-
1
المؤلفون: Richard E. Showalter, Jim Thomson, Yudou He, Mario Meng-Chiang Kuo, Richard Hickey, Wei-Jong Shia, Li-Chang Chen, Elena Brin, Eleanor Dagostino, Katherine Wu, Robert Almassy, Mariusz Stempniak
المصدر: Oncotarget
مصطلحات موضوعية: 0301 basic medicine, Chemistry, apoptosis, Cancer, TRAIL, medicine.disease, Fusion protein, arginine deiminase, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Oncology, Apoptosis, anti-cancer biologic, 030220 oncology & carcinogenesis, Cancer cell, Survivin, medicine, Cancer research, fusion protein, Tumor necrosis factor alpha, Receptor, Arginine deiminase, Research Paper
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::920a1fcfc2cf7ef29450ed87d9dde742
http://europepmc.org/articles/PMC6319333 -
2
المؤلفون: Richard E. Showalter, Wei-Jong Shia, Jim Thomson, Elena Brin, Bob Almassy, Eleanor Dagostino, Li-Chang Chen, Richard Hickey, Mario Meng-Chiang Kuo, Katherine Wu, Yudou He
المصدر: Cancer Research. 78:3902-3902
مصطلحات موضوعية: Cancer Research, chemistry.chemical_compound, Oncology, chemistry, Arginine, Apoptosis, In vivo, Cancer cell, Citrulline, Cancer research, Fusion protein, Arginine deiminase, In vitro
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ba05403b029c18e218eec9451a77fafd
https://doi.org/10.1158/1538-7445.am2018-3902 -
3
المؤلفون: Laurie A. LeBrun, Mei Tsan, Yuefen Zhou, Frank Ruebsam, Darian M. Bartkowski, Alan X. Xiang, Ruhi Kamran, Lian-Sheng Li, Richard E. Showalter, Jingjing Zhao, Rupal Patel, Matthew Lardy, Maria V. Sergeeva, Stephen E. Webber, Amit M. Shah, David Archer Ellis, Zhongxiang Sun, Mcguire Helen, Julie Blazel, Leo Kirkovsky, Daniel A. Norris, Tran Chinh Viet, Charles R. Kissinger, Thomas G. Nolan, Peter S. Dragovich, Qing Han
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:4628-4632
مصطلحات موضوعية: Time Factors, Stereochemistry, Chemistry, Pharmaceutical, Clinical Biochemistry, Molecular Conformation, Thiazines, Pharmaceutical Science, Hepacivirus, Viral Nonstructural Proteins, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Humans, Transferase, Replicon, Molecular Biology, chemistry.chemical_classification, biology, Bicyclic molecule, Organic Chemistry, Sulfoxide, In vitro, Pyridazines, Enzyme, Models, Chemical, chemistry, Enzyme inhibitor, Drug Design, Microsomes, Liver, biology.protein, Molecular Medicine, Caco-2 Cells
-
4
المؤلفون: Tran Chinh Viet, Charles R. Kissinger, Daniel A. Norris, Ruhi Kamran, Amit M. Shah, Jingjing Zhao, Yuefen Zhou, Rupal Patel, Matthew Lardy, Darian M. Bartkowski, Richard E. Showalter, Stephen E. Webber, Laurie A. LeBrun, Mei Tsan, Douglas E. Murphy, Sun Hee Kim, Maria V. Sergeeva, Leo Kirkovsky, Martin T. Tran, Thomas G. Nolan, Qing Han, Frank Ruebsam, Lian-Sheng Li, Peter S. Dragovich
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:3616-3621
مصطلحات موضوعية: Models, Molecular, Hepatitis C virus, Clinical Biochemistry, Pharmaceutical Science, Microbial Sensitivity Tests, Viral Nonstructural Proteins, Crystallography, X-Ray, medicine.disease_cause, Antiviral Agents, Biochemistry, Cell Line, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Humans, Transferase, Structure–activity relationship, Pyrroles, Replicon, Molecular Biology, chemistry.chemical_classification, Binding Sites, Molecular Structure, biology, Chemistry, Organic Chemistry, Hydrogen Bonding, Nucleotidyltransferase, In vitro, Pyridazines, Enzyme, Enzyme inhibitor, biology.protein, Molecular Medicine
-
5
المؤلفون: Bin Li, Lindsay J. Howett, Shaohui Wang, Rupal Patel, Richard E. Showalter, Mei-Mei Wang, April Averill, Peggy A. Thompson, James R. Appleman
المصدر: ASSAY and Drug Development Technologies. 6:69-81
مصطلحات موضوعية: Protein Denaturation, Hot Temperature, Light, Protein Conformation, Biophysics, Drug Evaluation, Preclinical, Calorimetry, Ligands, Biophysical Phenomena, Adenosine Triphosphate, Genes, Reporter, Drug Discovery, Scattering, Radiation, Histidine, Luciferase, Enzyme Inhibitors, Luciferases, chemistry.chemical_classification, Dose-Response Relationship, Drug, Atlas (topology), Circular Dichroism, Ligand binding assay, Proteins, Ligand (biochemistry), Kinetics, Enzyme, chemistry, Biochemistry, Homogeneous, Calibration, Molecular Medicine, Indicators and Reagents, Target protein, Protein stabilization, Oligopeptides
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c585bb5acb0d990ed60e17ee0dab5dc
https://doi.org/10.1089/adt.2007.100 -
6
المؤلفون: Tran Chinh Viet, Douglas E. Murphy, Stephen E. Webber, Bin Li, Thomas Hermann, Zhongxiang Sun, Charles R. Kissinger, Rupal Patel, Frank Ruebsam, Maria V. Sergeeva, Peter S. Dragovich, Lian-Sheng Li, Yuefen Zhou, Richard E. Showalter, Amit M. Shah, Laurie A. LeBrun, Qing Han, Qiang Zhao, Leo Kirkovsky, Mei Tsan
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:1413-1418
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Viral Nonstructural Proteins, Benzothiadiazines, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Ns5b polymerase, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Drug Stability, Drug Discovery, Humans, Transferase, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, biology, Organic Chemistry, virus diseases, Hydrogen Bonding, Metabolic stability, RNA-Dependent RNA Polymerase, Small molecule, digestive system diseases, Pyridazines, Enzyme, chemistry, Benzothiadiazine, Enzyme inhibitor, Drug Design, Microsomes, Liver, biology.protein, Molecular Medicine
-
7
المؤلفون: Yuefen Zhou, Frank Ruebsam, Richard E. Showalter, Thomas Hermann, Lian-Sheng Li, Rupal Patel, Mei Tsan, April Averill, Qiang Zhao, Douglas E. Murphy, Qing Han, Peter S. Dragovich, Charles R. Kissinger, Laurie A. LeBrun, Maria V. Sergeeva, Amit M. Shah, Stephen E. Webber, Tran Chinh Viet
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:1419-1424
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Viral Nonstructural Proteins, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Ns5b polymerase, Inhibitory Concentration 50, Drug Stability, Drug Discovery, Humans, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Thiadiazines, biology, Organic Chemistry, Metabolic stability, RNA-Dependent RNA Polymerase, Nucleotidyltransferase, Small molecule, Pyridazines, Enzyme, RNA-Directed RNA Polymerase, chemistry, Enzyme inhibitor, Drug Design, Microsomes, Liver, biology.protein, Molecular Medicine
-
8
المؤلفون: Stephen E. Webber, Amit M. Shah, Kevin R. Steffy, James R. Appleman, Alan X. Xiang, Robert M. Aust, Thomas Doundoulakis, Richard E. Showalter, Klaus B. Simonsen, William T. Biller, Virginia N. Banh, Wes Sisson, Ricardo Lira, Konstantinos A. Agrios
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:6797-6800
مصطلحات موضوعية: Staphylococcus aureus, Clinical Biochemistry, Pharmaceutical Science, medicine.disease_cause, Methylation, Biochemistry, Microbiology, Inhibitory Concentration 50, Lactones, chemistry.chemical_compound, RNA polymerase, Drug Discovery, Escherichia coli, medicine, Enzyme Inhibitors, Molecular Biology, Polymerase, Antibacterial agent, chemistry.chemical_classification, Molecular Structure, biology, Organic Chemistry, DNA-Directed RNA Polymerases, Anti-Bacterial Agents, Enzyme, chemistry, Myxopyronin, biology.protein, Molecular Medicine, Antibacterial activity
-
9
المؤلفون: Dong Liming, Xinjun Hou, Elizabeth A. Lunney, Corinne E. Augelli-Szafran, Deal Judith G, Christopher F. Bigge, Darin Vanderpool, Raymond Andrew Hudack, Nancy Sue Barta, Bradley William Caprathe, Chuangxing Guo, Steve Bender, Richard E. Showalter, Lorraine Kathleen Fay, Arindam Chatterjee
المصدر: Journal of Medicinal Chemistry. 49:1202-1206
مصطلحات موضوعية: Peptidylprolyl isomerase, Aza Compounds, Binding Sites, Neurite, Chemistry, Hydrogen Bonding, Biological activity, Tacrolimus Binding Protein 1A, Isoquinolines, Ligands, Amides, Heterocyclic Compounds, 4 or More Rings, Tacrolimus, Structure-Activity Relationship, Neuroprotective Agents, FKBP, Biochemistry, Cis-trans-Isomerases, Drug Discovery, Molecular Medicine, Structure–activity relationship, Binding site, Cognitive decline
-
10
المؤلفون: Michele Ann Mctigue, Michael R Gehring, Chris Pinko, J. Ernest Villafranca, Chen-Chen Kan, Camran V Parast, Krzysztof Appelt, Richard E. Showalter, Barbara Mroczkowski, John A Wickersham, Anna Tempczyk-Russell
المصدر: Structure. 7:319-330
مصطلحات موضوعية: Models, Molecular, Protein Folding, Protein Conformation, Recombinant Fusion Proteins, Molecular Sequence Data, Neovascularization, Physiologic, Mitogen-activated protein kinase kinase, Crystallography, X-Ray, Protein Structure, Secondary, Receptor tyrosine kinase, Substrate Specificity, MAP2K7, angiogenesis, Structure-Activity Relationship, kinase insert domain, Adenosine Triphosphate, Structural Biology, Catalytic Domain, Humans, Receptors, Growth Factor, ASK1, Amino Acid Sequence, Kinase activity, Growth Substances, Molecular Biology, Binding Sites, Sequence Homology, Amino Acid, biology, MAP kinase kinase kinase, tyrosine kinase, Receptor Protein-Tyrosine Kinases, Protein-Tyrosine Kinases, Peptide Fragments, Cell biology, Kinetics, Receptors, Vascular Endothelial Growth Factor, Biochemistry, Multigene Family, Mutagenesis, Site-Directed, biology.protein, Cyclin-dependent kinase 9, X-ray structure, Sequence Alignment, signal transduction, Proto-oncogene tyrosine-protein kinase Src
Find this issue from the American Chemical Society