-
1
المؤلفون: William J. Ray, Mark T. Bilodeau, Matthew A. Seager, Marion Wittmann, Thomas J. Greshock, Scott D. Kuduk, Joy Fuerst, Lei Ma, Douglas C. Beshore, Kenneth A. Koeplinger, Christina N. Di Marco, Charles D. Thompson, George D. Hartman, Ronald K. Chang
المصدر: ACS Medicinal Chemistry Letters. 9:652-656
مصطلحات موضوعية: 0301 basic medicine, Allosteric modulator, business.industry, Organic Chemistry, M1 muscarinic receptor, Highly selective, Biochemistry, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Drug Discovery, Muscarinic acetylcholine receptor, Medicine, In patient, Signal transduction, business, Neuroscience, 030217 neurology & neurosurgery
-
2
المؤلفون: Douglas C, Beshore, Christina, N Di Marco, Ronald K, Chang, Thomas J, Greshock, Lei, Ma, Marion, Wittmann, Matthew A, Seager, Kenneth A, Koeplinger, Charles D, Thompson, Joy, Fuerst, George D, Hartman, Mark T, Bilodeau, William J, Ray, Scott D, Kuduk
المصدر: ACS medicinal chemistry letters. 9(7)
-
3
المؤلفون: Joel M. Harris, Xiaoping Zhou, John A. Morrow, Sue-Ing Lin, Marco A. S. Baptista, John M. Sanders, Xiaoping Zhang, Hong Mei, Mark W. Embrey, Sylvie M. Sur, Duane E. DeMong, Ravi P. Nargund, Alan Hruza, Heather E. Tiscia, Matthew J. Fell, Zhizhang Yin, Gautam Agnihotri, Honglu Zhang, Thomas J. Greshock, Jack D. Scott, Yinghui Lin, Zhi-Cai Shi, John A. Mccauley, Sarah W. Li, Ronald K. Chang, Mark T. Bilodeau, Michael W. Miller, Reshma Kuvelkar, Andrew Stamford, Marc Poirier, Hong Liu, Megan K. Macala, Kallol Basu, Li Xiao, Lynn A. Hyde, Jonathan T. Kern, Xing Dai, Christian Mirescu, Paul L. Walsh, Matthew E. Kennedy, John J. Renger, Zhiyong Hu, John Columbus, Robert E. Drolet, Eric M. Parker
المصدر: Journal of medicinal chemistry. 60(7)
مصطلحات موضوعية: 0301 basic medicine, Male, Indazoles, Leucine-rich repeat, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, Animals, Humans, c-Raf, Kinase activity, Enzyme Inhibitors, Rats, Wistar, biology, Cyclin-dependent kinase 4, Kinase, Chemistry, Cyclin-dependent kinase 2, Brain, Parkinson Disease, LRRK2, nervous system diseases, Rats, Molecular Docking Simulation, 030104 developmental biology, Protein kinase domain, Biochemistry, biology.protein, Molecular Medicine, 030217 neurology & neurosurgery
-
4
المؤلفون: Marion Wittmann, William J. Ray, Scott D. Kuduk, Matthew A. Seager, Ronald K. Chang, George D. Hartman, Mark T. Bilodeau, Kenneth A. Koeplinger, Charles D. Thompson, Lei Ma, Thomas J. Greshock
المصدر: ACS Medicinal Chemistry Letters. 3:1070-1074
مصطلحات موضوعية: chemistry.chemical_classification, business.industry, Stereochemistry, Carboxylic acid, Organic Chemistry, Allosteric regulation, M1 muscarinic receptor, Biochemistry, chemistry.chemical_compound, chemistry, Pyran, In vivo, Drug Discovery, Medicine, Moiety, In patient, Cognitive decline, business
-
5
المؤلفون: Li Hao, Carolyn Bahnck-Teets, Catherine M. Wiscount, Daniel J. McKay, Carmela Molinaro, Ronald K. Chang, S S Carroll, Sivalenka Vijayasaradhi, Philippe G. Nantermet, Sanjay Kumar Singh, Christopher J. Bungard, Dubost David C, David Jonathan Bennett, Thomas J. Greshock, Hua-Poo Su, Rosa I. Sanchez, Vouy Linh Truong, Xu Min, John F. Fay, Jeanine E. Ballard, John A. McCauley, Christian Beaulieu, M. Katharine Holloway, Joseph P. Vacca, Michael W. Miller, Tummanapalli Satyanarayana, Sheldon Crane, William D. Shipe, Jesse J. Manikowski, Peter D. Williams, Christian Nadeau, Jennifer J. Gesell, Tracy L. Diamond, Peter J. Felock, Oscar Miguel Moradei
مصطلحات موضوعية: Hydrolase inhibitor, chemistry.chemical_classification, Protease, 010405 organic chemistry, Chemistry, Stereochemistry, medicine.medical_treatment, Organic Chemistry, Human immunodeficiency virus (HIV), 010402 general chemistry, medicine.disease_cause, 01 natural sciences, Biochemistry, 0104 chemical sciences, chemistry.chemical_compound, Aspartate binding, Enzyme, Morpholine, Drug Discovery, medicine, Potency, HIV Protease Inhibitor
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f685aed82b9b428b5b9e7330d8f427
https://europepmc.org/articles/PMC4948015/ -
6
المؤلفون: John A. McCauley, Ronald K. Chang, Thomas J. Greshock, Ming-Tain Lai, John M. Sanders, Hemaka A. Rajapakse, Hua Su, Robert E. Drolet, Rosa I. Sanchez, Sylvie M. Sur, John J. Renger, Jonathan T. Kern, Heather E. Tiscia, Rada Vanessa L, Mark T. Bilodeau, Boyoung Kim
المصدر: Bioorganicmedicinal chemistry letters. 26(11)
مصطلحات موضوعية: 0301 basic medicine, Parkinson's disease, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Biological Availability, Thiophenes, Leucine-rich repeat, Pharmacology, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, 0302 clinical medicine, Drug Discovery, medicine, Structure–activity relationship, Humans, Molecular Biology, Protein Kinase Inhibitors, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Kinase, Organic Chemistry, medicine.disease, LRRK2, Small molecule, nervous system diseases, Molecular Docking Simulation, 030104 developmental biology, Lactam, Molecular Medicine, Sample collection, 030217 neurology & neurosurgery
-
7
المؤلفون: Ronald K. Chang, Scott D. Kuduk, Vanita Puri, William J. Ray, J. A. Vivian, Christopher E. Cannon, Jane Sutcliffe, Michelle Pearson, Marion Wittmann, Chan Sing Chew, Donnie Eddins, Jason M. Uslaner
المصدر: Psychopharmacology. 225:21-30
مصطلحات موضوعية: Male, Allosteric modulator, Scopolamine, Allosteric regulation, Mice, Cognition, Allosteric Regulation, Piperidines, Species Specificity, Alzheimer Disease, Muscarinic acetylcholine receptor, medicine, Muscarinic acetylcholine receptor M4, Animals, Rats, Wistar, Receptor, Pharmacology, Dose-Response Relationship, Drug, biology, Receptor, Muscarinic M1, Brain, Muscarinic acetylcholine receptor M1, biology.organism_classification, Macaca mulatta, Rats, Disease Models, Animal, Macaca fascicularis, Rhesus macaque, Regional Blood Flow, Female, Cognition Disorders, Psychology, Neuroscience, Quinolizines, Acetylcholine, medicine.drug
-
8
المؤلفون: William J. Ray, Kenneth A. Koeplinger, Thomas J. Greshock, Matthew A. Seager, Christina N. Di Marco, Scott D. Kuduk, Ronald K. Chang, Lei Ma, George D. Hartman, Daniel R. Pitts, Charles D. Thompson, Marion Wittmann, Mark T. Bilodeau
المصدر: Journal of Medicinal Chemistry. 54:4773-4780
مصطلحات موضوعية: Male, Quinolizidines, Allosteric regulation, Cholinergic Agents, Biological Availability, CHO Cells, Pharmacology, Mice, Structure-Activity Relationship, Acetylcholine binding, Cricetulus, Allosteric Regulation, Piperidines, Cricetinae, Nitriles, Drug Discovery, Muscarinic acetylcholine receptor, Animals, Humans, Cognitive decline, Receptor, Nootropic Agents, Basal forebrain, Chemistry, Receptor, Muscarinic M1, Fear, Muscarinic acetylcholine receptor M1, Biochemistry, Molecular Medicine, Cholinergic, Quinolizines
-
9
المؤلفون: Thomas J. Greshock, Scott D. Kuduk, Ronald K. Chang, Daniel R. Pitts, Christina N. Di Marco
المصدر: Tetrahedron Letters. 50:6303-6306
مصطلحات موضوعية: Substitution reaction, Nucleophilic aromatic substitution, Chemistry, Organic Chemistry, Drug Discovery, Rapid access, Organic chemistry, Biochemistry, Combinatorial chemistry
-
10
المؤلفون: Duane R. Reiss, Ronald K. Chang, Scott D. Kuduk, Kathy L. Murphy, Douglas J. Pettibone, Thomayant Prueksaritanont, Robert M. DiPardo, Cuyue Tang, Mark G. Bock, Christina N. Di Marco, Richard W. Ransom
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:5107-5110
مصطلحات موضوعية: Central Nervous System, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Tetrazoles, Pharmaceutical Science, Oxadiazole, Bradykinin, Carboxamide, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Amide, Drug Discovery, medicine, Animals, Combinatorial Chemistry Techniques, Humans, Tetrazole, Molecular Biology, G protein-coupled receptor, Molecular Structure, Chemistry, Organic Chemistry, Metabolism, Amides, Rats, Bradykinin B1 Receptor Antagonists, Drug Design, Molecular Medicine