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1
المؤلفون: John J. Renger, Joyce Stellabott, Swati P. Mercer, Wei Lemaire, Thomas S. Reger, Christopher D. Cox, Pamela L. Tannenbaum, Christopher J. Winrow, Joanne Stevens, Donghui Cui, Joseph G. Bruno, Susan L. Garson, Rowena V. Cube, M. Christa Mattern, Dansu Li, C. Meacham Harrell, Paul J. Coleman, John D. Schreier, Tamara D. Cabalu, George D. Hartman, Anthony L. Gotter, Steven V. Fox, Jeffrey M. Bergman, Anthony J. Roecker, Thomayant Prueksaritanont, Steven D. Young
المصدر: Bioorganic & Medicinal Chemistry Letters. 24:4884-4890
مصطلحات موضوعية: medicine.medical_specialty, Pyridines, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Doras, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Sleep Initiation and Maintenance Disorders, Internal medicine, mental disorders, Drug Discovery, medicine, Animals, Humans, Isonicotinamide, Receptor, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, biology, CYP3A4, Organic Chemistry, Antagonist, biology.organism_classification, Small molecule, Orexin receptor, Rats, Orexin, Thiazoles, Endocrinology, chemistry, Molecular Medicine, Orexin Receptor Antagonists
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2
المؤلفون: Rowena V. Cube, Cindy E. Nuss, Thomayant Prueksaritanont, Scott M. Doran, Jim Small, Wei Zeng, Julie Ann Luk, Cynthia Chavez-Eng, William O. Cook, T Laethem, Victor N. Uebele, Susan L. Garson, Thomas S. Reger, Richard L. Kraus, Yuhsin Kuo, Christa Mattern, Wei Fang, Cuyue Tang, John J. Renger, Paul J. Coleman, Kelly Ann S. Schlegel, Adekemi B. Taylor, Yuxing Li, Zhi Qiang Yang, James C. Barrow, Shu Youheng, Jeanine E. Ballard, Matthew D. Troyer, George D. Hartman, Steven V. Fox
المصدر: ACS Medicinal Chemistry Letters. 1:504-509
مصطلحات موضوعية: business.industry, Calcium channel, Organic Chemistry, T-type calcium channel, Cmax, Pharmacology, Biochemistry, In vitro, chemistry.chemical_compound, Pharmacokinetics, chemistry, In vivo, Drug Discovery, Medicine, business, Lead compound, Acetamide
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3
المؤلفون: Pasquale P. Vicario, Thomas Wisniewski, Sima R. Patel, Julia M. Ayala, Julie A. DeMartino, Anthony B. Pinkerton, Jean-Michel Vernier, Hutchinson John H, Dehua Huang, Rowena V. Cube, Mary Struthers
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:807-813
مصطلحات موضوعية: CCR2, Receptors, CCR2, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, In Vitro Techniques, Biochemistry, Chemical synthesis, Monocytes, Structure-Activity Relationship, Chemokine receptor, Drug Discovery, Humans, Potency, Structure–activity relationship, Receptor, Molecular Biology, IC50, G protein-coupled receptor, Chemistry, Chemotaxis, Organic Chemistry, Pyrazoles, Molecular Medicine, Indicators and Reagents, Receptors, Chemokine, Oxidation-Reduction
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4
المؤلفون: Joyce K. James, Hutchinson John H, Michael F. Gardner, Blake A. Rowe, Hervé Schaffhauser, Lorrie P. Daggett, Rowena V. Cube, Anthony B. Pinkerton, Jean-Michel Vernier
المصدر: Bioorganic & Medicinal Chemistry Letters. 15:2389-2393
مصطلحات موضوعية: Allosteric modulator, Stereochemistry, Clinical Biochemistry, Allosteric regulation, Molecular Conformation, Pharmaceutical Science, Receptors, Metabotropic Glutamate, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Allosteric Regulation, Drug Discovery, Animals, Molecular Biology, Metabotropic glutamate receptor 5, Phenyl Ethers, Organic Chemistry, Glutamate receptor, Brain, Potentiator, Rats, Kinetics, Propanoic acid, Metabotropic receptor, chemistry, Guanosine 5'-O-(3-Thiotriphosphate), Butanes, Molecular Medicine, Propionates, Metabotropic glutamate receptor 2
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5
المؤلفون: Dana E. Rodriguez, Jean-Michel Vernier, Hutchinson John H, Hervé Schaffhauser, Anthony B. Pinkerton, Lorrie P. Daggett, Joyce K. James, Michael F. Gardner, Blake A. Rowe, Una Campbell, Rowena V. Cube
المصدر: Bioorganic & Medicinal Chemistry Letters. 15:1565-1571
مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Receptors, Metabotropic Glutamate, Biochemistry, Structure-Activity Relationship, Allosteric Regulation, Drug Discovery, Animals, Molecular Biology, Molecular Structure, Metabotropic glutamate receptor 5, Chemistry, Metabotropic glutamate receptor 4, Organic Chemistry, Metabotropic glutamate receptor 7, Metabotropic glutamate receptor 6, Brain, Potentiator, Rats, Disease Models, Animal, Metabotropic receptor, Models, Chemical, Indans, Schizophrenia, Molecular Medicine, Metabotropic glutamate receptor 1, Metabotropic glutamate receptor 2, Protein Binding
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6
المؤلفون: Ian A. McDonald, Rowena V. Cube, Bruce M. Baron, Jeffrey P. Whitten
المصدر: Bioorganic & Medicinal Chemistry Letters. 3:19-22
مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, Carboxylic acid, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, chemistry.chemical_compound, chemistry, Drug Discovery, Competitive NMDA Receptor Antagonists, Molecular Medicine, NMDA receptor, Piperidine, Molecular Biology, IC50, Methyl group
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7
المؤلفون: Cindy E. Nuss, Thomayant Prueksaritanont, Jeanine E. Ballard, John J. Renger, Yuhsin Kuo, Steven V. Fox, Rowena V. Cube, Thomas S. Reger, Shu Youheng, James C. Barrow, Kelly Ann S. Schlegel, George D. Hartman, Cuyue Tang, Georgia B. McGaughey, Yuxing Li, Zhi Qiang Yang, Victor N. Uebele, Christa Mattern, Scott M. Doran, Susan L. Garson, Richard L. Kraus, Kenneth E. Rittle
المصدر: Bioorganicmedicinal chemistry letters. 21(6)
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Calcium Channels, T-Type, Mice, In vivo, Amide, Drug Discovery, Animals, Rats, Wistar, Molecular Biology, Pregnane X receptor, Calcium channel, Organic Chemistry, T-type calcium channel, Antagonist, Calcium Channel Blockers, Amides, In vitro, Rats, chemistry, Molecular Medicine
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8
المؤلفون: Cindy E. Nuss, John J. Renger, Thomas S. Reger, Jeanine E. Ballard, Thomayant Prueksaritanont, Susan L. Garson, Mark G. Bock, Youheng Shu, Yuxing Li, Zhi Qiang Yang, Richard L. Kraus, Scott M. Doran, Kenneth E. Rittle, Victor N. Uebele, Rowena V. Cube, Cuyue Tang, Phung Bondiskey, Schlegel Kelly-Ann, Yuhsin Kuo, Steven V. Fox, James C. Barrow, George D. Hartman
المصدر: Bioorganicmedicinal chemistry letters. 20(17)
مصطلحات موضوعية: medicine.medical_specialty, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, Biological Availability, Biochemistry, Chemical synthesis, Calcium Channels, T-Type, Structure-Activity Relationship, In vivo, Internal medicine, Drug Discovery, medicine, Potency, Animals, Humans, Molecular Biology, Chromatography, High Pressure Liquid, Quinazolinones, Chemistry, Calcium channel, Organic Chemistry, T-type calcium channel, Antagonist, Biological activity, Haplorhini, Calcium Channel Blockers, Rats, Endocrinology, Anticonvulsant, Molecular Medicine
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9
المؤلفون: Daniel M. Muench, Bruce M. Baron, Jeffrey P. Whitten, Philip L. Nyce, Ian A. McDonald, Rowena V. Cube
المصدر: Bioorganic & Medicinal Chemistry Letters. 1:441-444
مصطلحات موضوعية: Stereochemistry, Chemistry, Organic Chemistry, Clinical Biochemistry, Antagonist, Glutamate receptor, Pharmaceutical Science, Biochemistry, Drug Discovery, Molecular Medicine, NMDA receptor, Molecular Biology, IC50
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10
المؤلفون: Ronald C. Bernotas, Rowena V. Cube
المصدر: Tetrahedron Letters. 32:161-164
مصطلحات موضوعية: Diethyl azodicarboxylate, chemistry.chemical_compound, chemistry, Reagent, Yield (chemistry), Organic Chemistry, Drug Discovery, Organic chemistry, Triphenylphosphine, Aliphatic compound, Biochemistry