المؤلفون: Park S; Department of Health Science and Technology, SAIHST, Sungkyunkwan University, 81 Irwon-Ro, Gangnam-Gu, Seoul, 06351, South Korea., Kim J; Samsung Medical Center, 81 Irwon- Ro, Gangnam-Gu, Seoul, 06351, South Korea. jh7289.kim@samsung.com., Yang S; Samsung Medical Center, 81 Irwon- Ro, Gangnam-Gu, Seoul, 06351, South Korea., Kang SH; Samsung Medical Center, 81 Irwon- Ro, Gangnam-Gu, Seoul, 06351, South Korea., Kang W; Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-Gu, Seoul, 06351, South Korea.; Samsung Medical Center, 81 Irwon- Ro, Gangnam-Gu, Seoul, 06351, South Korea., Paik YH; Department of Health Science and Technology, SAIHST, Sungkyunkwan University, 81 Irwon-Ro, Gangnam-Gu, Seoul, 06351, South Korea. yh.paik@skku.edu.; Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-Gu, Seoul, 06351, South Korea. yh.paik@skku.edu.; Samsung Medical Center, 81 Irwon- Ro, Gangnam-Gu, Seoul, 06351, South Korea. yh.paik@skku.edu.

المصدر: Molecular biology reports [Mol Biol Rep] 2024 Sep 02; Vol. 51 (1), pp. 950. Date of Electronic Publication: 2024 Sep 02.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE

مواضيع طبية MeSH: Hepatic Stellate Cells*/metabolism , Hepatic Stellate Cells*/drug effects , Connective Tissue Growth Factor*/metabolism , Connective Tissue Growth Factor*/genetics , Lysophospholipids*/metabolism , Lysophospholipids*/pharmacology , rho-Associated Kinases*/metabolism , rho-Associated Kinases*/genetics , Sphingosine*/analogs & derivatives , Sphingosine*/metabolism , Signal Transduction* , YAP-Signaling Proteins*/metabolism , rhoA GTP-Binding Protein*/metabolism , Transcription Factors*/metabolism , Transcription Factors*/genetics, Humans ; Sphingosine-1-Phosphate Receptors/metabolism ; Sphingosine-1-Phosphate Receptors/genetics ; Cell Line ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/genetics ; Liver Cirrhosis/pathology ; src-Family Kinases/metabolism ; Adaptor Proteins, Signal Transducing/metabolism ; Adaptor Proteins, Signal Transducing/genetics ; Receptors, Lysosphingolipid/metabolism ; Receptors, Lysosphingolipid/genetics ; Collagen Type I/metabolism ; Collagen Type I/genetics ; Hippo Signaling Pathway

المؤلفون: Qian W; Department of Radiology, The Fifth Hospital of Wuhan, Wuhan, China., Han Y; Department of General Medicine, Qin Duankou Street Community Health Service Center Affiliated to The Fifth Hospital of Wuhan, Wuhan, China., Jin Y; Department of Emergency, The Second Hospital of Dalian Medical University, Liaoning, China., Lei C; Department of Oncology, The Fifth Hospital of Wuhan, Wuhan, China., Lin X; Department of Emergency, The Second Hospital of Dalian Medical University, Liaoning, China.

المصدر: General physiology and biophysics [Gen Physiol Biophys] 2024 Sep; Vol. 43 (5), pp. 399-409.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Ústav molekulárnej fyziológie a genetiky SAV Country of Publication: Slovakia NLM ID: 8400604 Publication Model: Print Cited Medium: Print ISSN: 0231-5882 (Print) Linking ISSN: 02315882 NLM ISO Abbreviation: Gen Physiol Biophys Subsets: MEDLINE

مواضيع طبية MeSH: RNA, Long Noncoding*/genetics , RNA, Long Noncoding*/metabolism , Acute Lung Injury*/chemically induced , Acute Lung Injury*/metabolism , Acute Lung Injury*/genetics , Lipopolysaccharides* , MicroRNAs*/metabolism , MicroRNAs*/genetics , rho-Associated Kinases*/metabolism , rho-Associated Kinases*/genetics , Gene Knockdown Techniques*, Animals ; Mice ; Humans ; Male ; A549 Cells ; Signal Transduction ; Mice, Inbred C57BL ; Apoptosis/genetics

المؤلفون: Xu QX; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China., Guo L; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China., Li Y; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China., Wang ZW; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China., Hu P; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China., Yang GM; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China., Pan Y; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.

المصدر: Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2024 Sep; Vol. 42 (14), pp. 7467-7484. Date of Electronic Publication: 2023 Sep 05.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: England NLM ID: 8404176 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-0254 (Electronic) Linking ISSN: 07391102 NLM ISO Abbreviation: J Biomol Struct Dyn Subsets: MEDLINE

مواضيع طبية MeSH: rho-Associated Kinases*/antagonists & inhibitors , rho-Associated Kinases*/chemistry , rho-Associated Kinases*/metabolism , Quantitative Structure-Activity Relationship* , Molecular Docking Simulation* , Protein Kinase Inhibitors*/chemistry , Protein Kinase Inhibitors*/pharmacology , Molecular Dynamics Simulation* , Benzamides*/chemistry , Benzamides*/pharmacology, Humans ; Binding Sites ; Protein Binding ; Drug Discovery/methods ; Hydrogen Bonding

المؤلفون: Ouellette J; Neuroscience Program, The Ottawa Hospital Research Institute, Ottawa, ON, Canada; Cellular & Molecular Medicine, University of Ottawa, Ottawa, ON, Canada., Lacoste B; Neuroscience Program, The Ottawa Hospital Research Institute, Ottawa, ON, Canada; Cellular & Molecular Medicine, University of Ottawa, Ottawa, ON, Canada; University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada. Electronic address: blacoste@uottawa.ca.

المصدر: Neuroscience letters [Neurosci Lett] 2024 Aug 10; Vol. 837, pp. 137904. Date of Electronic Publication: 2024 Jul 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Scientific Publishers Ireland Country of Publication: Ireland NLM ID: 7600130 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7972 (Electronic) Linking ISSN: 03043940 NLM ISO Abbreviation: Neurosci Lett Subsets: MEDLINE

مواضيع طبية MeSH: rho-Associated Kinases*/genetics , rho-Associated Kinases*/metabolism , Chromosomes, Human, Pair 16*/genetics , Chromosome Deletion* , Disease Models, Animal* , Autistic Disorder*/genetics , Chromosome Disorders*/genetics, Animals ; Mice ; Heterozygote ; Recognition, Psychology/physiology ; Endothelial Cells/metabolism ; Haploinsufficiency ; Male ; Mice, Inbred C57BL ; Craniofacial Abnormalities/genetics ; Intellectual Disability/genetics

SCR Disease Name: 16p11.2 Deletion Syndrome

المؤلفون: Gholamhosseinzadeh E; Immunogenetics Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.; Department of Medical Microbiology and Virology, Faculty of Medicine, Mazandaran University of Medical Sciences, Farah Abad blv, Khazar square, Sari, Mazandaran, Iran., Ghalehnoei H; Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran., Kazemi Veisari A; Gut and Liver Research Center, Non-communicable Disease Institute, Mazandaran University of Medical Sciences, Sari, Iran., Jafari N; Immunogenetics Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran., Goli HR; Immunogenetics Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. goli59@gmail.com.; Department of Medical Microbiology and Virology, Faculty of Medicine, Mazandaran University of Medical Sciences, Farah Abad blv, Khazar square, Sari, Mazandaran, Iran. goli59@gmail.com.

المصدر: BMC gastroenterology [BMC Gastroenterol] 2024 Aug 07; Vol. 24 (1), pp. 251. Date of Electronic Publication: 2024 Aug 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968547 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-230X (Electronic) Linking ISSN: 1471230X NLM ISO Abbreviation: BMC Gastroenterol Subsets: MEDLINE

مواضيع طبية MeSH: Gastritis*/microbiology , Gastritis*/pathology , Gastritis*/metabolism , MicroRNAs*/metabolism , MicroRNAs*/genetics , Helicobacter Infections*/pathology , rho-Associated Kinases*/metabolism , rho-Associated Kinases*/genetics , Helicobacter pylori*/isolation & purification, Humans ; Biopsy ; Male ; Female ; Middle Aged ; Adult ; Gastric Mucosa/pathology ; Gastric Mucosa/microbiology ; Aged

المؤلفون: Doody NE; School of Biomedical Sciences, University of Leeds, Leeds, United Kingdom.; School of Psychology and Neuroscience, University of St Andrews, St Andrews, United Kingdom., Smith NJ; School of Biomedical Sciences, University of Leeds, Leeds, United Kingdom.; Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden., Akam EC; School of Sport, Exercise, and Health Sciences, Loughborough University, Loughborough, United Kingdom., Askew GN; School of Biomedical Sciences, University of Leeds, Leeds, United Kingdom., Kwok JCF; School of Biomedical Sciences, University of Leeds, Leeds, United Kingdom.; Institute of Experimental Medicine, The Czech Academy of Sciences, Prague 4, Czech Republic., Ichiyama RM; School of Biomedical Sciences, University of Leeds, Leeds, United Kingdom.

المصدر: Journal of neurophysiology [J Neurophysiol] 2024 Aug 01; Vol. 132 (2), pp. 531-543. Date of Electronic Publication: 2024 Jul 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Physiological Society Country of Publication: United States NLM ID: 0375404 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1598 (Electronic) Linking ISSN: 00223077 NLM ISO Abbreviation: J Neurophysiol Subsets: MEDLINE

مواضيع طبية MeSH: rho-Associated Kinases*/metabolism , rho-Associated Kinases*/genetics , Rats, Wistar* , Hippocampus*/metabolism , Signal Transduction*/physiology , High-Intensity Interval Training*, Animals ; Male ; Rats ; Hypoxia/metabolism ; Hypoxia/physiopathology ; Cerebral Cortex/metabolism ; Cerebral Cortex/physiology ; Neuronal Plasticity/physiology ; rhoA GTP-Binding Protein/metabolism ; Spinal Cord/metabolism ; Spinal Cord/physiology ; rho GTP-Binding Proteins

المؤلفون: Deng BL; Department and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China., Lin DX; Department and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China., Li ZP; Department and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China., Li K; Department and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China., Wei PY; Department and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China., Luo CC; Department and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China., Zhang MY; Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China., Zhou Q; School of Mechanical Science and Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China., Yang ZL; School of Mechanical Science and Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China., Chen Z; Department and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. chenzhongtj@126.com.

المصدر: Current medical science [Curr Med Sci] 2024 Aug; Vol. 44 (4), pp. 718-725. Date of Electronic Publication: 2024 Jun 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Huazhong University of Science and Technology Country of Publication: China NLM ID: 101729993 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2523-899X (Electronic) Linking ISSN: 2523899X NLM ISO Abbreviation: Curr Med Sci Subsets: MEDLINE

مواضيع طبية MeSH: Urinary Bladder*/pathology , Urinary Bladder*/metabolism , rho-Associated Kinases*/metabolism , rho-Associated Kinases*/genetics , Fibroblasts*/metabolism , Fibroblasts*/pathology , Fibrosis* , Hydrostatic Pressure* , YAP-Signaling Proteins*/metabolism, Animals ; Rats ; Ion Channels/metabolism ; Ion Channels/genetics ; Urinary Bladder Neck Obstruction/metabolism ; Urinary Bladder Neck Obstruction/pathology ; Urinary Bladder Neck Obstruction/genetics ; Cell Proliferation ; Rats, Sprague-Dawley ; Mechanotransduction, Cellular ; Cells, Cultured ; Female ; Pyrazines ; Thiadiazoles

المؤلفون: Yu Z; Department of Orthopedics, Wuhan Hospital of Traditional Chinese Medicine, Wuhan, China., Yuan J; Department of Orthopedics 3, Wuhan Hospital of Traditional Chinese Medicine, Wuhan, China., Yu Y; Department of Geriatrics, Wuhan Hospital of Traditional Chinese Medicine, Wuhan, China. yuyuandoctor@hotmail.com.

المصدر: Histology and histopathology [Histol Histopathol] 2024 Aug; Vol. 39 (8), pp. 1065-1077. Date of Electronic Publication: 2024 Jan 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Histology and Histopathology Country of Publication: Spain NLM ID: 8609357 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1699-5848 (Electronic) Linking ISSN: 02133911 NLM ISO Abbreviation: Histol Histopathol Subsets: MEDLINE

مواضيع طبية MeSH: Cell Differentiation*/drug effects , Mesenchymal Stem Cells*/drug effects , Mesenchymal Stem Cells*/metabolism , Osteogenesis*/drug effects , rho-Associated Kinases*/metabolism , rho-Associated Kinases*/antagonists & inhibitors , rhoA GTP-Binding Protein*/metabolism , Signal Transduction*/drug effects, Humans ; Cell Survival/drug effects ; Cells, Cultured ; Furocoumarins/pharmacology

المؤلفون: Yao M; Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; NHC Key laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai, China.; Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China., Zeng Z; Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; NHC Key laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai, China.; Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China., Li S; Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; NHC Key laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai, China.; School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China., Zou Z; School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China., Chen Z; Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; NHC Key laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai, China.; Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China., Chen X; School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China., Gao Q; Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; NHC Key laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai, China.; Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China., Zhao G; Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; NHC Key laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai, China.; Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China., Chen A; School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China., Li Z; School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China., Wang Y; Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; NHC Key laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai, China.; Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China., Ning R; Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; NHC Key laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai, China.; Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China., McAlinden C; Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; NHC Key laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai, China.; Corneo Plastic Unit & Eye Bank, Queen Victoria Hospital, East Grinstead, UK., Zhou X; Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; NHC Key laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai, China. xingtaozhou@fudan.edu.cn.; Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China. xingtaozhou@fudan.edu.cn., Huang J; Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; NHC Key laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai, China. jinhaihuang@fudan.edu.cn.; Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China. jinhaihuang@fudan.edu.cn.

المصدر: Nature communications [Nat Commun] 2024 Jul 30; Vol. 15 (1), pp. 6395. Date of Electronic Publication: 2024 Jul 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Retinal Ganglion Cells*/metabolism , Retinal Ganglion Cells*/pathology , rho-Associated Kinases*/metabolism , rho-Associated Kinases*/genetics , Intraocular Pressure* , Aquaporin 1*/metabolism , Aquaporin 1*/genetics , Glaucoma*/genetics , Glaucoma*/metabolism , CRISPR-Cas Systems*, Animals ; Female ; Mice ; Aqueous Humor/metabolism ; Mice, Inbred C57BL ; Disease Models, Animal ; RNA Interference ; Humans

المؤلفون: Parekh M; Schepens Eye Research Institute of Mass Eye and Ear, Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA., Miall A; Schepens Eye Research Institute of Mass Eye and Ear, Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA., Chou A; Faculty of Arts and Sciences, Harvard College, Boston, MA 02138, USA., Buhl L; Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA., Deshpande N; Schepens Eye Research Institute of Mass Eye and Ear, Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA., Price MO; Cornea Research Foundation of America, Indianapolis, IN 46260, USA., Price FW; Cornea Research Foundation of America, Indianapolis, IN 46260, USA., Jurkunas UV; Schepens Eye Research Institute of Mass Eye and Ear, Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA.; Cornea and Refractive Surgery Service, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA.

المصدر: Cells [Cells] 2024 Jul 19; Vol. 13 (14). Date of Electronic Publication: 2024 Jul 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE

مواضيع طبية MeSH: rho-Associated Kinases*/metabolism , rho-Associated Kinases*/antagonists & inhibitors , Cell Movement*/drug effects , Fuchs' Endothelial Dystrophy*/pathology , Fuchs' Endothelial Dystrophy*/drug therapy, Humans ; Isoquinolines/pharmacology ; Sulfonamides/pharmacology ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Endothelium, Corneal/drug effects ; Endothelium, Corneal/metabolism ; Endothelium, Corneal/pathology ; Descemet Membrane/drug effects ; Epithelial-Mesenchymal Transition/drug effects ; Protein Kinase Inhibitors/pharmacology ; Descemet Stripping Endothelial Keratoplasty/methods ; Cell Proliferation/drug effects ; Models, Biological ; Wound Healing/drug effects