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المؤلفون: Jitender D. Gaddameedi, Tristan Chou, Benjamin S. Geller, Amithvikram Rangarajan, Tarun A. Swaminathan, Danielle Dixon, Katherine Long, Caiden J. Golder, Van A. Vuong, Selene Banuelos, Robert Greenhouse, Michael P. Snyder, Andrew M. Lipchik, Joshua J. Gruber
المصدر: Journal of Medicinal Chemistry. 66:5774-5801
مصطلحات موضوعية: Drug Discovery, Molecular Medicine
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المؤلفون: Rangarajan A, Selene Banuelos, Lipchik Am, Snyder M, Joshua J. Gruber, Geller Bs, Robert Greenhouse, Tom Chou
مصطلحات موضوعية: Histone H3, Enzyme complex, Histone, biology, Chemistry, Acetylation, biology.protein, Histone acetyltransferase, HAT1, Small molecule, Chromatin, Cell biology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3926e86a5deb4df579c94d3dfc471610
https://doi.org/10.1101/2021.06.25.449993 -
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المؤلفون: Mary O'Sullivan, Yohan Song, Zehra Siddiqui, Dennis Lagasca, Adela Perez, Jacob P MacDonald, Randy Lin, Kate Comstock, Alan G. Cheng, Robert Greenhouse, Markus E. Huth, Anthony J. Ricci, Patrick J. Atkinson
المصدر: Proc Natl Acad Sci U S A
مصطلحات موضوعية: 0301 basic medicine, Drug, medicine.drug_class, media_common.quotation_subject, Antibiotics, Microbial Sensitivity Tests, Pharmacology, Mechanotransduction, Cellular, Ion Channels, Rats, Sprague-Dawley, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, Ototoxicity, Hair Cells, Auditory, medicine, Animals, 610 Medicine & health, media_common, Multidisciplinary, Chemistry, Aminoglycoside, Correction, Biological Sciences, Antimicrobial, medicine.disease, Hospitals, Anti-Bacterial Agents, Cochlea, 030104 developmental biology, medicine.anatomical_structure, Toxicity, Sisomicin, Gentamicin, Hair cell, Gentamicins, Drug Contamination, 030217 neurology & neurosurgery, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6703f3cd38fc2a7d95ddd214cdb60139
https://pubmed.ncbi.nlm.nih.gov/34493689 -
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المؤلفون: Frédéric Poitevin, Matthew Seaberg, Yashas Rao, Nicholas C. Corsepius, Alex McGurk, Robert Greenhouse, Mengling Liang, Cornelius Gati, Trevor Obrinsky, Hasan DeMirci, Raymond G. Sierra, Fátima Pardo-Avila, Mary O'Sullivan, Paul Mbgam, Fulya Aksit, Mark S. Hunter, Alan G. Cheng, Halil I. Ciftci, Brandon Hayes, E. Han Dao, Anthony J. Ricci
المصدر: Nucleic Acids Research
مصطلحات موضوعية: 0301 basic medicine, Protein subunit, Biology, Tetraloop, Ribosome, 03 medical and health sciences, 0302 clinical medicine, Structural Biology, Escherichia coli, Genetics, medicine, Humans, 30S, Binding site, 030304 developmental biology, Protein Synthesis Inhibitors, 0303 health sciences, Binding Sites, Chemistry, Aminoglycoside, Hexosamines, Ribosomal RNA, Anti-Bacterial Agents, Aminoglycosides, 030104 developmental biology, RNA, Ribosomal, Protein Biosynthesis, Sisomicin, Streptomycin, Biophysics, Nucleic Acid Conformation, Ribosomes, 030217 neurology & neurosurgery, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97bc81b758763489bb6f8c421296d435
https://doi.org/10.1101/372144 -
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المؤلفون: Andrea Stojakovic, Sergey Trushin, Benjamin Gateno, Liang Zhang, Kevin Greenman, Olga Isaakova, Eugenia Trushina, William Guilford, Robert Greenhouse
المصدر: Alzheimer's & Dementia. 14
مصطلحات موضوعية: Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, business.industry, Health Policy, Cancer research, Medicine, Neurology (clinical), Disease, Geriatrics and Gerontology, business, Mitochondrial Complex I
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المؤلفون: Robert Greenhouse, Hai-Ying Cai, Ryan Craig Schoenfeld, David S. Carter, Stephen M. Lynch, Ann Marie Madera, Sandra Steiner, Yansheng Zhai, Eun Kyung Lee, Robert James Weikert, Clara Jeou Jen Lin, Kerem Erol Ozboya, Amy Geraldine Moore, Pravin Iyer, Matthew C. Lucas
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:5559-5566
مصطلحات موضوعية: Serotonin, Pyrrolidines, Dopamine, Clinical Biochemistry, hERG, Pain, Pharmaceutical Science, Antidepressive Agents, Tricyclic, Biochemistry, Norepinephrine, chemistry.chemical_compound, Dopamine Uptake Inhibitors, In vivo, Drug Discovery, medicine, Animals, Humans, Neurotransmitter Uptake Inhibitors, Neurotransmitter, Molecular Biology, biology, Depression, Organic Chemistry, Rats, Monoamine neurotransmitter, chemistry, Drug Design, Catecholamine, biology.protein, Molecular Medicine, Caco-2 Cells, Reuptake inhibitor, Selective Serotonin Reuptake Inhibitors, medicine.drug
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المؤلفون: Kayvon Sotoudeh, Markus E. Huth, Yi-Ju Hsieh, Andrew A. Vu, Robert Greenhouse, Anthony J. Ricci, Thomas Effertz, Alan G. Cheng, Sarah Verhoeven, Kyu-Hee Han, Michael H. Hsieh
المصدر: Huth, Markus; Han, Kyu-Hee; Sotoudeh, Kayvon; Hsieh, Yi-Ju; Effertz, Thomas; Vu, Andrew A; Verhoeven, Sarah; Hsieh, Michael H; Greenhouse, Robert; Cheng, Alan G; Ricci, Anthony J (2015). Designer aminoglycosides prevent cochlear hair cell loss and hearing loss. Journal of clinical investigation, 125(2), pp. 583-592. American Society for Clinical Investigation 10.1172/JCI77424 <http://dx.doi.org/10.1172/JCI77424>
مصطلحات موضوعية: medicine.medical_specialty, Hearing loss, medicine.drug_class, Urinary system, Hearing Loss, Sensorineural, Antibiotics, Drug Evaluation, Preclinical, 610 Medicine & health, Pharmacology, Biology, Rats, Sprague-Dawley, Mice, Ototoxicity, Hair Cells, Auditory, medicine, otorhinolaryngologic diseases, Animals, Humans, Kidney, Bacteria, Aminoglycoside, General Medicine, Bacterial Infections, medicine.disease, Surgery, Anti-Bacterial Agents, Rats, medicine.anatomical_structure, Aminoglycosides, Drug Design, Sisomicin, Hair cell, medicine.symptom, medicine.drug, Research Article
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9b069fcc3a424df3987f56bb512214
https://europepmc.org/articles/PMC4319422/ -
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المؤلفون: Joel R Gever, Fernando Padilla, Saul Jaime-Figueroa, Robert Greenhouse, Michael Patrick Dillon, Anthony P.D.W. Ford
المصدر: Bioorganic & Medicinal Chemistry Letters. 15:3292-3295
مصطلحات موضوعية: Drug, Cell Survival, medicine.drug_class, media_common.quotation_subject, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Ligands, Transfection, Biochemistry, Cell Line, Inhibitory Concentration 50, Structure-Activity Relationship, Drug Discovery, Purinergic P2 Receptor Antagonists, medicine, Animals, Humans, Structure–activity relationship, Selective receptor modulator, Receptor, Molecular Biology, media_common, Chemistry, Organic Chemistry, Purinergic receptor, Antagonist, Biological activity, General Medicine, Subtype selective, Receptor antagonist, Amides, P2 Purinoceptors, Receptors, Purinergic P2X, Molecular Medicine, Calcium
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المؤلفون: Richard M. Eglen, Tess Pulido-Rios, Saul Jaime, Cindy Rocha, Flippin Lee Allen, Mark Dawson, E. Leung, Graeme R. Martin, Robert Greenhouse, Kristine Van Natta, L K Chang, Andrea Webber, Douglas W. Bonhaus
المصدر: British Journal of Pharmacology. 127:1075-1082
مصطلحات موضوعية: Pharmacology, medicine.medical_specialty, RS-127445, Intrinsic activity, medicine.drug_class, Chemistry, Antagonist, Receptor antagonist, 5-HT2B receptor, chemistry.chemical_compound, Endocrinology, Internal medicine, medicine, Receptor, Ion channel binding, 5-HT receptor
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المؤلفون: Francisco Xavier Talamas, Rene Villena, Moises Romero, Robert Greenhouse, Joseph M. Muchowski, Angel Guzman
المصدر: The Journal of Organic Chemistry. 61:2470-2483
مصطلحات موضوعية: Dimethyl acetylenedicarboxylate, Reaction conditions, chemistry.chemical_compound, 1h nmr spectroscopy, Pyrimidine, chemistry, Organic Chemistry, Leaving group, Organic chemistry, Medicinal chemistry, Cycloaddition, Adduct