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المؤلفون: Barrett TD, Lagaud G, Wagaman P, Freedman JM, Yan W, Andries L, Rizzolio MC, Morton MF, Shankley NP, Barrett, T D, Lagaud, G, Wagaman, P, Freedman, J M, Yan, W, Andries, L, Rizzolio, M C, Morton, M F, Shankley, N P

المصدر: British Journal of Pharmacology; Jul2012, Vol. 166 Issue 5, p1684-1693, 10p

المؤلفون: Barrett, TD, Lagaud, G, Wagaman, P, Freedman, JM, Yan, W, Andries, L, Rizzolio, MC, Morton, MF, Shankley, NP

المصدر: British Journal of Pharmacology; Jul2012, Vol. 166 Issue 5, p1684-1693, 10p

مصطلحات موضوعية: CHOLECYSTOKININ receptors, GASTRIC acid, OMEPRAZOLE, LABORATORY rats, GASTROESOPHAGEAL reflux treatment, PARIETAL cells, GASTRIN, PROTON pump inhibitors

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المؤلفون: Leonard KA; Janssen Research and Development, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Madge LA; Janssen Research and Development, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Krawczuk PJ; Janssen Research and Development, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Wang A; Janssen Research and Development, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Kreutter KD; Janssen Research and Development, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Bacani GM; Janssen Research and Development, 3210 Merryfield Row, San Diego, California 92121, United States., Chai W; Janssen Research and Development, 3210 Merryfield Row, San Diego, California 92121, United States., Smith RC; Janssen Research and Development, 3210 Merryfield Row, San Diego, California 92121, United States., Tichenor MS; Janssen Research and Development, 3210 Merryfield Row, San Diego, California 92121, United States., Harris MC; Janssen Research and Development, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Malaviya R; Janssen Research and Development, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Seierstad M; Janssen Research and Development, 3210 Merryfield Row, San Diego, California 92121, United States., Johnson ME; Janssen Research and Development, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Venable JD; Janssen Research and Development, 3210 Merryfield Row, San Diego, California 92121, United States., Kim S; Janssen Research and Development, 3210 Merryfield Row, San Diego, California 92121, United States., Hirst GC; Janssen Research and Development, 3210 Merryfield Row, San Diego, California 92121, United States., Mathur AS; Janssen Research and Development, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Rao TS; Janssen Research and Development, 3210 Merryfield Row, San Diego, California 92121, United States., Edwards JP; Janssen Research and Development, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Rizzolio MC; Janssen Research and Development, 3210 Merryfield Row, San Diego, California 92121, United States., Koudriakova T; Janssen Research and Development, 3210 Merryfield Row, San Diego, California 92121, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2020 Mar 26; Vol. 63 (6), pp. 2915-2929. Date of Electronic Publication: 2020 Mar 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Inflammatory Bowel Diseases/*drug therapy , Janus Kinase Inhibitors/*pharmacokinetics , Janus Kinase Inhibitors/*pharmacology , Pyridines/*pharmacokinetics , Pyridines/*pharmacology, Administration, Oral ; Animals ; Dogs ; Drug Discovery ; Female ; Humans ; Inflammatory Bowel Diseases/metabolism ; Janus Kinase Inhibitors/administration & dosage ; Janus Kinase Inhibitors/chemistry ; Janus Kinases/antagonists & inhibitors ; Janus Kinases/metabolism ; Madin Darby Canine Kidney Cells ; Mice ; Mice, Inbred C57BL ; Permeability ; Phosphorylation/drug effects ; Pyridines/administration & dosage ; Pyridines/chemistry

المؤلفون: Morton MF; Johnson & Johnson Pharmaceutical Research & Development, LLC San Diego, California 92101, USA., Barrett TD, Freedman J, Li L, Rizzolio MC, Prendergast CE, Wu X, Moreno V, Pyati J, Figueroa K, Cagnon L, Lagaud G, Ver Donck L, Ghoos E, Allison B, Rabinowitz MH, Shankley NP

المصدر: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2011 Jul; Vol. 338 (1), pp. 328-36. Date of Electronic Publication: 2011 Apr 14.

نوع المنشور: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE

مواضيع طبية MeSH: Benzodiazepinones/*administration & dosage , Benzodiazepinones/*metabolism , Phenylurea Compounds/*administration & dosage , Phenylurea Compounds/*metabolism , Quinoxalines/*administration & dosage , Receptor, Cholecystokinin B/*antagonists & inhibitors , Receptor, Cholecystokinin B/*metabolism , Sulfonamides/*administration & dosage, Administration, Oral ; Animals ; Benzodiazepinones/chemistry ; Biological Availability ; CHO Cells ; Caco-2 Cells ; Cricetinae ; Cricetulus ; Dogs ; Dose-Response Relationship, Drug ; Female ; Guinea Pigs ; Humans ; Male ; Mice ; Phenylurea Compounds/chemistry ; Quinoxalines/chemistry ; Quinoxalines/metabolism ; Rats ; Rats, Sprague-Dawley ; Species Specificity ; Sulfonamides/chemistry ; Sulfonamides/metabolism

المؤلفون: Barrett TD; Cardiovascular Metabolic Research, Johnson and Johnson Pharmaceutical Research and Development LLC, 3210 Merryfield Row, San Diego, CA 92121, USA. tbarret1@its.jnj.com, Palomino HL, Brondstetter TI, Kanelakis KC, Wu X, Haug PV, Yan W, Young A, Hua H, Hart JC, Tran DT, Venkatesan H, Rosen MD, Peltier HM, Sepassi K, Rizzolio MC, Bembenek SD, Mirzadegan T, Rabinowitz MH, Shankley NP

المصدر: Molecular pharmacology [Mol Pharmacol] 2011 Jun; Vol. 79 (6), pp. 910-20. Date of Electronic Publication: 2011 Mar 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0035623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0111 (Electronic) Linking ISSN: 0026895X NLM ISO Abbreviation: Mol Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Benzimidazoles/*pharmacology , Enzyme Inhibitors/*pharmacology , Hypoxia-Inducible Factor 1, alpha Subunit/*antagonists & inhibitors , Procollagen-Proline Dioxygenase/*antagonists & inhibitors , Pyrazoles/*pharmacology, Amino Acid Sequence ; Animals ; Cell Line, Tumor ; Female ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Mice ; Molecular Sequence Data ; Procollagen-Proline Dioxygenase/chemistry ; Procollagen-Proline Dioxygenase/metabolism ; Protein Binding ; Rats ; Rats, Inbred Lew

المؤلفون: Kanelakis KC; Department of Drug Discovery, Johnson & Johnson Pharmaceutical Research & Development L.L.C., San Diego, California, USA. kkanelak@its.jnj.com, Palomino HL, Li L, Wu J, Yan W, Rosen MD, Rizzolio MC, Trivedi M, Morton MF, Yang Y, Venkatesan H, Rabinowitz MH, Shankley NP, Barrett TD

المصدر: Journal of biomolecular screening [J Biomol Screen] 2009 Jul; Vol. 14 (6), pp. 627-35. Date of Electronic Publication: 2009 Jun 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Sage Publications Country of Publication: United States NLM ID: 9612112 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1087-0571 (Print) Linking ISSN: 10870571 NLM ISO Abbreviation: J Biomol Screen Subsets: MEDLINE

مواضيع طبية MeSH: Biological Assay/*methods , Enzyme Inhibitors/*analysis , Enzyme Inhibitors/*pharmacology , Ketoglutaric Acids/*metabolism , Procollagen-Proline Dioxygenase/*antagonists & inhibitors, Chemical Precipitation ; Chromatography, Ion Exchange ; Humans ; Hydrazines/metabolism ; Hydroxylation/drug effects ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Hypoxia-Inducible Factor-Proline Dioxygenases ; Ketoglutaric Acids/chemistry ; Ketoglutaric Acids/isolation & purification ; Kinetics ; Peptides/metabolism ; Repressor Proteins/metabolism ; Substrate Specificity/drug effects ; Succinic Acid/chemistry ; Succinic Acid/isolation & purification ; Titrimetry

المؤلفون: Allison BD; Johnson and Johnson Pharmaceutical Research and Development, LLC, 3210 Merryfield Row, San Diego, California 92121, USA., Phuong VK, McAtee LC, Rosen M, Morton M, Prendergast C, Barrett T, Lagaud G, Freedman J, Li L, Wu X, Venkatesan H, Pippel M, Woods C, Rizzolio MC, Hack M, Hoey K, Deng X, King C, Shankley NP, Rabinowitz MH

المصدر: Journal of medicinal chemistry [J Med Chem] 2006 Oct 19; Vol. 49 (21), pp. 6371-90.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Morpholines/*chemical synthesis , Quinoxalines/*chemical synthesis , Receptor, Cholecystokinin B/*antagonists & inhibitors , Sulfonamides/*chemical synthesis , ortho-Aminobenzoates/*chemical synthesis, Animals ; Binding, Competitive ; Biological Availability ; Dogs ; Drug Stability ; Gallbladder/drug effects ; Gallbladder/physiology ; Gastric Acid/metabolism ; Guinea Pigs ; Humans ; In Vitro Techniques ; Male ; Microsomes, Liver/metabolism ; Morpholines/chemistry ; Morpholines/pharmacology ; Muscle Contraction ; Muscle, Smooth/drug effects ; Muscle, Smooth/physiology ; Quinoxalines/chemistry ; Quinoxalines/pharmacology ; Radioligand Assay ; Rats ; Rats, Sprague-Dawley ; Receptor, Cholecystokinin A/antagonists & inhibitors ; Stereoisomerism ; Stomach/drug effects ; Stomach/physiology ; Structure-Activity Relationship ; Sulfonamides/chemistry ; Sulfonamides/pharmacology ; ortho-Aminobenzoates/chemistry ; ortho-Aminobenzoates/pharmacology