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المؤلفون: Robert J. Ternansky, Patricia L. Gladstone, Zhuoqi Zhang, Graham Parry, Fernando Donate, Renzhong Fu, Jose Juarez, Amy L. Allan, Jinbao Xiang, Andrew P. Mazar, Xu Bai
المصدر: MedChemComm. 7:1946-1951
مصطلحات موضوعية: 0301 basic medicine, Pharmacology, chemistry.chemical_classification, 010405 organic chemistry, Kinase Family, Drug discovery, Kinase, Stereochemistry, Organic Chemistry, Pharmaceutical Science, Biology, 01 natural sciences, Biochemistry, In vitro, 0104 chemical sciences, 03 medical and health sciences, 030104 developmental biology, Enzyme, chemistry, Drug Discovery, Molecular Medicine, Phosphorylation, IC50, Tricyclic
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6d5f7ca18a4f4a40c7af850c56c2e9e9
https://doi.org/10.1039/c6md00351f -
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المؤلفون: Kevin J. Tomaselli, Julia Herrmann, Robert O. Sayers, Joe C. Wu, Lalitha Kodandapani, Kathy G. Jahangiri, Craig D. Fisher, David T. Winn, Edward D. Robinson, Steven P. Meduna, Robert J. Ternansky, Pauline Yeo, Karen L. Valentino, Jose-Luis Diaz, Vincent J. Kalish, Steven D. Linton, Kristen Sebring, Robert A. Armstrong, Joseph F. Krebs, Niel C. Hoglen, Alfred P. Spada, Brad P. Hirakawa, Ning Chen, Brett R. Ullman, Brett Weylan Ching, Cheng-zhi Zhang, Xu Bai, Xin Gu, Kip Nalley, Long-Shiuh Chen, Patricia L. Gladstone, Jeff McQuiston, Teresa Aja, Todd Groessl, Donald S. Karanewsky, Suzanne Weeks, Lawrence C. Fritz, Patricia C. Contreras
المصدر: Journal of Medicinal Chemistry. 48:6779-6782
مصطلحات موضوعية: Adult, Biological Availability, Phases of clinical research, Apoptosis, Pharmacology, Jurkat Cells, Mice, Structure-Activity Relationship, Liver disease, Pharmacokinetics, In vivo, Drug Discovery, medicine, Animals, Humans, Aspartate Aminotransferases, Pentanoic Acids, Caspase, Liver injury, Cholestasis, Clinical Trials, Phase I as Topic, biology, Caspase 3, Chemistry, Liver Diseases, Alanine Transaminase, Hepatitis C, Chronic, medicine.disease, Caspase Inhibitors, In vitro, Rats, Liver, Biochemistry, Enzyme inhibitor, Hepatocytes, biology.protein, Molecular Medicine, Half-Life
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المؤلفون: Robert Smidt, Silvio Roggo, Julia Herrmann, Edward D. Robinson, Kathy G. Jahangiri, Teresa Aja, Kip Nalley, Thomas L. Deckwerth, Giorgio Rovelli, Kevin J. Tomaselli, Joe C. Wu, Bastian Hengerer, Steven P. Meduna, André Sauter, Jose-Luis Diaz, Joerg Kallen, Albert Schmitz, Donald S. Karanewsky, Brett R. Ullman, Steven D. Linton, Christoph Wiessner, Robert J. Ternansky, Peter R. Allegrini, Robert O. Sayers
المصدر: Bioorganic & Medicinal Chemistry Letters. 14:2685-2691
مصطلحات موضوعية: Peptidomimetic, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Oxamyl, Apoptosis, Peptide, Biochemistry, Cell Line, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Humans, Structure–activity relationship, Molecular Biology, Caspase, chemistry.chemical_classification, Dipeptide, biology, Organic Chemistry, Neurodegenerative Diseases, Dipeptides, Caspase Inhibitors, In vitro, Stroke, Kinetics, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Carbamates
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المؤلفون: Edward D. Robinson, Silvio Roggo, Joe C. Wu, Robert J. Ternansky, Jose-Luis Diaz, Teresa Aja, Kevin J. Tomaselli, Steven P. Meduna, Vincent J. Kalish, Donald S. Karanewsky, Robert O. Sayers, Albert Schmitz, Brett R. Ullman, Julia Herrmann, Kip Nalley, Thomas L. Deckwerth
المصدر: Bioorganic & Medicinal Chemistry Letters. 13:3623-3626
مصطلحات موضوعية: chemistry.chemical_classification, Programmed cell death, biology, Chemistry, Organic Chemistry, Clinical Biochemistry, Leaving group, Pharmaceutical Science, Inflammation, Cysteine Proteinase Inhibitors, Caspase Inhibitors, Biochemistry, In vitro, Structure-Activity Relationship, Enzyme, Enzyme inhibitor, Drug Discovery, biology.protein, medicine, Molecular Medicine, Structure–activity relationship, medicine.symptom, Molecular Biology, Caspase
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المؤلفون: Wayne C. Guida, Robert J. Ternansky, Fernando Donate, Jason A Nydick, Patricia L. Gladstone, Tara E. Jackson, Jose Juarez, Melissa L. P. Price
المصدر: Bioorganic & Medicinal Chemistry Letters. 13:107-110
مصطلحات موضوعية: Models, Molecular, Molecular model, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Guanidines, Biochemistry, Chemical synthesis, Drug Discovery, Humans, Computer Simulation, Homology modeling, Enzyme Inhibitors, Thymidine phosphorylase, Molecular Biology, chemistry.chemical_classification, Thymidine Phosphorylase, Binding Sites, biology, Bicyclic molecule, Chemistry, Organic Chemistry, Enzyme, Structural Homology, Protein, Docking (molecular), Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Protein Binding
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المؤلفون: Julia Chang, Robert J. Ternansky, Brian L. Baker, Lin Yu, Stephen Coutts, Jackie F. Crisologo
المصدر: Analytical Biochemistry. 265:35-41
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Biophysics, Phospholipid, Biochemistry, Micelle, Mass Spectrometry, Phospholipases A, Substrate Specificity, Hydrolysis, Enzyme activator, chemistry.chemical_compound, Phospholipase A2, Spectroscopy, Fourier Transform Infrared, Molecular Biology, Micelles, Phospholipids, Phosphocholine, Elapid Venoms, chemistry.chemical_classification, Chromatography, biology, Chemistry, Substrate (chemistry), Cell Biology, Enzyme Activation, Kinetics, Phospholipases A2, Enzyme, biology.protein, lipids (amino acids, peptides, and proteins)
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المؤلفون: Stephen M. Coutts, Julia Chang, Lin Yu, Edward J. Victoria, Robert J. Ternansky
المصدر: Bioorganic & Medicinal Chemistry Letters. 8:2129-2132
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Phospholipid, Pharmaceutical Science, Inhibitory postsynaptic potential, Biochemistry, Phospholipases A, Structure-Activity Relationship, chemistry.chemical_compound, Phospholipase A2, Phenols, Phosphatidylcholine, Drug Discovery, Animals, Elapidae, Enzyme Inhibitors, Molecular Biology, Phospholipids, Elapid Venoms, chemistry.chemical_classification, Phospholipase B, Molecular Structure, biology, Organic Chemistry, Leaving group, Kinetics, Phospholipases A2, Enzyme, chemistry, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine
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المؤلفون: Mark A. Muesing, Robert Theodore Vasileff, Sahlberg C, Robert J. Ternansky, Cantrell As, C. L. Jordan, Jaskunas, L. Vrang, P. Engelhardt, Peter Thomas Lind, H. Zhang, Kinnick, R. Noreen, West Sj, Marita Högberg, Pranc P, J. Kangasmetsa, B. Oberg, N. G. Johansson, J. M. Jun. Morin
المصدر: Journal of Medicinal Chemistry. 39:4261-4274
مصطلحات موضوعية: chemistry.chemical_classification, biology, Anti-HIV Agents, Chemistry, Stereochemistry, Hydrochloride, Thiourea, Chemical synthesis, HIV Reverse Transcriptase, Intercalating Agents, Reverse transcriptase, Structure-Activity Relationship, Thiazoles, chemistry.chemical_compound, Enzyme, Enzyme inhibitor, Trovirdine, Drug Discovery, biology.protein, Animals, Molecular Medicine, Structure–activity relationship, Cells, Cultured
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المؤلفون: Robert Smidt, Jose-Luis Diaz, Lalitha Kodandapani, Joe C. Wu, Brian Pham, Donald S. Karanewsky, Kevin J. Tomaselli, Robert J. Ternansky, Lawrence C. Fritz, Steven D. Linton
المصدر: Bioorganic & Medicinal Chemistry Letters. 12:2969-2971
مصطلحات موضوعية: medicine.drug_class, Stereochemistry, Peptidomimetic, Acylation, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, Structure-Activity Relationship, Drug Discovery, medicine, Enzyme Inhibitors, Molecular Biology, Caspase, chemistry.chemical_classification, biology, Chemistry, Organic Chemistry, Dipeptides, Caspase Inhibitors, In vitro, Isoenzymes, Enzyme, Enzyme inhibitor, biology.protein, Molecular Medicine, Indicators and Reagents, Oligopeptides, Lactone
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المؤلفون: C. L. Jordan, Robert J. Ternansky
المصدر: Bioorganic & Medicinal Chemistry Letters. 3:2443-2446
مصطلحات موضوعية: Organic Chemistry, Clinical Biochemistry, Closure (topology), Pharmaceutical Science, Ring (chemistry), Biochemistry, Combinatorial chemistry, Beta-lactam, chemistry.chemical_compound, chemistry, Intramolecular force, Drug Discovery, Molecular Medicine, Molecular Biology, Derivative (chemistry)
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