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1
المؤلفون: Shuping Dong, Yolanda Sanchez, Tindy Li, Claudia E. Murar, Anthony J. Wilson, Brent W. Mccleland, Hongwei Qi, Patricia L. Podolin, Marc Galop, Christopher J. Moody, Hongxing Yan, John Yonchuk, Roderick S. Davis, Alan P. Graves, Catherine Booth-Genthe, Joseph P. Foley, Jen-Pyng Kou, Jeffrey K. Kerns, Brian Bolognese, James F. Callahan, Mary Mentzer, Lawrence Wolfe, Jeffrey C. Boehm, Robin Carr
المصدر: Bioorganic & Medicinal Chemistry. 27:579-588
مصطلحات موضوعية: Antioxidant, NF-E2-Related Factor 2, medicine.medical_treatment, Clinical Biochemistry, Gene Expression, Pharmaceutical Science, medicine.disease_cause, Biochemistry, Antioxidants, Cell Line, Structure-Activity Relationship, chemistry.chemical_compound, Isothiocyanates, Thiocarbamates, In vivo, Drug Discovery, medicine, Animals, Humans, Thermal stability, Molecular Biology, Kelch-Like ECH-Associated Protein 1, Natural product, Molecular Structure, Organic Chemistry, KEAP1, Rats, Mice, Inbred C57BL, Oxidative Stress, Solubility, chemistry, Sulfoxides, Isothiocyanate, Biophysics, Molecular Medicine, Cyclobutanes, Heme Oxygenase-1, Oxidative stress, Signal Transduction, Sulforaphane
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2
المؤلفون: Xichen Lin, Michael E. Muratore, Huijie Li, Ami S. Lakdawala, Jakob Busch-Petersen, Ruth R. Osborn, David D. Miller, Jeffrey K. Kerns, Rick P. C. Cousins, Ian Robert Baldwin, Paul Bamborough, John Yonchuk, Ann M. Bullion, Lin Guoliang, Jeffrey C. Boehm, Wei Fu, John A. Christopher, Edward F. Webb, Roderick S. Davis, William L. Rumsey, Rita Field, Jeremy John Payne, Hong Nie
المصدر: ACS Medicinal Chemistry Letters. 9:1164-1169
مصطلحات موضوعية: 0301 basic medicine, Indole test, Ligand efficiency, Chemistry, Stereochemistry, Organic Chemistry, Regulator, Substituent, NF-κB, IκB kinase, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, In vivo, Drug Discovery, Potency
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3
المؤلفون: James F. Callahan, Hongxing Yan, Roderick S. Davis, Venkatraman Junnotula, Catherine Booth-Genthe, Hermes Licea Perez, Yolanda Sanchez, Hong Nie, Dana Knecht, Jeffrey C. Boehm
المصدر: The Analyst. 139:1902-1912
مصطلحات موضوعية: Male, Edman degradation, Dimethyl fumarate, NF-E2-Related Factor 2, Chemistry, Activator (genetics), Glutathione, Reference Standards, Biochemistry, Rats, Analytical Chemistry, chemistry.chemical_compound, Tandem Mass Spectrometry, Area Under Curve, Toxicity Tests, Electrochemistry, Animals, Environmental Chemistry, Moiety, Spectroscopy, Chromatography, Liquid, Macromolecule, Cysteine, Sulforaphane
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4
المؤلفون: Peter T. Buckley, James J. Foley, Edward F. Webb, Roderick S. Davis, Dulcie B. Schmidt, Jakob Busch-Petersen, Michael Salmon, Jian Jin, Widdowson Katherine L, Kristen E. Belmonte, Henry M. Sarau, Yonghui Wang, Qi Jin, Palovich Michael R, Ann M. Bullion
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:7087-7091
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Bronchi, Muscarinic Antagonists, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Solid-phase synthesis, In vivo, Drug Discovery, Muscarinic acetylcholine receptor, Animals, Urea, Structure–activity relationship, Moiety, Ammonium, Tyrosine, Molecular Biology, Chemistry, Organic Chemistry, Receptors, Muscarinic, Quaternary Ammonium Compounds, Molecular Medicine
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5
المؤلفون: Henry M. Sarau, Sandra Umbrecht, Widdowson Katherine L, Palovich Michael R, Michael Salmon, Haibo Xie, Hongxing Yan, Jakob Busch-Petersen, Mark A. Luttmann, James J. Foley, Brian Peck, Jeremy Dufour, Zehong Wan, Gerald E. Hunsberger, Philip S. Landis, Dramane I. Laine, Alicia M. Bacon, Miriam Burman, Edward F. Webb, Roderick S. Davis, Dulcie B. Schmidt
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:3366-3369
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Muscarinic Antagonists, Biochemistry, Mice, Structure-Activity Relationship, DAROTROPIUM, chemistry.chemical_compound, Drug Discovery, Muscarinic acetylcholine receptor, medicine, Animals, Structure–activity relationship, Molecular Biology, Bronchial Diseases, Organic Chemistry, Muscarinic antagonist, Tropane, Receptors, Muscarinic, chemistry, Design synthesis, Drug Design, Molecular Medicine, Tropanes, medicine.drug
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6
المؤلفون: Roderick S. Davis, Emilie Veronique Petitjean, Jessica L. Schneck, Alicia Bacon Davis, Palovich Michael R, Haibo Xie, Deng Jianghe, Jim Villa, David Bettoun, Baoguang Zhao, Brian Peck, Robert Midgett, Patrick McDevitt, Casey Kmett, Dramane I. Laine, Neysa Nevins, Brent W. Mccleland, Lin Guoliang, Anais Jolit, Sandra Umbrecht, Isabelle Delhom
المصدر: ACS Medicinal Chemistry Letters. 2:142-147
مصطلحات موضوعية: Cathepsin, Organic Chemistry, Pharmacology, Biochemistry, Cysteine protease, Cathepsin C, chemistry.chemical_compound, Cathepsin O, chemistry, In vivo, Drug Discovery, Cigarette smoke, Cyanamide, Selectivity
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7
المؤلفون: Palovich Michael R, Miriam Burman, Edward F. Webb, Roderick S. Davis, Henry M. Sarau, Yonghui Wang, Wei Fu, Dwight M. Morrow, Jian Jin, Feng Wang, Qi Jin, Kristen E. Belmonte, Parvathi Rao, Michael L. Moore, Manuela Berlanga, James J. Foley, Chris J. Dehaas, Michael Salmon, Ralph A. Rivero, Lorena A. Kallal, Jakob Busch-Petersen, Dongchuan Shi
المصدر: Journal of Medicinal Chemistry. 51:4866-4869
مصطلحات موضوعية: medicine.drug_class, Bronchoconstriction, Guinea Pigs, Drug Evaluation, Preclinical, Muscarinic Antagonists, Pharmacology, Inhibitory postsynaptic potential, Mice, In vivo, Bronchodilator, Drug Discovery, Muscarinic acetylcholine receptor, medicine, Animals, Acetylcholine receptor, Chemistry, Phenylurea Compounds, Antagonist, Bridged Bicyclo Compounds, Heterocyclic, Rats, Quaternary Ammonium Compounds, Biochemistry, Tyrosine, Molecular Medicine, Nasal administration, medicine.symptom
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8
المؤلفون: Mason Helen J, Karen D. Brown, Valeria Chu, Guyan Liang, Daniel M. Green, Alfred P. Spada, Henry W. Pauls, Ross Bentley, Cuong Ly, Roderick S. Davis, Dennis J. Colussi, Daniel L. Cheney, Michael R. Becker, Y.M. Choi-Sledeski, Christopher T. Dunwiddie, Robert J. Leadley, Ewing William R, John H. Barton
المصدر: Bioorganic & Medicinal Chemistry Letters. 9:2539-2544
مصطلحات موضوعية: Serine Proteinase Inhibitors, medicine.drug_mechanism_of_action, Isostere, Stereochemistry, Clinical Biochemistry, Factor Xa Inhibitor, Administration, Oral, Pharmaceutical Science, Biochemistry, Chemical synthesis, Benzamidine, Amidine, Serine, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Drug Discovery, medicine, Animals, Structure–activity relationship, Molecular Biology, Binding Sites, Organic Chemistry, Isoquinolines, Benzamidines, chemistry, Molecular Medicine, Factor Xa Inhibitors
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9
المؤلفون: Alfred P. Spada, Robert J. Leadley, Jonathan S. Mason, Dennis J. Colussi, Ewing William R, Mark H. Perrone, Karen D. Brown, Michael R. Becker, Don D. Cha, Daniel M. Green, Ross Bentley, Henry W. Pauls, Christopher T. Dunwiddie, Jean-Pierre Guilloteau, Y.M. Choi-Sledeski, Sebastien Maignan, Mason Helen J, Vincent E. Manetta, Charles Kasiewski, Valeria Chu, Roderick S. Davis, Suzanne Morgan, Daniel L. Cheney, Jeff Bostwick
المصدر: Journal of Medicinal Chemistry. 42:3557-3571
مصطلحات موضوعية: Models, Molecular, Serine Proteinase Inhibitors, medicine.drug_mechanism_of_action, medicine.drug_class, Factor Xa Inhibitor, Thiophenes, Crystallography, X-Ray, Amidine, Structure-Activity Relationship, chemistry.chemical_compound, Thrombin, In vivo, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Sulfonamides, Molecular Structure, biology, Chemistry, Anticoagulant, Anticoagulants, Stereoisomerism, Thrombosis, Trypsin, Pyrrolidinones, Rats, Biochemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Rabbits, Factor Xa Inhibitors, medicine.drug
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10
المؤلفون: Roderick S. Davis, Walter J. Boyko, Robert M. Giuliano
المصدر: Journal of Carbohydrate Chemistry. 13:1135-1143
مصطلحات موضوعية: Addition reaction, Organic Chemistry, Regioselectivity, Biochemistry, Medicinal chemistry, Chloride, chemistry.chemical_compound, chemistry, medicine, Sodium azide, Dimethylformamide, Glycosyl, Stereoselectivity, Azide, medicine.drug