المؤلفون: Jitender D. Gaddameedi, Tristan Chou, Benjamin S. Geller, Amithvikram Rangarajan, Tarun A. Swaminathan, Danielle Dixon, Katherine Long, Caiden J. Golder, Van A. Vuong, Selene Banuelos, Robert Greenhouse, Michael P. Snyder, Andrew M. Lipchik, Joshua J. Gruber

المصدر: Journal of Medicinal Chemistry. 66:5774-5801

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f9e3f4382327fd01bd7c4a377634370c
https://doi.org/10.1021/acs.jmedchem.3c00039

المؤلفون: Rangarajan A, Selene Banuelos, Lipchik Am, Snyder M, Joshua J. Gruber, Geller Bs, Robert Greenhouse, Tom Chou

مصطلحات موضوعية: Histone H3, Enzyme complex, Histone, biology, Chemistry, Acetylation, biology.protein, Histone acetyltransferase, HAT1, Small molecule, Chromatin, Cell biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3926e86a5deb4df579c94d3dfc471610
https://doi.org/10.1101/2021.06.25.449993

المؤلفون: Mary O'Sullivan, Yohan Song, Zehra Siddiqui, Dennis Lagasca, Adela Perez, Jacob P MacDonald, Randy Lin, Kate Comstock, Alan G. Cheng, Robert Greenhouse, Markus E. Huth, Anthony J. Ricci, Patrick J. Atkinson

المصدر: Proc Natl Acad Sci U S A

مصطلحات موضوعية: 0301 basic medicine, Drug, medicine.drug_class, media_common.quotation_subject, Antibiotics, Microbial Sensitivity Tests, Pharmacology, Mechanotransduction, Cellular, Ion Channels, Rats, Sprague-Dawley, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, Ototoxicity, Hair Cells, Auditory, medicine, Animals, 610 Medicine & health, media_common, Multidisciplinary, Chemistry, Aminoglycoside, Correction, Biological Sciences, Antimicrobial, medicine.disease, Hospitals, Anti-Bacterial Agents, Cochlea, 030104 developmental biology, medicine.anatomical_structure, Toxicity, Sisomicin, Gentamicin, Hair cell, Gentamicins, Drug Contamination, 030217 neurology & neurosurgery, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6703f3cd38fc2a7d95ddd214cdb60139
https://pubmed.ncbi.nlm.nih.gov/34493689

المؤلفون: Frédéric Poitevin, Matthew Seaberg, Yashas Rao, Nicholas C. Corsepius, Alex McGurk, Robert Greenhouse, Mengling Liang, Cornelius Gati, Trevor Obrinsky, Hasan DeMirci, Raymond G. Sierra, Fátima Pardo-Avila, Mary O'Sullivan, Paul Mbgam, Fulya Aksit, Mark S. Hunter, Alan G. Cheng, Halil I. Ciftci, Brandon Hayes, E. Han Dao, Anthony J. Ricci

المصدر: Nucleic Acids Research

مصطلحات موضوعية: 0301 basic medicine, Protein subunit, Biology, Tetraloop, Ribosome, 03 medical and health sciences, 0302 clinical medicine, Structural Biology, Escherichia coli, Genetics, medicine, Humans, 30S, Binding site, 030304 developmental biology, Protein Synthesis Inhibitors, 0303 health sciences, Binding Sites, Chemistry, Aminoglycoside, Hexosamines, Ribosomal RNA, Anti-Bacterial Agents, Aminoglycosides, 030104 developmental biology, RNA, Ribosomal, Protein Biosynthesis, Sisomicin, Streptomycin, Biophysics, Nucleic Acid Conformation, Ribosomes, 030217 neurology & neurosurgery, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97bc81b758763489bb6f8c421296d435
https://doi.org/10.1101/372144

المؤلفون: Andrea Stojakovic, Sergey Trushin, Benjamin Gateno, Liang Zhang, Kevin Greenman, Olga Isaakova, Eugenia Trushina, William Guilford, Robert Greenhouse

المصدر: Alzheimer's & Dementia. 14

مصطلحات موضوعية: Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, business.industry, Health Policy, Cancer research, Medicine, Neurology (clinical), Disease, Geriatrics and Gerontology, business, Mitochondrial Complex I

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8ea46360bf8636b063f6129873f02cbe
https://doi.org/10.1016/j.jalz.2018.06.080

المؤلفون: Robert Greenhouse, Hai-Ying Cai, Ryan Craig Schoenfeld, David S. Carter, Stephen M. Lynch, Ann Marie Madera, Sandra Steiner, Yansheng Zhai, Eun Kyung Lee, Robert James Weikert, Clara Jeou Jen Lin, Kerem Erol Ozboya, Amy Geraldine Moore, Pravin Iyer, Matthew C. Lucas

المصدر: Bioorganic & Medicinal Chemistry Letters. 20:5559-5566

مصطلحات موضوعية: Serotonin, Pyrrolidines, Dopamine, Clinical Biochemistry, hERG, Pain, Pharmaceutical Science, Antidepressive Agents, Tricyclic, Biochemistry, Norepinephrine, chemistry.chemical_compound, Dopamine Uptake Inhibitors, In vivo, Drug Discovery, medicine, Animals, Humans, Neurotransmitter Uptake Inhibitors, Neurotransmitter, Molecular Biology, biology, Depression, Organic Chemistry, Rats, Monoamine neurotransmitter, chemistry, Drug Design, Catecholamine, biology.protein, Molecular Medicine, Caco-2 Cells, Reuptake inhibitor, Selective Serotonin Reuptake Inhibitors, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::146634f68c518c5e1ecacbf422b1a636
https://doi.org/10.1016/j.bmcl.2010.07.020

المؤلفون: Kayvon Sotoudeh, Markus E. Huth, Yi-Ju Hsieh, Andrew A. Vu, Robert Greenhouse, Anthony J. Ricci, Thomas Effertz, Alan G. Cheng, Sarah Verhoeven, Kyu-Hee Han, Michael H. Hsieh

المصدر: Huth, Markus; Han, Kyu-Hee; Sotoudeh, Kayvon; Hsieh, Yi-Ju; Effertz, Thomas; Vu, Andrew A; Verhoeven, Sarah; Hsieh, Michael H; Greenhouse, Robert; Cheng, Alan G; Ricci, Anthony J (2015). Designer aminoglycosides prevent cochlear hair cell loss and hearing loss. Journal of clinical investigation, 125(2), pp. 583-592. American Society for Clinical Investigation 10.1172/JCI77424 <http://dx.doi.org/10.1172/JCI77424>

مصطلحات موضوعية: medicine.medical_specialty, Hearing loss, medicine.drug_class, Urinary system, Hearing Loss, Sensorineural, Antibiotics, Drug Evaluation, Preclinical, 610 Medicine & health, Pharmacology, Biology, Rats, Sprague-Dawley, Mice, Ototoxicity, Hair Cells, Auditory, medicine, otorhinolaryngologic diseases, Animals, Humans, Kidney, Bacteria, Aminoglycoside, General Medicine, Bacterial Infections, medicine.disease, Surgery, Anti-Bacterial Agents, Rats, medicine.anatomical_structure, Aminoglycosides, Drug Design, Sisomicin, Hair cell, medicine.symptom, medicine.drug, Research Article

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9b069fcc3a424df3987f56bb512214
https://europepmc.org/articles/PMC4319422/

المؤلفون: Joel R Gever, Fernando Padilla, Saul Jaime-Figueroa, Robert Greenhouse, Michael Patrick Dillon, Anthony P.D.W. Ford

المصدر: Bioorganic & Medicinal Chemistry Letters. 15:3292-3295

مصطلحات موضوعية: Drug, Cell Survival, medicine.drug_class, media_common.quotation_subject, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Ligands, Transfection, Biochemistry, Cell Line, Inhibitory Concentration 50, Structure-Activity Relationship, Drug Discovery, Purinergic P2 Receptor Antagonists, medicine, Animals, Humans, Structure–activity relationship, Selective receptor modulator, Receptor, Molecular Biology, media_common, Chemistry, Organic Chemistry, Purinergic receptor, Antagonist, Biological activity, General Medicine, Subtype selective, Receptor antagonist, Amides, P2 Purinoceptors, Receptors, Purinergic P2X, Molecular Medicine, Calcium

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::080ddc21ca889f24efcc043b46f9d0c0
https://doi.org/10.1016/j.bmcl.2005.04.049

المؤلفون: Richard M. Eglen, Tess Pulido-Rios, Saul Jaime, Cindy Rocha, Flippin Lee Allen, Mark Dawson, E. Leung, Graeme R. Martin, Robert Greenhouse, Kristine Van Natta, L K Chang, Andrea Webber, Douglas W. Bonhaus

المصدر: British Journal of Pharmacology. 127:1075-1082

مصطلحات موضوعية: Pharmacology, medicine.medical_specialty, RS-127445, Intrinsic activity, medicine.drug_class, Chemistry, Antagonist, Receptor antagonist, 5-HT2B receptor, chemistry.chemical_compound, Endocrinology, Internal medicine, medicine, Receptor, Ion channel binding, 5-HT receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a87e1f04819abfd7a86970c50c7bb391
https://doi.org/10.1038/sj.bjp.0702632

المؤلفون: Francisco Xavier Talamas, Rene Villena, Moises Romero, Robert Greenhouse, Joseph M. Muchowski, Angel Guzman

المصدر: The Journal of Organic Chemistry. 61:2470-2483

مصطلحات موضوعية: Dimethyl acetylenedicarboxylate, Reaction conditions, chemistry.chemical_compound, 1h nmr spectroscopy, Pyrimidine, chemistry, Organic Chemistry, Leaving group, Organic chemistry, Medicinal chemistry, Cycloaddition, Adduct

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b02c7a8c0df09d46dd761b0c7007dd9b
https://doi.org/10.1021/jo952106w