المؤلفون: Phillips, MA, White, KL, Kokkonda, S, Deng, X, White, J, El Mazouni, F, Marsh, KC, Tomchick, DR, Manjalanagara, K, Rudra, KR, Wirjanata, G, Noviyanti, R, Price, R, Marfurt, J, Shackleford, DM, Chiu, FCK, Campbell, M, Jimenez Diaz, MB, Ferrer-Bazaga, S, Angulo-Barturen, I, Martínez-Martínez, MS, Lafuente-Monasterio, MJ, Kaminsky, W, Silue, K, Zeeman, AM, Kocken, C, Leroy, D, Blasco, B, Rossignol, E, Rueckle, T, Matthews, D, Burrows, JN, Waterson, D, Palmer, MJ, Rathod, PK, Charman, SA

مصطلحات موضوعية: parasitic diseases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::00e11b608b9c68666f8abe95af7f779d
https://doi.org/10.1021/acsinfecdis.6b00144

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

المؤلفون: Phillips MA, White KL; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, VIC 3052, Australia., Kokkonda S; Departments of Chemistry and Global Health, University of Washington , Seattle, Washington 98195, United States., Deng X, White J; Departments of Chemistry and Global Health, University of Washington , Seattle, Washington 98195, United States., El Mazouni F, Marsh K; AbbVie Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064-6104, United States., Tomchick DR, Manjalanagara K; Syngene International Ltd. , 560 099 Bangalore, India., Rudra KR; Syngene International Ltd. , 560 099 Bangalore, India., Wirjanata G; Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University , P.O. Box 41096, Casuarina, NT 0811, Australia., Noviyanti R; Eijkman Institute for Molecular Biology , Jl. Diponegoro 69, 10430 Jakarta, Indonesia., Price RN; Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University , P.O. Box 41096, Casuarina, NT 0811, Australia.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford , Oxford OX3 7LJ, U.K., Marfurt J; Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University , P.O. Box 41096, Casuarina, NT 0811, Australia., Shackleford DM; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, VIC 3052, Australia., Chiu FC; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, VIC 3052, Australia., Campbell M; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, VIC 3052, Australia., Jimenez-Diaz MB; GlaxoSmithKline , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760, Spain., Bazaga SF; GlaxoSmithKline , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760, Spain., Angulo-Barturen I; GlaxoSmithKline , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760, Spain., Martinez MS; GlaxoSmithKline , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760, Spain., Lafuente-Monasterio M; GlaxoSmithKline , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760, Spain., Kaminsky W; Departments of Chemistry and Global Health, University of Washington , Seattle, Washington 98195, United States., Silue K; Centre Suisse de Recherches Scientifiques en Côte d'Ivoire , Km17, Route de Dabou, Adiopodoumé, BP 1303 Abidjan, Ivory Coast., Zeeman AM; Biomedical Primate Research Centre , 2288 GJ Rijswijk, The Netherlands., Kocken C; Biomedical Primate Research Centre , 2288 GJ Rijswijk, The Netherlands., Leroy D; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Blasco B; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Rossignol E; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Rueckle T; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Matthews D; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Burrows JN; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Waterson D; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Palmer MJ; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Rathod PK; Departments of Chemistry and Global Health, University of Washington , Seattle, Washington 98195, United States., Charman SA; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, VIC 3052, Australia.

المصدر: ACS infectious diseases [ACS Infect Dis] 2016 Dec 09; Vol. 2 (12), pp. 945-957. Date of Electronic Publication: 2016 Oct 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE

مواضيع طبية MeSH: Enzyme Inhibitors/*administration & dosage , Malaria, Falciparum/*prevention & control , Oxidoreductases Acting on CH-CH Group Donors/*antagonists & inhibitors , Plasmodium falciparum/*drug effects , Plasmodium falciparum/*enzymology , Protozoan Proteins/*antagonists & inhibitors , Pyrimidines/*pharmacology, Animals ; Antimalarials/chemistry ; Antimalarials/pharmacokinetics ; Dihydroorotate Dehydrogenase ; Dogs ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacokinetics ; Humans ; Malaria, Falciparum/drug therapy ; Malaria, Falciparum/parasitology ; Mice ; Oxidoreductases Acting on CH-CH Group Donors/genetics ; Oxidoreductases Acting on CH-CH Group Donors/metabolism ; Plasmodium falciparum/genetics ; Protozoan Proteins/genetics ; Protozoan Proteins/metabolism ; Pyrimidines/chemistry ; Rats ; Structure-Activity Relationship

المؤلفون: Kokkonda S; Departments of Chemistry and Global Health, University of Washington , Seattle, Washington 98195, United States., Deng X, White KL; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, VIC 3052, Australia., Coteron JM; GSK , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760 Spain., Marco M; GSK , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760 Spain., de Las Heras L; GSK , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760 Spain., White J; Departments of Chemistry and Global Health, University of Washington , Seattle, Washington 98195, United States., El Mazouni F, Tomchick DR, Manjalanagara K; Syngene International Ltd. , Bangalore 560 099, India., Rudra KR; Syngene International Ltd. , Bangalore 560 099, India., Chen G; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, VIC 3052, Australia., Morizzi J; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, VIC 3052, Australia., Ryan E; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, VIC 3052, Australia., Kaminsky W; Departments of Chemistry and Global Health, University of Washington , Seattle, Washington 98195, United States., Leroy D; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Martínez-Martínez MS; GSK , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760 Spain., Jimenez-Diaz MB; GSK , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760 Spain., Bazaga SF; GSK , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760 Spain., Angulo-Barturen I; GSK , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760 Spain., Waterson D; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Burrows JN; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Matthews D; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Charman SA; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, VIC 3052, Australia., Phillips MA, Rathod PK; Departments of Chemistry and Global Health, University of Washington , Seattle, Washington 98195, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2016 Jun 09; Vol. 59 (11), pp. 5416-31. Date of Electronic Publication: 2016 May 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antimalarials/*pharmacology , Enzyme Inhibitors/*pharmacology , Malaria, Falciparum/*drug therapy , Oxidoreductases Acting on CH-CH Group Donors/*antagonists & inhibitors , Plasmodium falciparum/*drug effects , Pyrimidines/*pharmacology , Triazoles/*pharmacology, Animals ; Antimalarials/chemical synthesis ; Antimalarials/chemistry ; Dihydroorotate Dehydrogenase ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Humans ; Mice ; Mice, SCID ; Molecular Structure ; Oxidoreductases Acting on CH-CH Group Donors/metabolism ; Parasitic Sensitivity Tests ; Plasmodium falciparum/enzymology ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Rats ; Structure-Activity Relationship ; Triazoles/chemical synthesis ; Triazoles/chemistry