المؤلفون: Robin M. Gierse, Rick Oerlemans, Eswar R. Reddem, Victor O. Gawriljuk, Alaa Alhayek, Dominik Baitinger, Harald Jakobi, Bernd Laber, Gudrun Lange, Anna K. H. Hirsch, Matthew R. Groves

المصدر: Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/2b8bfdc100064a6dbd3b456cb371d4e2

المؤلفون: Victor Oliveira Gawriljuk, Rick Oerlemans, Robin M. Gierse, Riya Jotwani, Anna K. H. Hirsch, Matthew R. Groves

المصدر: Crystals, Vol 13, Iss 5, p 737 (2023)

مصطلحات موضوعية: 1-deoxy-D-xylulose 5-phosphate synthase, MEP pathway, butylacetylphosphonate, antibiotics, Mycobacterium tuberculosis, DXPS, Crystallography, QD901-999

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2073-4352/13/5/737; https://doaj.org/toc/2073-4352

URL الوصول: https://doaj.org/article/d0c31101d36c42e5a1d40f6228cd1a04

المؤلفون: Ravindra P. Jumde, Alaa Alhayek, Robin M. Gierse, Anna K. H. Hirsch

المصدر: Proceedings, Vol 22, Iss 1, p 81 (2019)

مصطلحات موضوعية: methylerythritol phosphate pathway, DXS-enzyme, Protein templated dynamic combinatorial chemistry, anti-infectives (List three to ten pertinent keywords specific to the article, yet reasonably common within the subject discipline), General Works

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2504-3900/22/1/81; https://doaj.org/toc/2504-3900

URL الوصول: https://doaj.org/article/566d357a435b4b38b4a4f41b10fbea82

المؤلفون: Sandra Johannsen, Robin M. Gierse, Aleksandra Olshanova, Ellie Smerznak, Christian Laggner, Lea Eschweiler, Zahra Adeli, Rawia Hamid, Alaa Alhayek, Norbert Reiling, Jörg Haupenthal, Anna K. H. Hirsch

المساهمون: Chemical Biology 2

المصدر: ChemMedChem, 18(11):e202200590. WILEY-V C H VERLAG GMBH

مصطلحات موضوعية: Pharmacology, Drug discovery, 2-C-methyl-D-erythritol 4-phosphate pathway, Organic Chemistry, inhibitors, Molecular Medicine, General Pharmacology, Toxicology and Pharmaceutics, 1-deoxy-D-xylulose 5-phosphate synthase, neural networks, Biochemistry

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c747ff42335fe0c202598f5cf07c481f
https://doi.org/10.1002/cmdc.202200590

المؤلفون: Di Zhu, Sandra Johannsen, Tiziana Masini, Céline Simonin, Jörg Haupenthal, Boris Illarionov, Anastasia Andreas, Mahendra Awale, Robin M. Gierse, Tridia van der Laan, Ramon van der Vlag, Rita Nasti, Mael Poizat, Eric Buhler, Norbert Reiling, Rolf Müller, Markus Fischer, Jean-Louis Reymond, Anna K. H. Hirsch

المساهمون: Stratingh Institute of Chemistry, Chemical Biology 2

المصدر: Chemical Science, 13(36), 10686-10698. ROYAL SOC CHEMISTRY
Zhu, Di; Johannsen, Sandra; Masini, Tiziana; Simonin, Céline; Haupenthal, Jörg; Illarionov, Boris; Andreas, Anastasia; Awale, Mahendra; Gierse, Robin M; van der Laan, Tridia; van der Vlag, Ramon; Nasti, Rita; Poizat, Mael; Buhler, Eric; Reiling, Norbert; Müller, Rolf; Fischer, Markus; Reymond, Jean-Louis; Hirsch, Anna K H (2022). Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening. Chemical Science, 13(36), pp. 10686-10698. The Royal Society of Chemistry 10.1039/d2sc02371g <http://dx.doi.org/10.1039/d2sc02371g>

مصطلحات موضوعية: DXPS, ligand-based virtual screening, Tuberculosis, MEP, 540 Chemie, 540 Chemistry, 570 Life sciences, biology, General Chemistry, 580 Plants (Botany), Settore CHIM/08 - Chimica Farmaceutica, 570 Biowissenschaften, Biologie

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d037a73a79e9b4607948d4bb961dcdb1
https://research.rug.nl/en/publications/47d91e4b-c3e0-48f1-b774-6f2c690412a0

المؤلفون: Sandra Johannsen, Robin M. Gierse, Arne Krüger, Rachel L. Edwards, Vittoria Nanna, Anna Fontana, Di Zhu, Tizina Masini, Lais Pessanha de Carvalho, Mael Poizat, Bart Kieftenbelt, Dana M. Hodge, Sophie Alvarez, Daan Bunt, Kamila Anna Meissner, Edmarcia Elisa de Souza, Melloney Dröge, Bernard van Vliet, Jack de Hartog, Michael C. Hutter, Jana Held, Audrey R. Odom John, Carsten Wrenger, Anna K. H. Hirsch

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::968d2b347432557d44f960aef4313c60
https://doi.org/10.26434/chemrxiv-2022-npslc

المؤلفون: Alaa Alhayek, Christian Nehls, Philipp J. Neusens, Walid A. M. Elgaher, Zhoor Hamid, Ravindra P. Jumde, Jörg Haupenthal, Melissa Guardigni, Norbert Reiling, Di Zhu, Robin M. Gierse, Anna K. H. Hirsch, Sandra Johannsen

المساهمون: Chemical Biology 2, HIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.

المصدر: Chemical Science, 12(22), 7775-7785. ROYAL SOC CHEMISTRY
Chemical Science
Chemical science
England

مصطلحات موضوعية: Chemistry, 010405 organic chemistry, Dynamic combinatorial chemistry, Anti infectives, General Chemistry, Computational biology, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, 1-deoxy-D-xylulose-5-phosphate synthase

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2113aa57d97261e800b50866f049b04b
https://research.rug.nl/en/publications/a2d48f55-2cb5-45ff-a034-9f6c9ad79496

المؤلفون: Alwin M. Hartman, Anna K. H. Hirsch, Robin M. Gierse

المصدر: European Journal of Organic Chemistry. 2019:3581-3590

مصطلحات موضوعية: Protein stability, 010405 organic chemistry, Chemistry, Organic Chemistry, Dynamic combinatorial chemistry, Computational biology, Physical and Theoretical Chemistry, Biochemical Activity, 010402 general chemistry, 01 natural sciences, Protocol (object-oriented programming), 0104 chemical sciences

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::68ad40d6087ea841dc1c7ff1a8d84054
https://doi.org/10.1002/ejoc.201900327

المؤلفون: Gudrun Lange, Zhoor Hamid, Matthew Groves, Eswar R. Reddem, Robin M. Gierse, Dominik Baitinger, Alaa Alhayek, Harald Jakobi, Bernd Laber, Anna K. H. Hirsch

المساهمون: Chemical Biology 2, Biomolecular Chemistry & Catalysis, Drug Design, Medicinal Chemistry and Bioanalysis (MCB), HIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.

المصدر: Biochemical and Biophysical Research Communications, 539, 42-47. ACADEMIC PRESS INC ELSEVIER SCIENCE
Biochemical and biophysical research communications 539, 42-47 (2021). doi:10.1016/j.bbrc.2020.12.069
Biochemical and biophysical research communications
United States

مصطلحات موضوعية: 0301 basic medicine, MEP-Pathway, Mutant, Biophysics, Sequence Homology, Protein degradation, (DXS), medicine.disease_cause, Antimicrobial resistance, Crystallography, X-Ray, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Biosynthesis, Deinococcus radiodurans, Transferases, 1-deoxy-D-xylulose-5-phosphate synthase (DXS), ddc:570, medicine, Escherichia coli, Amino Acid Sequence, Molecular Biology, chemistry.chemical_classification, ATP synthase, biology, Chemistry, Cell Biology, biology.organism_classification, Recombinant Proteins, 030104 developmental biology, Enzyme, 1-deoxy-D-xylulose-5-phosphate synthase, 030220 oncology & carcinogenesis, Mutation, biology.protein, Mutant Proteins, Protein Structural Elements, Structure-based drug design, Deinococcus, Bacteria

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d470f9adf00c7cae6ab43b48214a10d2

المؤلفون: Sandra Johannsen, Di Zhu, Alaa Alhayek, Melissa Guardigni, Robin M. Gierse, Jörg Haupenthal, Walid A. M. Elgaher, Ravindra P. Jumde, Zhoor Hamed, Anna K. H. Hirsch

المصدر: ChemRxiv

مصطلحات موضوعية: Chemistry, Drug discovery, Dynamic combinatorial chemistry, Anti infectives, Computational biology, Non-mevalonate pathway, 1-deoxy-D-xylulose-5-phosphate synthase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f274e6ab3d8d6fca583c9ae37e69461
https://doi.org/10.26434/chemrxiv.12681761