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المؤلفون: Judith Günther, Roman C. Hillig, Katja Zimmermann, Stefan Kaulfuss, Clara Lemos, Duy Nguyen, Hartmut Rehwinkel, Matthew Habgood, Christian Lechner, Roland Neuhaus, Ursula Ganzer, Mark Drewes, Jijie Chai, Léa Bouché
المصدر: Journal of Medicinal Chemistry. 65:14366-14390
مصطلحات موضوعية: Drug Discovery, Molecular Medicine, Keto Acids, Transaminases, Amino Acids, Branched-Chain
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المؤلفون: Niels Böhnke, Markus Berger, Nils Griebenow, Antje Rottmann, Michael Erkelenz, Stefanie Hammer, Sandra Berndt, Judith Günther, Antje M. Wengner, Beatrix Stelte-Ludwig, Christoph Mahlert, Simone Greven, Lisa Dietz, Hannah Jörißen, Naomi Barak, Ulf Bömer, Roman C. Hillig, Uwe Eberspaecher, Jörg Weiske, Anja Giese, Dominik Mumberg, Carl Friedrich Nising, Hilmar Weinmann, Anette Sommer
المصدر: Bioconjugate chemistry. 33(6)
مصطلحات موضوعية: Pharmacology, B7 Antigens, Immunoconjugates, Organic Chemistry, Biomedical Engineering, Pharmaceutical Science, Bioengineering, Antineoplastic Agents, Xenograft Model Antitumor Assays, Mice, Structure-Activity Relationship, Cell Line, Tumor, Neoplasms, Animals, Humans, Nicotinamide Phosphoribosyltransferase, Biotechnology
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المؤلفون: Stuart L. Schreiber, Lennart Schnirch, Katja Zimmermann, A. Hilpmann, Dieter Moosmayer, Laura Furst, Jutta Hoffmann, Vasanthi S. Viswanathan, John K. Eaton, Roman C. Hillig, Stefan Gradl, Volker Badock
المصدر: Acta Crystallographica. Section D, Structural Biology
مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, Stereochemistry, Crystal structure, ML162, Crystallography, X-Ray, 010402 general chemistry, GPX4, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, Structural Biology, Humans, Enzyme Inhibitors, glutathione peroxidase 4, chemistry.chemical_classification, biology, Selenocysteine, Chemistry, HEK 293 cells, Active site, Phospholipid Hydroperoxide Glutathione Peroxidase, Research Papers, anti-oxidative defense system, ferroptosis, oxidoreductases, 0104 chemical sciences, HEK293 Cells, 030104 developmental biology, Structural biology, Covalent bond, biology.protein, covalent inhibitors, Selenoprotein, Protein Binding
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المؤلفون: Jeffrey Mowat, Alexander H. M. Ehrmann, Sven Christian, Carolyn Sperl, Stephan Menz, Judith Günther, Roman C. Hillig, Marcus Bauser, Wolfgang Schwede
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Organic Chemistry, Drug Discovery, Biochemistry
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المؤلفون: J. Schroeder, Stefan Gradl, Volker Badock, Knut Eis, Benjamin Bader, Hans Briem, Clara D. Christ, Patrick Steigemann, Roman C. Hillig, Duy Nguyen, Jérémie Mortier, Marcus Bauser, Anders Friberg, Dieter Moosmayer, Franziska Siegel
المصدر: ChemMedChem. 15:827-832
مصطلحات موضوعية: Pharmacology, 010405 organic chemistry, Chemistry, Organic Chemistry, Allosteric regulation, Naphthyridinone, Druggability, Computational biology, 01 natural sciences, Biochemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Workflow, Covalent bond, Docking (molecular), Drug Discovery, Molecular Medicine, General Pharmacology, Toxicology and Pharmaceutics, Pharmacophore
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المؤلفون: Roman C. Hillig, Ursula Egner
المصدر: Structural Biology in Drug Discovery
مصطلحات موضوعية: Nuclear receptor, Chemistry, Druggability, Biophysics, Binding site, Ion channel, Protein–protein interaction, G protein-coupled receptor
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::17ef568bf60524a9bb0e5612545c4050
https://doi.org/10.1002/9781118681121.ch2 -
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المؤلفون: Roman C. Hillig, Ioana Neagoe, Andreas Steinmeyer, Thomas M. Zollner, Stefanie Mesch, Henrik Dahllöf, Julie Klint, Simone Schulz, Vera Puetter, Reinhard Nubbemeyer, Antonius Ter Laak, Stefan Werner, Alexis Laux-Biehlmann, Nico Bräuer, Michaela Bairlein
المصدر: Journal of Medicinal Chemistry. 62:11194-11217
مصطلحات موضوعية: 0303 health sciences, Pregnane X receptor, CYP3A4, biology, Drug discovery, Chemistry, Cell growth, Antagonist, Pharmacology, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, In vivo, Drug Discovery, biology.protein, Molecular Medicine, Enzyme inducer, Receptor, 030304 developmental biology
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المؤلفون: Steven M. Corsello, Huajia Zhang, Rajesha Rupaimoole, Volker K. Schulze, Clara Lemos, Kasia B. Handing, Douglas L. Orsi, Mrinal Shekhar, Ulrike Sack, Sven Christian, Wilhelm Bone, Ranad Humeidi, William Colgan, Stephanie Hoyt, Andrew Cherniack, Jens Schroder, Stefan Kaulfuss, Krzysztof Brzezinka, Oliver von Ahsen, Anne Mengel, Roman C. Hillig, Detlev Suelzle, Jeremie Mortier, Caitlin Harrington, Rohith Nagari, Justyna Wierzbinska, Derek Chiang, Georg Beckmann, Meagan Olive, Namrata Udeshi, Annie Apffel, Steven Carr, Philip Lienau, Christian Lechner, Ulf Boemer, Alisha Caliman, David McKinney, Florence Wagner, Dominik Mumberg, Marcus Bauser, Andrea Haegebarth, Knut Eis, Ashley Eheim, Todd R. Golub
المصدر: Cancer Research. 82:3588-3588
مصطلحات موضوعية: Cancer Research, Oncology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::eda27f4110e552a48e195fe20ca593a7
https://doi.org/10.1158/1538-7445.am2022-3588 -
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المؤلفون: Hans Briem, Benjamin Bader, Ulf Boemer, Brice Sautier, N. Bohnke, A. Hilpmann, Nicolas Werbeck, J. Kahmann, Volker Badock, D. Wegener, Knut Eis, J. Schroeder, K. Graham, Dieter Moosmayer, Christian Stegmann, J. Mastouri, K. Petersen, Jörg Weiske, Gerhard Siemeister, Roman C. Hillig, Lars Wortmann, F. von Nussbaum
المصدر: 'Proceedings of the National Academy of Sciences of the USA ', vol: 116, pages: 2551-2560 (2019)
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America 116(7), 2551-2560 (2019). doi:10.1073/pnas.1812963116مصطلحات موضوعية: crystal structure, GTP', Crystallography, X-Ray, medicine.disease_cause, Biochemistry, Cell Line, Proto-Oncogene Proteins p21(ras), Drug Discovery, Fluorescence Resonance Energy Transfer, medicine, Humans, Small GTPase, Mode of action, Multidisciplinary, Chemistry, Drug discovery, fragment screen, SOS, Biological Sciences, High-Throughput Screening Assays, Cell biology, PNAS Plus, SOS1, ddc:500, Guanine nucleotide exchange factor, KRAS, Signal transduction, SOS1 Protein, small-molecule inhibitor, Protein Binding, Signal Transduction, RAS
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b81d68c52d5b8e57b984ebab279c8e8
https://doi.org/10.1073/pnas.1812963116 -
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المؤلفون: Susanne Roehrig, Kersten Matthias Gericke, Simone Schulz, Roman C. Hillig, Mark Jean Gnoth, Philip Lienau, Martina Schaefer, Swen Allerheiligen, Alexander Hillisch, Adrian Tersteegen, Stefan Heitmeier, Vera Puetter
المصدر: Journal of medicinal chemistry. 63(21)
مصطلحات موضوعية: Male, Transcriptional Activation, Administration, Oral, Pharmacology, 01 natural sciences, 03 medical and health sciences, Inhibitory Concentration 50, Structure-Activity Relationship, Thrombin, Pharmacokinetics, Drug Discovery, medicine, Structure–activity relationship, Animals, Cytochrome P-450 CYP3A, Humans, Rats, Wistar, Oxazolidinones, 030304 developmental biology, 0303 health sciences, Benzoxazoles, Binding Sites, CYP3A4, Chemistry, Imidazoles, Pregnane X Receptor, Anticoagulants, Prodrug, Small molecule, 0104 chemical sciences, Bioavailability, Rats, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Drug Design, Molecular Medicine, medicine.drug, Discovery and development of direct thrombin inhibitors, Half-Life
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