المؤلفون: Wilhelm CM; Laboratório de Pesquisa em Resistência Bacteriana (LABRESIS), Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil. Electronic address: camilawilhelm@gmail.com., Antochevis LC; Laboratório de Pesquisa em Resistência Bacteriana (LABRESIS), Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Magagnin CM; Laboratório de Pesquisa em Resistência Bacteriana (LABRESIS), Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Arns B; Infectious Diseases Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Vieceli T; Infectious Diseases Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Pereira DC; Serviço de Diagnóstico Laboratorial - Unidade de Microbiologia, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brasil., Lutz L; Serviço de Diagnóstico Laboratorial - Unidade de Microbiologia, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brasil., de Souza ÂC; Pontifícia Universidade Católica do Rio Grande do Sul, Hospital São Lucas - Setor de Microbiologia, Porto Alegre, Brasil., Dos Santos JN; Laboratório de Pesquisa em Resistência Bacteriana (LABRESIS), Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Guerra RR; Laboratório de Pesquisa em Resistência Bacteriana (LABRESIS), Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Medeiros GS; Intensive Care Service, Hospital Moinhos de Vento, Porto Alegre, Brazil., Santoro L; Department of Clinical Medicine, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil., Falci DR; Infectious Diseases Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Department of Clinical Medicine, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil., Rigatto MH; Infectious Diseases Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Department of Internal Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Barth AL; Laboratório de Pesquisa em Resistência Bacteriana (LABRESIS), Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Martins AF; Laboratório de Pesquisa em Resistência Bacteriana (LABRESIS), Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Zavascki AP; Infectious Diseases Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Department of Internal Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

المصدر: Journal of global antimicrobial resistance [J Glob Antimicrob Resist] 2024 Jun 25; Vol. 38, pp. 247-251. Date of Electronic Publication: 2024 Jun 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Published by Elsevier Ltd. on behalf of International Society of Chemotherapy for Infection and Cancer Country of Publication: Netherlands NLM ID: 101622459 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-7173 (Electronic) Linking ISSN: 22137165 NLM ISO Abbreviation: J Glob Antimicrob Resist Subsets: MEDLINE

المؤلفون: Arns B; Medical Science Post-Graduation Program, Federal University of Rio Grande do Sul, Porto Alegre, Brazil; Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Infectious Diseases and Infection Control Service, Hospital Moinhos de Vento, Porto Alegre, Brazil., Sorio GGL; Medical Science Post-Graduation Program, Federal University of Rio Grande do Sul, Porto Alegre, Brazil., Vieceli T; Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Pereira D; Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Celestino de Souza Â; Hospital São Lucas da PUC-RS, Porto Alegre, Brazil., Lamb Wink P; Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Paes JH; Pontifícia Universidade Católica do Rio Grande do Sul Medical School, Porto Alegre, Brazil., David L; Pontifícia Universidade Católica do Rio Grande do Sul Medical School, Porto Alegre, Brazil., Barboza F; Pontifícia Universidade Católica do Rio Grande do Sul Medical School, Porto Alegre, Brazil., Hickmann S; Pontifícia Universidade Católica do Rio Grande do Sul Medical School, Porto Alegre, Brazil., Alves G; Hospital Mãe de Deus, Porto Alegre, Brazil., Santos AC; Infectious Diseases and Infection Control Service, Hospital Moinhos de Vento, Porto Alegre, Brazil., da Rosa A; Hospital Ernesto Dornelles, Porto Alegre, Brazil., Duarte Alves M; Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Grupo Fleury, Laboratório Weinmann Medicina Diagnóstica, Porto Alegre, Brazil., Massotti Magagnin C; Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Gomes E; Medical Science Post-Graduation Program, Federal University of Rio Grande do Sul, Porto Alegre, Brazil., Zavascki AP; Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Infectious Diseases and Infection Control Service, Hospital Moinhos de Vento, Porto Alegre, Brazil; Internal Medicine Department, Federal University of Rio Grande do Sul Medical School, Porto Alegre, Brazil., Rigatto MH; Medical Science Post-Graduation Program, Federal University of Rio Grande do Sul, Porto Alegre, Brazil; Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Internal Medicine Department, Federal University of Rio Grande do Sul Medical School, Porto Alegre, Brazil. Electronic address: mrigatto@hcpa.edu.br.

المصدر: Journal of global antimicrobial resistance [J Glob Antimicrob Resist] 2024 Mar; Vol. 36, pp. 393-398. Date of Electronic Publication: 2024 Feb 09.

نوع المنشور: Multicenter Study; Journal Article

بيانات الدورية: Publisher: Published by Elsevier Ltd. on behalf of International Society of Chemotherapy for Infection and Cancer Country of Publication: Netherlands NLM ID: 101622459 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-7173 (Electronic) Linking ISSN: 22137165 NLM ISO Abbreviation: J Glob Antimicrob Resist Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Bacterial Agents*/adverse effects , Anti-Bacterial Agents*/pharmacology , Azabicyclo Compounds* , Gram-Negative Bacterial Infections*/drug therapy, Adult ; Humans ; beta-Lactamase Inhibitors/adverse effects ; Ceftazidime/adverse effects ; Drug Combinations ; Drug Resistance, Multiple, Bacterial ; Prospective Studies

المؤلفون: Garcia RCL; Medical Sciences Post-Graduation Program, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-003, Brazil., Rodrigues RD; Healthcare-Associated Infection Control Service, Hospital Universitário Professor Polydoro Ernani de São Thiago, Universidade Federal de Santa Catarina, Florianópolis 88036-800, Brazil., Garcia ECL; Medical School, Pontifícia Universidade Católica do Paraná, Curitiba 80215-901, Brazil., Rigatto MH; Medical Sciences Post-Graduation Program, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-003, Brazil.; Internal Medicine Department, School of Medicine of the Federal University of Rio Grande do Sul, Porto Alegre 90035-903, Brazil.; Infectious Diseases Service, Hospital de Clínicas de Porto Alegre, 2350 Ramiro Barcelos St, Porto Alegre 90035-903, Brazil.

المصدر: Antibiotics (Basel, Switzerland) [Antibiotics (Basel)] 2023 Aug 15; Vol. 12 (8). Date of Electronic Publication: 2023 Aug 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101637404 Publication Model: Electronic Cited Medium: Print ISSN: 2079-6382 (Print) Linking ISSN: 20796382 NLM ISO Abbreviation: Antibiotics (Basel) Subsets: PubMed not MEDLINE

المؤلفون: Rigatto MH; Medical School and Medical Sciences Post-Graduation Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Infectious Diseases Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Department of Internal Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. Electronic address: mrigatto@hcpa.edu.br., Bergo P; Pontifícia Universidade Católica do Rio Grande do Sul Medical School, Porto Alegre, Brazil., Baldissera G; Infectious Diseases Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Beck E; Pontifícia Universidade Católica do Rio Grande do Sul Medical School, Porto Alegre, Brazil., David L; Pontifícia Universidade Católica do Rio Grande do Sul Medical School, Porto Alegre, Brazil., Santoro L; Pontifícia Universidade Católica do Rio Grande do Sul Medical School, Porto Alegre, Brazil., Barros A; Infection Control Service, Hospital São Lucas da PUCRS, Porto Alegre, Brazil., Zanin R; Pontifícia Universidade Católica do Rio Grande do Sul, Health and Life Sciences School, Porto Alegre, Brazil., Budelon Gonçalves JI; Pontifícia Universidade Católica do Rio Grande do Sul, Health and Life Sciences School, Porto Alegre, Brazil., Falci D; Infectious Diseases Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Pontifícia Universidade Católica do Rio Grande do Sul Medical School, Porto Alegre, Brazil; Infection Control Service, Hospital São Lucas da PUCRS, Porto Alegre, Brazil., Caumo W; Medical School and Medical Sciences Post-Graduation Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Pain and Palliative Care Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Zavascki AP; Infectious Diseases Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Department of Internal Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

المصدر: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases [Clin Microbiol Infect] 2023 May; Vol. 29 (5), pp. 623-628. Date of Electronic Publication: 2022 Dec 28.

نوع المنشور: Randomized Controlled Trial; Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 9516420 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-0691 (Electronic) Linking ISSN: 1198743X NLM ISO Abbreviation: Clin Microbiol Infect Subsets: MEDLINE

مواضيع طبية MeSH: Melatonin*/adverse effects , COVID-19*/epidemiology , Acute Kidney Injury*/chemically induced , Acute Kidney Injury*/epidemiology , Acute Kidney Injury*/prevention & control, Male ; Humans ; Adolescent ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Female ; Polymyxin B/adverse effects ; Pandemics ; Double-Blind Method

المؤلفون: Rodrigues RD; Medical Sciences Post Graduation Program, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-903, Brazil., Garcia RCL; Medical Sciences Post Graduation Program, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-903, Brazil., Bittencourt GA; Medical School, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre 90619-900, Brazil., Waichel VB; Medical School, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre 90619-900, Brazil., Garcia ECL; Medical School, Pontifícia Universidade Católica do Paraná, Curitiba 80215-901, Brazil., Rigatto MH; Medical Sciences Post Graduation Program, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-903, Brazil.; Medical School, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-903, Brazil.; Infectious Disease Service, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-903, Brazil.

المصدر: Antibiotics (Basel, Switzerland) [Antibiotics (Basel)] 2023 Mar 08; Vol. 12 (3). Date of Electronic Publication: 2023 Mar 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101637404 Publication Model: Electronic Cited Medium: Print ISSN: 2079-6382 (Print) Linking ISSN: 20796382 NLM ISO Abbreviation: Antibiotics (Basel) Subsets: PubMed not MEDLINE

المؤلفون: Schonardie AP; Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Ciências Médicas, Porto Alegre, RS, Brazil., Beck E; Pontifícia Universidade Católica do Rio Grande do Sul, Faculdade de Medicina, Porto Alegre, RS, Brazil., Rigatto MH; Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Ciências Médicas, Porto Alegre, RS, Brazil; Universidade Federal do Rio Grande do Sul, Faculdade de Medicina, Departamento de Medicina Interna, Porto Alegre, RS, Brazil; Programa de Liderança Médica Jovem da Academia Nacional de Medicina, Rio de Janeiro, RJ, Brazil; Infectious Disease Service, Hospital de Clínicas de Porto Alegre, RS, Brazil. Electronic address: mrigatto@hcpa.edu.br.

المصدر: The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases [Braz J Infect Dis] 2023 Mar-Apr; Vol. 27 (2), pp. 102758. Date of Electronic Publication: 2023 Feb 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Editora Country of Publication: Brazil NLM ID: 9812937 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1678-4391 (Electronic) Linking ISSN: 14138670 NLM ISO Abbreviation: Braz J Infect Dis Subsets: MEDLINE

مواضيع طبية MeSH: Bacteremia*/microbiology , Gram-Negative Bacterial Infections*/drug therapy , Gram-Negative Bacterial Infections*/epidemiology , Gram-Negative Bacterial Infections*/microbiology , Sepsis* , Hematologic Neoplasms*/complications , Febrile Neutropenia*/drug therapy, Humans ; Adolescent ; Adult ; Carbapenems/pharmacology ; Carbapenems/therapeutic use ; Prevalence ; Retrospective Studies ; Gram-Negative Bacteria ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use

المؤلفون: Rigatto MH; Medical Sciences Post-Graduation Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Department of Internal Medicine, Medical School, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Infectious Diseases Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Ramos F; Medical Sciences Post-Graduation Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Infection Control Service, Hospital São Lucas da PUCRS, Porto Alegre, Brazil., Barros A; Medical Sciences Post-Graduation Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Pedroso S; Infection Control Service, Hospital São Lucas da PUCRS, Porto Alegre, Brazil., Guasso I; Infection Control Service, Hospital São Lucas da PUCRS, Porto Alegre, Brazil., Gonçalves L; Pontifícia Universidade Católica do Rio Grande do Sul, Medical School, Porto Alegre, Brazil., Bergo P; Pontifícia Universidade Católica do Rio Grande do Sul, Medical School, Porto Alegre, Brazil., Zavascki AP; Department of Internal Medicine, Medical School, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Infectious Diseases Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.

المصدر: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2022 Oct 28; Vol. 77 (11), pp. 3118-3125.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 7513617 Publication Model: Print Cited Medium: Internet ISSN: 1460-2091 (Electronic) Linking ISSN: 03057453 NLM ISO Abbreviation: J Antimicrob Chemother Subsets: MEDLINE

مواضيع طبية MeSH: Carbapenem-Resistant Enterobacteriaceae* , Bacteremia*/drug therapy , Sepsis*/drug therapy, Humans ; Adolescent ; Carbapenems/pharmacology ; Carbapenems/therapeutic use ; Retrospective Studies ; Anti-Bacterial Agents/therapeutic use ; Anti-Bacterial Agents/pharmacology ; Cohort Studies

المؤلفون: Barros A; Medical Sciences Postgraduate Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Infection Control Service, Hospital São Lucas da PUCRS, Porto Alegre, RS, Brazil., Monroy H; Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) Medical School, Porto Alegre, RS, Brazil., Bergo P; Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) Medical School, Porto Alegre, RS, Brazil., Beck E; Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) Medical School, Porto Alegre, RS, Brazil., David L; Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) Medical School, Porto Alegre, RS, Brazil., Rigatto MH; Medical Sciences Postgraduate Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) Medical School, Porto Alegre, RS, Brazil; Infectious Disease Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil; Young Medical Leadership Program of the National Academy of Medicine in Brazil. Electronic address: mhprigatto@gmail.com.

المصدر: Journal of global antimicrobial resistance [J Glob Antimicrob Resist] 2022 Mar; Vol. 28, pp. 130-135. Date of Electronic Publication: 2021 Dec 18.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Published by Elsevier Ltd. on behalf of International Society of Chemotherapy for Infection and Cancer Country of Publication: Netherlands NLM ID: 101622459 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-7173 (Electronic) Linking ISSN: 22137165 NLM ISO Abbreviation: J Glob Antimicrob Resist Subsets: MEDLINE

مواضيع طبية MeSH: Antimicrobial Stewardship* , Bacteremia*/microbiology , Drug Resistance, Bacterial* , Gammaproteobacteria* , Shock, Septic*/drug therapy, Anti-Bacterial Agents/therapeutic use ; Carbapenems/therapeutic use ; Cohort Studies ; Humans ; Prescriptions ; Retrospective Studies

المؤلفون: Rodrigues D; Medical Sciences Post-Graduation Program, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil., Baldissera GS; Pontifícia Universidade Católica Do Rio Grande Do Sul Medical School, Porto Alegre, Brazil., Mathos D; Medical School, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Sartori A; Pontifícia Universidade Católica Do Rio Grande Do Sul Medical School, Porto Alegre, Brazil., Zavascki AP; Medical Sciences Post-Graduation Program, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil.; Medical School, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Infectious Diseases Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Rigatto MH; Medical Sciences Post-Graduation Program, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil. mrigatto@hcpa.edu.br.; Infectious Diseases Service, Hospital São Lucas da PUCRS, Porto Alegre, Brazil. mrigatto@hcpa.edu.br.; Infectious Diseases Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil. mrigatto@hcpa.edu.br.; Pontifícia Universidade Católica Do Rio Grande Do Sul Medical School, Porto Alegre, Brazil. mrigatto@hcpa.edu.br.

المصدر: Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] [Braz J Microbiol] 2021 Dec; Vol. 52 (4), pp. 1913-1919. Date of Electronic Publication: 2021 Jun 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer International Publishing Country of Publication: Brazil NLM ID: 101095924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1678-4405 (Electronic) Linking ISSN: 15178382 NLM ISO Abbreviation: Braz J Microbiol Subsets: MEDLINE

مواضيع طبية MeSH: Amikacin*/adverse effects , Amikacin*/pharmacology , Amikacin*/therapeutic use , Amikacin*/toxicity , Carbapenem-Resistant Enterobacteriaceae*/drug effects , Klebsiella Infections*/drug therapy , Klebsiella Infections*/microbiology , Klebsiella pneumoniae*/drug effects, Acute Kidney Injury/drug therapy ; Acute Kidney Injury/microbiology ; Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents/adverse effects ; Carbapenems/pharmacology ; Colistin/adverse effects ; Female ; Humans ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Retrospective Studies ; Treatment Outcome ; Young Adult

المؤلفون: D Moro AL; Infectious Diseases Service, Nossa Senhora da Conceição Hospital, Porto Alegre, RS, Brazil; Medical Sciences Post-Graduate Program, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil., Rigatto MH; Medical Sciences Post-Graduate Program, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; School of Medicine, Pontifícia Universidade Católica of Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: mrigatto@hcpa.edu.br.

المصدر: Journal of global antimicrobial resistance [J Glob Antimicrob Resist] 2020 Mar; Vol. 20, pp. 33-35. Date of Electronic Publication: 2019 Nov 16.

نوع المنشور: Letter; Multicenter Study

بيانات الدورية: Publisher: Published by Elsevier Ltd. on behalf of International Society of Chemotherapy for Infection and Cancer Country of Publication: Netherlands NLM ID: 101622459 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-7173 (Electronic) Linking ISSN: 22137165 NLM ISO Abbreviation: J Glob Antimicrob Resist Subsets: MEDLINE

مواضيع طبية MeSH: Drug Resistance, Viral*, Anti-HIV Agents/*pharmacology , HIV Infections/*transmission , HIV-1/*genetics, Adult ; Anti-HIV Agents/therapeutic use ; Brazil ; Female ; HIV Infections/drug therapy ; HIV-1/classification ; HIV-1/drug effects ; HIV-1/isolation & purification ; Humans ; Male ; Mutation ; Prevalence ; Retrospective Studies ; Tertiary Care Centers ; Treatment Failure