المؤلفون: Huseman ED; Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States., Lo A; Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States., Fedorova O; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, United States.; Howard Hughes Medical Institute, New Haven, Connecticut 06520, United States., Elia JL; Department of Pathology, Yale School of Medicine, New Haven, Connecticut 06520, United States., Gueble SE; Department of Therapeutic Radiology, Yale School of Medicine, New Haven, Connecticut 06520, United States., Lin K; Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States.; Department of Pathology, Yale School of Medicine, New Haven, Connecticut 06520, United States.; Department of Therapeutic Radiology, Yale School of Medicine, New Haven, Connecticut 06520, United States., Sundaram RK; Department of Therapeutic Radiology, Yale School of Medicine, New Haven, Connecticut 06520, United States., Oh J; Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States.; Institute of Biomolecular Design & Discovery, Yale University, West Haven, Connecticut 06516, United States., Liu J; Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States., Menges F; Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States.; Department of Chemistry, Chemical and Biophysical Instrumentation Center, Yale University, New Haven, Connecticut 06520, United States., Rees MG; Broad Institute of MIT and Harvard; Cambridge, Massachusetts 02142, United States., Ronan MM; Broad Institute of MIT and Harvard; Cambridge, Massachusetts 02142, United States., Roth JA; Broad Institute of MIT and Harvard; Cambridge, Massachusetts 02142, United States., Batista VS; Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States., Crawford JM; Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States.; Department of Chemistry, Chemical and Biophysical Instrumentation Center, Yale University, New Haven, Connecticut 06520, United States.; Department of Microbial Pathogenesis, Yale School of Medicine; New Haven, Connecticut 06520, United States., Pyle AM; Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States.; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, United States.; Howard Hughes Medical Institute, New Haven, Connecticut 06520, United States., Bindra RS; Department of Pathology, Yale School of Medicine, New Haven, Connecticut 06520, United States.; Department of Therapeutic Radiology, Yale School of Medicine, New Haven, Connecticut 06520, United States., Herzon SB; Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States.; Department of Therapeutic Radiology, Yale School of Medicine, New Haven, Connecticut 06520, United States.; Department of Pharmacology, Yale School of Medicine; New Haven, Connecticut 06520, United States.

المصدر: Journal of the American Chemical Society [J Am Chem Soc] 2024 Jul 10; Vol. 146 (27), pp. 18241-18252. Date of Electronic Publication: 2024 May 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

مواضيع طبية MeSH: Drug Resistance, Neoplasm*/drug effects , Brain Neoplasms*/drug therapy , Brain Neoplasms*/pathology, Humans ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/therapeutic use ; Cell Line, Tumor ; DNA Repair/drug effects ; O(6)-Methylguanine-DNA Methyltransferase/metabolism ; O(6)-Methylguanine-DNA Methyltransferase/antagonists & inhibitors ; Imidazoles/chemistry ; Imidazoles/pharmacology ; Imidazoles/therapeutic use

المؤلفون: Thatikonda V; Boehringer Ingelheim RCV GmbH & Co KG, Doktor-Boehringer-Gasse 5-11, Vienna 1120, Austria. Electronic address: vthatikonda@exscientia.co.uk., Supper V; Boehringer Ingelheim RCV GmbH & Co KG, Doktor-Boehringer-Gasse 5-11, Vienna 1120, Austria., Wachter J; Boehringer Ingelheim RCV GmbH & Co KG, Doktor-Boehringer-Gasse 5-11, Vienna 1120, Austria., Kaya O; Boehringer Ingelheim RCV GmbH & Co KG, Doktor-Boehringer-Gasse 5-11, Vienna 1120, Austria., Kombara A; Boehringer Ingelheim RCV GmbH & Co KG, Doktor-Boehringer-Gasse 5-11, Vienna 1120, Austria., Bilgilier C; Boehringer Ingelheim RCV GmbH & Co KG, Doktor-Boehringer-Gasse 5-11, Vienna 1120, Austria., Ravichandran MC; Boehringer Ingelheim RCV GmbH & Co KG, Doktor-Boehringer-Gasse 5-11, Vienna 1120, Austria., Lipp JJ; Boehringer Ingelheim RCV GmbH & Co KG, Doktor-Boehringer-Gasse 5-11, Vienna 1120, Austria., Sharma R; Myllia Biotechnology GmbH, Am Kanal 27, Vienna 1110, Austria., Badertscher L; Myllia Biotechnology GmbH, Am Kanal 27, Vienna 1110, Austria., Boghossian AS; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Rees MG; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Ronan MM; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Roth JA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Grosche S; Boehringer Ingelheim RCV GmbH & Co KG, Doktor-Boehringer-Gasse 5-11, Vienna 1120, Austria., Neumüller RA; Boehringer Ingelheim RCV GmbH & Co KG, Doktor-Boehringer-Gasse 5-11, Vienna 1120, Austria., Mair B; Boehringer Ingelheim RCV GmbH & Co KG, Doktor-Boehringer-Gasse 5-11, Vienna 1120, Austria., Mauri F; Boehringer Ingelheim RCV GmbH & Co KG, Doktor-Boehringer-Gasse 5-11, Vienna 1120, Austria., Popa A; Boehringer Ingelheim RCV GmbH & Co KG, Doktor-Boehringer-Gasse 5-11, Vienna 1120, Austria. Electronic address: alexandra.popa@boehringer-ingelheim.com.

المصدر: Cell reports [Cell Rep] 2024 May 28; Vol. 43 (5), pp. 114175. Date of Electronic Publication: 2024 Apr 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

مواضيع طبية MeSH: Transcription Factors*/metabolism , Transcription Factors*/genetics , Neoplasms*/genetics , Neoplasms*/metabolism , Neoplasms*/pathology, Humans ; Cell Line, Tumor ; TEA Domain Transcription Factors/metabolism ; Gene Expression Regulation, Neoplastic ; DNA-Binding Proteins/metabolism ; DNA-Binding Proteins/genetics ; Biomarkers, Tumor/metabolism ; Biomarkers, Tumor/genetics ; Cell Proliferation

المؤلفون: Calbert ML; Department of Biochemistry and Molecular Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania., Chandramouly G; Department of Biochemistry and Molecular Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Adams CM; Department of Pharmacology, Physiology, and Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Saez-Ayala M; Centre de Recherche en Cancérologie de Marseille (CRCM), CNRS, INSERM, Aix-Marseille Univ, Institut Paoli-Calmettes, Marseille, France., Kent T; Department of Biochemistry and Molecular Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Tyagi M; Department of Biochemistry and Molecular Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Ayyadevara VSSA; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania., Wang Y; Fox Chase Cancer Center, Philadelphia, Pennsylvania., Krais JJ; Fox Chase Cancer Center, Philadelphia, Pennsylvania., Gordon J; Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, Philadelphia, Pennsylvania., Atkins J; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania., Toma MM; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania., Betzi S; Centre de Recherche en Cancérologie de Marseille (CRCM), CNRS, INSERM, Aix-Marseille Univ, Institut Paoli-Calmettes, Marseille, France., Boghossian AS; Broad Institute of MIT and Harvard, Cambridge Massachusetts., Rees MG; Broad Institute of MIT and Harvard, Cambridge Massachusetts., Ronan MM; Broad Institute of MIT and Harvard, Cambridge Massachusetts., Roth JA; Broad Institute of MIT and Harvard, Cambridge Massachusetts., Goldman AR; The Wistar Institute, Philadelphia, Pennsylvania., Gorman N; The Wistar Institute, Philadelphia, Pennsylvania., Mitra R; Division of Biostatistics, Department of Pharmacology, Physiology, and Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Childers WE; Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, Philadelphia, Pennsylvania., Graña X; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania., Skorski T; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania., Johnson N; Fox Chase Cancer Center, Philadelphia, Pennsylvania., Hurtz C; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania., Morelli X; Centre de Recherche en Cancérologie de Marseille (CRCM), CNRS, INSERM, Aix-Marseille Univ, Institut Paoli-Calmettes, Marseille, France., Eischen CM; Department of Pharmacology, Physiology, and Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Pomerantz RT; Department of Biochemistry and Molecular Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

المصدر: Molecular cancer therapeutics [Mol Cancer Ther] 2024 May 02; Vol. 23 (5), pp. 683-699.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

مواضيع طبية MeSH: Deoxycytidine*/analogs & derivatives , Deoxycytidine*/pharmacology, Humans ; Animals ; Mice ; Cell Line, Tumor ; Lymphoma/drug therapy ; Lymphoma/pathology ; Lymphoma/metabolism ; Xenograft Model Antitumor Assays ; Leukemia/drug therapy ; Leukemia/pathology ; Deoxycytidine Kinase/metabolism

المؤلفون: Wasko UN; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA., Jiang J; Revolution Medicines, Redwood City, CA, USA., Dalton TC; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA., Curiel-Garcia A; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA., Edwards AC; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Wang Y; Revolution Medicines, Redwood City, CA, USA., Lee B; Revolution Medicines, Redwood City, CA, USA., Orlen M; University of Pennsylvania Perelman School of Medicine, Department of Medicine, Philadelphia, PA, USA., Tian S; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Stalnecker CA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Drizyte-Miller K; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Menard M; Revolution Medicines, Redwood City, CA, USA., Dilly J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Sastra SA; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA., Palermo CF; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA., Hasselluhn MC; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA., Decker-Farrell AR; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA., Chang S; Revolution Medicines, Redwood City, CA, USA., Jiang L; Revolution Medicines, Redwood City, CA, USA., Wei X; Revolution Medicines, Redwood City, CA, USA., Yang YC; Revolution Medicines, Redwood City, CA, USA., Helland C; Revolution Medicines, Redwood City, CA, USA., Courtney H; Revolution Medicines, Redwood City, CA, USA., Gindin Y; Revolution Medicines, Redwood City, CA, USA., Muonio K; Revolution Medicines, Redwood City, CA, USA., Zhao R; Revolution Medicines, Redwood City, CA, USA., Kemp SB; University of Pennsylvania Perelman School of Medicine, Department of Medicine, Philadelphia, PA, USA., Clendenin C; University of Pennsylvania Perelman School of Medicine, Abramson Cancer Center, Philadelphia, PA, USA., Sor R; University of Pennsylvania Perelman School of Medicine, Abramson Cancer Center, Philadelphia, PA, USA., Vostrejs WP; University of Pennsylvania Perelman School of Medicine, Department of Medicine, Philadelphia, PA, USA., Hibshman PS; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Amparo AM; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Hennessey C; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Rees MG; The Broad Institute of Harvard and MIT, Cambridge, MA, USA., Ronan MM; The Broad Institute of Harvard and MIT, Cambridge, MA, USA., Roth JA; The Broad Institute of Harvard and MIT, Cambridge, MA, USA., Brodbeck J; Revolution Medicines, Redwood City, CA, USA., Tomassoni L; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA., Bakir B; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA., Socci ND; Bioinformatics Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Herring LE; UNC Michael Hooker Proteomics Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Barker NK; UNC Michael Hooker Proteomics Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Wang J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Cleary JM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Wolpin BM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Chabot JA; Department of Surgery, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA., Kluger MD; Department of Surgery, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA., Manji GA; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA., Tsai KY; Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.; Department of Tumor Microenvironment and Metastasis, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Sekulic M; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Lagana SM; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Califano A; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.; J. P. Sulzberger Columbia Genome Center, Columbia University, New York, NY, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.; Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, NY, USA.; Chan Zuckerberg Biohub New York, New York, NY, USA., Quintana E; Revolution Medicines, Redwood City, CA, USA., Wang Z; Revolution Medicines, Redwood City, CA, USA., Smith JAM; Revolution Medicines, Redwood City, CA, USA., Holderfield M; Revolution Medicines, Redwood City, CA, USA., Wildes D; Revolution Medicines, Redwood City, CA, USA., Lowe SW; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Badgley MA; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA., Aguirre AJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; The Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Vonderheide RH; University of Pennsylvania Perelman School of Medicine, Department of Medicine, Philadelphia, PA, USA.; University of Pennsylvania Perelman School of Medicine, Abramson Cancer Center, Philadelphia, PA, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA., Stanger BZ; University of Pennsylvania Perelman School of Medicine, Department of Medicine, Philadelphia, PA, USA.; University of Pennsylvania Perelman School of Medicine, Abramson Cancer Center, Philadelphia, PA, USA., Baslan T; Department of Biomedical Sciences, School of Veterinary Medicine, The University of Pennsylvania, Philadelphia, PA, USA., Der CJ; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Singh M; Revolution Medicines, Redwood City, CA, USA. msingh@revmed.com., Olive KP; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA. kenolive@columbia.edu.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA. kenolive@columbia.edu.

المصدر: Nature [Nature] 2024 May; Vol. 629 (8013), pp. 927-936. Date of Electronic Publication: 2024 Apr 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/therapeutic use , Carcinoma, Pancreatic Ductal*/drug therapy , Carcinoma, Pancreatic Ductal*/pathology , Carcinoma, Pancreatic Ductal*/genetics , Carcinoma, Pancreatic Ductal*/metabolism , Guanosine Triphosphate*/metabolism , Pancreatic Neoplasms*/drug therapy , Pancreatic Neoplasms*/pathology , Pancreatic Neoplasms*/genetics , Pancreatic Neoplasms*/metabolism , Proto-Oncogene Proteins p21(ras)*/genetics , Proto-Oncogene Proteins p21(ras)*/metabolism , Proto-Oncogene Proteins p21(ras)*/antagonists & inhibitors, Animals ; Female ; Humans ; Mice ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Disease Models, Animal ; DNA Copy Number Variations ; Drug Resistance, Neoplasm/drug effects ; Genes, myc ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/genetics ; Treatment Outcome ; Xenograft Model Antitumor Assays ; Mutation

المؤلفون: Pichavaram P; Department of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee., Jablonowski CM; Department of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee., Fang J; Department of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee., Fleming AM; Department of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee.; Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee., Gil HJ; Department of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee., Boghossian AS; Broad Institute of Harvard and MIT, Cambridge, Massachusetts., Rees MG; Broad Institute of Harvard and MIT, Cambridge, Massachusetts., Ronan MM; Broad Institute of Harvard and MIT, Cambridge, Massachusetts., Roth JA; Broad Institute of Harvard and MIT, Cambridge, Massachusetts., Morton CL; Department of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee., Zambetti GP; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee., Davidoff AM; Department of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee.; Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee.; Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee., Yang J; Department of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee.; Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee., Murphy AJ; Department of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee.; Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee.

المصدر: Molecular cancer therapeutics [Mol Cancer Ther] 2024 Apr 02; Vol. 23 (4), pp. 478-491.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

مواضيع طبية MeSH: Jumonji Domain-Containing Histone Demethylases*/genetics , Ribosomal Proteins* , Heterocyclic Compounds, 4 or More Rings*, Humans ; HEK293 Cells ; Cell Line, Tumor ; Kidney/metabolism ; Ribosomes/metabolism

المؤلفون: Hwang GH; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Neurobiology, Harvard Medical School, Boston, Massachusetts., Pazyra-Murphy MF; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Neurobiology, Harvard Medical School, Boston, Massachusetts., Seo HS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts., Dhe-Paganon S; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts., Stopka SA; Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., DiPiazza M; Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Sutter N; Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.; Brigham Young University-Hawaii, Kulanui St, Hawaii., Gero TW; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts., Volkert A; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts., Ombelets L; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts., Dittemore G; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts., Rees MG; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Ronan MM; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Roth JA; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Agar NYR; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.; Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Scott DA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts., Segal RA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Neurobiology, Harvard Medical School, Boston, Massachusetts.

المصدر: Cancer research [Cancer Res] 2024 Mar 15; Vol. 84 (6), pp. 872-886.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Medulloblastoma*/drug therapy , Medulloblastoma*/genetics , Brain Neoplasms* , Cerebellar Neoplasms*/drug therapy, Benzbromarone/*analogs & derivatives, Animals ; Mice ; Humans ; Child ; Hedgehog Proteins

المؤلفون: Maw JJ; Center for Therapeutics Discovery, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, United States., Coker JA; Center for Therapeutics Discovery, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, United States., Arya T; Center for Therapeutics Discovery, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, United States., Goins CM; Center for Therapeutics Discovery, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, United States., Sonawane D; Center for Therapeutics Discovery, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, United States., Han SH; Center for Therapeutics Discovery, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, United States., Rees MG; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge Massachusetts 02142, United States., Ronan MM; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge Massachusetts 02142, United States., Roth JA; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge Massachusetts 02142, United States., Wang NS; Center for Therapeutics Discovery, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, United States., Heemers HV; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, United States., Macdonald JD; Center for Therapeutics Discovery, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, United States., Stauffer SR; Center for Therapeutics Discovery, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Feb 22; Vol. 67 (4), pp. 2631-2666. Date of Electronic Publication: 2024 Feb 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Protein Serine-Threonine Kinases*/metabolism , Cytokinesis*/physiology, Humans ; Cell Division ; Phosphorylation ; Cell Proliferation

المؤلفون: Payton M; Oncology Research, Amgen Research, Thousand Oaks, CA, USA. mpayton@amgen.com., Belmontes B; Oncology Research, Amgen Research, Thousand Oaks, CA, USA., Hanestad K; Oncology Research, Amgen Research, Thousand Oaks, CA, USA., Moriguchi J; Oncology Research, Amgen Research, Thousand Oaks, CA, USA., Chen K; Lead Discovery and Characterization, Amgen Research, Thousand Oaks, CA, USA., McCarter JD; Lead Discovery and Characterization, Amgen Research, Thousand Oaks, CA, USA., Chung G; Oncology Research, Amgen Research, Thousand Oaks, CA, USA., Ninniri MS; Oncology Research, Amgen Research, Thousand Oaks, CA, USA., Sun J; Oncology Research, Amgen Research, Thousand Oaks, CA, USA., Manoukian R; Cytometry Sciences, Amgen Research, Cambridge, MA, USA., Chambers S; Research Biomics, Amgen Research, San Francisco, CA, USA., Ho SM; Research Biomics, Amgen Research, San Francisco, CA, USA., Kurzeja RJM; Protein Technologies, Amgen Research, Thousand Oaks, CA, USA., Edson KZ; PKDM, Amgen Research, Thousand Oaks, CA, USA., Dahal UP; PKDM, Amgen Research, San Francisco, CA, USA., Wu T; Pre-Pivotal Drug Product, Amgen Process Development, Thousand Oaks, CA, USA., Wannberg S; Inflammation, Amgen Research, Thousand Oaks, CA, USA., Beltran PJ; Oncology Research, Amgen Research, Thousand Oaks, CA, USA., Canon J; Oncology Research, Amgen Research, Thousand Oaks, CA, USA., Boghossian AS; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Rees MG; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ronan MM; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Roth JA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Minocherhomji S; Translational Safety and Bioanalytical Sciences, Amgen Research, Thousand Oaks, CA, USA., Bourbeau MP; Medicinal Chemistry, Amgen Research, Thousand Oaks, CA, USA., Allen JR; Medicinal Chemistry, Amgen Research, Thousand Oaks, CA, USA., Coxon A; Oncology Research, Amgen Research, Thousand Oaks, CA, USA., Tamayo NA; Medicinal Chemistry, Amgen Research, Thousand Oaks, CA, USA., Hughes PE; Oncology Research, Amgen Research, Thousand Oaks, CA, USA.

المصدر: Nature cancer [Nat Cancer] 2024 Jan; Vol. 5 (1), pp. 66-84. Date of Electronic Publication: 2023 Dec 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Kinesins*/genetics , Kinesins*/metabolism , Triple Negative Breast Neoplasms*, Humans ; Animals ; Mice ; Mitosis/genetics ; Cell Line ; M Phase Cell Cycle Checkpoints

المؤلفون: Wasko UN; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY., Jiang J; Revolution Medicines, Inc., Redwood City, CA., Curiel-Garcia A; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY., Wang Y; Revolution Medicines, Inc., Redwood City, CA., Lee B; Revolution Medicines, Inc., Redwood City, CA., Orlen M; University of Pennsylvania Perelman School of Medicine, Department of Medicine., Drizyte-Miller K; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Menard M; Revolution Medicines, Inc., Redwood City, CA., Dilly J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.; Harvard Medical School, Boston, MA., Sastra SA; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY., Palermo CF; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY., Dalton T; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY., Hasselluhn MC; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY., Decker-Farrell AR; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY., Chang S; Revolution Medicines, Inc., Redwood City, CA., Jiang L; Revolution Medicines, Inc., Redwood City, CA., Wei X; Revolution Medicines, Inc., Redwood City, CA., Yang YC; Revolution Medicines, Inc., Redwood City, CA., Helland C; Revolution Medicines, Inc., Redwood City, CA., Courtney H; Revolution Medicines, Inc., Redwood City, CA., Gindin Y; Revolution Medicines, Inc., Redwood City, CA., Zhao R; Revolution Medicines, Inc., Redwood City, CA., Kemp SB; University of Pennsylvania Perelman School of Medicine, Department of Medicine., Clendenin C; University of Pennsylvania Perelman School of Medicine, Abramson Cancer Center., Sor R; University of Pennsylvania Perelman School of Medicine, Abramson Cancer Center., Vostrejs W; University of Pennsylvania Perelman School of Medicine, Department of Medicine., Amparo AA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Hibshman PS; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Rees MG; The Broad Institute of Harvard and MIT, Cambridge, MA., Ronan MM; The Broad Institute of Harvard and MIT, Cambridge, MA., Roth JA; The Broad Institute of Harvard and MIT, Cambridge, MA., Bakir B; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY., Badgley MA; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY., Chabot JA; Department of Surgery, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY., Kluger MD; Department of Surgery, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY., Manji GA; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY., Quintana E; Revolution Medicines, Inc., Redwood City, CA., Wang Z; Revolution Medicines, Inc., Redwood City, CA., Smith JAM; Revolution Medicines, Inc., Redwood City, CA., Holderfield M; Revolution Medicines, Inc., Redwood City, CA., Wildes D; Revolution Medicines, Inc., Redwood City, CA., Aguirre AJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.; Harvard Medical School, Boston, MA.; The Broad Institute of Harvard and MIT, Cambridge, MA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA., Der CJ; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Vonderheide RH; University of Pennsylvania Perelman School of Medicine, Department of Medicine.; University of Pennsylvania Perelman School of Medicine, Abramson Cancer Center.; Parker Institute for Cancer Immunotherapy., Stanger BZ; University of Pennsylvania Perelman School of Medicine, Department of Medicine.; University of Pennsylvania Perelman School of Medicine, Abramson Cancer Center., Singh M; Revolution Medicines, Inc., Redwood City, CA., Olive KP; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY.

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2023 Dec 04. Date of Electronic Publication: 2023 Dec 04.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Reis J; Department of Biology and Biotechnology Lazzaro Spallanzani, University of Pavia, Pavia, Italy.; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Gorgulla C; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Physics, Faculty of Arts and Sciences, Harvard University, Cambridge, MA, USA., Massari M; Department of Biology and Biotechnology Lazzaro Spallanzani, University of Pavia, Pavia, Italy., Marchese S; Department of Biology and Biotechnology Lazzaro Spallanzani, University of Pavia, Pavia, Italy., Valente S; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy., Noce B; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy., Basile L; Department of Biology and Biotechnology Lazzaro Spallanzani, University of Pavia, Pavia, Italy., Törner R; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Cox H 3rd; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Viennet T; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Yang MH; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Ronan MM; Broad Institute of Harvard and MIT, Cambridge, USA., Rees MG; Broad Institute of Harvard and MIT, Cambridge, USA., Roth JA; Broad Institute of Harvard and MIT, Cambridge, USA., Capasso L; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Naples, Italy., Nebbioso A; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Naples, Italy., Altucci L; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Naples, Italy., Mai A; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy. Antonello.Mai@uniroma1.it., Arthanari H; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. hari_arthanari@hms.harvard.edu.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. hari_arthanari@hms.harvard.edu., Mattevi A; Department of Biology and Biotechnology Lazzaro Spallanzani, University of Pavia, Pavia, Italy. andrea.mattevi@unipv.it.

المصدر: Nature chemical biology [Nat Chem Biol] 2023 Dec; Vol. 19 (12), pp. 1540-1550. Date of Electronic Publication: 2023 Oct 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: NADPH Oxidases*/chemistry , NADPH Oxidases*/metabolism , Neoplasms*/drug therapy, Humans ; Reactive Oxygen Species/metabolism ; Oxidation-Reduction ; Cell Line