المؤلفون: Berglund, U. Warpman, Sanjiv, K., Gad, H., Kalderen, C., Koolmeister, T., Pham, T., Gokturk, C., Jafari, R., Maddalo, G., Seashore-Ludlow, B., Chernobrovkin, A., Manoilov, A., Pateras, I. S., Rasti, A., Jemth, A. -S, Almlof, I., Loseva, O., Visnes, T., Einarsdottir, B. O., Gaugaz, Fabienne Z., Saleh, Aljona, Platzack, B., Wallner, O. A., Vallin, K. S. A., Henriksson, M., Wakchaure, P., Borhade, S., Herr, P., Kallberg, Y., Baranczewski, Pawel, Homan, E. J., Wiita, E., Nagpal, V., Meijer, T., Schipper, N., Rudd, S. G., Brautigam, L., Lindqvist, Annika, Filppula, Anne, Lee, T-C, Artursson, Per, Nilsson, J. A., Gorgoulis, V. G., Lehtio, J., Zubarev, R. A., Scobie, M., Helleday, T.

المصدر: Annals of Oncology. 27(12):2275-2283

مصطلحات موضوعية: MTH1, reactive oxygen species, cancer, small molecule inhibitors, DNA damage

وصف الملف: electronic

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-316436
https://uu.diva-portal.org/smash/get/diva2:1077890/FULLTEXT01.pdf

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المؤلفون: Rudd, S. G., Paulin, C. B., Nikolaos, T., Sanjiv, K., Juliane, K., Myrberg, I. Hed, Axelsson, H., Rasti, A., Witta, E., Lee, S., Rassidakis, G. Z., Tamm, K. Pokrovskaja, Heyman, M., Grander, D., Lundback, T., Lehmann, Sören, Helleday, T., Henter, J. I., Schaller, T., Herold, N.

المصدر: Pediatric Blood & Cancer. 65(Suppl. 2):S419-S420

وصف الملف: print

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-365104

المؤلفون: Warpman Berglund U; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics., Sanjiv K; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics., Gad H; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics., Kalderén C; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics., Koolmeister T; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics., Pham T; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics., Gokturk C; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics., Jafari R; Clinical Proteomics Mass Spectrometry, Department of Oncology-Pathology., Maddalo G; Clinical Proteomics Mass Spectrometry, Department of Oncology-Pathology., Seashore-Ludlow B; Chemical Biology Consortium Sweden, Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics., Chernobrovkin A; Division of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Manoilov A; Division of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Pateras IS; Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece., Rasti A; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics., Jemth AS; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics., Almlöf I; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics., Loseva O; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics., Visnes T; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics., Einarsdottir BO; Sahlgrenska Translational Melanoma Group (SATMEG), Sahlgrenska Cancer Center, Department of Surgery, Institute of Clinical Sciences, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg., Gaugaz FZ; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics.; Department of Pharmacy and., Saleh A; Science for Life Laboratory Drug Discovery and Development Platform, ADME of Therapeutics facility, Department of Phamracy, Uppsala University, Uppsala, Sweden., Platzack B; Swedish Toxicology Sciences Research Center, Södertälje, Sweden., Wallner OA; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics., Vallin KS; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics., Henriksson M; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics., Wakchaure P; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics., Borhade S; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics., Herr P; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics., Kallberg Y; National Bioinformatics Infrastructure Sweden (NBIS), Science for Life Laboratory, Department of Medicine Solna, Karolinska Institutet, Stockholm., Baranczewski P; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics.; Science for Life Laboratory Drug Discovery and Development Platform, ADME of Therapeutics facility, Department of Phamracy, Uppsala University, Uppsala, Sweden., Homan EJ; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics., Wiita E; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics., Nagpal V; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics.; SP Process Development, Södertälje, Sweden., Meijer T; SP Process Development, Södertälje, Sweden., Schipper N; SP Process Development, Södertälje, Sweden., Rudd SG; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics., Bräutigam L; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics., Lindqvist A; Science for Life Laboratory Drug Discovery and Development Platform, ADME of Therapeutics facility, Department of Phamracy, Uppsala University, Uppsala, Sweden., Filppula A; Uppsala Drug Optimisation and Pharmaceutical Profiling Platform (UDOPP), Department of Pharmacy, Uppsala University, Uppsala, Sweden., Lee TC; Institute of biomedical sciences, Academia Sinica, Taipei-115, Taiwan., Artursson P; Department of Pharmacy and.; Science for Life Laboratory Drug Discovery and Development Platform, ADME of Therapeutics facility, Department of Phamracy, Uppsala University, Uppsala, Sweden.; Uppsala Drug Optimisation and Pharmaceutical Profiling Platform (UDOPP), Department of Pharmacy, Uppsala University, Uppsala, Sweden., Nilsson JA; Sahlgrenska Translational Melanoma Group (SATMEG), Sahlgrenska Cancer Center, Department of Surgery, Institute of Clinical Sciences, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg., Gorgoulis VG; Biomedical Research Foundation of the Academy of Athens, Athens, Greece.; Faculty Institute for Cancer Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK., Lehtiö J; Clinical Proteomics Mass Spectrometry, Department of Oncology-Pathology., Zubarev RA; Division of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Scobie M; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics., Helleday T; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics thomas.helleday@scilifelab.se.

المصدر: Annals of oncology : official journal of the European Society for Medical Oncology [Ann Oncol] 2016 Dec; Vol. 27 (12), pp. 2275-2283. Date of Electronic Publication: 2016 Nov 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 9007735 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1569-8041 (Electronic) Linking ISSN: 09237534 NLM ISO Abbreviation: Ann Oncol Subsets: MEDLINE

مواضيع طبية MeSH: DNA Repair Enzymes/*antagonists & inhibitors , Enzyme Inhibitors/*therapeutic use , Neoplasms/*drug therapy , Phosphoric Monoester Hydrolases/*antagonists & inhibitors , Pyrimidines/*administration & dosage, 8-Hydroxy-2'-Deoxyguanosine ; Animals ; Cell Line, Tumor ; DNA/genetics ; DNA/metabolism ; DNA Repair Enzymes/genetics ; DNA Repair Enzymes/metabolism ; Deoxyguanosine/analogs & derivatives ; Deoxyguanosine/isolation & purification ; Deoxyguanosine/metabolism ; Humans ; Mice ; Neoplasms/genetics ; Neoplasms/pathology ; Nucleotides/metabolism ; Oxidation-Reduction ; Phosphoric Monoester Hydrolases/genetics ; Phosphoric Monoester Hydrolases/metabolism ; Proto-Oncogene Proteins B-raf/genetics ; RNA, Small Interfering/genetics ; Xenograft Model Antitumor Assays