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المؤلفون: Margaret S. Landis, Robert F. Day, Joseph DiBrino, David A. Griffith, Robert L. Dow, Rebecca E. O’Connor, Philip A. Carpino, Paul DaSilva-Jardine, Shawn C Black, John R. Hadcock, Philip A. Iredale, Dennis O. Scott
المصدر: Journal of Medicinal Chemistry. 52:234-237
مصطلحات موضوعية: Cannabinoid receptor, Stereochemistry, Hydrochloride, medicine.drug_class, Carboxylic acid, medicine.medical_treatment, Pharmacology, Fats, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Piperidines, Receptor, Cannabinoid, CB1, Amide, Drug Discovery, medicine, Animals, Structure–activity relationship, Receptor, chemistry.chemical_classification, Receptor antagonist, chemistry, Purines, Molecular Medicine, lipids (amino acids, peptides, and proteins), Cannabinoid, Energy Metabolism, Oxidation-Reduction
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المؤلفون: Oicheng Ng, Thomas A. Brown, Robert F. Day, Amy Brault, Robert L. Rosati, Bruce Allen Lefker, Pia Perry, Bihong Lu, Thomas A. Owen, Michael P. Zawistoski, Richard Chesworth, Tessa A. Castleberry, Kimberly O. Cameron, Lydia C. Pan, David D. Thompson, Paul DaSilva-Jardine, F.Michael Mangano, Stacy Colella, Donna N. Petersen
المصدر: Bioorganic & Medicinal Chemistry Letters. 14:2729-2733
مصطلحات موضوعية: Selective Estrogen Receptor Modulators, medicine.medical_specialty, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Estrogen receptor, Ligands, Biochemistry, Chemical synthesis, Inhibitory Concentration 50, Structure-Activity Relationship, Cell Line, Tumor, Tetrahydroisoquinolines, Internal medicine, Drug Discovery, medicine, Estrogen Receptor beta, Humans, Molecular Biology, Cell Proliferation, Cell growth, Chemistry, Organic Chemistry, Estrogen Receptor alpha, Subtype selective, In vitro, Endocrinology, Estrogen, Cell culture, Molecular Medicine, Female, Protein Binding
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المؤلفون: Dennis O. Scott, David A. Griffith, Robert F. Day, Zhuang Miao, Chandra Prakash
المصدر: Drug metabolism and disposition: the biological fate of chemicals. 39(12)
مصطلحات موضوعية: Male, medicine.medical_specialty, Metabolite, medicine.medical_treatment, Pharmaceutical Science, Administration, Oral, Mice, Transgenic, Biology, Pharmacology, Excretion, Rats, Sprague-Dawley, chemistry.chemical_compound, Feces, Mice, Dogs, Pharmacokinetics, Piperidines, Receptor, Cannabinoid, CB1, Oral administration, Tandem Mass Spectrometry, Internal medicine, medicine, Animals, Chromatography, High Pressure Liquid, Antagonist, Metabolism, Rats, Endocrinology, chemistry, Purines, Cannabinoid receptor antagonist, Female, Cannabinoid
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4704d8b2a8e8d0c2759c7ce00e1077e2
https://pubmed.ncbi.nlm.nih.gov/21875952 -
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المؤلفون: Tristan S. Maurer, Kelly A. Martin, Robert F. Day, Jennifer Lafontaine, Diane M. Hargrove, John R. Hadcock, David A. Tess, Nancy A. Nardone, Paul DaSilva-Jardine, Joe Dibrino, Michael C. Linhares
المصدر: Bioorganicmedicinal chemistry letters. 17(18)
مصطلحات موضوعية: Agonist, medicine.medical_specialty, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Biological Availability, Adrenergic beta-3 Receptor Agonists, Biochemistry, Pharmacokinetics, In vivo, Internal medicine, Drug Discovery, medicine, Functional selectivity, Animals, Obesity, Receptor, Beta (finance), Molecular Biology, Chemistry, Organic Chemistry, Biological activity, Adrenergic beta-Agonists, In vitro, Rats, Endocrinology, Molecular Medicine
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المؤلفون: Karen M. Ward, Mary Butler, Denise Gautreau, Subas M. Sakya, Joseph DiBrino, Jeff S. Lizano, Colin R. Rose, David A. Griffith, Shawn C Black, John R. Hadcock, Darrin Dutcher, Rebecca E. O’Connor, Dawn Kelly-Sullivan, Philip A. Iredale, Dennis O. Scott, Demetria B. DeBartolo, Philip A. Carpino, Michael Fichtner, Robert L. Dow, Michelle A. Sands, Robert F. Day
المصدر: Bioorganicmedicinal chemistry letters. 16(3)
مصطلحات موضوعية: Cannabinoid receptor, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Rodentia, Pyrimidinones, Biochemistry, Chemical synthesis, Models, Biological, Pyrazolopyrimidine, chemistry.chemical_compound, Structure-Activity Relationship, Piperidines, Receptor, Cannabinoid, CB1, Drug Discovery, Pyrazolopyridine, Structure–activity relationship, Inverse agonist, Animals, Pyrazolones, Molecular Biology, Analgesics, Binding Sites, Bicyclic molecule, Chemistry, Organic Chemistry, Feeding Behavior, Bridged Bicyclo Compounds, Heterocyclic, Molecular Medicine, Cannabinoid receptor antagonist, Pyrazoles, Rimonabant