المؤلفون: Shawn P. Walsh, Lee-Yuh Pai, Yuping Zhu, John P. Felix, Caryn Hampton, Xiaoyan Zhou, Melba Hernandez, Brande Thomas-Fowlkes, Richard M. Brochu, Nardos Teumelsan, Gregory J. Kaczorowski, Emma R. Parmee, Maria L. Garcia, Alexander Pasternak, Jinlong Jiang, Sookhee Ha, Sophie Roy, Kathleen A. Sullivan, Haifeng Tang, Lihu Yang, Karen Owens, Reynalda K. de Jesus, Xin Gu, Birgit T. Priest, Barbara Pio, Fa-Xiang Ding, Andrew M. Swensen, Magdalena Alonso-Galicia, Aurash Shahripour, Juliann Ehrhart, Timothy Bailey

المصدر: Bioorganic & Medicinal Chemistry Letters. 26:5695-5702

مصطلحات موضوعية: 0301 basic medicine, QTC PROLONGATION, Clinical Biochemistry, hERG, Pharmaceutical Science, Pharmacology, Biochemistry, Dog model, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Dogs, 0302 clinical medicine, Transcriptional Regulator ERG, Pharmacokinetics, In vivo, Oxazines, Drug Discovery, Animals, Humans, Potassium Channels, Inwardly Rectifying, Molecular Biology, Heart Failure, biology, Chemistry, Organic Chemistry, Macaca mulatta, Small molecule, Diuresis, Piperazine, 030104 developmental biology, 030220 oncology & carcinogenesis, Hypertension, ROMK, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f5ba115f699ab80f9a1176691245bcc
https://doi.org/10.1016/j.bmcl.2016.10.064

المؤلفون: Michael J. Forrest, John P. Felix, Lee-Yuh Pai, Melba Hernandez, Yuping Zhu, Aaron Corona, Joseph M. Metzger, Gregory J. Kaczorowski, Nardos Teumelsan, Lihu Yang, Karen Owens, Timothy Bailey, Caryn Hampton, Vincent Tong, Alexander Pasternak, Brande Thomas-Fowlkes, Shawn P. Walsh, Emma R. Parmee, Haifeng Tang, Richard M. Brochu, Maria L. Garcia, Xiaoyan Zhou, Magdalena Alonso-Galicia, Sophie Roy, Birgit T. Priest, Andrew M. Swensen, Aurash Shahripour

المصدر: ACS Medicinal Chemistry Letters. 7:697-701

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Kidney, biology, Chemistry, Organic Chemistry, hERG, Diuresis, Nephron, Pharmacology, Biochemistry, Natriuresis, 03 medical and health sciences, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, Internal medicine, Drug Discovery, medicine, biology.protein, Loop of Henle, ROMK, Thiazide, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::415e7bac5379921d8eb6098d8804f901
https://doi.org/10.1021/acsmedchemlett.6b00122

المؤلفون: Lee-Yuh Pai, Yuping Zhu, Richard Visconti, Xiaoyan Zhou, John P. Felix, Melba Hernandez, Jing Chen, Michael Margulis, Nardos Teumelsan, Sophie Roy, Kathleen A. Sullivan, Jessica Liu, Joseph M. Metzger, Aaron Corona, Gregory J. Kaczorowski, Maria L. Garcia, Lihu Yang, Shawn P. Walsh, Birgit T. Priest, Alexander Pasternak, Caryn Hampton, Emma R. Parmee, Vincent Tong, Brande Thomas-Fowlkes, Haifeng Tang, Magdalena Alonso-Galicia, Kashmira Shah, Michael J. Forrest, Richard M. Brochu, Ross Bentley, Sookhee Ha, Karen Owens, Aurash Shahripour, Andrew M. Swensen, Jessica Frie, Adam B. Weinglass, Timothy Bailey

المصدر: ACS Medicinal Chemistry Letters. 6:747-752

مصطلحات موضوعية: Pharmacokinetics, Chemistry, Pharmacodynamics, Organic Chemistry, Drug Discovery, ROMK, Pharmacology, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454c1f32ec6c3f7a915fe446fd2867a1
https://doi.org/10.1021/ml500440u

المؤلفون: Yan Yan, Richard M. Brochu, Maria L. Garcia, Lihu Yang, Sophie Roy, Gregory J. Kaczorowski, Reynald K. de Jesus, Birgit T. Priest, Xiaoyan Zhou, Lee-Yuh Pai, Shawn P. Walsh, Yuping Zhu, Karen Owens, Caryn Hampton, Timothy Bailey, Andrew M. Swensen, Brande Thomas-Fowlkes, Magdalena Alonso-Galicia, John P. Felix, Melba Hernandez, Alexander Pasternak, Haifeng Tang

المصدر: Bioorganic & Medicinal Chemistry Letters. 23:5829-5832

مصطلحات موضوعية: Natriuretic Agents, Isobenzofuran, Stereochemistry, Clinical Biochemistry, hERG, Tetrazoles, Pharmaceutical Science, Biochemistry, Rats, Sprague-Dawley, chemistry.chemical_compound, In vivo, Drug Discovery, Animals, Humans, Potassium Channels, Inwardly Rectifying, Molecular Biology, Benzofurans, biology, Chemistry, Organic Chemistry, Small molecule, Ether-A-Go-Go Potassium Channels, Diuresis, Rats, ROMK, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5c348f365905a62caacd72f218a844
https://doi.org/10.1016/j.bmcl.2013.08.104

المؤلفون: John P. Felix, Chou J. Liu, Magdalena Alonso-Galicia, Kelli Solly, Maria L. Garcia, Laszlo Kiss, Birgit T. Priest, Martin Köhler, Richard M. Brochu, Timothy Bailey, Gregory J. Kaczorowski, Alexander Pasternak, Haifeng Tang

المصدر: ASSAY and Drug Development Technologies. 10:417-431

مصطلحات موضوعية: medicine.medical_specialty, Potassium, chemistry.chemical_element, CHO Cells, Pharmacology, Madin Darby Canine Kidney Cells, Cricetulus, Dogs, Cricetinae, Internal medicine, Drug Discovery, Potassium Channel Blockers, medicine, Animals, Humans, Potassium Channels, Inwardly Rectifying, Thallium, Kidney, Reabsorption, Molecular Pharmacology, Potassium channel, Rats, Blood pressure, medicine.anatomical_structure, Endocrinology, chemistry, ROMK, Molecular Medicine, Flux (metabolism)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f65844b5beafbaedd26a919aa78e8004
https://doi.org/10.1089/adt.2012.462

المؤلفون: Shawn P. Walsh, Jessica Frie, Nardos Teumelsan, Maria L. Garcia, Karen Owens, Sophie Roy, Caryn Hampton, Reynalda K. de Jesus, Birgit T. Priest, Magdalena Alonso-Galicia, Aurash Shahripour, Richard M. Brochu, Juliann Ehrhart, Andrew M. Swensen, Haifeng Tang, Timothy Bailey, Alexander Pasternak, Lee-Yuh Pai, Yuping Zhu, Lihu Yang, Gregory J. Kaczorowski, John P. Felix, Melba Hernandez, Brande Thomas-Fowlkes, Xiaoyan Zhou

المصدر: Bioorganicmedicinal chemistry letters. 26(9)

مصطلحات موضوعية: 0301 basic medicine, ERG1 Potassium Channel, medicine.medical_treatment, Clinical Biochemistry, hERG, Pharmaceutical Science, Pharmacology, Biochemistry, Piperazines, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, 0302 clinical medicine, In vivo, Heterocyclic Compounds, Drug Discovery, medicine, Potency, Structure–activity relationship, Molecular Biology, biology, Chemistry, Organic Chemistry, Small molecule, Piperazine, 030104 developmental biology, 030220 oncology & carcinogenesis, biology.protein, ROMK, Molecular Medicine, Diuretic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26fbe8f6e22893cf2f312c30961b9cd2
https://pubmed.ncbi.nlm.nih.gov/27017115

المؤلفون: Brande S. Williams, Mathew J. Wyvratt, Sriram Tyagarajan, Vivien A. Warren, Catherine Abbadie, Brett Taylor, William J. Martin, Xiaohua Li, William H. Parsons, Nina Jochnowitz, Erin McGowan, Sanjeev Kumar, Ann E. Weber, Gregory J. Kaczorowski, Michael H. Fisher, Bishan Zhou, John P. Felix, Tracy Klatt, McHardy M. Smith, Birgit T. Priest, Prasun K. Chakravarty, Kathryn A. Lyons, Joseph L. Duffy, Ronsar Eid, Maria L. Garcia, Richard M. Brochu

المصدر: Bioorganic & Medicinal Chemistry Letters. 20:7479-7482

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Analgesic, Drug Evaluation, Preclinical, Biphenyl derivatives, Pharmaceutical Science, Motor Activity, Pyrazole, Pharmacology, Biochemistry, Sodium Channels, Mice, chemistry.chemical_compound, Dogs, Sodium channel blocker, Drug Discovery, Animals, Humans, Spinal nerve ligation, Molecular Biology, Biphenyl Compounds, Organic Chemistry, Metabolic stability, Rats, Liver metabolism, chemistry, Neuropathic pain, Microsomes, Liver, Neuralgia, Pyrazoles, Molecular Medicine, Sodium Channel Blockers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44809e16a6cd04e26b06d5a57716c59e
https://doi.org/10.1016/j.bmcl.2010.10.017

المؤلفون: James B Herrington, Owen B. McManus, Manuel Sánchez, Birgit T. Priest, Randal M. Bugianesi, Ivy E. Dick, Lizhen Yan, Martin Köhler, Richard M. Brochu, Denize Wunderler, Sam A. Clark

المصدر: The Journal of Physiology. 567:159-175

مصطلحات موضوعية: Membrane potential, Tetraethylammonium, Voltage-gated ion channel, Physiology, Chemistry, Margatoxin, Analytical chemistry, Kaliotoxin, Potassium channel blocker, chemistry.chemical_compound, medicine, Biophysics, Hanatoxin, Patch clamp, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d3408e596f99b848063af60aa2921862
https://doi.org/10.1113/jphysiol.2005.089375

المؤلفون: Jason W. Tarpley, Maria L. Garcia, Richard M. Brochu, Peter T. Meinke, McHardy M. Smith, Ivy E. Dick, Jun Liang, Michael H. Fisher, William J. Martin, William H. Parsons, Brande S. Williams, Gregory J. Kaczorowski, Charles J. Cohen, William A. Schmalhofer, John P. Felix, Birgit T. Priest, Kathryn A. Lyons

المصدر: Bioorganic & Medicinal Chemistry Letters. 15:2943-2947

مصطلحات موضوعية: Clinical Biochemistry, Analgesic, hERG, Molecular Conformation, Pain, Pharmaceutical Science, Pharmacology, Biochemistry, Sodium channel blocker, Pharmacokinetics, In vivo, Drug Discovery, medicine, Humans, Molecular Biology, biology, Chemistry, Sodium channel, Organic Chemistry, Chronic pain, medicine.disease, Potassium channel, Molecular Probes, Chronic Disease, biology.protein, Molecular Medicine, Sodium Channel Blockers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::478113a44a68c5b7de2f418fb2b827b0
https://doi.org/10.1016/j.bmcl.2005.02.093

المؤلفون: Charles J. Cohen, Margaret Z Chou, Brande S. Williams, Yui S. Tang, Ivy E. Dick, Brita S. Reiseter, Maria L. Garcia, Gregory J. Kaczorowski, Keith A. Wafford, William J. Martin, Samantha Clark, Vivien A. Warren, Peter T. Meinke, Ge Dai, William H. Parsons, Richard E. Middleton, William A. Schmalhofer, Martin Köhler, McHardy M. Smith, Richard M. Brochu, Shao Pengcheng Patrick, Chou J. Liu, Birgit T. Priest, John P. Felix

المصدر: Biochemistry. 43:9866-9876

مصطلحات موضوعية: Patch-Clamp Techniques, medicine.medical_treatment, Muscle Proteins, Nerve Tissue Proteins, Tetrodotoxin, NAV1.5 Voltage-Gated Sodium Channel, Pharmacology, Biochemistry, Sodium Channels, Cell Line, Mice, Sodium channel blocker, Therapeutic index, Formaldehyde, Ganglia, Spinal, medicine, Animals, Humans, Potency, Patch clamp, Pain Measurement, Analgesics, Binding Sites, NAV1.2 Voltage-Gated Sodium Channel, Chemistry, Sodium channel, Biphenyl Compounds, NAV1.7 Voltage-Gated Sodium Channel, Brain, Succinates, Amides, Recombinant Proteins, Rats, Disease Models, Animal, Anticonvulsant, Neuropathic pain, Sodium Channel Blockers, Synaptosomes

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d3ddd47eae5772bd4e88e362138fc4d
https://doi.org/10.1021/bi0493259