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1دورية أكاديمية
المؤلفون: Karin Regnström, Jiangli Yan, Lan Nguyen, Kari Callaway, Yanli Yang, Linnea Diep, Weimei Xing, Anirban Adhikari, Paul Beroza, Roy K Hom, Brigit Riley, Don Rudolph, Michael F Jobling, Jeanne Baker, Jennifer Johnston, Andrei Konradi, Michael P Bova, Dean R Artis
المصدر: PLoS ONE, Vol 8, Iss 7, p e66879 (2013)
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: Karin Regnström, Jiangli Yan, Lan Nguyen, Kari Callaway, Yanli Yang, Linnea Diep, Weimei Xing, Anirban Adhikari, Paul Beroza, Roy K. Hom, Brigit Riley, Don Rudolph, Michael F. Jobling, Jeanne Baker, Jennifer Johnston, Andrei Konradi, Michael P. Bova, Dean R. Artis
المصدر: PLoS ONE, Vol 8, Iss 7 (2013)
وصف الملف: electronic resource
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3
المؤلفون: David F. Nakamura, Hing L. Sham, John-Michael Sauer, Dean R. Artis, Lany Ruslim, Ted Yednock, Michael A. Pleiss, Gary Probst, Marc Adler, Minghua Sun, Louis Brogley, Michael S. Dappen, Roy K. Hom, Michel Maillard, Nanhua Yao, Simeon Bowers, Andrei W. Konradi, Jay S. Tung, Raymond A. Ng, Andrea Gailunas, Wes Zmolek, Kevin P. Quinn, Fang Lawrence Y, Varghese John, R. Jeffrey Neitz, Michael P. Bova
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:4674-4679
مصطلحات موضوعية: Models, Molecular, Binding Sites, Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Substituent, Pharmaceutical Science, Biochemistry, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Drug Design, Drug Discovery, Ethylamines, Aspartic Acid Endopeptidases, Molecular Medicine, Structure–activity relationship, Chromane, Amyloid Precursor Protein Secretases, Chromans, Enzyme Inhibitors, Selectivity, Molecular Biology, Cells, Cultured
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4
المؤلفون: John P. Anderson, Dean R. Artis, Hing L. Sham, Roy K. Hom, Michael S. Dappen, Andrei W. Konradi, Simeon Bowers, Hu Pan, Robert A. Galemmo, Marc Adler, Pearl Tanaka, May Lin, Jeanne Baker, Lany Ruslim, Donald J. Fauss, Zhao Ren, Yong L. Zhu, Anh P. Truong, Danny Tam, Marcelle Bergeron, Lee H. Latimer, Paul Beroza, Jacek Jagodzinski, Heather Zhang, Michael P. Bova, George Tonn, Linnea Diep, Ruth Motter, Kent Fitzgerald, Nanhua Yao, Wayman Chan, Jennifer K. Hoffman, R. Jeffrey Neitz, Danielle L. Aubele
المصدر: ChemMedChem. 8:1295-1313
مصطلحات موضوعية: Male, Parkinson's disease, Polo-like kinase, Molecular Dynamics Simulation, Protein Serine-Threonine Kinases, Pharmacology, Biology, Blood–brain barrier, Biochemistry, Rats, Sprague-Dawley, Mice, chemistry.chemical_compound, In vivo, Drug Discovery, medicine, Animals, Humans, Protein Isoforms, Phosphorylation, General Pharmacology, Toxicology and Pharmaceutics, Protein Kinase Inhibitors, Alpha-synuclein, Binding Sites, Kinase, Drug discovery, Organic Chemistry, Brain, medicine.disease, Protein Structure, Tertiary, Rats, HEK293 Cells, medicine.anatomical_structure, chemistry, Blood-Brain Barrier, alpha-Synuclein, Molecular Medicine, Female, Half-Life
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5
المؤلفون: Anna Liao, Gary Probst, Pamela S. Keim, Kang Hu, Roy K. Hom, David A. Quincy, Michael S. Dappen, Grace T. Kwong, Jenifer Smith, Martin L. Neitzel, Ying-zi Xu, Elizabeth F. Brigham, Kevin P. Quinn, Frédérique Bard, Minghua Sun, Jing Wu, John-Michael Sauer, Dora Kholodenko, Hongbin Zhang, William Wallace, Matthew N. Mattson, Patricia Sacayon, Jacek Jagodzinski, Hing L. Sham, Brian T. Peterson, Simeon Bowers, Jennifer Marugg, Guriqbal S. Basi, Lee H. Latimer, Susanna S. Hemphill, Darren B. Dressen, Karina Wong, Kevin Tanaka, Michael P. Bova, Pamela Santiago, Daniel K. Ness, Anh P. Truong, Wes Zmolek, Lany Ruslim, Christopher Willits, Michael K. Lee, Andrei W. Konradi, Xiaocong M. Ye, Lam Nguyen, Chris M. Semko, Ted A. Yednock, Ruth N. Motter, Albert W. Garofalo, Erich Goldbach, Pearl Tanaka, Danielle L. Aubele
المصدر: Journal of Medicinal Chemistry. 56:5261-5274
مصطلحات موضوعية: Trifluoromethyl, biology, Stereochemistry, Quinoline, In vitro, chemistry.chemical_compound, chemistry, In vivo, Drug Discovery, biology.protein, medicine, Molecular Medicine, Structure–activity relationship, Chirality (chemistry), Amyloid precursor protein secretase, Semagacestat, medicine.drug
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6
المؤلفون: Roy K. Hom, Hing L. Sham, Kyle Powell, Gary Probst, Irene Griswold-Prenner, Simeon Bowers, Brian T. Peterson, Heather Zhang, Gergely Tóth, Frederique Bard, Jennifer Sealy, Karina Wong, Wayman Chan, May Lin, R. Jeffrey Neitz, Lany Ruslim, Bhushan Samant, David A. Quincy, Anh P. Truong, Robert A. Galemmo, Colin Lorentzen, Zhao Ren, Andrei W. Konradi, Mark Dryer, Wes Zmolek, Ted Yednock, Nanhua Yao, Erich Goldbach, Sarah J Wright, Hu Pan, Kevin P. Quinn, John-Michael Sauer, Dean R. Artis, George Tonn, Linda Chen
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:5521-5527
مصطلحات موضوعية: Models, Molecular, Drug, Metabolite, media_common.quotation_subject, Clinical Biochemistry, Pharmaceutical Science, Chemistry Techniques, Synthetic, Thiophenes, Pharmacology, Crystallography, X-Ray, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Pharmacokinetics, Drug Discovery, medicine, Animals, Structure–activity relationship, Protein Kinase Inhibitors, Molecular Biology, media_common, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Neurodegeneration, JNK Mitogen-Activated Protein Kinases, Brain, Stereoisomerism, medicine.disease, chemistry, Drug Design, Nerve Degeneration, Molecular Medicine, Penetrant (biochemical), Half-Life
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7
المؤلفون: Hing L. Sham, Gergley Tóth, Karina Wong, Ann Qin, Kyle Powell, David A. Quincy, Andrei W. Konradi, Nanhua Yao, Jennifer Sealy, David Chereau, Lany Ruslim, Gary Probst, Sarah J Wright, May Lin, Ted Yednock, Irene Griswold-Prenner, Wes Zmolek, Kevin P. Quinn, Hu Pan, Roy K. Hom, Simeon Bowers, Colin Lorentzen, Frederique Bard, John P. Anderson, Anh P. Truong, Zhao Ren, Robert A. Galemmo, John-Michael Sauer, Dean R. Artis, David F. Nakamura
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:315-319
مصطلحات موضوعية: Central Nervous System, Stereochemistry, Clinical Biochemistry, Aminopyridines, Pharmaceutical Science, Biochemistry, Mice, Structure-Activity Relationship, Mitogen-Activated Protein Kinase 10, Drug Discovery, medicine, Animals, Humans, Mitogen-Activated Protein Kinase 9, Structure–activity relationship, Computer Simulation, Protein Kinase Inhibitors, Molecular Biology, Binding Sites, biology, Triazines, Kinase, Chemistry, Organic Chemistry, Neurodegeneration, c-jun, Neurotoxicity, Neurodegenerative Diseases, medicine.disease, In vitro, Neuroprotective Agents, Mitogen-activated protein kinase, Microsomes, Liver, biology.protein, Molecular Medicine, Selectivity
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8
المؤلفون: Gergley Tóth, Hu Pan, Gary Probst, John-Michael Sauer, Dean R. Artis, Anh P. Truong, Michael P. Bova, Wes Zmolek, Ted Yednock, Jose Aquino, Michael S. Dappen, Kevin P. Quinn, Sukanto Sinha, Varghese John, Hing L. Sham, Michael A. Pleiss, Roy K. Hom, Lany Ruslim, Louis Brogley, Jennifer Sealy, Nanhua Yao, Larry Fang, Jay S. Tung, John A. Tucker, Eric Brecht, Andrei W. Konradi
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:4789-4794
مصطلحات موضوعية: Cell Membrane Permeability, Stereochemistry, Butanols, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Cns penetration, Structure-Activity Relationship, Acetamides, Drug Discovery, Aspartic Acid Endopeptidases, Humans, Structure–activity relationship, Protease Inhibitors, Molecular Biology, Cyclohexylamines, Binding Sites, Chemistry, Cellular Assay, Organic Chemistry, Passive permeability, Permeability (electromagnetism), Biophysics, Molecular Medicine, Amyloid Precursor Protein Secretases
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9
المؤلفون: Karina Wong, Erich Goldbach, Gary Probst, John-Michael Sauer, Andrei W. Konradi, Michael P. Bova, Hing L. Sham, Susanna S. Hemphill, Kevin P. Quinn, Guriqbal S. Basi, Simeon Bowers, Anh P. Truong, William Wallace, Roy K. Hom, Lan K. Nguyen, Albert W. Garofalo
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:6952-6956
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, Bridged Bicyclo Compounds, Structure-Activity Relationship, Alzheimer Disease, In vivo, Drug Discovery, Amyloid precursor protein, Humans, Protease Inhibitors, Molecular Biology, chemistry.chemical_classification, Sulfonamides, biology, Bicyclic molecule, Organic Chemistry, In vitro, Sulfonamide, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Amyloid Precursor Protein Secretases
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10
المؤلفون: Roy K. Hom
المصدر: Expert Opinion on Therapeutic Patents. 17:737-740
مصطلحات موضوعية: Pharmacology, chemistry.chemical_classification, Bicyclic molecule, Chemistry, Stereochemistry, General Medicine, Enzyme, Biochemistry, Mechanism of action, mental disorders, Drug Discovery, β secretase, medicine, medicine.symptom