نتائج البحث - "Rob Roovers"

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686 Mechanism of action of LAVA-051, a bispecific Vγ9Vδ2 T-cell engager (bsTCE), confirmed in the clinical setting

المؤلفون: Roeland Lameris, Jurjen Ruben, Rob Roovers, Arnon Kater, Thilo Riedl, Victoria Iglesias, Annemiek Broijl, Ilse Tuinhof, Sanjana Umarale, Anton Adang, Tanja de Gruijl, Paul Parren, Benjamin Winograd, Hans Van der Vliet

المصدر: Regular and Young Investigator Award Abstracts.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::83456939e62d3bb10a33762661955d5d
https://doi.org/10.1136/jitc-2022-sitc2022.0686

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MCLA-117, a CLEC12AxCD3 bispecific antibody targeting a leukaemic stem cell antigen, induces T cell-mediated AML blast lysis

المؤلفون: Harry Dolstra, Andres Sirulnik, Rob Roovers, Alexander Berthold Hendrik Bakker, Linda Johanna Aleida Hendriks, Arjen Kramer, M. Leenders, Mark Throsby, Pieter Fokko Van Loo, Basav N. Hangalapura, John de Kruif, Henrike Veninga, Soley Thordardottir, Robert Doornbos, Ton Logtenberg, John D Gibbins

المصدر: Expert Opinion on Biological Therapy, 19, 721-733
Expert Opinion on Biological Therapy, 19(7), 721. Informa Healthcare
Expert Opinion on Biological Therapy, 19, 7, pp. 721-733

مصطلحات موضوعية: 0301 basic medicine, CD4-Positive T-Lymphocytes, Lysis, T cell engager, CD3 Complex, Cancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2], CD3, T cell, T-Lymphocytes, Cell, Clinical Biochemistry, T cells, HL-60 Cells, CD8-Positive T-Lymphocytes, Lymphocyte Activation, 03 medical and health sciences, Mice, All institutes and research themes of the Radboud University Medical Center, 0302 clinical medicine, Antigen, AML, hemic and lymphatic diseases, Antibodies, Bispecific, Drug Discovery, medicine, Animals, Humans, Lectins, C-Type, Cell Proliferation, CLEC12A, Pharmacology, biology, Chemistry, Drug discovery, Mice, Inbred C57BL, Leukemia, Myeloid, Acute, bispecific antibody, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Receptors, Mitogen, biology.protein, Cancer research, Cytokines, Stem cell, Antibody, Half-Life

وصف الملف: image/pdf; application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90820939a92daf92169026666cef0b2b
https://dspace.library.uu.nl/handle/1874/390555

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A 3D image-based phenotypic screen of bi-specific antibodies targeting stem cells in a panel of patient derived colon carcinoma organoids

المؤلفون: Bram Herpers, B. Ebbink, M.D. van de Wetering, Mark Throsby, Rob Roovers, Kuan Yan, W. De Lau, Leo S. Price, Hans Clevers, Robert R G Vries, Lucia Salinaro

المصدر: European Journal of Cancer. 61:S130-S131

مصطلحات موضوعية: Cancer Research, Specific antibody, Pathology, medicine.medical_specialty, Oncology, Colon carcinoma, 3d image, business.industry, Phenotypic screening, Organoid, Medicine, Stem cell, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::169a8b93a898e798c3695e5a525ac859
https://doi.org/10.1016/s0959-8049(16)61462-4

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Abstract 32: Preclinical evaluation of MCLA-158: A bispecific antibody targeting LGR5 and EGFR using patient-derived colon carcinoma organoids

المصدر: Cancer Research. 77:32-32

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b8a0489206cfa657f3f0b4e95b882eb4
https://doi.org/10.1158/1538-7445.am2017-32

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Abstract PR05: A 3D image-based phenotypic screen of bi-specific antibodies targeting stem cells in a panel of patient derived colon carcinoma organoids

المؤلفون: Berina Eppink, Bram Herpers, Rob Roovers, Robert P. de Vries, Wim de Lau, Lucia Salinaro, Mark Throsby, Leo S. Price, Marc van de Wetering, Hans Clevers, Kuan Yan

المصدر: Clinical Cancer Research. 22:PR05-PR05

مصطلحات موضوعية: Cancer Research, Pathology, medicine.medical_specialty, Colorectal cancer, Phenotypic screening, LGR5, Cancer, Biology, medicine.disease, Phenotype, Oncology, High-content screening, medicine, Organoid, Cancer research, Stem cell

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::797636dac5858f93e3262007e00d983a
https://doi.org/10.1158/1557-3265.pdx16-pr05

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Abstract C21: Generation of Wnt- and mitogenic receptor binding bispecific antibodies to target cancer stem cells

المؤلفون: Wim de Lau, Marc van de Wetering, Berina Eppink, Robert P. de Vries, Abdul Basmeleh, Carina Clements, Leo S. Price, Mark Throsby, Vanessa Zondag-van der Zande, Willem Bartelink, Rob Roovers, John de Kruif, Bram Herpers

المصدر: Molecular Cancer Therapeutics. 14:C21-C21

مصطلحات موضوعية: Cancer Research, Wnt signaling pathway, LGR5, Cancer, Biology, medicine.disease, Molecular biology, Oncology, Growth factor receptor, Antigen, Cancer stem cell, Cancer research, medicine, Erlotinib, Stem cell, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bf07bcfef0ac74f3473eb417286f21c9
https://doi.org/10.1158/1535-7163.targ-15-c21

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Abstract LB-261: Mechanism of action of MCLA-128, a humanized bispecific IgG1 antibody targeting the HER2:HER3 heterodimer

المصدر: Cancer Research. 75:LB-261

مصطلحات موضوعية: Antibody-dependent cell-mediated cytotoxicity, Cancer Research, medicine.drug_class, Cell growth, Biology, Monoclonal antibody, Molecular biology, chemistry.chemical_compound, Oncology, chemistry, medicine, Pertuzumab, Growth inhibition, skin and connective tissue diseases, Protein kinase B, Tyrosine kinase, PI3K/AKT/mTOR pathway, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8e4ddd222a9fec86a3788cee73ea3cb8
https://doi.org/10.1158/1538-7445.am2015-lb-261

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Preclinical activity of MCLA-128, an ADCC enhanced bispecific IgG1 antibody targeting the HER2:HER3 heterodimer

المصدر: Journal of Clinical Oncology. 32:560-560

مصطلحات موضوعية: Antibody-dependent cell-mediated cytotoxicity, Cancer Research, Oncology, Immunology, Antibody targeting, Cancer research, Malignant cells, Biology, skin and connective tissue diseases, neoplasms

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ddf52a08abed45c298121afe95212dea
https://doi.org/10.1200/jco.2014.32.15_suppl.560

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