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1
المؤلفون: Robert Francis Kester, Linda Marcus, Marek M. Kabat, Lida Qi, Wang Ka, Michael Pignatello, Wendy Lea Corbett, Cheryl Spence, Franz M. Matschinsky, Lisa M. Garofalo, Roumen Nikolaev Radinov, Ramakanth Sarabu, David J Moore, Yi Ren, Nancy-Ellen Haynes, Zhenmin Liang, Fred Thomas Bizzarro, Darryl W. Hilliard, John Tengi, Wanping Geng, Stanley D. Hutchings, Thomas G. Steele, Joseph Grimsby, Mark T. Dvorozniak, Joseph F. Grippo, Kevin Richard Guertin, Paige Erin Mahaney, Jagdish Kumar Racha
المصدر: Journal of Medicinal Chemistry. 55:7021-7036
مصطلحات موضوعية: Male, medicine.medical_specialty, Metabolite, medicine.medical_treatment, Benzeneacetamides, Enzyme Activators, Type 2 diabetes, Lipidoses, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, In vivo, Internal medicine, Glucokinase, Drug Discovery, medicine, Animals, Humans, Hypoglycemic Agents, Rats, Wistar, Thiazole, Insulin, Stereoisomerism, Postprandial Period, medicine.disease, Rats, Mice, Inbred C57BL, Macaca fascicularis, Glucose, Endocrinology, Postprandial, Diabetes Mellitus, Type 2, Liver, chemistry, Toxicity, Molecular Medicine, Female, Rabbits
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2
المؤلفون: Ramakanth Sarabu, Jianping Lou, Achyutharao Sidduri, David J Moore, Jagdish Kumar Racha, Joseph Grimsby, Wendy Lea Corbett, Cheryl Spence, Robert Francis Kester, Linda Marcus, Mark T. Dvorozniak, Joseph F. Grippo
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:5673-5676
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Benzeneacetamides, Pharmaceutical Science, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Glucokinase, Drug Discovery, Glucokinase activator, Animals, Hypoglycemic Agents, Sulfones, Rats, Wistar, Molecular Biology, Alkyl, chemistry.chemical_classification, Acrylamides, Chemistry, Organic Chemistry, In vitro, Rats, Enzyme, Acrylamide, Molecular Medicine
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3
المؤلفون: Joseph Grimsby, Robert Francis Kester, Aruna Railkar, Cheryl Spence, Nancy-Ellen Haynes, Kevin Richard Guertin, Paige Erin Mahaney, Lida Qi, John Tengi, Wendy Lea Corbett, Fred Thomas Bizzarro, Mark T. Dvorozniak, George W. Holland, Joseph F. Grippo, Franz M. Matschinsky, Darryl W. Hilliard, Ramakanth Sarabu
المصدر: Journal of Medicinal Chemistry. 53:3618-3625
مصطلحات موضوعية: Blood Glucose, Male, medicine.medical_treatment, Allosteric regulation, Carbohydrate metabolism, Cell Line, Mice, Structure-Activity Relationship, Pharmacokinetics, Glucokinase, Drug Discovery, medicine, Animals, Humans, Hypoglycemic Agents, Insulin, Structure–activity relationship, Glucose homeostasis, Sulfones, Dose-Response Relationship, Drug, Cytotoxins, Chemistry, Drug discovery, Thiazoles, Diabetes Mellitus, Type 2, Biochemistry, Molecular Medicine
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4
المصدر: Expert Opinion on Therapeutic Patents. 18:759-768
مصطلحات موضوعية: Pharmacology, medicine.medical_specialty, Chemistry, Glucokinase, General Medicine, Type 2 diabetes, medicine.disease, Small molecule, PIRAGLIATIN, Endocrinology, Internal medicine, Drug Discovery, medicine, Glucokinase activator
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5
المؤلفون: Cheryl Janson, Martin Weisel, Barry Goggin, Liang Weiling, Adrian J. Fretland, Robert Francis Kester, Christine Lukacs, Edmund Lee, Jennifer Lo, J. Heather Hogg, Xiaochun Han, Kyoungja Hong, Stacy Remiszewski, Shirley Li, Ann Polonskaia, John Anthony Moliterni, Kang Le, Lin Gao, Nam T. Le, Christophe Michoud, A. Schutt, Shahid Tannu, Andrew F. Donnell, Shaoqing Chen, Louis J. Lombardo, Steven Gregory Mischke, Mark T. Dvorozniak, Yan Lou, Christine Tardell, Kenneth Carey Rupert, Doug Aguilar, Dave S. Solis
المصدر: Journal of medicinal chemistry. 56(20)
مصطلحات موضوعية: Models, Molecular, Cell Survival, Ubiquitin-Protein Ligases, Blotting, Western, Mice, Nude, Apoptosis, X-Linked Inhibitor of Apoptosis Protein, Inhibitor of apoptosis, Crystallography, X-Ray, Inhibitor of Apoptosis Proteins, Mice, Heterocyclic Compounds, Cell Line, Tumor, Drug Discovery, Animals, Humans, Caspase, Caspase-9, Caspase 7, Benzodiazepinones, Alanine, biology, Molecular Structure, Chemistry, Caspase 3, Xenograft Model Antitumor Assays, In vitro, Cell biology, XIAP, Protein Structure, Tertiary, Models, Chemical, Cell culture, Cancer cell, biology.protein, Molecular Medicine, Female
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6
المؤلفون: Kang Le, Christophe Michoud, Robert T. Taylor, Christine Lukacs, Andrew D. Schutt, Lin Gao, Anthony Specian, Kenneth Carey Rupert, Stacy Remiszewski, Ann Polonskaia, Douglas Aguilar, Barry Goggin, John Anthony Moliterni, J. Heather Hogg, Liang Weiling, Xiaochun Han, Cheryl Janson, Louis J. Lombardo, Martin Weisel, Adrian J. Fretland, Steven Gregory Mischke, Norman Kong, Shirley Li, Robert Francis Kester, Andrew F. Donnell, Kyoungja Hong, Dave S. Solis, Karl Frank, Yan Lou
المصدر: Journal of medicinal chemistry. 56(20)
مصطلحات موضوعية: Models, Molecular, Cell Survival, Ubiquitin-Protein Ligases, Blotting, Western, Regulator, Mice, Nude, Apoptosis, X-Linked Inhibitor of Apoptosis Protein, Inhibitor of apoptosis, Crystallography, X-Ray, Inhibitor of Apoptosis Proteins, Mice, In vivo, Heterocyclic Compounds, Cell Line, Tumor, Drug Discovery, Animals, Humans, Caspase, Caspase 7, Alanine, biology, Molecular Structure, Chemistry, Caspase 3, Antibodies, Monoclonal, Xenograft Model Antitumor Assays, Cell biology, XIAP, Protein Structure, Tertiary, Rats, Oxazepines, Models, Chemical, Cell culture, Cancer cell, biology.protein, Molecular Medicine, Female
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7
المؤلفون: Joseph Grimsby, Wanping Geng, Navita L. Mallalieu, Mark T. Dvorozniak, Wendy Lea Corbett, Nancy-Ellen Haynes, Jagdish Kumar Racha, Yimin Qian, David J Moore, Kevin Richard Guertin, Nathan Robert Scott, Robert Francis Kester, Steven Joseph Berthel, Roumen Nikolaev Radinov, Francis A. Mennona, Ramakanth Sarabu, Duk Soon Choi, Paul Gillespie
المصدر: ACS medicinal chemistry letters. 4(4)
مصطلحات موضوعية: Drug, Ligand efficiency, Safety studies, business.industry, media_common.quotation_subject, Metabolite, Organic Chemistry, Metabolism, Type 2 diabetes, Pharmacology, medicine.disease, Biochemistry, chemistry.chemical_compound, chemistry, Drug Discovery, Glucokinase activator, Medicine, business, Redox cycling, media_common
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8
المصدر: Expert opinion on therapeutic patents. 21(1)
مصطلحات موضوعية: Blood Glucose, medicine.medical_specialty, Drug Industry, Type 2 diabetes, Pharmacology, Patents as Topic, Diabetes mellitus, Internal medicine, Drug Discovery, Glucokinase, medicine, Glucose homeostasis, Animals, Humans, Hypoglycemic Agents, Glucose lowering, Activator (genetics), Chemistry, General Medicine, Plasma glucose concentration, medicine.disease, Enzyme Activation, medicine.anatomical_structure, Endocrinology, Diabetes Mellitus, Type 2, Drug Design, Pancreas
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9
المصدر: Topics in Heterocyclic Chemistry ISBN: 9783642157325
مصطلحات موضوعية: Indole test, Chemistry, Organic chemistry, Cycloaddition, Diels–Alder reaction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bd339739080e5df30acd4182c366a670
https://doi.org/10.1007/7081_2010_55 -
10
المصدر: Topics in Heterocyclic Chemistry ISBN: 9783642157325
مصطلحات موضوعية: Indole test, medicine.anatomical_structure, Stereochemistry, Chemistry, medicine, Nucleus, Cycloaddition
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::afc7bd1f0b59c6577c105316a1ed14f6
https://doi.org/10.1007/7081_2010_53