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المؤلفون: Jordan M. Mattheisen, Chris Limberakis, Roger B. Ruggeri, Matthew S. Dowling, Christopher W. am Ende, Emilie Ceraudo, Thomas Huber, Christopher L. McClendon, Thomas P. Sakmar
المصدر: Journal of the American Chemical Society. 145:11173-11184
مصطلحات موضوعية: Colloid and Surface Chemistry, General Chemistry, Biochemistry, Catalysis
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المؤلفون: Allyn T. Londregan, Karlygash Aitmakhanova, James Bennett, Laura J. Byrnes, Daniel P. Canterbury, Xiayun Cheng, Thomas Christott, Jennifer Clemens, Steven B. Coffey, João M. Dias, Matthew S. Dowling, Gillian Farnie, Oleg Fedorov, Kimberly F. Fennell, Vicki Gamble, Carina Gileadi, Charline Giroud, Michael R. Harris, Brett D. Hollingshead, Kilian Huber, Magdalena Korczynska, Kimberly Lapham, Paula M. Loria, Arjun Narayanan, Dafydd R. Owen, Brigitt Raux, Parag V. Sahasrabudhe, Roger B. Ruggeri, Laura Díaz Sáez, Ingrid A. Stock, Benjamin A. Thuma, Andy Tsai, Alison E. Varghese
المصدر: Journal of medicinal chemistry.
مصطلحات موضوعية: Drug Discovery, Molecular Medicine
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المؤلفون: David A. Griffith, David J. Edmonds, Jean-Philippe Fortin, Amit S. Kalgutkar, J. Brent Kuzmiski, Paula M. Loria, Aditi R. Saxena, Scott W. Bagley, Clare Buckeridge, John M. Curto, David R. Derksen, João M. Dias, Matthew C. Griffor, Seungil Han, V. Margaret Jackson, Margaret S. Landis, Daniel Lettiere, Chris Limberakis, Yuhang Liu, Alan M. Mathiowetz, Jayesh C. Patel, David W. Piotrowski, David A. Price, Roger B. Ruggeri, David A. Tess
المصدر: Journal of medicinal chemistry. 65(12)
مصطلحات موضوعية: Drug Discovery, Molecular Medicine, Animals, Humans, Hypoglycemic Agents, Peptides, Glucagon-Like Peptide-1 Receptor
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4دورية أكاديمية
المؤلفون: Ronald W. Clark, Roger B. Ruggeri, David Cunningham, Mark J. Bamberger
المصدر: Journal of Lipid Research, Vol 47, Iss 3, Pp 537-552 (2006)
مصطلحات موضوعية: lipid transfer, high density lipoprotein, atherosclerosis, cardiovascular disease, Biochemistry, QD415-436
وصف الملف: electronic resource
Relation: http://www.sciencedirect.com/science/article/pii/S0022227520336087; https://doaj.org/toc/0022-2275
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المؤلفون: J. Brent Kuzmiski, João M. Dias, Seungil Han, Chris Limberakis, David Price, David J. Edmonds, John M. Curto, Amit S. Kalgutkar, Daniel J. Lettiere, David A. Tess, Clare Buckeridge, Matthew C. Griffor, David R. Derksen, Alan M. Mathiowetz, Roger B. Ruggeri, Paula M. Loria, Aditi R. Saxena, Scott W. Bagley, Yuhang Liu, Margaret S. Landis, David W. Piotrowski, V. Margaret Jackson, David A. Griffith, Jean-Phillipe Fortin
مصطلحات موضوعية: chemistry.chemical_classification, Agonist, Chemistry, medicine.drug_class, Insulin, medicine.medical_treatment, Endogeny, Peptide, Pharmacology, Small molecule, Glucagon-like peptide-1, Oral administration, medicine, Receptor
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::064b771366df377937229b83ffb7a9bf
https://doi.org/10.1101/2020.09.29.319483 -
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المؤلفون: Dennis O. Scott, Spiros Liras, Roger B. Ruggeri, Heather Eng, Adam S. Kamlet, Ryosuke Arakawa, David W. Piotrowski, Robert Dullea, Christopher T. Salatto, Karen Atkinson, Michael W. Bolt, Anne-Marie R. Dechert-Schmitt, Paul DaSilva-Jardine, Allyn T. Londregan, Brian Raymer, Kenneth Dahl, Daniel P. Canterbury, Donna N. Petersen, Paula M. Loria, Chris Limberakis, Emi Kimoto, Kim F. McClure, Kevin Beaumont, Liuqing Wei, Akihiro Takano, Kevin P. Maresca, Jun Xiao, Amanda King-Ahmad, Christer Halldin, Benjamin Reidich, Jeffrey R. Chabot
المصدر: Angewandte Chemie International Edition. 56:16218-16222
مصطلحات موضوعية: 0301 basic medicine, Drug, media_common.quotation_subject, Ribosome, Catalysis, Small Molecule Libraries, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Humans, media_common, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, PCSK9, PCSK9 Inhibitors, Subtilisin, General Medicine, General Chemistry, Prodrug, Proprotein convertase, Small molecule, 030104 developmental biology, Liver, Biochemistry, 030220 oncology & carcinogenesis, Hepatocytes, Kexin, Proprotein Convertase 9
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المؤلفون: Ingo Hilgendorf, Filip K. Swirski, Amit Kalgukar, Leonard Buckbinder, Roger B. Ruggeri, Stefan Schob, John W. Chen, Matthew Sebas, Benoit Tricot, Yoshiko Iwamoto, Christian Cortes, Benjamin Pulli, Gabriel Courties, Anping Dong, Wei Zheng, Athanasia Skoura, Muhammad Ali, Matthias Nahrendorf
المصدر: JACC: Basic to Translational Science, Vol 1, Iss 7, Pp 633-643 (2016)
JACC: Basic to Translational Scienceمصطلحات موضوعية: MPO−/−, myeloperoxidase knock out, 0301 basic medicine, Cardiac function curve, lcsh:Diseases of the circulatory (Cardiovascular) system, medicine.medical_specialty, CNR, contrast to noise ratio, MPO, myeloperoxidase, Infarction, Inflammation, 030204 cardiovascular system & hematology, medicine.disease_cause, EDV, end-diastolic volume, PRECLINICAL RESEARCH, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, EF, ejection fraction, oxidative stress, Myocardial infarction, treatment, biology, Ventricular function, business.industry, Therapeutic effect, Ly-6C, lymphocyte antigen 6C, MPO-Gd, bis-5-hydroxytryptamide-diethylenetriaminepentaacetate-gadolinium, medicine.disease, 3. Good health, myeloperoxidase, myocardial infarction, 030104 developmental biology, inflammation, lcsh:RC666-701, Myeloperoxidase, LAR, lesion activation ratio, MI, myocardial infarction, biology.protein, Cardiology, IRI, ischemia reperfusion injury, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Oxidative stress
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8
المؤلفون: Wanida Ruangsiriluk, Kimberly A. Stevens, Markus Boehm, Benjamin N. Rocke, Paula M. Loria, Julie Jia Li Hawkins, Thomas N. O'Connell, Tim Rolph, Roger B. Ruggeri, Philip A. Carpino, David Hepworth, Bruce A. Maguire, Donna N. Petersen
المصدر: Cell Chemical Biology. 23:1362-1371
مصطلحات موضوعية: 0301 basic medicine, Clinical Biochemistry, Biology, Biochemistry, Small Molecule Libraries, 03 medical and health sciences, 0302 clinical medicine, Eukaryotic translation, Cell Line, Tumor, Drug Discovery, medicine, Humans, Secretion, Molecular Biology, Pharmacology, PCSK9 Inhibitors, Isoquinolines, Proprotein convertase, 030104 developmental biology, Mechanism of action, Protein Biosynthesis, 030220 oncology & carcinogenesis, LDL receptor, Molecular Medicine, Kexin, lipids (amino acids, peptides, and proteins), Secretagogue, Proprotein Convertase 9, medicine.symptom, Eukaryotic Ribosome, Ribosomes
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المؤلفون: Donna N. Petersen, David W. Piotrowski, Allyn T. Londregan, Brian Raymer, Paula M. Loria, Liuqing Wei, Kim F. McClure, Gary Erik Aspnes, Jun Xiao, Chris Limberakis, Roger B. Ruggeri
المصدر: Bioorganicmedicinal chemistry letters. 28(23-24)
مصطلحات موضوعية: 0301 basic medicine, Cell Membrane Permeability, Stereochemistry, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, 010402 general chemistry, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Madin Darby Canine Kidney Cells, 03 medical and health sciences, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, Dogs, Piperidines, Drug Discovery, Potency, Animals, Humans, Protease Inhibitors, Molecular Biology, ADME, Chemistry, Organic Chemistry, PCSK9 Inhibitors, Small molecule, Amides, In vitro, 0104 chemical sciences, Piperazine, 030104 developmental biology, Molecular Medicine, Piperidine, Proprotein Convertase 9
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المؤلفون: Angela Wolford, Heather Eng, Li Di, Amit S. Kalgutkar, Deepak Dalvie, Roger B. Ruggeri, Raman Sharma, Leonard Buckbinder, Edward L. Conn
المصدر: Drug Metabolism and Disposition. 44:1262-1269
مصطلحات موضوعية: Male, 0301 basic medicine, Metabolic Clearance Rate, Stereochemistry, Metabolite, Pharmaceutical Science, Flavin-containing monooxygenase, Oxidative phosphorylation, Models, Biological, 030226 pharmacology & pharmacy, Thiouracil, 03 medical and health sciences, chemistry.chemical_compound, Dogs, 0302 clinical medicine, Species Specificity, Animals, Humans, Enzyme Inhibitors, Rats, Wistar, Biotransformation, Peroxidase, Pharmacology, Chemistry, Glutathione, Monooxygenase, 030104 developmental biology, Liver, Microsomes, Liver, Oxygenases, Microsome, Administration, Intravenous, Sulfenic acid, Oxidation-Reduction, Half-Life
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5a3f704ca958ecb409d06f83a0de310
https://doi.org/10.1124/dmd.116.070185
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