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1
المؤلفون: Mairi, Sime, Amanda C, Allan, Paul, Chapman, Charlotte, Fieldhouse, Gerard M P, Giblin, Mark P, Healy, Millard H, Lambert, Lisa M, Leesnitzer, Ann, Lewis, Raymond V, Merrihew, Richard A, Rutter, Rosemary, Sasse, Barry G, Shearer, Timothy M, Willson, Timothy M, Wilson, Robert X, Xu, David J, Virley
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:5568-5572
مصطلحات موضوعية: chemistry.chemical_classification, Benzimidazole, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Drug discovery, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Peroxisome proliferator-activated receptor, Stereoisomerism, Pharmacology, Biochemistry, Partial agonist, PPAR gamma, Structure-Activity Relationship, chemistry.chemical_compound, Nuclear receptor, Drug Discovery, Molecular Medicine, Glucose homeostasis, Benzimidazoles, Penetrant (biochemical), Receptor, Molecular Biology
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2
المؤلفون: Adam Ashe, Thomas B. Stanley, Todd W Shearer, Craig D. Wagner, John C. Ulrich, Lisa M. Leesnitzer, Barry G. Shearer, Raymond V. Merrihew, Robert W. Wiethe, James M. Way, Robert X. Xu, Andrew N. Billin, Timothy M. Willson, Michael R. Jeune
المصدر: Journal of Medicinal Chemistry. 53:1857-1861
مصطلحات موضوعية: Male, Transcription, Genetic, Stereochemistry, Muscle Fibers, Skeletal, Peroxisome proliferator-activated receptor, Antineoplastic Agents, Protein Serine-Threonine Kinases, Ligands, Mass Spectrometry, Sulfone, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Genes, Reporter, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, Tissue Distribution, Cysteine, PPAR delta, Sulfones, Binding site, Benzamide, chemistry.chemical_classification, Sulfonyl, Binding Sites, Carnitine O-Palmitoyltransferase, Ligand, Antagonist, Pyruvate Dehydrogenase Acetyl-Transferring Kinase, Mice, Inbred C57BL, chemistry, Benzamides, Molecular Medicine, Drug Screening Assays, Antitumor
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3
المؤلفون: Jon D. Williams, Millard H. Lambert, Bruce Wisely, Robert X. Xu, John T. Moore, Linda B. Moore, Gregory M. Waitt, Erin N. Warren, Timothy M. Willson, Jon L. Collins, Emily E. Weinert
المصدر: Molecular Cell. 16(6):919-928
مصطلحات موضوعية: Binding Sites, Retinoid X Receptor alpha, Receptors, Cytoplasmic and Nuclear, Cell Biology, Biology, Retinoid X receptor, Ligand (biochemistry), Ligands, DNA-binding protein, Protein Structure, Tertiary, Thiazoles, Nuclear receptor, Biochemistry, Transcription (biology), Constitutive androstane receptor, Oximes, Biophysics, Inverse agonist, Humans, Receptor, Dimerization, Molecular Biology, Constitutive Androstane Receptor, Transcription Factors
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4
المؤلفون: Mark Raymond Adams, Joyce Fuhrmann, Ung Jin Kim, Tanya Mason, J. Craig Venter, Robert X. Xu, Victoria P. Sneddon, Steve Mitchell, Marie L. Crosby, Hyung Lyun Kang, Anne Deslattes Mays, Peter C. Harris, Yicheng Cao, Evan E. Eichler, Lisa A. Cronin, Francis Kalush, Brendan J. Loftus, Mary Barnstead, Rhonda Brandon
المصدر: Genomics. 60:295-308
مصطلحات موضوعية: Genetic Markers, Databases, Factual, Centromere, Molecular Sequence Data, Biology, Genome, Contig Mapping, Gene mapping, Peptide Initiation Factors, Gene Duplication, Gene density, Gene duplication, Genetics, Animals, Humans, Gene, Expressed Sequence Tags, Polycystic Kidney Diseases, Base Sequence, Genome project, Physical Chromosome Mapping, Rats, Human genome, Chromosomes, Human, Pair 16, Reference genome
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5
المؤلفون: Robert X. Xu, Tai-He Xia, Stephen C. Brown, Tadeucz Pawelczyk
المصدر: Biochemistry. 36:10709-10717
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Molecular Sequence Data, Protein Data Bank (RCSB PDB), Crystallography, X-Ray, Biochemistry, Diglycerides, chemistry.chemical_compound, Protein structure, Animals, Amino Acid Sequence, Binding site, Micelles, Phorbol 12,13-Dibutyrate, Protein Kinase C, Protein kinase C, Diacylglycerol kinase, Binding Sites, Brain, Lipid Metabolism, Lipids, Protein tertiary structure, Protein Structure, Tertiary, Rats, chemistry, Phorbol, Biophysics, Protein Binding, Binding domain
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6
المؤلفون: D.G. Davis, Robert X. Xu, R.T. Gampe Jr., Weigl D, Thomas G. Consler, Ann M. Edison, Renee J. Boerner, Loganzo F, Daniel B. Kassel, Derril H. Willard
المصدر: Biochemistry. 34:15351-15358
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Stereochemistry, Molecular Sequence Data, Proto-Oncogene Proteins pp60(c-src), Phosphatase, Mass spectrometry, SH2 domain, Biochemistry, Catalysis, Mass Spectrometry, Hydrolysis, Humans, Magnesium, Amino Acid Sequence, Disulfides, Enzyme kinetics, Enzyme Inhibitors, Phosphorylation, Binding site, Site-directed mutagenesis, Chromatography, High Pressure Liquid, Edetic Acid, Binding Sites, Isoelectric focusing, Chemistry, Peptide Fragments, Phosphoric Monoester Hydrolases, Recombinant Proteins, Kinetics, Mutagenesis, Site-Directed, Calcium, Isoelectric Focusing
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66bf6ad679befc4e136e4ee678af4d84
https://doi.org/10.1021/bi00046a044 -
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المؤلفون: Robert X. Xu, J.M. Word, D.G. Davis, M.J. Rink, Derril H. Willard, R.T. Gampe Jr.
المصدر: Biochemistry. 34:2107-2121
مصطلحات موضوعية: Models, Molecular, Magnetic Resonance Spectroscopy, Stereochemistry, Molecular Sequence Data, Proto-Oncogene Proteins pp60(c-src), Crystallography, X-Ray, SH2 domain, Biochemistry, Pentapeptide repeat, Protein Structure, Secondary, Protein structure, Consensus Sequence, Amino Acid Sequence, Phosphotyrosine, Protein secondary structure, Tyrosine binding, Phospholipase C gamma, Chemistry, Nuclear magnetic resonance spectroscopy, Protein Structure, Tertiary, Isoenzymes, Solutions, Crystallography, Type C Phospholipases, Intramolecular force, Tyrosine, Protein Binding, Signal Transduction, Proto-oncogene tyrosine-protein kinase Src
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4475c21fbd7799bb6ab37137093e19
https://doi.org/10.1021/bi00007a003 -
8
المؤلفون: Holly A. Ingraham, Fang Cai, Robert X. Xu, Sally Dixon, Raymond D. Blind, Timothy M. Willson, Lisa A. Orband-Miller, Jozef Stec, Shawn P. Williams, William J. Zuercher, Richard J. Whitby, Lisa M. Leesnitzer
مصطلحات موضوعية: Steroidogenic factor 1, Agonist, Models, Molecular, Transcriptional Activation, medicine.drug_class, Protein Conformation, Molecular Sequence Data, Receptors, Cytoplasmic and Nuclear, Peptide, Crystallography, X-Ray, Ligands, Steroidogenic Factor 1, Article, Small Molecule Libraries, Mice, Drug Discovery, medicine, Animals, Humans, Amino Acid Sequence, Receptor, Regulation of gene expression, chemistry.chemical_classification, Bicyclic molecule, Sequence Homology, Amino Acid, Chemistry, Liver receptor homolog-1, Small molecule, HEK293 Cells, Biochemistry, Molecular Medicine
وصف الملف: text
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de6ed19fac6b1406a6ee2287dedd5de0
https://eprints.soton.ac.uk/176807/ -
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المؤلفون: James M. Way, Lisa M. Leesnitzer, Jian Jin, Steven M. Sparks, Millard H. Lambert, Daniel D. Sternbach, Christy S. Britt, Raymond V. Merrihew, Robert X. Xu, Dongchuan Shi, Deborah A. Winegar, Andrea H. Epperly, Barry G. Shearer, Andrew N. Billin, David D. Wisnoski, Karen A. Evans
المصدر: Bioorganicmedicinal chemistry letters. 21(8)
مصطلحات موضوعية: Male, Carboxylic acid, Clinical Biochemistry, Biphenyl derivatives, Pharmaceutical Science, Acetates, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Partial agonist, Mice, Structure-Activity Relationship, In vivo, Drug Discovery, Animals, Humans, PPAR delta, Molecular Biology, chemistry.chemical_classification, Binding Sites, Chemistry, Organic Chemistry, Subtype selective, In vitro, Rats, Rapid identification, Microsomes, Liver, Molecular Medicine
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10
المؤلفون: Edward T. Olejniczak, Robert X. Xu, Andrew M. Petros, Stephen W. Fesik
المصدر: Journal of Magnetic Resonance (1969). 100:444-450
مصطلحات موضوعية: Crystallography, Nuclear magnetic resonance, FKBP, Chemistry, General Engineering, medicine, Pulse sequence, Ascomycin, Nuclear magnetic resonance spectroscopy, Constant (mathematics), medicine.drug