms*/pathology , Stomach Neoplasms*/genetics , Stomach Neoplasms*/metabolism , DNA (Cytosine-5-)-Methyltransferase 1*/metabolism , DNA (Cytosine-5-)-Methyltransferase 1*/genetics , Gene Expression Regulation, Neoplastic* , Cell Proliferation*/genetics , Retinoblastoma Binding Proteins*/genetics , Retinoblastoma Binding Proteins*/metabolism, Humans ; Cell Line, Tumor ; Animals ; Mice ; Neoplasm Metastasis ; Cell Movement/genetics ; Mice, Nude ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Retinoblastoma Protein/metabolism ; Retinoblastoma Protein/genetics ; Mice, Inbred BALB C ; Repressor Proteins
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9دورية أكاديمية
المؤلفون: Gong L; Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan., Voon DC; Institute for Frontier Science Initiative, Kanazawa University, Kanazawa, Ishikawa, Japan., Nakayama J; Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan., Takahashi C; Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan., Kohno S; Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.
المصدر: Cancer science [Cancer Sci] 2024 May; Vol. 115 (5), pp. 1576-1586. Date of Electronic Publication: 2024 Mar 11.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Wiley Publishing on behalf of the Japanese Cancer Association Country of Publication: England NLM ID: 101168776 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1349-7006 (Electronic) Linking ISSN: 13479032 NLM ISO Abbreviation: Cancer Sci Subsets: MEDLINE
مواضيع طبية MeSH: Epithelial Cells*/metabolism , Down-Regulation* , Retinoblastoma Binding Proteins*/metabolism , Retinoblastoma Binding Proteins*/genetics , ras Proteins*/metabolism , ras Proteins*/genetics , Signal Transduction*, Humans ; Female ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Breast Neoplasms/pathology ; Breast Neoplasms/metabolism ; Breast Neoplasms/genetics ; Epithelial-Mesenchymal Transition/genetics ; Mammary Glands, Human/metabolism ; Mammary Glands, Human/pathology ; Mammary Glands, Human/cytology ; Cell Line, Tumor ; Retinoblastoma Protein/metabolism ; Retinoblastoma Protein/genetics ; Cyclin-Dependent Kinase Inhibitor p27/metabolism ; Cyclin-Dependent Kinase Inhibitor p27/genetics
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10دورية أكاديمية
المؤلفون: Choi H; School of Biological Sciences, Seoul National University, South Korea.; Center for Systems Geroscience, Seoul National University, South Korea., Kang C; School of Biological Sciences, Seoul National University, South Korea.; Center for Systems Geroscience, Seoul National University, South Korea.
المصدر: The FEBS journal [FEBS J] 2024 May; Vol. 291 (10), pp. 2091-2093. Date of Electronic Publication: 2024 Apr 22.
نوع المنشور: Journal Article; Review
بيانات الدورية: Publisher: Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 101229646 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1742-4658 (Electronic) Linking ISSN: 1742464X NLM ISO Abbreviation: FEBS J Subsets: MEDLINE
مواضيع طبية MeSH: Cellular Senescence*/genetics , Genomic Instability* , Tumor Suppressor Protein p53*/genetics , Tumor Suppressor Protein p53*/metabolism , Lamin B Receptor*, Humans ; Receptors, Cytoplasmic and Nuclear/genetics ; Receptors, Cytoplasmic and Nuclear/metabolism ; Animals ; Retinoblastoma Protein/genetics ; Retinoblastoma Protein/metabolism ; Neoplasms/genetics ; Neoplasms/pathology ; Neoplasms/metabolism ; Cell Proliferation/genetics ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Cell Transformation, Neoplastic/pathology