يعرض 1 - 10 نتائج من 29 نتيجة بحث عن '"Riikka Kärnä"', وقت الاستعلام: 1.80s تنقيح النتائج
  1. 1
    The calcium-activated chloride channel-associated protein rCLCA2 is expressed throughout rat epidermis, facilitates apoptosis and is downmodulated by UVB

    المؤلفون: Sanna Pasonen-Seppänen, Genevieve Bart, Timo Kumlin, Leena Rauhala, Raija Tammi, Piia Takabe, Markku Tammi, E Kärkkäinen, Riikka Kärnä, Ashik Jawahar Deen, L. Hämäläinen

    المصدر: Histochemistry and Cell Biology

    مصطلحات موضوعية: Keratinocytes, 0301 basic medicine, Histology, Ultraviolet Rays, Short Communication, Down-Regulation, Apoptosis, UVR, Mice, rCLCA2, 03 medical and health sciences, 0302 clinical medicine, Chloride Channels, In vivo, Animals, Gene silencing, Molecular Biology, Cells, Cultured, Messenger RNA, integumentary system, Epidermis (botany), Chemistry, Cell Biology, REK, Rats, Cell biology, Medical Laboratory Technology, 030104 developmental biology, 030220 oncology & carcinogenesis, Chloride channel, Immunohistochemistry, Epidermis, Immunostaining

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33495e94a1e5c1a9f792bab13960c422
    https://doi.org/10.1007/s00418-021-01962-5

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  2. 2
    Extracellular ATP activates hyaluronan synthase 2 (HAS2) in epidermal keratinocytes via P2Y2, Ca2+ signaling, and MAPK pathways

    المؤلفون: Piia Takabe, Raija Tammi, Leena Rauhala, Tiina A. Jokela, Sanna Pasonen-Seppänen, Genevieve Bart, Markku Tammi, Riikka Kärnä, Sanna Oikari

    المصدر: Biochemical Journal. 475:1755-1772

    مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Cell signaling, integumentary system, Chemistry, Purinergic receptor, Cell Biology, Hyaluronan Synthase 2, Biochemistry, Cell biology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Downregulation and upregulation, 030220 oncology & carcinogenesis, Extracellular, Phosphorylation, Molecular Biology, HAS1

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::77d3bc714da2a3325ae882bf199daaab
    https://doi.org/10.1042/bcj20180054

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  3. 3
    Hyaluronan metabolism enhanced during epidermal differentiation is suppressed by vitamin C

    المؤلفون: Sanna Pasonen-Seppänen, Piia Takabe, Raija Tammi, Markku Tammi, L. Hämäläinen, E Kärkkäinen, Sanna Oikari, Leena Rauhala, Genevieve Bart, Riikka Kärnä

    المصدر: British Journal of Dermatology. 179:651-661

    مصطلحات موضوعية: Keratinocytes, 0301 basic medicine, Hyaluronoglucosaminidase, Ascorbic Acid, Dermatology, Cell Line, Glycosaminoglycan, 03 medical and health sciences, Downregulation and upregulation, Extracellular, Animals, Hyaluronic Acid, RNA, Small Interfering, HAS1, integumentary system, 030102 biochemistry & molecular biology, biology, Chemistry, Gene Expression Profiling, CD44, Cell Differentiation, Hyaluronan-mediated motility receptor, Rats, Up-Regulation, Cell biology, carbohydrates (lipids), Blot, Hyaluronan Receptors, 030104 developmental biology, biology.protein, Epidermis, Wound healing, Hyaluronan Synthases

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7cb1a564f505106976360cf1f706b53
    https://doi.org/10.1111/bjd.16423

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  4. 4
    EMT induced by EGF and wounding activates hyaluronan synthesis machinery and EV shedding in rat primary mesothelial cells

    المؤلفون: Kirsi Rilla, Kai Härkönen, Uma Thanigai Arasu, Riikka Kärnä, Ville Koistinen, Sanna Oikari

    المصدر: Matrix Biology. 63:38-54

    مصطلحات موضوعية: Male, 0301 basic medicine, Epithelial-Mesenchymal Transition, Primary Cell Culture, Apoptosis, Biology, Epithelium, Extracellular Vesicles, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Epithelial–mesenchymal transition, Hyaluronic Acid, Rats, Wistar, Cell Shape, Molecular Biology, Wound Healing, Epidermal Growth Factor, integumentary system, Caspase 3, Epithelial Cells, Extracellular vesicle, Hyaluronan-mediated motility receptor, Cell biology, Mesothelium, Hyaluronan Receptors, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Wound healing, Filopodia, Mesothelial Cell

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91ad23211404a6836a339fe271f11bf3
    https://doi.org/10.1016/j.matbio.2016.12.007

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  5. 5
    HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells

    المؤلفون: Petri I. Mäkinen, Maciej Lalowski, Sanna Pasonen-Seppänen, Pia Siljander, Ashik Jawahar Deen, Uma Thanigai Arasu, Kai Härkönen, Riikka Kärnä, Kirsi Rilla, Elisa Lázaro-Ibáñez, Sanna Oikari, Sami Heikkinen, Anna-Liisa Levonen

    المساهمون: Department of Biochemistry and Developmental Biology, Faculty of Medicine, Helsinki Institute of Life Science HiLIFE, University of Helsinki, Extracellular Vesicles, Divisions of Faculty of Pharmacy, Faculty of Pharmacy, Division of Pharmaceutical Biosciences, Molecular and Integrative Biosciences Research Programme, Drug Research Program, Faculty of Biological and Environmental Sciences

    المصدر: Cellular and Molecular Life Sciences

    مصطلحات موضوعية: IHH, TUMOR-CELLS, Cell, Proliferation, Hedgehog signaling, SHEDDING LIGHT, ACTIVATION, 0302 clinical medicine, Hyaluronan synthase, Melanoma, Hyaluronan, Cancer, 0303 health sciences, biology, Chemistry, Extracellular vesicles, PANCREATIC-CANCER, Hedgehog signaling pathway, Cell biology, Up-Regulation, TRANSCRIPTION FACTORS, medicine.anatomical_structure, Hyaluronan Receptors, c-Myc, 030220 oncology & carcinogenesis, Molecular Medicine, Original Article, Claspin, O-GLCNACYLATION, Signal Transduction, Epithelial-Mesenchymal Transition, Cell Line, Proto-Oncogene Proteins c-myc, 03 medical and health sciences, Cellular and Molecular Neuroscience, Downregulation and upregulation, Cell Line, Tumor, medicine, Humans, Hedgehog Proteins, CYCLE, Molecular Biology, 030304 developmental biology, Cell Proliferation, EXOSOMES, Pharmacology, Cell growth, CD44, Cell Biology, Microvesicles, Cancer cell, biology.protein, 1182 Biochemistry, cell and molecular biology, 3111 Biomedicine, Hyaluronan Synthases

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b332b14193b8e567681992e758baa23
    https://pubmed.ncbi.nlm.nih.gov/31820036

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  6. 6
    Melanocyte Hyaluronan Coat Fragmentation Enhances the UVB-Induced TLR-4 Receptor Signaling and Expression of Proinflammatory Mediators IL6, IL8, CXCL1, and CXCL10 via NF-κB Activation

    المؤلفون: Piia Takabe, Raija Tammi, Riikka Kärnä, Sanna Pasonen-Seppänen, Leena Rauhala, Markku Tammi

    المصدر: The Journal of investigative dermatology. 139(9)

    مصطلحات موضوعية: 0301 basic medicine, Skin Neoplasms, Carcinogenesis, Ultraviolet Rays, Chemokine CXCL1, Primary Cell Culture, Inflammation, Dermatology, Biochemistry, Proinflammatory cytokine, 03 medical and health sciences, 0302 clinical medicine, Hyaluronidase, medicine, Humans, Hyaluronic Acid, Molecular Biology, Melanoma, Cells, Cultured, Toll-like receptor, integumentary system, biology, Chemistry, Interleukin-6, Interleukin-8, Cell Biology, Hyaluronan-mediated motility receptor, Cell biology, Extracellular Matrix, carbohydrates (lipids), CXCL1, Chemokine CXCL10, Toll-Like Receptor 4, Hyaluronan synthase, 030104 developmental biology, Hyaluronan Receptors, 030220 oncology & carcinogenesis, TLR4, biology.protein, Melanocytes, medicine.symptom, Epidermis, Hyaluronan Synthases, medicine.drug, Signal Transduction

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80ead944670c394b850cb95d496808e2
    https://pubmed.ncbi.nlm.nih.gov/30935974

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  7. 7
    Hexosamine biosynthesis in keratinocytes: roles of GFAT and GNPDA enzymes in the maintenance of UDP-GlcNAc content and hyaluronan synthesis

    المؤلفون: Riikka Kärnä, Raija Tammi, Ashik Jawahar Deen, Sanna Oikari, Ilari Tyni, Katri M. Makkonen, Markku Tammi

    المصدر: Glycobiology. 26:710-722

    مصطلحات موضوعية: Keratinocytes, 0301 basic medicine, Glucose-6-Phosphate, Cellular homeostasis, Hyaluronan Synthase 2, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Biosynthesis, Cell Movement, Hyaluronic acid, Gene expression, Humans, Gene silencing, Hyaluronic Acid, RNA, Small Interfering, Aldose-Ketose Isomerases, Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing), chemistry.chemical_classification, Glucosamine, Uridine Diphosphate N-Acetylglucosamine, Fructosephosphates, Hexosamines, carbohydrates (lipids), Glucose, 030104 developmental biology, Enzyme, Uridine diphosphate N-acetylglucosamine, chemistry, Hyaluronan Synthases

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62838583adcaaacb3e5f04642057ea6d
    https://doi.org/10.1093/glycob/cww019

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  8. 8
    Cell protrusions induced by hyaluronan synthase 3 (HAS3) resemble mesothelial microvilli and share cytoskeletal features of filopodia

    المؤلفون: Markku Tammi, Antti Arjonen, Ville Koistinen, Kirsi Rilla, Arto Koistinen, Riikka Kärnä

    المساهمون: Faculty of Health Sciences

    المصدر: Experimental Cell Research. 337:179-191

    مصطلحات موضوعية: Green Fluorescent Proteins, Fluorescent Antibody Technique, macromolecular substances, Filamentous actin, Epithelium, Ezrin, Microscopy, Electron, Transmission, Animals, Humans, ta219, Pseudopodia, Glucuronosyltransferase, Hyaluronic Acid, Cytoskeleton, Actin, Fascin, Microscopy, Confocal, Microvilli, biology, Cell Membrane, Cell Biology, Rats, Cell biology, Hyaluronan synthase, MCF-7 Cells, biology.protein, Cell Surface Extensions, Villin, Hyaluronan Synthases, Filopodia

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8947eb4e662f0f5b52786963ab6a23
    https://doi.org/10.1016/j.yexcr.2015.06.016

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  9. 9
    Effects of mutations in the post-translational modification sites on the trafficking of hyaluronan synthase 2 (HAS2)

    المؤلفون: Davide Vigetti, Uma Thanigai Arasu, Paraskevi Heldin, Riikka Kärnä, Kirsi Rilla, R. M. Melero-Fernandez de Mera, Ashik Jawahar Deen, Alberto Passi, Markku Tammi, Sanna Oikari

    المصدر: Matrix biology : journal of the International Society for Matrix Biology. 80

    مصطلحات موضوعية: 0301 basic medicine, endocrine system, Glycosylation, Endosome, Golgi Apparatus, Protein traffic, Hyaluronan Synthase 2, Endocytosis, Endoplasmic Reticulum, 03 medical and health sciences, symbols.namesake, O-GlcNAcylation, 0302 clinical medicine, Hyaluronan synthase, Monoubiquitination, Chlorocebus aethiops, Hyaluronan, Phosphorylation, Animals, Humans, Secretion, Molecular Biology, biology, Chemistry, Endoplasmic reticulum, Cell Membrane, Wild type, Ubiquitination, Golgi apparatus, Cell biology, Protein Transport, 030104 developmental biology, Gene Expression Regulation, 030220 oncology & carcinogenesis, COS Cells, Mutation, symbols, biology.protein, Hyaluronan Synthases, Protein Processing, Post-Translational

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a9312c85544714db7c6cf6bb18a9e63
    https://pubmed.ncbi.nlm.nih.gov/30394292

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  10. 10
    Extracellular ATP activates hyaluronan synthase 2 (

    المؤلفون: Leena, Rauhala, Tiina, Jokela, Riikka, Kärnä, Geneviève, Bart, Piia, Takabe, Sanna, Oikari, Markku I, Tammi, Sanna, Pasonen-Seppänen, Raija H, Tammi

    المصدر: The Biochemical journal. 475(10)

    مصطلحات موضوعية: Keratinocytes, Gene Expression Regulation, Enzymologic, Extracellular Matrix, Receptors, Purinergic P2Y2, Adenosine Triphosphate, Humans, Calcium, Epidermis, Mitogen-Activated Protein Kinases, Phosphorylation, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Hyaluronan Synthases, Cells, Cultured, Signal Transduction

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::5d7f7902e4f2896fee7893186bb0e32a
    https://pubmed.ncbi.nlm.nih.gov/29626161

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