المؤلفون: Babbe H; Janssen Research and Development, LLC., Spring House, PA 19477., Sundberg TB; Broad Institute of MIT and Harvard, Center for the Development of Therapeutics, Cambridge, MA 02142., Tichenor M; Janssen Research and Development, LLC., San Diego, CA 92121., Seierstad M; Janssen Research and Development, LLC., San Diego, CA 92121., Bacani G; Janssen Research and Development, LLC., San Diego, CA 92121., Berstler J; Broad Institute of MIT and Harvard, Center for the Development of Therapeutics, Cambridge, MA 02142., Chai W; Janssen Research and Development, LLC., San Diego, CA 92121., Chang L; Janssen Research and Development, LLC., San Diego, CA 92121., Chung M; Janssen Research and Development, LLC., San Diego, CA 92121., Coe K; Janssen Research and Development, LLC., San Diego, CA 92121., Collins B; Janssen Research and Development, LLC., San Diego, CA 92121., Finley M; Janssen Research and Development, LLC., Spring House, PA 19477., Guletsky A; Broad Institute of MIT and Harvard, Center for the Development of Therapeutics, Cambridge, MA 02142., Lemke CT; Broad Institute of MIT and Harvard, Center for the Development of Therapeutics, Cambridge, MA 02142., Mak PA; Janssen Research and Development, LLC., San Diego, CA 92121., Mathur A; Janssen Research and Development, LLC., Spring House, PA 19477., Mercado-Marin EV; Janssen Research and Development, LLC., San Diego, CA 92121., Metkar S; Broad Institute of MIT and Harvard, Center for the Development of Therapeutics, Cambridge, MA 02142., Raymond DD; Broad Institute of MIT and Harvard, Center for the Development of Therapeutics, Cambridge, MA 02142., Rives ML; Janssen Research and Development, LLC., San Diego, CA 92121., Rizzolio M; Janssen Research and Development, LLC., San Diego, CA 92121., Shaffer PL; Janssen Research and Development, LLC., Spring House, PA 19477., Smith R; Janssen Research and Development, LLC., San Diego, CA 92121., Smith J; Janssen Research and Development, LLC., San Diego, CA 92121., Steele R; Janssen Research and Development, LLC., Spring House, PA 19477., Steffens H; Janssen Research and Development, LLC., San Diego, CA 92121., Suarez J; Janssen Research and Development, LLC., Spring House, PA 19477., Tian G; Janssen Research and Development, LLC., Spring House, PA 19477., Majewski N; Janssen Research and Development, LLC., Spring House, PA 19477., Volak LP; Janssen Research and Development, LLC., San Diego, CA 92121., Wei J; Janssen Research and Development, LLC., San Diego, CA 92121., Desai PT; Janssen Research and Development, LLC., Spring House, PA 19477., Ong LL; Janssen Research and Development, LLC., Spring House, PA 19477., Koudriakova T; Janssen Research and Development, LLC., San Diego, CA 92121., Goldberg SD; Janssen Research and Development, LLC., San Diego, CA 92121., Hirst G; Janssen Research and Development, LLC., San Diego, CA 92121., Kaushik VK; Broad Institute of MIT and Harvard, Center for the Development of Therapeutics, Cambridge, MA 02142., Ort T; Janssen Research and Development, LLC., Spring House, PA 19477., Seth N; Janssen Research and Development, LLC., Spring House, PA 19477., Graham DB; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114.; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142., Plevy S; Janssen Research and Development, LLC., Spring House, PA 19477., Venable JD; Janssen Research and Development, LLC., San Diego, CA 92121., Xavier RJ; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114.; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142., Towne JE; Janssen Research and Development, LLC., San Diego, CA 92121.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Jan 02; Vol. 121 (1), pp. e2307086120. Date of Electronic Publication: 2023 Dec 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Protein Serine-Threonine Kinases*/metabolism , Cyclic AMP Response Element-Binding Protein*/metabolism, Mice ; Humans ; Animals ; Cytokines ; Inflammation/drug therapy ; Protein Isoforms ; Anti-Inflammatory Agents/pharmacology ; Immunity, Innate ; Transcription Factors

المؤلفون: Wang J; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States. Electronic address: jwang301@its.jnj.com., Nakafuku KM; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States. Electronic address: knakafuk@its.jnj.com., Ziff J; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Gelin CF; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Gholami H; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Thompson AA; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Karpowich NK; Janssen Research & Development L.L.C., 1400 McKean Rd., Spring House, PA 19477, United States., Limon L; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Coate HR; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Damm-Ganamet KL; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Shih AY; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Grant JC; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Côte M; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Mak PA; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Pascual HA; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Rives ML; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Edwards JP; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Venable JD; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Venkatesan H; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Shi Z; Janssen Research & Development L.L.C., 1400 McKean Rd., Spring House, PA 19477, United States., Allen SJ; Janssen Research & Development L.L.C., 1400 McKean Rd., Spring House, PA 19477, United States., Sharma S; Janssen Research & Development L.L.C., 1400 McKean Rd., Spring House, PA 19477, United States., Kung PP; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Shireman BT; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2023 Nov 15; Vol. 96, pp. 129492. Date of Electronic Publication: 2023 Sep 29.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: NK Cell Lectin-Like Receptor Subfamily K*/metabolism , Carrier Proteins*/metabolism, Humans ; Histocompatibility Antigens Class I/metabolism ; Protein Binding ; Killer Cells, Natural/metabolism ; Ligands

المؤلفون: Stalewski J; Departments of Chemistry (J.S.); Computer-Aided Drug Discovery (A.Y.S.); Gastroenterology (R.P., B.C.F.); Molecular and Cellular Pharmacology-Target Validation and Functional Genomics (J.R., M.-L.R.); In Vivo Pharmacology (G.I.); DMPK (P.H.); Computational Biology (Y.Y., J.Y., C.B.), Ferring Research Institute Inc., San Diego, California; and Biosensing Instrument, Tempe, Arizona (S.W., A.U.)., Shih AY; Departments of Chemistry (J.S.); Computer-Aided Drug Discovery (A.Y.S.); Gastroenterology (R.P., B.C.F.); Molecular and Cellular Pharmacology-Target Validation and Functional Genomics (J.R., M.-L.R.); In Vivo Pharmacology (G.I.); DMPK (P.H.); Computational Biology (Y.Y., J.Y., C.B.), Ferring Research Institute Inc., San Diego, California; and Biosensing Instrument, Tempe, Arizona (S.W., A.U.)., Papazyan R; Departments of Chemistry (J.S.); Computer-Aided Drug Discovery (A.Y.S.); Gastroenterology (R.P., B.C.F.); Molecular and Cellular Pharmacology-Target Validation and Functional Genomics (J.R., M.-L.R.); In Vivo Pharmacology (G.I.); DMPK (P.H.); Computational Biology (Y.Y., J.Y., C.B.), Ferring Research Institute Inc., San Diego, California; and Biosensing Instrument, Tempe, Arizona (S.W., A.U.)., Ramirez J; Departments of Chemistry (J.S.); Computer-Aided Drug Discovery (A.Y.S.); Gastroenterology (R.P., B.C.F.); Molecular and Cellular Pharmacology-Target Validation and Functional Genomics (J.R., M.-L.R.); In Vivo Pharmacology (G.I.); DMPK (P.H.); Computational Biology (Y.Y., J.Y., C.B.), Ferring Research Institute Inc., San Diego, California; and Biosensing Instrument, Tempe, Arizona (S.W., A.U.)., Ibanez G; Departments of Chemistry (J.S.); Computer-Aided Drug Discovery (A.Y.S.); Gastroenterology (R.P., B.C.F.); Molecular and Cellular Pharmacology-Target Validation and Functional Genomics (J.R., M.-L.R.); In Vivo Pharmacology (G.I.); DMPK (P.H.); Computational Biology (Y.Y., J.Y., C.B.), Ferring Research Institute Inc., San Diego, California; and Biosensing Instrument, Tempe, Arizona (S.W., A.U.)., Hsiao P; Departments of Chemistry (J.S.); Computer-Aided Drug Discovery (A.Y.S.); Gastroenterology (R.P., B.C.F.); Molecular and Cellular Pharmacology-Target Validation and Functional Genomics (J.R., M.-L.R.); In Vivo Pharmacology (G.I.); DMPK (P.H.); Computational Biology (Y.Y., J.Y., C.B.), Ferring Research Institute Inc., San Diego, California; and Biosensing Instrument, Tempe, Arizona (S.W., A.U.)., Yue Y; Departments of Chemistry (J.S.); Computer-Aided Drug Discovery (A.Y.S.); Gastroenterology (R.P., B.C.F.); Molecular and Cellular Pharmacology-Target Validation and Functional Genomics (J.R., M.-L.R.); In Vivo Pharmacology (G.I.); DMPK (P.H.); Computational Biology (Y.Y., J.Y., C.B.), Ferring Research Institute Inc., San Diego, California; and Biosensing Instrument, Tempe, Arizona (S.W., A.U.)., Yin J; Departments of Chemistry (J.S.); Computer-Aided Drug Discovery (A.Y.S.); Gastroenterology (R.P., B.C.F.); Molecular and Cellular Pharmacology-Target Validation and Functional Genomics (J.R., M.-L.R.); In Vivo Pharmacology (G.I.); DMPK (P.H.); Computational Biology (Y.Y., J.Y., C.B.), Ferring Research Institute Inc., San Diego, California; and Biosensing Instrument, Tempe, Arizona (S.W., A.U.)., Badger C; Departments of Chemistry (J.S.); Computer-Aided Drug Discovery (A.Y.S.); Gastroenterology (R.P., B.C.F.); Molecular and Cellular Pharmacology-Target Validation and Functional Genomics (J.R., M.-L.R.); In Vivo Pharmacology (G.I.); DMPK (P.H.); Computational Biology (Y.Y., J.Y., C.B.), Ferring Research Institute Inc., San Diego, California; and Biosensing Instrument, Tempe, Arizona (S.W., A.U.)., Wu S; Departments of Chemistry (J.S.); Computer-Aided Drug Discovery (A.Y.S.); Gastroenterology (R.P., B.C.F.); Molecular and Cellular Pharmacology-Target Validation and Functional Genomics (J.R., M.-L.R.); In Vivo Pharmacology (G.I.); DMPK (P.H.); Computational Biology (Y.Y., J.Y., C.B.), Ferring Research Institute Inc., San Diego, California; and Biosensing Instrument, Tempe, Arizona (S.W., A.U.)., Ueki A; Departments of Chemistry (J.S.); Computer-Aided Drug Discovery (A.Y.S.); Gastroenterology (R.P., B.C.F.); Molecular and Cellular Pharmacology-Target Validation and Functional Genomics (J.R., M.-L.R.); In Vivo Pharmacology (G.I.); DMPK (P.H.); Computational Biology (Y.Y., J.Y., C.B.), Ferring Research Institute Inc., San Diego, California; and Biosensing Instrument, Tempe, Arizona (S.W., A.U.)., Fuchs BC; Departments of Chemistry (J.S.); Computer-Aided Drug Discovery (A.Y.S.); Gastroenterology (R.P., B.C.F.); Molecular and Cellular Pharmacology-Target Validation and Functional Genomics (J.R., M.-L.R.); In Vivo Pharmacology (G.I.); DMPK (P.H.); Computational Biology (Y.Y., J.Y., C.B.), Ferring Research Institute Inc., San Diego, California; and Biosensing Instrument, Tempe, Arizona (S.W., A.U.)., Rives ML; Departments of Chemistry (J.S.); Computer-Aided Drug Discovery (A.Y.S.); Gastroenterology (R.P., B.C.F.); Molecular and Cellular Pharmacology-Target Validation and Functional Genomics (J.R., M.-L.R.); In Vivo Pharmacology (G.I.); DMPK (P.H.); Computational Biology (Y.Y., J.Y., C.B.), Ferring Research Institute Inc., San Diego, California; and Biosensing Instrument, Tempe, Arizona (S.W., A.U.) marie-laure.rives@ferring.com.

المصدر: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2023 Jul; Vol. 386 (1), pp. 35-44. Date of Electronic Publication: 2023 May 04.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE

مواضيع طبية MeSH: Colitis*/metabolism , Inflammatory Bowel Diseases*/drug therapy, Humans ; Animals ; Mice ; Receptors, G-Protein-Coupled/metabolism ; Inflammation ; Hydrogen-Ion Concentration

المؤلفون: Thompson AA; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Harbut MB; Therapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002., Kung PP; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Karpowich NK; Therapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002., Branson JD; Therapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002., Grant JC; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Hagan D; Therapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002., Pascual HA; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Bai G; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Zavareh RB; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Coate HR; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Collins BC; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Côte M; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Gelin CF; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Damm-Ganamet KL; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Gholami H; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Huff AR; Therapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002., Limon L; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Lumb KJ; Therapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002., Mak PA; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Nakafuku KM; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Price EV; Therapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002., Shih AY; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Tootoonchi M; Discovery Immunology, Janssen Research & Development, San Diego, CA 92121., Vellore NA; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Wang J; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Wei N; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Ziff J; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Berger SB; Discovery Immunology, Janssen Research & Development, Lower Gwynedd Township, PA 19002., Edwards JP; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Gardet A; Discovery Immunology, Janssen Research & Development, San Diego, CA 92121., Sun S; Discovery Immunology, Janssen Research & Development, San Diego, CA 92121., Towne JE; Discovery Immunology, Janssen Research & Development, San Diego, CA 92121., Venable JD; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Shi Z; Therapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002., Venkatesan H; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Rives ML; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Sharma S; Therapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002., Shireman BT; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Allen SJ; Therapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 May 02; Vol. 120 (18), pp. e2216342120. Date of Electronic Publication: 2023 Apr 25.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Killer Cells, Natural* , NK Cell Lectin-Like Receptor Subfamily K*, Ligands ; CD8-Positive T-Lymphocytes ; Protein Binding

المؤلفون: Patch RJ; Janssen Research & Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, USA. Electronic address: rpatch2@its.jnj.com., Zhang R; Janssen Research & Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, USA., Edavettal S; Janssen Research & Development, LLC, 3210 Merryfield Row, La Jolla, CA, 92121, USA., Macielag MJ; Janssen Research & Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, USA., Eckardt AJ; Janssen Research & Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, USA., Li J; Janssen Research & Development, LLC, 3210 Merryfield Row, La Jolla, CA, 92121, USA., Rives ML; Janssen Research & Development, LLC, 3210 Merryfield Row, La Jolla, CA, 92121, USA., Edwards W; Janssen Research & Development, LLC, 3210 Merryfield Row, La Jolla, CA, 92121, USA., Hinke SA; Janssen Research & Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, USA., Qiu X; Janssen Research & Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, USA., Jian W; Janssen Research & Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, USA., Libiger O; Janssen Research & Development, LLC, 3210 Merryfield Row, La Jolla, CA, 92121, USA., Zheng S; Janssen Research & Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, USA., Jeyaseelan J; Janssen Research & Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, USA., Liang Y; Janssen Research & Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, USA., Rangwala SM; Janssen Research & Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, USA., Leonard JN; Janssen Research & Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, USA., Hornby P; Janssen Research & Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, USA.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2022 Jun 05; Vol. 236, pp. 114330. Date of Electronic Publication: 2022 Apr 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Amylin Receptor Agonists*/pharmacology , Amylin Receptor Agonists*/therapeutic use, Amyloid ; Animals ; Body Weight ; Humans ; Hypoglycemic Agents/therapeutic use ; Islet Amyloid Polypeptide/pharmacology ; Mice ; Obesity/chemically induced ; Obesity/drug therapy

المؤلفون: Damm-Ganamet KL; Discovery Sciences, Janssen Research and Development, San Diego, California 92121. Electronic address: kganamet@its.jnj.com., Rives ML; Discovery Sciences, Janssen Research and Development, San Diego, California 92121., Wickenden AD; Discovery Sciences, Janssen Research and Development, San Diego, California 92121., McAllister HM; Discovery Sciences, Janssen Research and Development, San Diego, California 92121., Mirzadegan T; Discovery Sciences, Janssen Research and Development, San Diego, California 92121.

المصدر: The Journal of biological chemistry [J Biol Chem] 2020 Mar 27; Vol. 295 (13), pp. 4359-4366. Date of Electronic Publication: 2020 Feb 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Amino Acid Transport System X-AG/*antagonists & inhibitors , Binding Sites/*drug effects , Central Nervous System Diseases/*drug therapy , Excitatory Amino Acid Transporter 2/*antagonists & inhibitors, Amino Acid Transport System X-AG/chemistry ; Amino Acid Transport System X-AG/genetics ; Animals ; Binding Sites/genetics ; Biological Transport/drug effects ; Central Nervous System Diseases/genetics ; Central Nervous System Diseases/pathology ; Computational Biology ; Excitatory Amino Acid Transporter 2/chemistry ; Excitatory Amino Acid Transporter 2/genetics ; Humans ; Protein Binding/drug effects ; Synaptic Transmission/drug effects ; User-Computer Interface

المؤلفون: Miles LA; ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, VIC 3056, Australia; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia. Electronic address: lmiles@svi.edu.au., Hermans SJ; ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, VIC 3056, Australia; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia., Crespi GAN; ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, VIC 3056, Australia; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia., Gooi JH; ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, VIC 3056, Australia; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia., Doughty L; ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, VIC 3056, Australia; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia., Nero TL; ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, VIC 3056, Australia; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia., Markulić J; ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, VIC 3056, Australia; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia., Ebneth A; Janssen Research & Development, a Division of Janssen Pharmaceutica N.V, 2340 Beerse, Belgium., Wroblowski B; Janssen Research & Development, a Division of Janssen Pharmaceutica N.V, 2340 Beerse, Belgium., Oehlrich D; Janssen Research & Development, a Division of Janssen Pharmaceutica N.V, 2340 Beerse, Belgium., Trabanco AA; Neuroscience Medicinal Chemistry, Janssen Research & Development, 45007 Toledo, Spain., Rives ML; Molecular and Cellular Pharmacology, Janssen Research & Development, LLC, La Jolla, CA 92121, USA., Royaux I; Janssen Research & Development, a Division of Janssen Pharmaceutica N.V, 2340 Beerse, Belgium., Hancock NC; ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, VIC 3056, Australia; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia., Parker MW; ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, VIC 3056, Australia; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia. Electronic address: mparker@svi.edu.au.

المصدر: IScience [iScience] 2019 Sep 27; Vol. 19, pp. 110-118. Date of Electronic Publication: 2019 Jul 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE

المؤلفون: Rives ML; Molecular and Cellular Pharmacology, Janssen Research & Development, LLC, La Jolla, California (M.-L.R., N.S.); Cardiovascular and Metabolism (B.R., S.Z., J.Q., I.B., S.P.L., M.R.P., A.P.), and Computational Chemistry (E.A.), Janssen Research & Development, LLC, Spring House, Pennsylvania; and Domain Therapeutics NA Inc., Montreal, Quebec, Canada (A.M., B.B.) mrives1@its.jnj.com., Rady B; Molecular and Cellular Pharmacology, Janssen Research & Development, LLC, La Jolla, California (M.-L.R., N.S.); Cardiovascular and Metabolism (B.R., S.Z., J.Q., I.B., S.P.L., M.R.P., A.P.), and Computational Chemistry (E.A.), Janssen Research & Development, LLC, Spring House, Pennsylvania; and Domain Therapeutics NA Inc., Montreal, Quebec, Canada (A.M., B.B.)., Swanson N; Molecular and Cellular Pharmacology, Janssen Research & Development, LLC, La Jolla, California (M.-L.R., N.S.); Cardiovascular and Metabolism (B.R., S.Z., J.Q., I.B., S.P.L., M.R.P., A.P.), and Computational Chemistry (E.A.), Janssen Research & Development, LLC, Spring House, Pennsylvania; and Domain Therapeutics NA Inc., Montreal, Quebec, Canada (A.M., B.B.)., Zhao S; Molecular and Cellular Pharmacology, Janssen Research & Development, LLC, La Jolla, California (M.-L.R., N.S.); Cardiovascular and Metabolism (B.R., S.Z., J.Q., I.B., S.P.L., M.R.P., A.P.), and Computational Chemistry (E.A.), Janssen Research & Development, LLC, Spring House, Pennsylvania; and Domain Therapeutics NA Inc., Montreal, Quebec, Canada (A.M., B.B.)., Qi J; Molecular and Cellular Pharmacology, Janssen Research & Development, LLC, La Jolla, California (M.-L.R., N.S.); Cardiovascular and Metabolism (B.R., S.Z., J.Q., I.B., S.P.L., M.R.P., A.P.), and Computational Chemistry (E.A.), Janssen Research & Development, LLC, Spring House, Pennsylvania; and Domain Therapeutics NA Inc., Montreal, Quebec, Canada (A.M., B.B.)., Arnoult E; Molecular and Cellular Pharmacology, Janssen Research & Development, LLC, La Jolla, California (M.-L.R., N.S.); Cardiovascular and Metabolism (B.R., S.Z., J.Q., I.B., S.P.L., M.R.P., A.P.), and Computational Chemistry (E.A.), Janssen Research & Development, LLC, Spring House, Pennsylvania; and Domain Therapeutics NA Inc., Montreal, Quebec, Canada (A.M., B.B.)., Bakaj I; Molecular and Cellular Pharmacology, Janssen Research & Development, LLC, La Jolla, California (M.-L.R., N.S.); Cardiovascular and Metabolism (B.R., S.Z., J.Q., I.B., S.P.L., M.R.P., A.P.), and Computational Chemistry (E.A.), Janssen Research & Development, LLC, Spring House, Pennsylvania; and Domain Therapeutics NA Inc., Montreal, Quebec, Canada (A.M., B.B.)., Mancini A; Molecular and Cellular Pharmacology, Janssen Research & Development, LLC, La Jolla, California (M.-L.R., N.S.); Cardiovascular and Metabolism (B.R., S.Z., J.Q., I.B., S.P.L., M.R.P., A.P.), and Computational Chemistry (E.A.), Janssen Research & Development, LLC, Spring House, Pennsylvania; and Domain Therapeutics NA Inc., Montreal, Quebec, Canada (A.M., B.B.)., Breton B; Molecular and Cellular Pharmacology, Janssen Research & Development, LLC, La Jolla, California (M.-L.R., N.S.); Cardiovascular and Metabolism (B.R., S.Z., J.Q., I.B., S.P.L., M.R.P., A.P.), and Computational Chemistry (E.A.), Janssen Research & Development, LLC, Spring House, Pennsylvania; and Domain Therapeutics NA Inc., Montreal, Quebec, Canada (A.M., B.B.)., Lee SP; Molecular and Cellular Pharmacology, Janssen Research & Development, LLC, La Jolla, California (M.-L.R., N.S.); Cardiovascular and Metabolism (B.R., S.Z., J.Q., I.B., S.P.L., M.R.P., A.P.), and Computational Chemistry (E.A.), Janssen Research & Development, LLC, Spring House, Pennsylvania; and Domain Therapeutics NA Inc., Montreal, Quebec, Canada (A.M., B.B.)., Player MR; Molecular and Cellular Pharmacology, Janssen Research & Development, LLC, La Jolla, California (M.-L.R., N.S.); Cardiovascular and Metabolism (B.R., S.Z., J.Q., I.B., S.P.L., M.R.P., A.P.), and Computational Chemistry (E.A.), Janssen Research & Development, LLC, Spring House, Pennsylvania; and Domain Therapeutics NA Inc., Montreal, Quebec, Canada (A.M., B.B.)., Pocai A; Molecular and Cellular Pharmacology, Janssen Research & Development, LLC, La Jolla, California (M.-L.R., N.S.); Cardiovascular and Metabolism (B.R., S.Z., J.Q., I.B., S.P.L., M.R.P., A.P.), and Computational Chemistry (E.A.), Janssen Research & Development, LLC, Spring House, Pennsylvania; and Domain Therapeutics NA Inc., Montreal, Quebec, Canada (A.M., B.B.).

المصدر: Molecular pharmacology [Mol Pharmacol] 2018 Jun; Vol. 93 (6), pp. 581-591. Date of Electronic Publication: 2018 Mar 23.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0035623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0111 (Electronic) Linking ISSN: 0026895X NLM ISO Abbreviation: Mol Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: GTP-Binding Protein alpha Subunits, G12-G13/*metabolism , Glucose/*metabolism , Insulin/*metabolism , Insulin Secretion/*physiology , Islets of Langerhans/*metabolism , Receptors, G-Protein-Coupled/*metabolism, Animals ; Benzofurans/pharmacology ; CHO Cells ; Cell Line ; Cricetulus ; HEK293 Cells ; Humans ; Hypoglycemic Agents/pharmacology ; Insulin Secretion/drug effects ; Islets of Langerhans/drug effects ; Protein Kinase C/metabolism ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Sulfones/pharmacology

المؤلفون: Rives ML; Molecular and Cellular Pharmacology, Discovery Sciences, Janssen R&D, San Diego, CA 92121, United States., Javitch JA; Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, United States; Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, United States., Wickenden AD; Molecular and Cellular Pharmacology, Discovery Sciences, Janssen R&D, San Diego, CA 92121, United States. Electronic address: awickend@its.jnj.com.

المصدر: Biochemical pharmacology [Biochem Pharmacol] 2017 Jul 01; Vol. 135, pp. 1-11. Date of Electronic Publication: 2017 Feb 16.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery/*methods , Membrane Transport Proteins/*metabolism , Solute Carrier Proteins/*metabolism, Animals ; Biological Transport/drug effects ; Biological Transport/physiology ; Cell Membrane/drug effects ; Cell Membrane/metabolism ; Drug Discovery/trends ; Humans ; Membrane Transport Proteins/chemistry ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Protein Transport/drug effects ; Protein Transport/physiology ; Selective Serotonin Reuptake Inhibitors/metabolism ; Selective Serotonin Reuptake Inhibitors/pharmacology ; Solute Carrier Proteins/chemistry

المؤلفون: Rives ML; Molecular and Cellular Pharmacology, Discovery Sciences, Janssen R&D, LLC., San Diego, California (M.-L.R., M.S., A.D.W.) and Cardiovascular and Metabolism Discovery, Janssen R&D, LLC., Springhouse, Pennsylvania, (B.Z., S.A.H.)., Shaw M; Molecular and Cellular Pharmacology, Discovery Sciences, Janssen R&D, LLC., San Diego, California (M.-L.R., M.S., A.D.W.) and Cardiovascular and Metabolism Discovery, Janssen R&D, LLC., Springhouse, Pennsylvania, (B.Z., S.A.H.)., Zhu B; Molecular and Cellular Pharmacology, Discovery Sciences, Janssen R&D, LLC., San Diego, California (M.-L.R., M.S., A.D.W.) and Cardiovascular and Metabolism Discovery, Janssen R&D, LLC., Springhouse, Pennsylvania, (B.Z., S.A.H.)., Hinke SA; Molecular and Cellular Pharmacology, Discovery Sciences, Janssen R&D, LLC., San Diego, California (M.-L.R., M.S., A.D.W.) and Cardiovascular and Metabolism Discovery, Janssen R&D, LLC., Springhouse, Pennsylvania, (B.Z., S.A.H.)., Wickenden AD; Molecular and Cellular Pharmacology, Discovery Sciences, Janssen R&D, LLC., San Diego, California (M.-L.R., M.S., A.D.W.) and Cardiovascular and Metabolism Discovery, Janssen R&D, LLC., Springhouse, Pennsylvania, (B.Z., S.A.H.) awickend@its.jnj.com.

المصدر: Molecular pharmacology [Mol Pharmacol] 2016 Dec; Vol. 90 (6), pp. 766-774. Date of Electronic Publication: 2016 Oct 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0035623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0111 (Electronic) Linking ISSN: 0026895X NLM ISO Abbreviation: Mol Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Malates/*pharmacology , Phenylbutyrates/*pharmacology , Pyridines/*pharmacology , Succinates/*pharmacology , Symporters/*antagonists & inhibitors, Allosteric Regulation/drug effects ; Carbon Radioisotopes ; Citric Acid/metabolism ; HEK293 Cells ; Humans ; Ion Channel Gating/drug effects ; Malates/chemistry ; Models, Biological ; Patch-Clamp Techniques ; Phenylbutyrates/chemistry ; Pyridines/chemistry ; Substrate Specificity/drug effects ; Succinates/chemistry ; Symporters/metabolism