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1
المؤلفون: Jenny Xie, Tracy L. Taylor, Sandra Rex-Rabe, Joel C. Barrish, William J. Pitts, Kim W. McIntyre, Percy H. Carter, Scott H. Watterson, Murray McKinnon, Richard Liu, Bethanne M. Warrack, Suzanne J. Suchard, Mary Ellen Cvijic, Charles M. Langevine, Celia D’Arienzo, S. H. Spergel, Ding Ren Shen, Melissa Yarde, Dana Banas, Georgia Cornelius, Robert V. Moquin, Luisa Salter-Cid, Anthony M. Marino, Kathleen M. Gillooly, David J. Shuster, Praveen Balimane, Junqing Guo, Alaric J. Dyckman
المصدر: Journal of medicinal chemistry. 59(6)
مصطلحات موضوعية: 0301 basic medicine, Encephalomyelitis, Autoimmune, Experimental, Lymphocyte, Arthritis, Stimulation, CHO Cells, Thymus Gland, Pharmacology, Lymphatic System, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Cricetulus, Cell Movement, Sphingosine, Cricetinae, Drug Discovery, medicine, Animals, Humans, Sphingosine-1-phosphate, Lymphocytes, Isoxazole, Receptor, Cell Proliferation, Experimental autoimmune encephalomyelitis, Isoxazoles, medicine.disease, Arthritis, Experimental, Rats, Mice, Inbred C57BL, 030104 developmental biology, medicine.anatomical_structure, chemistry, Biochemistry, Rats, Inbred Lew, Molecular Medicine, Lysophospholipids, Immunosuppressive Agents
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2
المؤلفون: William J. Pitts, Alaric J. Dyckman, Scott H. Watterson, Robert V. Moquin, Kim W. McIntyre, Zheng Yang, Jagabandhu Das, Katy Van Kirk, James R. Burke, David B. Wang-Iverson, Hollie Booth-Lute, James Kempson, Laishun Chen, Charles M. Langevine, Joel C. Barrish, Guchen Yang, Xiaoxia Yang, John H. Dodd, David S. Nirschl, Murray McKinnon, Steven H. Spergel, Mark A. Pattoli, Michael Galella, Kurt R. Gregor, Junquing Guo
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:7006-7012
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Biochemistry, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Acetamides, Drug Discovery, Animals, Humans, Inhibitory concentration 50, Structure–activity relationship, Potency, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Molecular Structure, Drug discovery, Organic Chemistry, Inflammatory Bowel Diseases, In vitro, I-kappa B Kinase, Rats, Enzyme Activation, chemistry, Molecular Medicine, Heterocyclic Compounds, 3-Ring, Acetamide, Tricyclic
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3
المؤلفون: James Kempson, Joel C. Barrish, Laishun Chen, Alaric J. Dyckman, Robert V. Moquin, Kim W. McIntyre, Kathleen M. Gillooly, William J. Pitts, James R. Burke, Steven H. Spergel, Jagabandhu Das, Mark A. Pattoli, Scott H. Watterson, John H. Dodd, Murray McKinnon, Xiao Xia Yang, Junqing Guo, Charles M. Langevine
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:2646-2649
مصطلحات موضوعية: Lipopolysaccharides, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, IκB kinase, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Animals, Structure–activity relationship, skin and connective tissue diseases, Protein Kinase Inhibitors, Molecular Biology, chemistry.chemical_classification, Tumor Necrosis Factor-alpha, Organic Chemistry, Imidazoles, I-kappa B Kinase, Rats, Pyrimidines, Enzyme, chemistry, Molecular Medicine, Amine gas treating, Lead compound, Tricyclic
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4
المؤلفون: Charles M. Langevine, Joseph A. Furch, Dominique Belanger, Mark A. Pattoli, Joel C. Barrish, Alaric J. Dyckman, Marco Dodier, James Kempson, Jagabandhu Das, David S. Nirschl, Laishun Chen, Punit Marathe, Kathleen M. Gillooly, Junqing Guo, Robert V. Moquin, John H. Dodd, Murray McKinnon, Anne Marinier, Zheng Yang, Steven H. Spergel, Claude A. Quesnelle, Kim W. McIntyre, Katy Van Kirk, James R. Burke, William J. Pitts, Scott H. Watterson, Alain Martel, Patrice Gill, David B. Wang-Iverson, Tianle Li
المصدر: Journal of Medicinal Chemistry. 52:1994-2005
مصطلحات موضوعية: Lipopolysaccharides, Recombinant Fusion Proteins, IκB kinase, In Vitro Techniques, Crystallography, X-Ray, Chemical synthesis, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Animals, Humans, Thiazole, Oxazoles, Glutathione Transferase, Oxazole, chemistry.chemical_classification, Mice, Inbred BALB C, Tumor Necrosis Factor-alpha, Imidazoles, Biological activity, I-kappa B Kinase, Rats, Thiazoles, Enzyme, chemistry, Biochemistry, Leukocytes, Mononuclear, Microsomes, Liver, Molecular Medicine, Female, Signal transduction, Heterocyclic Compounds, 3-Ring, Tricyclic
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5
المؤلفون: Joel C. Barrish, David J. Shuster, Chunjian Liu, Kim W. McIntyre, Tai-An Lin, Amrita Kamath, Becky Penhallow, Kathleen D. O'Day, Steven B. Kanner, Joseph A. Furch, John H. Dodd, Steven H. Spergel, Hongjian Zhang, James Lin, Robert V. Moquin, Arthur M. Doweyko, John Wityak, Punit Marathe, Jagabandhu Das, Chen Yi Hung
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:3706-3712
مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Sulfides, Biochemistry, Jurkat cells, Jurkat Cells, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Aminothiazole, In vivo, Drug Discovery, Hypersensitivity, Animals, Humans, Enzyme Inhibitors, Molecular Biology, Cells, Cultured, chemistry.chemical_classification, biology, Organic Chemistry, Pneumonia, Protein-Tyrosine Kinases, Small molecule, Asthma, In vitro, Thiazoles, Ovalbumin, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine
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6
المؤلفون: Steven H. Spergel, Robert V. Moquin, Ding Ren Shen, Jagabundhu Das, Gary L. Schieven, Kamelia Behnia, James Lin, O. Kocy, Paul L. Stanley, Sydney Pitt, John Wityak, Ping Chen, Sara Thrall, David J. Shuster, Derek J. Norris, Suhong Pang, Edwin J. Iwanowicz, Steven B. Kanner, Henry F. De Fex, Joel C. Barrish, Henry H. Gu, Kim W. McIntyre, Mark R. Witmer, Saeho Chong, Arthur M. Doweyko
المصدر: Journal of Medicinal Chemistry. 47:4517-4529
مصطلحات موضوعية: chemistry.chemical_classification, Quantitative structure–activity relationship, Molecular model, Chemistry, In vivo, Stereochemistry, Drug Discovery, Molecular Medicine, Aromatic amine, Src family kinase, Chemical synthesis, In vitro, Proinflammatory cytokine
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7
المؤلفون: Jagabandhu Das, Sidney Pitt, Gary L. Schieven, Ding Ren Shen, Robert V. Moquin, Henry F. DeFex, James Lin, John Wityak, Qiong Fang, Suhong Pang, Zhongqi Shen, Joel C. Barrish, Steven H. Spergel, Arthur M. Doweyko
المصدر: Bioorganic & Medicinal Chemistry Letters. 13:2145-2149
مصطلحات موضوعية: Models, Molecular, Molecular model, Stereochemistry, T-Lymphocytes, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Biochemistry, Chemical synthesis, Substrate Specificity, Structure-Activity Relationship, chemistry.chemical_compound, Adenosine Triphosphate, Drug Discovery, Humans, Urea, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, Binding Sites, biology, Chemistry, Cell growth, Organic Chemistry, Small molecule, In vitro, Thiazoles, Benzothiazole, Lymphocyte Specific Protein Tyrosine Kinase p56(lck), Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Cell Division
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8
المؤلفون: Derek J. Norris, Bang-Chi Chen, Ping Chen, Joel C. Barrish, Jagabandhu Das, Robert V. Moquin, Peng Guo
المصدر: Tetrahedron Letters. 42:4297-4299
مصطلحات موضوعية: Chemistry, Stereochemistry, Yield (chemistry), Organic Chemistry, Drug Discovery, Intramolecular cyclization, Biochemistry
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9
المؤلفون: Alaric J. Dyckman, Rosemary Zhang, Tianle Li, Kathleen M. Gillooly, Jagabandhu Das, John H. Dodd, Sidney Pitt, Murray McKinnon, Ding Ren Shen, Katerina Leftheris, Joel C. Barrish, John A. Newitt, Hongjian Zhang, Robert V. Moquin, Gary L. Schieven, Susan E. Kiefer, John S. Sack, Kevin Kish, Kim W. McIntyre, Arthur M. Doweyko
المصدر: Bioorganicmedicinal chemistry letters. 20(23)
مصطلحات موضوعية: medicine.drug_class, Protein Conformation, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Mitogen-Activated Protein Kinase 14, Mice, Structure-Activity Relationship, In vivo, Drug Discovery, medicine, Structure–activity relationship, Animals, Molecular Biology, Protein Kinase Inhibitors, chemistry.chemical_classification, biology, Tumor Necrosis Factor-alpha, Organic Chemistry, In vitro, Enzyme, chemistry, Enzyme inhibitor, Mitogen-activated protein kinase, biology.protein, Molecular Medicine, Pyrazoles, Protein Binding
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10
المؤلفون: Ping Chen, Joel C. Barrish, Derek J. Norris, Jagabandhu Das, Robert V. Moquin, Peng Guo, Bang-Chi Chen
المصدر: ChemInform. 32
مصطلحات موضوعية: Chemistry, Scientific method, Yield (chemistry), Intramolecular cyclization, General Medicine, Combinatorial chemistry