يعرض 1 - 10 نتائج من 36 نتيجة بحث عن '"Roy K. Hom"', وقت الاستعلام: 0.87s تنقيح النتائج
  1. 1
    دورية أكاديمية
    Correction: Label Free Fragment Screening Using Surface Plasmon Resonance as a Tool for Fragment Finding – Analyzing Parkin, a Difficult CNS Target.

    المؤلفون: Karin Regnström, Jiangli Yan, Lan Nguyen, Kari Callaway, Yanli Yang, Linnea Diep, Weimei Xing, Anirban Adhikari, Paul Beroza, Roy K. Hom, Brigit Riley, Don Rudolph, Michael F. Jobling, Jeanne Baker, Jennifer Johnston, Andrei Konradi, Michael P. Bova, Dean R. Artis

    المصدر: PLoS ONE, Vol 8, Iss 7 (2013)

    مصطلحات موضوعية: Medicine, Science

    وصف الملف: electronic resource

    Relation: http://europepmc.org/articles/PMC3741026; https://doaj.org/toc/1932-6203

    URL الوصول: https://doaj.org/article/35a65012167b4ec79e99546bbcc2addb

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  2. 2
    دورية أكاديمية
    Label free fragment screening using surface plasmon resonance as a tool for fragment finding - analyzing parkin, a difficult CNS target.

    المؤلفون: Karin Regnström, Jiangli Yan, Lan Nguyen, Kari Callaway, Yanli Yang, Linnea Diep, Weimei Xing, Anirban Adhikari, Paul Beroza, Roy K Hom, Brigit Riley, Don Rudolph, Michael F Jobling, Jeanne Baker, Jennifer Johnston, Andrei Konradi, Michael P Bova, Dean R Artis

    المصدر: PLoS ONE, Vol 8, Iss 7, p e66879 (2013)

    مصطلحات موضوعية: Medicine, Science

    وصف الملف: electronic resource

    Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23861750/pdf/?tool=EBI; https://doaj.org/toc/1932-6203

    URL الوصول: https://doaj.org/article/49e73ef974d742cb8de3fc7bf2fab6d1

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  3. 3
    Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: Prime side chromane-containing inhibitors

    المؤلفون: David F. Nakamura, Hing L. Sham, John-Michael Sauer, Dean R. Artis, Lany Ruslim, Ted Yednock, Michael A. Pleiss, Gary Probst, Marc Adler, Minghua Sun, Louis Brogley, Michael S. Dappen, Roy K. Hom, Michel Maillard, Nanhua Yao, Simeon Bowers, Andrei W. Konradi, Jay S. Tung, Raymond A. Ng, Andrea Gailunas, Wes Zmolek, Kevin P. Quinn, Fang Lawrence Y, Varghese John, R. Jeffrey Neitz, Michael P. Bova

    المصدر: Bioorganic & Medicinal Chemistry Letters. 23:4674-4679

    مصطلحات موضوعية: Models, Molecular, Binding Sites, Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Substituent, Pharmaceutical Science, Biochemistry, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Drug Design, Drug Discovery, Ethylamines, Aspartic Acid Endopeptidases, Molecular Medicine, Structure–activity relationship, Chromane, Amyloid Precursor Protein Secretases, Chromans, Enzyme Inhibitors, Selectivity, Molecular Biology, Cells, Cultured

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7bd8b1a206227969363800a4024a00c
    https://doi.org/10.1016/j.bmcl.2013.06.006

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  4. 4
    Selective and Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors That Reduce α-Synuclein Phosphorylation in Rat Brain

    المؤلفون: John P. Anderson, Dean R. Artis, Hing L. Sham, Roy K. Hom, Michael S. Dappen, Andrei W. Konradi, Simeon Bowers, Hu Pan, Robert A. Galemmo, Marc Adler, Pearl Tanaka, May Lin, Jeanne Baker, Lany Ruslim, Donald J. Fauss, Zhao Ren, Yong L. Zhu, Anh P. Truong, Danny Tam, Marcelle Bergeron, Lee H. Latimer, Paul Beroza, Jacek Jagodzinski, Heather Zhang, Michael P. Bova, George Tonn, Linnea Diep, Ruth Motter, Kent Fitzgerald, Nanhua Yao, Wayman Chan, Jennifer K. Hoffman, R. Jeffrey Neitz, Danielle L. Aubele

    المصدر: ChemMedChem. 8:1295-1313

    مصطلحات موضوعية: Male, Parkinson's disease, Polo-like kinase, Molecular Dynamics Simulation, Protein Serine-Threonine Kinases, Pharmacology, Biology, Blood–brain barrier, Biochemistry, Rats, Sprague-Dawley, Mice, chemistry.chemical_compound, In vivo, Drug Discovery, medicine, Animals, Humans, Protein Isoforms, Phosphorylation, General Pharmacology, Toxicology and Pharmaceutics, Protein Kinase Inhibitors, Alpha-synuclein, Binding Sites, Kinase, Drug discovery, Organic Chemistry, Brain, medicine.disease, Protein Structure, Tertiary, Rats, HEK293 Cells, medicine.anatomical_structure, chemistry, Blood-Brain Barrier, alpha-Synuclein, Molecular Medicine, Female, Half-Life

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9de472a2de2bc218c1224fe31845aba
    https://doi.org/10.1002/cmdc.201300166

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  5. 5
    Discovery of (R)-4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-Cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): Metabolically Stable γ-Secretase Inhibitors that Selectively Inhibit the Production of Amyloid-β over Notch

    المؤلفون: Anna Liao, Gary Probst, Pamela S. Keim, Kang Hu, Roy K. Hom, David A. Quincy, Michael S. Dappen, Grace T. Kwong, Jenifer Smith, Martin L. Neitzel, Ying-zi Xu, Elizabeth F. Brigham, Kevin P. Quinn, Frédérique Bard, Minghua Sun, Jing Wu, John-Michael Sauer, Dora Kholodenko, Hongbin Zhang, William Wallace, Matthew N. Mattson, Patricia Sacayon, Jacek Jagodzinski, Hing L. Sham, Brian T. Peterson, Simeon Bowers, Jennifer Marugg, Guriqbal S. Basi, Lee H. Latimer, Susanna S. Hemphill, Darren B. Dressen, Karina Wong, Kevin Tanaka, Michael P. Bova, Pamela Santiago, Daniel K. Ness, Anh P. Truong, Wes Zmolek, Lany Ruslim, Christopher Willits, Michael K. Lee, Andrei W. Konradi, Xiaocong M. Ye, Lam Nguyen, Chris M. Semko, Ted A. Yednock, Ruth N. Motter, Albert W. Garofalo, Erich Goldbach, Pearl Tanaka, Danielle L. Aubele

    المصدر: Journal of Medicinal Chemistry. 56:5261-5274

    مصطلحات موضوعية: Trifluoromethyl, biology, Stereochemistry, Quinoline, In vitro, chemistry.chemical_compound, chemistry, In vivo, Drug Discovery, biology.protein, medicine, Molecular Medicine, Structure–activity relationship, Chirality (chemistry), Amyloid precursor protein secretase, Semagacestat, medicine.drug

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c5b61686f688dd0abd9c5edac66d7201
    https://doi.org/10.1021/jm301741t

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  6. 6
    Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration

    المؤلفون: Roy K. Hom, Hing L. Sham, Kyle Powell, Gary Probst, Irene Griswold-Prenner, Simeon Bowers, Brian T. Peterson, Heather Zhang, Gergely Tóth, Frederique Bard, Jennifer Sealy, Karina Wong, Wayman Chan, May Lin, R. Jeffrey Neitz, Lany Ruslim, Bhushan Samant, David A. Quincy, Anh P. Truong, Robert A. Galemmo, Colin Lorentzen, Zhao Ren, Andrei W. Konradi, Mark Dryer, Wes Zmolek, Ted Yednock, Nanhua Yao, Erich Goldbach, Sarah J Wright, Hu Pan, Kevin P. Quinn, John-Michael Sauer, Dean R. Artis, George Tonn, Linda Chen

    المصدر: Bioorganic & Medicinal Chemistry Letters. 21:5521-5527

    مصطلحات موضوعية: Models, Molecular, Drug, Metabolite, media_common.quotation_subject, Clinical Biochemistry, Pharmaceutical Science, Chemistry Techniques, Synthetic, Thiophenes, Pharmacology, Crystallography, X-Ray, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Pharmacokinetics, Drug Discovery, medicine, Animals, Structure–activity relationship, Protein Kinase Inhibitors, Molecular Biology, media_common, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Neurodegeneration, JNK Mitogen-Activated Protein Kinases, Brain, Stereoisomerism, medicine.disease, chemistry, Drug Design, Nerve Degeneration, Molecular Medicine, Penetrant (biochemical), Half-Life

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b679a372a052f80d8da68c92b9b5f4
    https://doi.org/10.1016/j.bmcl.2011.06.100

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  7. 7
    Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration

    المؤلفون: Hing L. Sham, Gergley Tóth, Karina Wong, Ann Qin, Kyle Powell, David A. Quincy, Andrei W. Konradi, Nanhua Yao, Jennifer Sealy, David Chereau, Lany Ruslim, Gary Probst, Sarah J Wright, May Lin, Ted Yednock, Irene Griswold-Prenner, Wes Zmolek, Kevin P. Quinn, Hu Pan, Roy K. Hom, Simeon Bowers, Colin Lorentzen, Frederique Bard, John P. Anderson, Anh P. Truong, Zhao Ren, Robert A. Galemmo, John-Michael Sauer, Dean R. Artis, David F. Nakamura

    المصدر: Bioorganic & Medicinal Chemistry Letters. 21:315-319

    مصطلحات موضوعية: Central Nervous System, Stereochemistry, Clinical Biochemistry, Aminopyridines, Pharmaceutical Science, Biochemistry, Mice, Structure-Activity Relationship, Mitogen-Activated Protein Kinase 10, Drug Discovery, medicine, Animals, Humans, Mitogen-Activated Protein Kinase 9, Structure–activity relationship, Computer Simulation, Protein Kinase Inhibitors, Molecular Biology, Binding Sites, biology, Triazines, Kinase, Chemistry, Organic Chemistry, Neurodegeneration, c-jun, Neurotoxicity, Neurodegenerative Diseases, medicine.disease, In vitro, Neuroprotective Agents, Mitogen-activated protein kinase, Microsomes, Liver, biology.protein, Molecular Medicine, Selectivity

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a612c27c0d960510e5c57743328c54cf
    https://doi.org/10.1016/j.bmcl.2010.11.010

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  8. 8
    Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: Structure–activity relationship of P2′ substituents

    المؤلفون: Gergley Tóth, Hu Pan, Gary Probst, John-Michael Sauer, Dean R. Artis, Anh P. Truong, Michael P. Bova, Wes Zmolek, Ted Yednock, Jose Aquino, Michael S. Dappen, Kevin P. Quinn, Sukanto Sinha, Varghese John, Hing L. Sham, Michael A. Pleiss, Roy K. Hom, Lany Ruslim, Louis Brogley, Jennifer Sealy, Nanhua Yao, Larry Fang, Jay S. Tung, John A. Tucker, Eric Brecht, Andrei W. Konradi

    المصدر: Bioorganic & Medicinal Chemistry Letters. 20:4789-4794

    مصطلحات موضوعية: Cell Membrane Permeability, Stereochemistry, Butanols, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Cns penetration, Structure-Activity Relationship, Acetamides, Drug Discovery, Aspartic Acid Endopeptidases, Humans, Structure–activity relationship, Protease Inhibitors, Molecular Biology, Cyclohexylamines, Binding Sites, Chemistry, Cellular Assay, Organic Chemistry, Passive permeability, Permeability (electromagnetism), Biophysics, Molecular Medicine, Amyloid Precursor Protein Secretases

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be5850a2826857f906d4175d1b9a311a
    https://doi.org/10.1016/j.bmcl.2010.06.112

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  9. 9
    N-Bridged bicyclic sulfonamides as inhibitors of γ-secretase

    المؤلفون: Karina Wong, Erich Goldbach, Gary Probst, John-Michael Sauer, Andrei W. Konradi, Michael P. Bova, Hing L. Sham, Susanna S. Hemphill, Kevin P. Quinn, Guriqbal S. Basi, Simeon Bowers, Anh P. Truong, William Wallace, Roy K. Hom, Lan K. Nguyen, Albert W. Garofalo

    المصدر: Bioorganic & Medicinal Chemistry Letters. 19:6952-6956

    مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, Bridged Bicyclo Compounds, Structure-Activity Relationship, Alzheimer Disease, In vivo, Drug Discovery, Amyloid precursor protein, Humans, Protease Inhibitors, Molecular Biology, chemistry.chemical_classification, Sulfonamides, biology, Bicyclic molecule, Organic Chemistry, In vitro, Sulfonamide, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Amyloid Precursor Protein Secretases

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f0f68b5faee06e48ea31b81668abdf3
    https://doi.org/10.1016/j.bmcl.2009.10.060

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  10. 10
    Bicyclic aminoimidazolone BACE1 inhibitors

    المؤلفون: Roy K. Hom

    المصدر: Expert Opinion on Therapeutic Patents. 17:737-740

    مصطلحات موضوعية: Pharmacology, chemistry.chemical_classification, Bicyclic molecule, Chemistry, Stereochemistry, General Medicine, Enzyme, Biochemistry, Mechanism of action, mental disorders, Drug Discovery, β secretase, medicine, medicine.symptom

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a743a0e7aafe38b8019de28d6034f5f1
    https://doi.org/10.1517/13543776.17.6.737

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