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المؤلفون: Frédéric Y. Bois, Ciarán Fisher, Ségolène Siméon, Iain Gardner, Katharina Brotzmann, Thomas Braunbeck, Steve Silvester, Richard Maclennan, Paul Walker
المصدر: Reproductive Toxicology. 98:300-303
مصطلحات موضوعية: Valproic Acid, Physiologically based pharmacokinetic modelling, medicine, Developmental toxicity, Zebrafish embryo, Pharmacology, Biology, Toxicology, medicine.drug
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المؤلفون: Alejandro Aguayo-Orozco, Liliana Capinha, Nazanin Golbamaki, Enrico Mombelli, Matthias Wehr, Bart van der Burg, Daria Goldmann, Nanette G Vrijenhoek, Thomas Exner, Richard Maclennan, Katharina Brotzmann, Ulf Norinder, Oliver Hatley, Alice Limonciel, Thomas Braunbeck, Sylvia Escher, Barbara Zdrazil, Frédéric Y. Bois, Paul Jennings, Emilio Benfenati, Domenico Gadaleta, Jose Castel, Ciarán Fisher, Sankalp Jain, Anthony Long, Rabea Graepel, Laia Tolosa, Andrew White, Bob van de Water, Barbara M.A. van Vugt-Lussenburg, Paul Walker, Annette Bitsch, Olivier Taboureau, Iain Gardner
المساهمون: AIMMS, Molecular and Computational Toxicology, Publica
المصدر: Toxicology in Vitro, 79:105269, 1-16. Elsevier Limited
Escher, S E, Aguayo-Orozco, A, Benfenati, E, Bitsch, A, Braunbeck, T, Brotzmann, K, Bois, F, van der Burg, B, Castel, J, Exner, T, Gadaleta, D, Gardner, I, Goldmann, D, Hatley, O, Golbamaki, N, Graepel, R, Jennings, P, Limonciel, A, Long, A, Maclennan, R, Mombelli, E, Norinder, U, Jain, S, Capinha, L S, Taboureau, O T, Tolosa, L, Vrijenhoek, N G, van Vugt-Lussenburg, B M A, Walker, P, van de Water, B, Wehr, M, White, A, Zdrazil, B & Fisher, C 2022, ' Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action ', Toxicology in Vitro, vol. 79, 105269, pp. 1-16 . https://doi.org/10.1016/j.tiv.2021.105269
Escher, S E, Aguayo-Orozco, A, Benfenati, E, Bitsch, A, Braunbeck, T, Brotzmann, K, Bois, F, van der Burg, B, Castel, J, Exner, T, Gadaleta, D, Gardner, I, Goldmann, D, Hatley, O, Golbamaki, N, Graepel, R, Jennings, P, Limonciel, A, Long, A, Maclennan, R, Mombelli, E, Norinder, U, Jain, S, Capinha, L S, Taboureau, O T, Tolosa, L, Vrijenhoek, N G, van Vugt-Lussenburg, B M A, Walker, P, van de Water, B, Wehr, M, White, A, Zdrazil, B & Fisher, C 2022, ' Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action ', Toxicology in Vitro, vol. 79, 105269 . https://doi.org/10.1016/j.tiv.2021.105269
Toxicology in Vitro
Toxicology In Vitro, 79مصطلحات موضوعية: Test strategy, Mechanistic hazard assessment, Adverse Outcome Pathways, Computer science, In silico, Gene Expression Profiling, Liver steatosis, Carboxylic Acids, General Medicine, Computational biology, Toxicology, AOP-network, Fatty Liver, Differentially expressed genes, Workflow, Action (philosophy), NAM, Read-across, Adverse Outcome Pathway, Animals, Humans, Computer Simulation, Zebrafish
وصف الملف: application/pdf
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المؤلفون: Tanja Hansen, Laia Tolosa, Jan G. Hengstler, Richard Maclennan, Paul Walker, Rajinder Gupta, Bob van de Water, Florian Caiment, Leroy Elenschneider, Patrick Guye, Bas ter Braak, Sylvia Escher, Jos C. S. Kleinjans, Marcel H. M. van Herwijnen, Wolfgang Moritz, Yannick Schrooders, Tim Brecklinghaus, Ahmed Ghallab, Tine Tricot, Duncan Hauser, Wiebke Albrecht, Marcel Leist, José V. Castell, Catherine M. Verfaillie
المساهمون: RS: GROW - R1 - Prevention, Toxicogenomics, Publica
المصدر: Archives of Toxicology, 95(2), 573-589. Springer
Archives of toxicology, 95:573-589
Archives of Toxicology
ARCHIVES OF TOXICOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instnameمصطلحات موضوعية: 0301 basic medicine, CellNet, Health, Toxicology and Mutagenesis, Cell, Toxicology, Non-DEGsDTU−, TOXICITY, 0302 clinical medicine, Pathway coverage, Gene Regulatory Networks, Induced pluripotent stem cell, Cells, Cultured, Liver cell, INDUCTION, Liver Neoplasms, In vivo liver, In vitro liver, RNA-seq, CellNet, Non-DEGs, Non-DEGsDTU−, Pathway coverage, High-Throughput Nucleotide Sequencing, Cell Differentiation, Hep G2 Cells, General Medicine, RNA-seq, Non-DEGs DTU, In vivo liver, Non-DEGs, In vitro liver, 3. Good health, In Vitro Systems, medicine.anatomical_structure, DIFFERENTIATION, Liver, 030220 oncology & carcinogenesis, Toxicity, HEPATOTOXICITY, Induced Pluripotent Stem Cells, CellNet, In vitro liver, In vivo liver, Non-DEGs, Non-DEGsDTU-, Pathway coverage, RNA-seq, In Vitro Techniques, Biology, METABOLISM, Models, Biological, PRIMARY HEPATOCYTES, 03 medical and health sciences, In vivo, SYSTEMS, Cell Line, Tumor, ddc:570, medicine, Humans, HEPARG CELLS, Non-DEGs(DTU), Gene Expression Profiling, Computational Biology, PLATFORM, Molecular biology, In vitro, EVOLUTION, 030104 developmental biology, Gene Expression Regulation, Cell culture, Hepatocytes, Transcriptome, Drug metabolism
وصف الملف: application/pdf; Print-Electronic
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المؤلفون: Dana M. Freeman, Alexandra Maertens, Marcel Leist, Alfredo Kirkwood, Sebastian Perez Orozco, Melanie Eschment, Daniel Severin, Lena Smirnova, David Pamies, Richard Maclennan, Andre Kleensang, J. Michael McCaffery, Helena T. Hogberg, Thomas Hartung, Georgina Harris
المصدر: Archives of Toxicology
مصطلحات موضوعية: 0301 basic medicine, Insecticides, Neurite, Cellular adaptation, Health, Toxicology and Mutagenesis, Neuronal Outgrowth, Cell Culture Techniques, Toxicology, Gene response, 3D LUHMES, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Adenosine Triphosphate, Recovery, ddc:570, Rotenone, Toxicity Tests, medicine, Humans, Neurodegeneration, Resilience, Cellular defence, Dopaminergic Neurons, Dopaminergic, In vitro toxicology, General Medicine, medicine.disease, Cell biology, Mitochondria, Pesticide, In Vitro Systems, 030104 developmental biology, chemistry, Gene Expression Regulation, Cell culture, Toxicity, Recovery, Resilience, Cellular defence, Gene response, 3D LUHMES, Neurodegeneration, Rotenone, Pesticide, 030217 neurology & neurosurgery
وصف الملف: application/pdf
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المؤلفون: Thomas Braunbeck, Ségolène Siméon, Paul Walker, Iain Gardner, Katharina Brotzmann, Steve Silvester, Richard Maclennan, Frédéric Y. Bois, Ciarán Fisher
المساهمون: Institut National de l'Environnement Industriel et des Risques (INERIS), Heidelberg University, Simcyp Division [UK], Certara UK Limited, Cyprotex PLC
المصدر: Reproductive Toxicology
Reproductive Toxicology, Elsevier, 2020, 93, pp.219-229. ⟨10.1016/j.reprotox.2020.02.010⟩مصطلحات موضوعية: Physiologically based pharmacokinetic modelling, Embryo, Nonmammalian, DANIO RERIO, Bayesian inference, Developmental toxicity, Danio, 010501 environmental sciences, Pharmacology, Toxicology, 01 natural sciences, Models, Biological, TOXICITY, 03 medical and health sciences, BAYESIAN, DEVELOPMENT, Pharmacokinetics, VALPROIC ACID, Animals, Dosing, ZEBRAFISH EMBRYO, Zebrafish, 030304 developmental biology, 0105 earth and related environmental sciences, 0303 health sciences, biology, Chemistry, Embryo, biology.organism_classification, EFFECT CONCENTRATION, INTERNAL CONCENTRATION, [SDV.TOX]Life Sciences [q-bio]/Toxicology, Toxicity, Anticonvulsants, PBPK MODEL
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaa25d38cbc767a01c5f184b3c407a2f
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