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1
المؤلفون: Norma Rogers, Stephan Krapp, Faika Mseeh, Richard T. Lewis, Keith Mikule, Michelle Han, Jay Theroff, Yongying Jiang, Keith M. Wilcoxen, Cross Jason, Dana Pfaffinger, Michael J. Soth, Paul G. Leonard, Philip Jones, Pijus K. Mandal, Angela L. Harris, Martin R. Tremblay, Simon S. Yu, Jason P Burke, Connor A. Parker, Barbara Czako, Alessia Petrocchi, Naphtali J. Reyna, Joseph R. Marszalek, Matthew M. Hamilton, Timothy McAfoos, Brett W. Virgin-Downey, Graham Trevitt, Alfred Lammens, Alan Xu
المصدر: Journal of Medicinal Chemistry. 64:11302-11329
مصطلحات موضوعية: chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, Context (language use), Metabolism, Pharmacology, Structure-Activity Relationship, chemistry.chemical_compound, Enzyme, chemistry, Pharmacodynamics, Drug Discovery, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, Molecular Medicine, Potency, Enzyme Inhibitors, Indoleamine 2,3-dioxygenase, Kynurenine, Whole blood
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2
المؤلفون: Zihao Hua, Michele Potashman, Carol Babij, Manory Fernando, Nobuko Nishimura, Josette Carnahan, Joseph L. Kim, Linda F. Epstein, Matthew R. Lee, Kevin Yang, Richard T. Lewis, Douglas A. Whittington, Longbin Liu, Karina R. Vaida, Howard Bregman, Shuyan Yi, Mark H. Norman, Matthew W. Martin
المصدر: Bioorganic & Medicinal Chemistry. 24:2215-2234
مصطلحات موضوعية: Models, Molecular, Protein Conformation, alpha-Helical, Proto-Oncogene Proteins B-raf, 0301 basic medicine, Pyridines, Clinical Biochemistry, Compound profiling, Mutant, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, Humans, Point Mutation, Protein Kinase Inhibitors, Molecular Biology, Amination, chemistry.chemical_classification, Organic Chemistry, Wild type, Small molecule, Sulfonamide, 030104 developmental biology, Monomer, chemistry, Purines, Drug Design, Helix, Molecular Medicine, Selectivity
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3
المؤلفون: Karen Rex, Douglas A. Whittington, David Bauer, Steven F. Bellon, Jean-Christophe Harmange, Martin A. Broome, Alessandro Boezio, Christiane Boezio, Karina R. Vaida, Deborah Choquette, Isabelle Dussault, Katrina W. Copeland, Emily A. Peterson, Yohannes Teffera, Roman Shimanovich, Brian K. Albrecht, Richard T. Lewis, Michele Potashman, Jingzhou Liu, Julia Lohman, Angela Coxon, Min-Hwa Jasmine Lin, Satoko Hirai
المصدر: Journal of Medicinal Chemistry. 59:2328-2342
مصطلحات موضوعية: 0301 basic medicine, Antitumor activity, biology, Drug discovery, Chemistry, Stereochemistry, Pharmacology, Small molecule, Receptor tyrosine kinase, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, In vivo, 030220 oncology & carcinogenesis, Drug Discovery, biology.protein, Molecular Medicine, Mesenchymal–epithelial transition, Phosphorylation, Kinase activity
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4
المؤلفون: Paul G. Leonard, Richard T. Lewis, Mario Cardozo, Naphtali J. Reyna, Carlo Toniatti, Philip Jones, Alessia Petrocchi, Elisabetta Leo, Faika Mseeh, Matthew M. Hamilton, Xi Shi, Connor A. Parker, Giulio Draetta, Sha Huang, Jennifer Bardenhagen, Yongying Jiang, Cross Jason, Joseph R. Marszalek
المصدر: Bioorganicmedicinal chemistry letters. 26(6)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Phosphoric monoester hydrolases, DNA repair, Clinical Biochemistry, Pharmaceutical Science, Context (language use), Biochemistry, Substrate Specificity, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, Drug Discovery, Structure–activity relationship, Humans, Enzyme Inhibitors, Molecular Biology, Cell permeability, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Metabolic stability, Phosphoric Monoester Hydrolases, 030104 developmental biology, DNA Repair Enzymes, 030220 oncology & carcinogenesis, Microsome, Molecular Medicine, Structure based
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5
المؤلفون: Christiane M, Bode, Alessandro A, Boezio, Brian K, Albrecht, Steven F, Bellon, Loren, Berry, Martin A, Broome, Deborah, Choquette, Isabelle, Dussault, Richard T, Lewis, Min-Hwa Jasmine, Lin, Karen, Rex, Douglas A, Whittington, Yajing, Yang, Jean-Christophe, Harmange
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:4089-4093
مصطلحات موضوعية: Male, Models, Molecular, Pyridones, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Crystallography, X-Ray, Biochemistry, Rats, Sprague-Dawley, Mice, Cell Line, Tumor, Drug Discovery, Animals, Humans, Phosphorylation, Protein Kinase Inhibitors, Molecular Biology, Hepatocyte Growth Factor, Organic Chemistry, Proto-Oncogene Proteins c-met, Triazoles, Rats, Microsomes, Liver, Quinolines, Molecular Medicine, Signal Transduction
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6
المؤلفون: Alessia Petrocchi, Naphtali J. Reyna, Faika Mseeh, Connor A. Parker, Simon Yu, Quanyun Xu, Ningping Feng, Paul Leonard, Norma Rogers, Jason B. Cross, Angela L. Harris, Yongying Jiang, Tin Oo Khor, Mikhila G. Mahendra, Jihai Pang, Qi Wu, Andy M. Zuniga, Timothy McAfoos, Matthew M. Hamilton, Joe R. Marszalek, Keith Mikule, Paul Vancutsem, Keith Wilcoxen, Martin Tremblay, Philip Jones, Richard T. Lewis
المصدر: Cancer Research. 78:LB-071
مصطلحات موضوعية: chemistry.chemical_classification, Cancer Research, Tumor microenvironment, Imidazopyridine, biology, Protein Data Bank (RCSB PDB), biology.organism_classification, HeLa, chemistry.chemical_compound, Enzyme, Oncology, chemistry, Cell culture, Cancer research, IC50, Kynurenine
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3c0efdf3558a82bc49107b3bec62cbd8
https://doi.org/10.1158/1538-7445.am2018-lb-071 -
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المؤلفون: Christiane Boezio, Michele Potashman, Yohannes Teffera, Brian K. Albrecht, Julia Lohman, Karina R. Vaida, Alessandro Boezio, Emily A. Peterson, Steven F. Bellon, Deborah Choquette, David Bauer, Katrina W. Copeland, Isabelle Dussault, Roman Shimanovich, Min-Hwa Jasmine Lin, Martin A. Broome, Richard T. Lewis, Jean-Christophe Harmange, Karen Rex, Douglas A. Whittington, Jingzhou Liu
المصدر: Journal of medicinal chemistry. 58(5)
مصطلحات موضوعية: Male, Models, Molecular, C-Met, Metabolite, Pharmacology, Metastasis, Rats, Sprague-Dawley, chemistry.chemical_compound, Mice, Drug Discovery, medicine, Animals, Humans, Tissue Distribution, Phosphorylation, Protein Kinase Inhibitors, Cell Proliferation, Molecular Structure, Drug discovery, Hepatocyte Growth Factor, Prostatic Neoplasms, Proto-Oncogene Proteins c-met, Triazoles, medicine.disease, Xenograft Model Antitumor Assays, Rats, chemistry, Protein kinase domain, Drug Design, Cancer research, Microsomes, Liver, Quinolines, Molecular Medicine, Hepatocyte growth factor, Signal transduction, medicine.drug, Signal Transduction
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8
المؤلفون: Zhiyang Zhao, Loren Berry, Rachael L. Brake, Earl Moore, Douglas Saffran, Richard T. Lewis, Jingzhou Liu, Yohannes Teffera
المصدر: Drug metabolism and disposition: the biological fate of chemicals. 41(1)
مصطلحات موضوعية: Male, Stereochemistry, Pharmaceutical Science, Rats, Sprague-Dawley, chemistry.chemical_compound, Inhibitory Concentration 50, Mice, Pharmacokinetics, In vivo, Tandem Mass Spectrometry, Enzymatic hydrolysis, Anaplastic lymphoma kinase, Animals, Anaplastic Lymphoma Kinase, Benzamide, Protein Kinase Inhibitors, Pharmacology, Trifluoromethyl, Hydrolysis, Receptor Protein-Tyrosine Kinases, In vitro, Rats, chemistry, Area Under Curve, Microsome, Chromatography, Liquid
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8572554a0552ffee5984c3b5dd729c3
https://pubmed.ncbi.nlm.nih.gov/23118327 -
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المؤلفون: Zihao Hua, Mark H. Norman, Nobuko Nishimura, Manory Fernando, Matthew W. Martin, Matthew R. Lee, Carol Babij, Joseph L. Kim, Kevin Yang, Karina R. Vaida, Longbin Liu, Michele Potashman, Richard T. Lewis, Linda F. Epstein, Douglas A. Whittington, Josette Carnahan, Howard Bregman, Shuyan Yi
المصدر: Bioorganic & Medicinal Chemistry. 24:3093
مصطلحات موضوعية: Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Mutant, Compound profiling, Wild type, Pharmaceutical Science, Biochemistry, Combinatorial chemistry, Drug Discovery, Helix, Molecular Medicine, Selectivity, Molecular Biology
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10
المؤلفون: William B. Motherwell, Michael Shipman, Richard T. Lewis, Hervé Corlay
المصدر: Tetrahedron. 51:3303-3318
مصطلحات موضوعية: chemistry.chemical_classification, Bicyclic molecule, Chemistry, Stereochemistry, Organic Chemistry, chemistry.chemical_element, Alkyne, Biochemistry, Medicinal chemistry, Acceptor, Cycloaddition, chemistry.chemical_compound, Intramolecular force, Drug Discovery, Nonane, Octane, Palladium